{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T06:02:32Z","timestamp":1771480952324,"version":"3.50.1"},"reference-count":73,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T00:00:00Z","timestamp":1593993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","award":["MIC-2016-018"],"award-info":[{"award-number":["MIC-2016-018"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0235605","type":"journal-article","created":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T17:25:05Z","timestamp":1594056305000},"page":"e0235605","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":28,"title":["In-vitro diagnostic point-of-care tests in paediatric ambulatory care: A systematic review and meta-analysis"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6229-5057","authenticated-orcid":true,"given":"Oliver","family":"Van Hecke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0442-9280","authenticated-orcid":true,"given":"Meriel","family":"Raymond","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph J.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7299-8939","authenticated-orcid":true,"given":"Philip","family":"Turner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clare R.","family":"Goyder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan Y.","family":"Verbakel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Van den Bruel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gail","family":"Hayward","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2020,7,6]]},"reference":[{"key":"pone.0235605.ref001","unstructured":"O\u2019Neill J. Tackling Drug-Resistant Infections Globally: final report and recommendations. 2016."},{"issue":"2","key":"pone.0235605.ref002","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1056\/NEJMoa1803185","article-title":"C-Reactive Protein Testing to Guide Antibiotic Prescribing for COPD Exacerbations","volume":"381","author":"CC Butler","year":"2019","journal-title":"The New England journal of medicine"},{"issue":"11","key":"pone.0235605.ref003","first-page":"Cd010130","article-title":"Biomarkers as point-of-care tests to guide prescription of antibiotics in patients with acute respiratory infections in primary care","author":"R Aabenhus","year":"2014","journal-title":"The Cochrane database of systematic reviews"},{"issue":"9899","key":"pone.0235605.ref004","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/S0140-6736(13)60994-0","article-title":"Effects of internet-based training on antibiotic prescribing rates for acute respiratory-tract infections: a multinational, cluster, randomised, factorial, controlled trial","volume":"382","author":"P Little","year":"2013","journal-title":"Lancet (London, England)"},{"issue":"1","key":"pone.0235605.ref005","doi-asserted-by":"crossref","first-page":"e119","DOI":"10.1016\/S2214-109X(18)30444-3","article-title":"Effect of point-of-care C-reactive protein testing on antibiotic prescription in febrile patients attending primary care in Thailand and Myanmar: an open-label, randomised, controlled trial","volume":"7","author":"T Althaus","year":"2019","journal-title":"The Lancet Global health"},{"issue":"69","key":"pone.0235605.ref006","first-page":"24","article-title":"The clinical utility of point-of-care tests for influenza in ambulatory care: A systematic review and meta-analysis. Clinical infectious diseases: an official publication of the","volume":"18","author":"JJ Lee","year":"2019","journal-title":"Infectious Diseases Society of America"},{"issue":"1","key":"pone.0235605.ref007","doi-asserted-by":"crossref","first-page":"e025036","DOI":"10.1136\/bmjopen-2018-025036","article-title":"Impact of point-of-care C reactive protein in ambulatory care: a systematic review and meta-analysis","volume":"9","author":"JY Verbakel","year":"2019","journal-title":"BMJ open"},{"issue":"1","key":"pone.0235605.ref008","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1093\/fampra\/cmx066","article-title":"Point-of-care testing in primary care patients with acute cardiopulmonary symptoms: a systematic review","volume":"35","author":"AMR Schols","year":"2018","journal-title":"Family practice"},{"key":"pone.0235605.ref009","doi-asserted-by":"crossref","first-page":"k1450","DOI":"10.1136\/bmj.k1450","article-title":"Diagnostic accuracy of point-of-care natriuretic peptide testing for chronic heart failure in ambulatory care: systematic review and meta-analysis","volume":"361","author":"KS Taylor","year":"2018","journal-title":"BMJ (Clinical research ed)"},{"issue":"9","key":"pone.0235605.ref010","doi-asserted-by":"crossref","first-page":"487","DOI":"10.5694\/j.1326-5377.2009.tb02910.x","article-title":"Does