{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:11:09Z","timestamp":1790475069392,"version":"4.1.0"},"reference-count":55,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0235463","type":"journal-article","created":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T17:38:23Z","timestamp":1593625103000},"page":"e0235463","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Chronic toxoplasmosis and sleepiness in obstructive sleep apnea: Is there a link?"],"prefix":"10.1371","volume":"15","author":[{"given":"C\u00e9line","family":"Dard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Bailly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"P\u00e9pin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Pierre","family":"Brenier-Pinchart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Fricker-Hidalgo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Peeters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5727-5441","authenticated-orcid":true,"given":"Herv\u00e9","family":"Pelloux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renaud","family":"Tamisier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,7,1]]},"reference":[{"issue":"4","key":"pone.0235463.ref001","first-page":"404","article-title":"Obstructive sleep apnea syndrome. Diagnostic strategies in various clinical settings","volume":"46","author":"M Netchita\u00eflo","year":"2017","journal-title":"Presse Med"},{"issue":"9","key":"pone.0235463.ref002","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1164\/rccm.2109080","article-title":"Epidemiology of obstructive sleep apnea: a population health perspective","volume":"165","author":"T Young","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"issue":"4","key":"pone.0235463.ref003","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/jsr.12039","article-title":"Residual sleepiness in sleep apnea patients treated by continuous positive airway pressure","volume":"22","author":"M Gasa","year":"2013","journal-title":"J Sleep Res"},{"issue":"6","key":"pone.0235463.ref004","doi-asserted-by":"crossref","first-page":"573","DOI":"10.5664\/jcsm.27662","article-title":"Obstructive sleep apnea and risk of motor vehicle crash: systematic review and meta-analysis","volume":"5","author":"S Tregear","year":"2009","journal-title":"J Clin Sleep Med"},{"issue":"6","key":"pone.0235463.ref005","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1183\/09031936.04.00127603","article-title":"Frontal brain lobe impairment in obstructive sleep apnoea: a proton MR spectroscopy study","volume":"24","author":"M Alchanatis","year":"2004","journal-title":"Eur Respir J"},{"issue":"1","key":"pone.0235463.ref006","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1183\/09031936.00040410","article-title":"Residual sleepiness in obstructive sleep apnoea: phenotype and related symptoms","volume":"38","author":"C Vernet","year":"2011","journal-title":"Eur Respir J"},{"issue":"6","key":"pone.0235463.ref007","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1183\/09031936.98.12061264","article-title":"Does arousal frequency predict daytime function?","volume":"12","author":"RN Kingshott","year":"1998","journal-title":"Eur Respir J"},{"issue":"4","key":"pone.0235463.ref008","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1556\/1886.2017.00033","article-title":"Toxoplasma gondii exposure and neurological disorders: an age- and gender-matched case-control pilot study","volume":"7","author":"C Alvarado-Esquivel","year":"2017","journal-title":"Eur J Microbiol Immunol"},{"issue":"9425","key":"pone.0235463.ref009","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/S0140-6736(04)16412-X","article-title":"Toxoplasmosis","volume":"363","author":"JG Montoya","year":"2004","journal-title":"Lancet"},{"key":"pone.0235463.ref010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/589295","article-title":"Toxoplasma on the brain: understanding host-pathogen interactions in chronic CNS infection","volume":"2012","author":"S Kamerkar","year":"2012","journal-title":"J Parasitol Res"},{"issue":"2","key":"pone.0235463.ref011","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.pt.2016.10.007","article-title":"Lifelong persistence of Toxoplasma cysts: a questionable dogma?","volume":"33","author":"S Rougier","year":"2017","journal-title":"Trends Parasitol"},{"issue":"5","key":"pone.0235463.ref012","doi-asserted-by":"crossref","first-page":"e01155","DOI":"10.1128\/mBio.01155-15","article-title":"Novel approaches reveal that Toxoplasma gondii bradyzoites within tissue cysts are dynamic and replicating entities in vivo","volume":"6","author":"E Watts","year":"2015","journal-title":"mBio"},{"issue":"12","key":"pone.0235463.ref013","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.pt.2015.10.005","article-title":"A