{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:26:33Z","timestamp":1791224793839,"version":"4.1.0"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T00:00:00Z","timestamp":1594080000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012041","name":"Versus Arthritis","doi-asserted-by":"publisher","award":["20194"],"award-info":[{"award-number":["20194"]}],"id":[{"id":"10.13039\/501100012041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012041","name":"Versus Arthritis","doi-asserted-by":"publisher","award":["20843"],"award-info":[{"award-number":["20843"]}],"id":[{"id":"10.13039\/501100012041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012041","name":"Versus Arthritis","doi-asserted-by":"publisher","award":["18769"],"award-info":[{"award-number":["18769"]}],"id":[{"id":"10.13039\/501100012041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012041","name":"Versus Arthritis","doi-asserted-by":"publisher","award":["20777"],"award-info":[{"award-number":["20777"]}],"id":[{"id":"10.13039\/501100012041","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0235702","type":"journal-article","created":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T17:43:30Z","timestamp":1594143810000},"page":"e0235702","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Skeletal muscle dysregulation in rheumatoid arthritis: Metabolic and molecular markers in a rodent model and patients"],"prefix":"10.1371","volume":"15","author":[{"given":"Nuria","family":"Casanova-Vallve","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dumitru","family":"Constantin-Teodosiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Filer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rowan S.","family":"Hardy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul L.","family":"Greenhaff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Chapman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,7,7]]},"reference":[{"key":"pone.0235702.ref001","article-title":"Diagnosis and early management of inflammatory arthritis","volume":"358","author":"J Ledingham","year":"2017","journal-title":"BMJ"},{"key":"pone.0235702.ref002","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/nrrheum.2016.179","article-title":"Sedentary behaviour in RA\u2014a new research agenda","volume":"12","author":"SAM Fenton","year":"2016","journal-title":"Nat Rev Rheum"},{"issue":"5","key":"pone.0235702.ref003","doi-asserted-by":"crossref","first-page":"495","DOI":"10.2220\/biomedres.3.495","article-title":"Histological, immunological and biochemicals dtudies on type II collagen-induced arthritis in rats","volume":"3","author":"Kuniaki Terato","year":"1982","journal-title":"Biomed Res"},{"issue":"1","key":"pone.0235702.ref004","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1177\/019262339902700125","article-title":"Animal models of arthritis: relevance to human Disease","volume":"27","author":"A Bendele","year":"1999","journal-title":"Toxicol Pathol"},{"issue":"3","key":"pone.0235702.ref005","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1002\/jcsm.12280","article-title":"Collagen\u2010induced arthritis as an animal model of rheumatoid cachexia","volume":"9","author":"PVG Alabarse","year":"2018","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"Pt 22","key":"pone.0235702.ref006","doi-asserted-by":"crossref","first-page":"5589","DOI":"10.1113\/jphysiol.2008.160150","article-title":"A potential role for Akt\/FOXO signalling in both protein loss and the impairment of muscle carbohydrate oxidation during sepsis in rodent skeletal muscle","volume":"586","author":"H Crossland","year":"2008","journal-title":"J Physiol"},{"issue":"Pt 15","key":"pone.0235702.ref007","doi-asserted-by":"crossref","first-page":"3883","DOI":"10.1113\/jphysiol.2011.206193","article-title":"Novel events in the molecular regulation of muscle mass in critically ill patients","volume":"589","author":"D Constantin","year":"2011","journal-title":"J Physiol"},{"key":"pone.0235702.ref008","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/2044-5040-1-4","article-title":"Regulation of skeletal muscle growth by the IGF1-Akt\/PKB pathway: insights from genetic models","volume":"1","author":"S Schiaffino","year":"2011","journal-title":"Skelet Muscle"},{"issue":"3","key":"pone.0235702.ref009","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S1097-2765(04)00211-4","article-title":"The IGF-1\/PI3K\/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors","volume":"14","author":"TN Stitt","year":"2004","journal-title":"Mol Cell"},{"issue":"1","key":"pone.0235702.ref010","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/joim.12743","article-title":"Defective glucose and lipid metabolism in rheumatoid arthritis is determined by chronic inflammation in metabolic tissues","volume":"284","author":"I Arias de la Rosa","year":"2018","journal-title":"J Intern Med"},{"issue":"4","key":"pone.0235702.ref011","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.jbspin.2016.09.001","article-title":"Rheumatoid arthritis, insulin resistance, and diabetes","volume":"84","author":"J Nicolau","year":"2017","journal-title":"Joint Bone Spine"},{"issue":"11","key":"pone.0235702.ref012","doi-asserted-by":"crossref","first-page":"E925","DOI":"10.1152\/ajpendo.00503.2015","article-title":"Formoterol decreases muscle wasting as well as inflammation in the rat model of rheumatoid arthritis","volume":"310","author":"AB