point-of-care testing lead to the same or better adherence to medication? A randomised controlled trial: the PoCT in General Practice Trial","volume":"191","author":"A Gialamas","year":"2009","journal-title":"The Medical journal of Australia"},{"issue":"10035","key":"pone.0235605.ref011","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1016\/S0140-6736(16)00620-6","article-title":"Clinical workload in UK primary care: a retrospective analysis of 100 million consultations in England, 2007\u201314","volume":"387","author":"FDR Hobbs","year":"2016","journal-title":"Lancet (London, England)"},{"issue":"5","key":"pone.0235605.ref012","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1136\/emj.2010.106229","article-title":"Medical problems presenting to paediatric emergency departments: 10 years on","volume":"29","author":"R Sands","year":"2012","journal-title":"Emergency medicine journal: EMJ"},{"issue":"1","key":"pone.0235605.ref013","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s12873-017-0145-2","article-title":"Who breaches the four-hour emergency department wait time target? A retrospective analysis of 374,000 emergency department attendances between 2008 and 2013 at a type 1 emergency department in England","volume":"17","author":"N Bobrovitz","year":"2017","journal-title":"BMC emergency medicine"},{"issue":"1","key":"pone.0235605.ref014","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1186\/s12936-018-2488-x","article-title":"Integrated fever management: disease severity markers to triage children with malaria and non-malarial febrile illness","volume":"17","author":"CR McDonald","year":"2018","journal-title":"Malaria journal"},{"key":"pone.0235605.ref015","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1471-2296-7-23","article-title":"Serious infections in children: an incidence study in family practice","volume":"7","author":"A Van den Bruel","year":"2006","journal-title":"BMC family practice"},{"issue":"9717","key":"pone.0235605.ref016","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/S0140-6736(09)62000-6","article-title":"Diagnostic value of clinical features at presentation to identify serious infection in children in developed countries: a systematic review","volume":"375","author":"A Van den Bruel","year":"2010","journal-title":"Lancet (London, England)"},{"issue":"10","key":"pone.0235605.ref017","doi-asserted-by":"crossref","first-page":"e7484","DOI":"10.1371\/journal.pone.0007484","article-title":"Increasing short-stay unplanned hospital admissions among children in England; time trends analysis \u201897-\u201906","volume":"4","author":"S Saxena","year":"2009","journal-title":"PloS one"},{"issue":"3","key":"pone.0235605.ref018","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1370\/afm.1786","article-title":"Impact of UK Primary Care Policy Reforms on Short-Stay Unplanned Hospital Admissions for Children With Primary Care-Sensitive Conditions","volume":"13","author":"E Cecil","year":"2015","journal-title":"Annals of family medicine"},{"issue":"5","key":"pone.0235605.ref019","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1136\/archdischild-2012-302383","article-title":"Increase in emergency admissions to hospital for children aged under 15 in England, 1999\u20132010: national database analysis","volume":"98","author":"PJ Gill","year":"2013","journal-title":"Archives of disease in childhood"},{"issue":"2","key":"pone.0235605.ref020","doi-asserted-by":"crossref","first-page":"e1002745","DOI":"10.1371\/journal.pmed.1002745","article-title":"The impact of targeted malaria elimination with mass drug administrations on falciparum malaria in Southeast Asia: A cluster randomised trial","volume":"16","author":"L von Seidlein","year":"2019","journal-title":"PLoS medicine"},{"issue":"3","key":"pone.0235605.ref021","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/inthealth\/ihy079","article-title":"The promise, problems and pitfalls of mass drug administration for malaria elimination: a qualitative study with scientists and policymakers","volume":"11","author":"N Kaehler","year":"2019","journal-title":"International health"},{"issue":"5","key":"pone.0235605.ref022","doi-asserted-by":"crossref","first-page":"e0007315","DOI":"10.1371\/journal.pntd.0007315","article-title":"Antibacterial mass drug administration for child mortality reduction: Opportunities, concerns, and possible next steps","volume":"13","author":"II Bogoch","year":"2019","journal-title":"PLoS neglected tropical diseases"},{"key":"pone.0235605.ref023","unstructured":"Systematic review to assess the impact of point-of-care tests on patients and healthcare processes [Internet]. PROSPERO. 