bradyzoite is a bradyzoite is a bradyzoite?","volume":"31","author":"K. Kim","year":"2015","journal-title":"Trends Parasitol"},{"issue":"4","key":"pone.0235463.ref014","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s40588-016-0045-3","article-title":"reexamining chronic Toxoplasma gondii infection: surprising activity for a \u201cdormant\u201d parasite","volume":"3","author":"AP Sinai","year":"2016","journal-title":"Curr Clin Microbiol Rep"},{"issue":"1452","key":"pone.0235463.ref015","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1098\/rspb.2000.1182","article-title":"Fatal attraction in rats infected with Toxoplasma gondii","volume":"267","author":"M Berdoy","year":"2000","journal-title":"Proc Biol Sci"},{"issue":"15","key":"pone.0235463.ref016","doi-asserted-by":"crossref","first-page":"6442","DOI":"10.1073\/pnas.0608310104","article-title":"Behavioral changes induced by Toxoplasma infection of rodents are highly specific to aversion of cat odors","volume":"104","author":"A Vyas","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"pone.0235463.ref017","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.pt.2017.04.001","article-title":"Brains and brawn: Toxoplasma infections of the central nervous system and skeletal muscle","volume":"33","author":"EA Wohlfert","year":"2017","journal-title":"Trends Parasitol"},{"key":"pone.0235463.ref018","doi-asserted-by":"crossref","DOI":"10.14411\/fp.2015.015","article-title":"Association between latent toxoplasmosis and clinical course of schizophrenia\u2014continuous course of the disease is characteristic for Toxoplasma gondii-infected patients","volume":"62","author":"T Celik","year":"2015","journal-title":"Folia Parasitol (Praha)"},{"issue":"3","key":"pone.0235463.ref019","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1093\/schbul\/sbm005","article-title":"Toxoplasma gondii in individuals with schizophrenia: association with clinical and demographic factors and with mortality","volume":"33","author":"F Dickerson","year":"2007","journal-title":"Schizophr Bull"},{"issue":"3","key":"pone.0235463.ref020","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1177\/1533317513517049","article-title":"Possible link between Toxoplasma gondii and the anosmia associated with neurodegenerative diseases","volume":"29","author":"J. Prandota","year":"2014","journal-title":"Am J Alzheimers Dis Other Demen"},{"issue":"2","key":"pone.0235463.ref021","doi-asserted-by":"crossref","first-page":"e0003525","DOI":"10.1371\/journal.pntd.0003525","article-title":"Toxoplasmosis and epilepsy\u2014systematic review and meta analysis","volume":"9","author":"EB Ngoungou","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"issue":"1","key":"pone.0235463.ref022","doi-asserted-by":"crossref","first-page":"196","DOI":"10.2466\/12.15.16.PR0.111.4.196-197","article-title":"Toxoplasma gondii and homicide","volume":"111","author":"D. Lester","year":"2012","journal-title":"Psychol Rep"},{"issue":"6","key":"pone.0235463.ref023","doi-asserted-by":"crossref","first-page":"621","DOI":"10.7205\/MILMED-D-14-00488","article-title":"Relationship between Toxoplasma gondii and mood disturbance in women veterans","volume":"180","author":"AR Duffy","year":"2015","journal-title":"Mil Med"},{"issue":"4","key":"pone.0235463.ref024","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.biopsych.2012.01.003","article-title":"The relationship between Toxoplasma gondii infection and mood disorders in the third national health and nutrition survey","volume":"72","author":"BD Pearce","year":"2012","journal-title":"Biol Psychiatry"},{"key":"pone.0235463.ref025","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1471-2334-2-11","article-title":"Increased risk of traffic accidents in subjects with latent toxoplasmosis: a retrospective case-control study","volume":"2","author":"J Flegr","year":"2002","journal-title":"BMC Infect Dis"},{"key":"pone.0235463.ref026","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/1471-2334-9-72","article-title":"Increased incidence of traffic accidents in Toxoplasma-infected military drivers and protective effect RhD molecule revealed by a large-scale prospective cohort study","volume":"9","author":"J Flegr","year":"2009","journal-title":"BMC Infect Dis"},{"issue":"6","key":"pone.0235463.ref027","doi-asserted-by":"crossref","first-page":"485","DOI":"10.14411\/fp.2014.061","article-title":"Does the prevalence of latent toxoplasmosis and frequency of Rhesus-negative subjects correlate with the nationwide rate of traffic accidents?","volume":"61","author":"J Flegr","year":"2014","journal-title":"Folia Parasitol (Praha)"},{"issue":"1","key":"pone.0235463.ref028","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1186\/1756-3305-6-294","article-title":"Seroepidemiology