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Stamova","year":"2014","journal-title":"PLoS ONE"},{"key":"pone.0235501.ref047","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1038\/jcbfm.2012.24","article-title":"TTC7B emerges as a novel risk factor for ischemic stroke through the convergence of several genome-wide approaches","volume":"32","author":"T Krug","year":"2012","journal-title":"Journal of Cerebral Blood Flow and Metabolism"},{"key":"pone.0235501.ref048","doi-asserted-by":"crossref","first-page":"3268","DOI":"10.1161\/STROKEAHA.108.517656","article-title":"The combined approach to lysis utilizing eptifibatide and rt-PA in acute ischemic stroke: the CLEAR stroke trial","volume":"39","author":"AM Pancioli","year":"2008","journal-title":"Stroke"},{"key":"pone.0235501.ref049","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nature10146","article-title":"Progress and challenges in translating the biology of atherosclerosis","volume":"473","author":"P 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(Interleukin-1\u03b2).","volume":"50","author":"C Diaz-Ca\u00f1estro","year":"2019","journal-title":"Stroke"},{"key":"pone.0235501.ref080","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1097\/MBC.0b013e328355111f","article-title":"Thrombin generation assay: a new tool to predict and optimize clinical outcome in cardiovascular patients?","volume":"23","author":"G Campo","year":"2012","journal-title":"Blood coagulation & fibrinolysis: an international journal in haemostasis and thrombosis"},{"key":"pone.0235501.ref081","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1194\/jlr.M064592","article-title":"Genetic association of long-chain acyl-CoA synthetase 1 variants with fasting glucose, diabetes, and subclinical atherosclerosis","volume":"57","author":"A Manichaikul","year":"2016","journal-title":"Journal of Lipid Research"},{"key":"pone.0235501.ref082","doi-asserted-by":"crossref","first-page":"E715","DOI":"10.1073\/pnas.1111600109","article-title":"Diabetes promotes an inflammatory macrophage phenotype and atherosclerosis through acyl-CoA synthetase 1","volume":"109","author":"JE Kanter","year":"2012","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"pone.0235501.ref083","doi-asserted-by":"crossref","first-page":"993","DOI":"10.2337\/db10-0607","article-title":"Serum Vascular Adhesion Protein-1 Predicts 10-Year Cardiovascular and Cancer Mortality in Individuals With Type 2 Diabetes.","volume":"60","author":"H-Y Li","year":"2011","journal-title":"Diabetes"},{"key":"pone.0235501.ref084","doi-asserted-by":"crossref","first-page":"3433","DOI":"10.1038\/s41598-019-39764-4","article-title":"Discovery and Validation of a Novel Neutrophil Activation Marker Associated with Obesity.","volume":"9","author":"Y Pan","year":"2019","journal-title":"Scientific Reports."},{"key":"pone.0235501.ref085","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.gene.2018.06.027","article-title":"Association between matrix metalloproteinase family gene polymorphisms and risk of ischemic stroke: A systematic review and meta-analysis of 29 studies","volume":"672","author":"S Misra","year":"2018","journal-title":"Gene"},{"key":"pone.0235501.ref086","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1161\/ATVBAHA.117.310340","article-title":"DNA Methylation and Age-Independent Cardiovascular Risk, an Epigenome-Wide Approach: The REGICOR Study (REgistre GIron\u00ed del COR).","volume":"38","author":"A Fern\u00e1ndez-Sanl\u00e9s","year":"2018","journal-title":"Arteriosclerosis, thrombosis, and vascular biology"},{"key":"pone.0235501.ref087","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2019.00112","article-title":"G Protein-Coupled Receptor Kinase 2 (GRK2) as a Potential Therapeutic Target in Cardiovascular and Metabolic Diseases.","volume":"10","author":"C Murga","year":"2019","journal-title":"Frontiers in Pharmacology."},{"key":"pone.0235501.ref088","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1084\/jem.20100239","article-title":"PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps","volume":"207","author":"P Li","year":"2010","journal-title":"The Journal of experimental medicine"},{"key":"pone.0235501.ref089","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1038\/nm.3887","article-title":"Diabetes primes neutrophils to undergo NETosis, which impairs wound healing","volume":"21","author":"SL Wong","year":"2015","journal-title":"Nature medicine"},{"key":"pone.0235501.ref090","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.99445","article-title":"Neutrophil accumulation and NET release contribute to thrombosis in HIT.","volume":"3","author":"K Gollomp","year":"2018","journal-title":"JCI Insight."},{"key":"pone.0235501.ref091","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1056\/NEJMoa1707914","article-title":"Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease.","volume":"377","author":"PM Ridker","year":"2017","journal-title":"New England Journal of Medicine"},{"key":"pone.0235501.ref092","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1182\/blood-2017-04-569111","article-title":"Coagulation factor XII in thrombosis and inflammation","volume":"131","author":"C Maas","year":"2018","journal-title":"Blood"},{"key":"pone.0235501.ref093","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1160\/TH17-08-0596","article-title":"Contact System Activation and Cancer: New Insights in the Pathophysiology of Cancer-Associated Thrombosis","volume":"118","author":"E Campello","year":"2018","journal-title":"Thrombosis and Haemostasis"},{"key":"pone.0235501.ref094","article-title":"Neutrophils: back in the thrombosis spotlight","author":"DF Noubouossie","year":"2019","journal-title":"Blood"},{"key":"pone.0235501.ref095","first-page":"5","article-title":"Anti-CD44 Antibody Treatment Lowers Hyperglycemia and Improves Insulin Resistance, Adipose Inflammation, and Hepatic Steatosis in Diet-Induced Obese Mice","author":"K Kodama","year":"2014","journal-title":"Diabetes"},{"key":"pone.0235501.ref096","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.ebiom.2019.07.046","article-title":"A 23 gene-based molecular prognostic score precisely predicts overall survival of breast cancer patients","volume":"46","author":"H Shimizu","year":"2019","journal-title":"EBioMedicine"},{"key":"pone.0235501.ref097","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.ebiom.2018.05.010","article-title":"RankProd Combined with Genetic Algorithm Optimized Artificial Neural Network Establishes a Diagnostic and Prognostic Prediction Model that Revealed C1QTNF3 as a Biomarker for Prostate 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