2016 [cited 5 June 2019]. http:\/\/www.crd.york.ac.uk\/PROSPERO\/display_record.php?ID=CRD42016035426."},{"key":"pone.0235605.ref024","doi-asserted-by":"crossref","DOI":"10.1002\/9780470712184","volume-title":"Cochrane handbook for systematic reviews of interventions","author":"JPT Higgins","year":"2008"},{"key":"pone.0235605.ref025","unstructured":"Covidence systematic review software. [www.covidence.org."},{"key":"pone.0235605.ref026","unstructured":"Review Manager (RevMan) Version 5.3. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration 2014."},{"key":"pone.0235605.ref027","unstructured":"Stata Statistical Software: Release 14. 2015."},{"issue":"7","key":"pone.0235605.ref028","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.cmi.2018.11.019","article-title":"Impact of bedside diagnosis of influenza in the paediatric emergency ward","volume":"25","author":"A Cantais","year":"2019","journal-title":"Clinical Microbiology & Infection"},{"issue":"8","key":"pone.0235605.ref029","doi-asserted-by":"crossref","first-page":"e187","DOI":"10.1097\/INF.0000000000002287","article-title":"Rapid Influenza Testing in Infants and Children Younger than 6 Years in Primary Care: Impact on Antibiotic Treatment and Use of Health Services","volume":"38","author":"DL van Esso","year":"2019","journal-title":"Pediatric Infectious Disease Journal"},{"issue":"7","key":"pone.0235605.ref030","doi-asserted-by":"crossref","first-page":"316","DOI":"10.5694\/mja2.50049","article-title":"The impact of rapid molecular diagnostic testing for respiratory viruses on outcomes for emergency department patients","volume":"210","author":"N Wabe","year":"2019","journal-title":"Medical Journal of Australia"},{"issue":"668","key":"pone.0235605.ref031","doi-asserted-by":"crossref","first-page":"e204","DOI":"10.3399\/bjgp18X695033","article-title":"Reducing inappropriate antibiotic prescribing for children in primary care: a cluster randomised controlled trial of two interventions","volume":"68","author":"MB Lemiengre","year":"2018","journal-title":"The British journal of general practice: the journal of the Royal College of General Practitioners"},{"issue":"1","key":"pone.0235605.ref032","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s12916-016-0679-2","article-title":"Should all acutely ill children in primary care be tested with point-of-care CRP: a cluster randomised trial","volume":"14","author":"JY Verbakel","year":"2016","journal-title":"BMC medicine"},{"issue":"11","key":"pone.0235605.ref033","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1097\/QAD.0000000000001846","article-title":"Effect of point-of-care early infant diagnosis on antiretroviral therapy initiation and retention of patients","volume":"32","author":"IV Jani","year":"2018","journal-title":"AIDS (London, England)"},{"key":"pone.0235605.ref034","first-page":"h1019","article-title":"The impact of providing rapid diagnostic malaria tests on fever management in the private retail sector in Ghana: a cluster randomized trial","volume":"350","author":"EK Ansah","year":"2015","journal-title":"BMJ (Clinical research ed)"},{"issue":"4","key":"pone.0235605.ref035","doi-asserted-by":"crossref","first-page":"e0152960","DOI":"10.1371\/journal.pone.0152960","article-title":"Effect of Test-Based versus Presumptive Treatment of Malaria in Under-Five Children in Rural Ghana\u2014A Cluster-Randomised Trial","volume":"11","author":"F Baiden","year":"2016","journal-title":"PloS one"},{"issue":"3","key":"pone.0235605.ref036","doi-asserted-by":"crossref","first-page":"e0170998","DOI":"10.1371\/journal.pone.0170998","article-title":"The impact of an intervention to introduce malaria rapid diagnostic tests on fever case management in a high transmission setting in Uganda: A mixed-methods cluster-randomized trial (PRIME)","volume":"12","author":"CI Chandler","year":"2017","journal-title":"PloS one"},{"issue":"6","key":"pone.0235605.ref037","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.4269\/ajtmh.16-0598","article-title":"Referral Patterns of Community Health Workers Diagnosing and Treating Malaria: Cluster-Randomized Trials in Two Areas of High- and Low-Malaria Transmission in Southwestern Uganda","volume":"95","author":"S Lal","year":"2016","journal-title":"The American journal of tropical medicine and hygiene"},{"issue":"7","key":"pone.0235605.ref038","doi-asserted-by":"crossref","first-page":"e0129545","DOI":"10.1371\/journal.pone.0129545","article-title":"A Cluster Randomised Trial Introducing Rapid Diagnostic Tests into