of Toxoplasma gondii infection in drivers involved in road traffic accidents in the metropolitan area of Guadalajara, Jalisco, Mexico","volume":"6","author":"L Galv\u00e1n-Ram\u00edrez Mde","year":"2013","journal-title":"Parasit Vectors"},{"issue":"1\u20133","key":"pone.0235463.ref029","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.forsciint.2009.03.007","article-title":"Higher prevalence of toxoplasmosis in victims of traffic accidents suggest increased risk of traffic accident in Toxoplasma-infected inhabitants of Istanbul and its suburbs","volume":"187","author":"B Kocazeybek","year":"2009","journal-title":"Forensic Sci Int"},{"issue":"1\u20132","key":"pone.0235463.ref030","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.forsciint.2005.11.002","article-title":"Is Toxoplasma gondii a potential risk for traffic accidents in Turkey?","volume":"163","author":"K Yereli","year":"2006","journal-title":"Forensic Sci Int"},{"issue":"2","key":"pone.0235463.ref031","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1080\/00034983.1985.11811902","article-title":"Changes in brain concentrations of catecholamines and indoleamines in Toxoplasma gondii infected mice","volume":"79","author":"HH Stibbs","year":"1985","journal-title":"Ann Trop Med Parasitol"},{"key":"pone.0235463.ref032","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.neuroscience.2015.08.005","article-title":"Effect of parasitic infection on dopamine biosynthesis in dopaminergic cells","volume":"306","author":"HL Martin","year":"2015","journal-title":"Neuroscience"},{"issue":"3","key":"pone.0235463.ref033","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/pim.12173","article-title":"Persistence of Toxoplasma gondii in the central nervous system: a fine-tuned balance between t ite, the brain he paras and the immune system","volume":"37","author":"N Blanchard","year":"2015","journal-title":"Parasite Immunol"},{"issue":"1\u20132","key":"pone.0235463.ref034","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jns.2015.02.028","article-title":"Neurobiological studies on the relationship between toxoplasmosis and neuropsychiatric diseases","volume":"351","author":"S Fabiani","year":"2015","journal-title":"J Neurol Sci"},{"issue":"7","key":"pone.0235463.ref035","first-page":"549","article-title":"Progress of dopamine in obstructive sleep apnea hypopnea syndrome","volume":"52","author":"ZY Song","year":"2017","journal-title":"Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi"},{"issue":"1","key":"pone.0235463.ref036","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1152\/physrev.00043.2008","article-title":"Pathophysiology of sleep apnea","volume":"90","author":"JA Dempsey","year":"2010","journal-title":"Physiol Rev"},{"issue":"12","key":"pone.0235463.ref037","doi-asserted-by":"crossref","first-page":"e28925","DOI":"10.1371\/journal.pone.0028925","article-title":"The distribution of Toxoplasma gondii cysts in the brain of a mouse with latent toxoplasmosis: implications for the behavioral manipulation hypothesis","volume":"6","author":"M Berenreiterov\u00e1","year":"2011","journal-title":"PLoS One"},{"issue":"2","key":"pone.0235463.ref038","first-page":"320","article-title":"Neuroinflammation-associated aspecific manipulation of mouse predator fear by Toxoplasma gondii","volume":"30","author":"M Boillat","journal-title":"Cell Rep. 2020"},{"key":"pone.0235463.ref039","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.neubiorev.2018.11.012","article-title":"Toxoplasmosis: A pathway to neuropsychiatric disorders","volume":"96","author":"S Tyebji","year":"2019","journal-title":"Neurosci Biobehav Rev"},{"issue":"5","key":"pone.0235463.ref040","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.celrep.2014.02.002","article-title":"miR-146a and miR-155 delineate a MicroRNA fingerprint associated with Toxoplasma persistence in the host brain","volume":"6","author":"D Cannella","year":"2014","journal-title":"Cell Rep"},{"issue":"3","key":"pone.0235463.ref041","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1378\/chest.10-2531","article-title":"Noninvasive ventilation in mild obesity hypoventilation syndrome: a randomized controlled trial","volume":"141","author":"JC Borel","year":"2012","journal-title":"Chest"},{"issue":"4","key":"pone.0235463.ref042","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1093\/sleep\/15.4.376","article-title":"Reliability and factor analysis of the Epworth sleepiness scale","volume":"15","author":"MW Johns","year":"1992","journal-title":"Sleep"},{"issue":"3","key":"pone.0235463.ref043","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1046\/j.1440-1819.2001.00810.x","article-title":"Proposed supplements and amendments to \u201cA manual of standardized terminology, techniques