Registered Drug Shops in Uganda: Impact on Appropriate Treatment of Malaria","volume":"10","author":"AK Mbonye","year":"2015","journal-title":"PloS one"},{"issue":"5 Suppl","key":"pone.0235605.ref039","doi-asserted-by":"crossref","first-page":"21","DOI":"10.4269\/ajtmh.2012.11-0816","article-title":"Integrated community case management of fever in children under five using rapid diagnostic tests and respiratory rate counting: a multi-country cluster randomized trial","volume":"87","author":"D Mukanga","year":"2012","journal-title":"The American journal of tropical medicine and hygiene"},{"issue":"9","key":"pone.0235605.ref040","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1111\/tmi.12748","article-title":"Appropriate targeting of artemisinin-based combination therapy by community health workers using malaria rapid diagnostic tests: findings from randomized trials in two contrasting areas of high and low malaria transmission in south-western Uganda","volume":"21","author":"R Ndyomugyenyi","year":"2016","journal-title":"Tropical medicine & international health: TM & IH"},{"issue":"9","key":"pone.0235605.ref041","doi-asserted-by":"crossref","first-page":"e1000340","DOI":"10.1371\/journal.pmed.1000340","article-title":"Community case management of fever due to malaria and pneumonia in children under five in Zambia: a cluster randomized controlled trial","volume":"7","author":"K Yeboah-Antwi","year":"2010","journal-title":"PLoS medicine"},{"issue":"6","key":"pone.0235605.ref042","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1093\/jac\/dkn376","article-title":"Evaluation of a rapid antigen detection test in the diagnosis of streptococcal pharyngitis in children and its impact on antibiotic prescription","volume":"62","author":"HC Maltezou","year":"2008","journal-title":"The Journal of antimicrobial chemotherapy"},{"issue":"7","key":"pone.0235605.ref043","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1111\/j.1399-5448.2009.00635.x","article-title":"Utility of immediate hemoglobin A1c in children with type I diabetes mellitus","volume":"11","author":"MS Agus","year":"2010","journal-title":"Pediatric diabetes"},{"key":"pone.0235605.ref044","doi-asserted-by":"crossref","first-page":"c930","DOI":"10.1136\/bmj.c930","article-title":"Rapid testing for malaria in settings where microscopy is available and peripheral clinics where only presumptive treatment is available: a randomised controlled trial in Ghana","volume":"340","author":"EK Ansah","year":"2010","journal-title":"BMJ (Clinical research ed)"},{"issue":"1","key":"pone.0235605.ref045","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1080\/02813430050202541","article-title":"Randomised controlled trial of CRP rapid test as a guide to treatment of respiratory infections in general practice","volume":"18","author":"HZ Diederichsen","year":"2000","journal-title":"Scandinavian journal of primary health care"},{"issue":"9","key":"pone.0235605.ref046","doi-asserted-by":"crossref","first-page":"e633","DOI":"10.1016\/S2214-109X(16)30142-5","article-title":"Point-of-care C-reactive protein testing to reduce inappropriate use of antibiotics for non-severe acute respiratory infections in Vietnamese primary health care: a randomised controlled trial","volume":"4","author":"NT Do","year":"2016","journal-title":"The Lancet Global health"},{"issue":"1","key":"pone.0235605.ref047","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.jpeds.2008.07.043","article-title":"A randomized, controlled trial of the impact of early and rapid diagnosis of viral infections in children brought to an emergency department with febrile respiratory tract illnesses","volume":"154","author":"QH Doan","year":"2009","journal-title":"The Journal of pediatrics"},{"issue":"2","key":"pone.0235605.ref048","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.pepo.2017.01.006","article-title":"Rapid strip tests as a decision-making tool about antibiotic treatment in children\u2013A prospective study","volume":"92","author":"M Ma\u0142ecki","year":"2017","journal-title":"Pediatria Polska"},{"issue":"7","key":"pone.0235605.ref049","doi-asserted-by":"crossref","first-page":"e19753","DOI":"10.1371\/journal.pone.0019753","article-title":"Malaria rapid testing by community health workers is effective and safe for targeting malaria treatment: randomised cross-over trial in Tanzania","volume":"6","author":"M Mubi","year":"2011","journal-title":"PloS one"},{"issue":"1","key":"pone.0235605.ref050","doi-asserted-by":"crossref","first-page":"e012992","DOI":"10.1136\/bmjopen-2016-012992","article-title":"Factors predicting antibiotic prescription and referral to hospital for children with respiratory symptoms: secondary analysis of a randomised controlled study at out-of-hours services in primary care","volume":"7","author":"IK Rebnord","year":"2017","journal-title":"BMJ open"},{"issue":"4","key":"pone.0235605.ref051","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1136\/archdischild-2015-309228","article-title":"C-reactive protein point-of-care testing in acutely ill children: a mixed methods study in primary care","volume":"101","author":"A Van den Bruel","year":"2016","journal-title":"Archives of disease in childhood"},{"issue":"11","key":"pone.0235605.ref052","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1093\/cid\/ciz080","article-title":"Safety and Efficacy of C-reactive Protein-guided Antibiotic Use to Treat Acute Respiratory Infections in Tanzanian Children: A Planned Subgroup Analysis of a Randomized Controlled Noninferiority Trial Evaluating a Novel Electronic Clinical Decision Algorithm (ePOCT)","volume":"69","author":"K Keitel","year":"2019","journal-title":"Clinical infectious diseases: an official publication of the Infectious Diseases Society of America"},{"issue":"3","key":"pone.0235605.ref053","article-title":"Point-of-care C-reactive protein to assist in primary care management of children with suspected non-serious lower respiratory tract infection: A randomised controlled trial","volume":"2","author":"MJC Schot","year":"2018","journal-title":"BJGP Open"},{"issue":"11","key":"pone.0235605.ref054","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1097\/PEC.0b013e3181bec88c","article-title":"Impact of rapid streptococcal test on antibiotic use in a pediatric emergency department","volume":"25","author":"S Ayanruoh","year":"2009","journal-title":"Pediatric emergency care"},{"key":"pone.0235605.ref055","doi-asserted-by":"crossref","first-page":"j1054","DOI":"10.1136\/bmj.j1054","article-title":"Impact of introduction of rapid diagnostic tests for malaria on antibiotic prescribing: analysis of observational and randomised studies in public and private healthcare settings","volume":"356","author":"H Hopkins","year":"2017","journal-title":"BMJ (Clinical research ed)"},{"issue":"8","key":"pone.0235605.ref056","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1001\/archinte.1990.00040031696018","article-title":"Effects of a rapid antigen test for group A streptococcal pharyngitis on physician prescribing and antibiotic costs","volume":"150","author":"FA Meier","year":"1990","journal-title":"Archives of internal medicine"},{"issue":"9","key":"pone.0235605.ref057","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1097\/PEC.0000000000000466","article-title":"C-Reactive Protein Bedside Testing in Febrile Children Lowers Length of Stay at the Emergency Department","volume":"31","author":"RG Nijman","year":"2015","journal-title":"Pediatric emergency care"},{"issue":"6","key":"pone.0235605.ref058","doi-asserted-by":"crossref","first-page":"e373","DOI":"10.1016\/S2352-3018(19)30033-5","article-title":"Evaluation of a routine point-of-care intervention for early infant diagnosis of HIV: an observational study in eight African countries","volume":"6","author":"F Bianchi","year":"2019","journal-title":"The Lancet HIV"},{"key":"pone.0235605.ref059","first-page":"24","article-title":"A Pragmatic Study to Evaluate the Use of a Rapid Diagnostic Test to Detect Group A Streptococcal Pharyngitis in Children With the Aim of Reducing Antibiotic Use in a UK Emergency Department","volume":"24","author":"C Bird","year":"2018","journal-title":"Pediatric emergency care"},{"issue":"4","key":"pone.0235605.ref060","doi-asserted-by":"crossref","first-page":"e1000070","DOI":"10.1371\/journal.pmed.1000070","article-title":"Influence of rapid malaria diagnostic tests on treatment and health outcome in fever patients, Zanzibar: a crossover validation study","volume":"6","author":"MI Msellem","year":"2009","journal-title":"PLoS medicine"},{"issue":"2","key":"pone.0235605.ref061","doi-asserted-by":"crossref","first-page":"343","DOI":"10.4269\/ajtmh.2009.81.343","article-title":"Use of a histidine-rich protein 2-based rapid diagnostic test for malaria by health personnel during routine consultation of febrile outpatients in a peripheral health facility in Yaounde, Cameroon","volume":"81","author":"C Sayang","year":"2009","journal-title":"The American journal of tropical medicine and hygiene"},{"issue":"6","key":"pone.0235605.ref062","first-page":"1126","article-title":"Evaluation of impact of CRP rapid test in management of febrile children in ambulatory pediatric practice","volume":"15","author":"R