and scoring system for sleep stages of human subjects\u201d, the Rechtschaffen & Kales (1968) standard","volume":"55","author":"T Hori","year":"2001","journal-title":"Psychiatry Clin Neurosci"},{"issue":"5","key":"pone.0235463.ref044","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1093\/sleep\/22.5.667","article-title":"Sleep-related breathing disorders in adults: recommendations for syndrome definition and measurement techniques in clinical research. The report of an American Academy of Sleep Medicine Task Force","volume":"22","year":"1999","journal-title":"Sleep"},{"issue":"5","key":"pone.0235463.ref045","first-page":"597","article-title":"Rules for scoring respiratory events in sleep: update of the 2007 AASM manual for the scoring of sleep and associated events","volume":"8","author":"RB Berry","year":"2012","journal-title":"Deliberations of the sleep apnea definitions task force of the American Academy of Sleep Medicine J Clin Sleep Med"},{"issue":"11","key":"pone.0235463.ref046","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1016\/j.jacc.2004.08.062","article-title":"Noninvasive identification of patients with early coronary atherosclerosis by assessment of digital reactive hyperemia","volume":"44","author":"PO Bonetti","year":"2004","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"pone.0235463.ref047","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1152\/japplphysiol.01285.2005","article-title":"Role of nitric oxide in the regulation of digital pulse volume amplitude in humans","volume":"101","author":"A Nohria","year":"2006","journal-title":"J Appl Physiol(1985)"},{"issue":"1","key":"pone.0235463.ref048","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.diagmicrobio.2005.04.005","article-title":"Comparative analysis of the VIDAS Toxo IgG IV assay in the detection of antibodies to Toxoplasma gondii","volume":"53","author":"N Roux-Buisson","year":"2005","journal-title":"Diagn Microbiol Infect Dis"},{"key":"pone.0235463.ref049","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.mimet.2017.01.003","article-title":"Long-term sera storage does not significantly modify the interpretation of toxoplasmosis serologies","volume":"134","author":"C Dard","year":"2017","journal-title":"J Microbiol Methods"},{"issue":"6","key":"pone.0235463.ref050","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.pt.2016.04.001","article-title":"Relevance of and new developments in serology for toxoplasmosis","volume":"32","author":"C Dard","year":"2016","journal-title":"Trends Parasitol"},{"issue":"9","key":"pone.0235463.ref051","doi-asserted-by":"crossref","first-page":"e75246","DOI":"10.1371\/journal.pone.0075246","article-title":"Mice infected with low-virulence strains of Toxoplasma gondii lose their innate aversion to cat urine, even after extensive parasite clearance","volume":"8","author":"WM Ingram","year":"2013","journal-title":"PloS One"},{"key":"pone.0235463.ref052","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.micpath.2018.11.021","article-title":"Behavioral evaluation of BALB\/c (Mus musculus) mice infected with genetically distinct strains of Toxoplasma gondii","volume":"126","author":"ECM Bezerra","year":"2019","journal-title":"Microb Pathog"},{"issue":"4","key":"pone.0235463.ref053","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1176\/appi.ajp.162.4.767","article-title":"Maternal exposure to toxoplasmosis and risk of schizophrenia in adult offspring","volume":"162","author":"AS Brown","year":"2005","journal-title":"Am J Psychiatry"},{"issue":"1\u20133","key":"pone.0235463.ref054","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.schres.2012.06.035","article-title":"Maternal antibodies to infectious agents and risk for non-affective psychoses in the offspring-a matched case-control study","volume":"140","author":"A Blomstr\u00f6m","year":"2012","journal-title":"Schizophr Res"},{"issue":"3","key":"pone.0235463.ref055","doi-asserted-by":"crossref","first-page":"e0116696","DOI":"10.1371\/journal.pone.0116696","article-title":"Infection and inflammation in schizophrenia and bipolar disorder: a genome wide study for interactions with genetic variation","volume":"10","author":"D Avramopoulos","year":"2015","journal-title":"PloS One"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0235463","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T17:38:53Z","timestamp":1593625133000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0235463"}},"subtitle":[],"editor":[{"given":"Andrea","family":"Romigi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,7,1]]},"references-count":55,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2020,7,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0235463","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,1]]}}}