Cohen","year":"2008","journal-title":"Archives de pediatrie: organe officiel de la Societe francaise de pediatrie"},{"issue":"5","key":"pone.0235605.ref063","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1093\/cid\/ciy169","article-title":"Significant Patient Impact Observed Upon Implementation of Point-of-Care Early Infant Diagnosis Technologies in an Observational Study in Malawi","volume":"67","author":"R Mwenda","year":"2018","journal-title":"Clinical infectious diseases: an official publication of the Infectious Diseases Society of America"},{"issue":"3","key":"pone.0235605.ref064","first-page":"179","article-title":"Outcome of presumptive versus rapid diagnostic tests-based management of childhood malaria\u2014pneumonia overlap in urban Nigeria: a pilot quasi-experimental study","volume":"20","author":"KN Ukwaja","year":"2010","journal-title":"Ethiopian journal of health sciences"},{"issue":"7549","key":"pone.0235605.ref065","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1136\/bmj.332.7549.1089","article-title":"Comparative accuracy: assessing new tests against existing diagnostic pathways","volume":"332","author":"PM Bossuyt","year":"2006","journal-title":"BMJ (Clinical research ed)"},{"key":"pone.0235605.ref066","first-page":"Cd010502","article-title":"Rapid antigen detection test for group A streptococcus in children with pharyngitis","volume":"7","author":"JF Cohen","year":"2016","journal-title":"The Cochrane database of systematic reviews"},{"issue":"1","key":"pone.0235605.ref067","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12874-016-0287-z","article-title":"Test-treatment RCTs are susceptible to bias: a review of the methodological quality of randomized trials that evaluate diagnostic tests","volume":"17","author":"L Ferrante di Ruffano","year":"2017","journal-title":"BMC medical research methodology"},{"issue":"11","key":"pone.0235605.ref068","doi-asserted-by":"crossref","first-page":"e029260","DOI":"10.1136\/bmjopen-2019-029260","article-title":"Introducing new point-of-care tests for common infections in publicly funded clinics in South Africa: a qualitative study with primary care clinicians","volume":"9","author":"O van Hecke","year":"2019","journal-title":"BMJ open"},{"issue":"1","key":"pone.0235605.ref069","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s13063-019-3215-9","article-title":"How context can impact clinical trials: a multi-country qualitative case study comparison of diagnostic biomarker test interventions","volume":"20","author":"MJ Haenssgen","year":"2019","journal-title":"Trials"},{"issue":"2","key":"pone.0235605.ref070","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD008998","article-title":"Rapid Diagnostic Tests versus clinical diagnosis for treating malaria","author":"J Odaga","year":"2011","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"5","key":"pone.0235605.ref071","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/j.1365-3156.2009.02246.x","article-title":"Rapid malaria diagnostic tests vs. clinical management of malaria in rural Burkina Faso: safety and effect on clinical decisions. A randomized trial","volume":"14","author":"Z Bisoffi","year":"2009","journal-title":"Tropical medicine & international health: TM & IH"},{"issue":"616","key":"pone.0235605.ref072","doi-asserted-by":"crossref","first-page":"e787","DOI":"10.3399\/bjgp13X674477","article-title":"Association between point-of-care CRP testing and antibiotic prescribing in respiratory tract infections: a systematic review and meta-analysis of primary care studies","volume":"63","author":"Y Huang","year":"2013","journal-title":"The British journal of general practice: the journal of the Royal College of General Practitioners"},{"issue":"9","key":"pone.0235605.ref073","doi-asserted-by":"crossref","first-page":"e015760","DOI":"10.1136\/bmjopen-2016-015760","article-title":"Common evidence gaps in point-of-care diagnostic test evaluation: a review of horizon scan reports","volume":"7","author":"JY Verbakel","year":"2017","journal-title":"BMJ open"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0235605","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,6]],"date-time":"2020-07-06T17:25:47Z","timestamp":1594056347000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0235605"}},"subtitle":[],"editor":[{"given":"Jos\u00e9","family":"Moreira","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,7,6]]},"references-count":73,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2020,7,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0235605","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,6]]}}}