G\u00f3mez-SanMiguel","year":"2016","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"6","key":"pone.0235702.ref013","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1172\/JCI117244","article-title":"Rheumatoid cachexia: cytokine-driven hypermetabolism accompanying reduced body cell mass in chronic inflammation","volume":"93","author":"R Roubenoff","year":"1994","journal-title":"J Clin Invest"},{"issue":"5","key":"pone.0235702.ref014","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1113\/JP275444","article-title":"The impact of immobilisation and inflammation on the regulation of muscle mass and insulin resistance: different routes to similar end-points","volume":"597","author":"H Crossland","year":"2019","journal-title":"J Physiol"},{"key":"pone.0235702.ref015","article-title":"The recent understanding of the neurotrophin's role in skeletal muscle adaptation","volume":"201696","author":"K Sakuma","year":"2011","journal-title":"J Biomed biotechnol"},{"issue":"6","key":"pone.0235702.ref016","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1002\/art.34351","article-title":"Spinal cathepsin S and fractalkine contribute to chronic pain in the collagen-induced arthritis model","volume":"64","author":"AK Clark","year":"2012","journal-title":"Arthritis Rheum"},{"issue":"1","key":"pone.0235702.ref017","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","article-title":"Quantitative assessment of tactile allodynia in the rat paw","volume":"53","author":"SR Chaplan","year":"1994","journal-title":"J Neurosci Methods"},{"issue":"12","key":"pone.0235702.ref018","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1002\/art.27698","article-title":"Tonic modulation of spinal hyperexcitability by the endocannabinoid receptor system in a rat model of osteoarthritis pain","volume":"62","author":"DR Sagar","year":"2010","journal-title":"Arthritis Rheum"},{"issue":"4","key":"pone.0235702.ref019","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1017\/S1461145711000435","article-title":"Blockade of dopamine D3 but not D2 receptors reverses the novel object discrimination impairment produced by post-weaning social isolation: implications for schizophrenia and its treatment","volume":"15","author":"DJG Watson","year":"2012","journal-title":"International J Neuropsychoph"},{"key":"pone.0235702.ref020","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1016\/j.joca.2010.05.030","article-title":"The OARSI histopathology initiative; recommendations for histological assessments of osteoarthritis in the rat","volume":"18","author":"N Gerwin","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"pone.0235702.ref021","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.joca.2007.05.017","article-title":"Angiogenesis in two animal models of osteoarthritis","volume":"16","author":"PI Mapp","year":"2008","journal-title":"Osteoarthritis Cartilage"},{"issue":"2","key":"pone.0235702.ref022","doi-asserted-by":"crossref","first-page":"109","DOI":"10.3109\/00365517409082477","article-title":"Glycogen, glycolytic intermediates and high-energy phosphates determined in biopsy samples of musculus quadriceps femoris of man at rest. Methods and variance of values","volume":"33","author":"RC Harris","year":"1974","journal-title":"Scand J Clin Lab Invest"},{"key":"pone.0235702.ref023","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"O Lowry","year":"1951","journal-title":"J biol Chem"},{"issue":"2","key":"pone.0235702.ref024","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1042\/cs0810249","article-title":"Muscle composition in relation to age and sex","volume":"81","author":"AM Forsberg","year":"1991","journal-title":"Clin Sci"},{"issue":"3","key":"pone.0235702.ref025","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.intimp.2004.10.012","article-title":"FK506 ameliorates spontaneous locomotor activity in collagen-induced arthritis: implication of distinct effect from suppression of inflammation","volume":"5","author":"T Sasakawa","year":"2005","journal-title":"International Immunopharmacol"},{"key":"pone.0235702.ref026","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1186\/s12891-015-0802-0","article-title":"Improvement of spontaneous locomotor activity with JAK inhibition by JTE-052 in rat adjuvant-induced arthritis","volume":"16","author":"A Tanimoto","year":"2015","journal-title":"BMC Musculoskelet Disord"},{"issue":"2","key":"pone.0235702.ref027","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/AIA.0b013e318034194e","article-title":"Cytokines, inflammation and pain","volume":"45","author":"J-M Zhang","year":"2007","journal-title":"Int Anesthesiol clin"},{"key":"pone.0235702.ref028","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.expneurol.2019.03.005","article-title":"Upregulation of interleukin-6 on Cav3.2 T-type calcium channels in dorsal root ganglion neurons contributes to neuropathic pain in rats with spinal nerve ligation","volume":"317","author":"Q Liu","year":"2019","journal-title":"Ex Neurol"},{"key":"pone.0235702.ref029","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/ncprheum0972","article-title":"The molecular basis of pain and its clinical implications in rheumatology","volume":"5","author":"B Bingham","year":"2009","journal-title":"Nat Clin Pract Rheumatol"},{"issue":"2","key":"pone.0235702.ref030","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/art.27186","article-title":"Up\u2010regulation of cytokines and chemokines predates the onset of rheumatoid arthritis","volume":"62","author":"H Kokkonen","year":"2010","journal-title":"Arthritis Rheum"},{"issue":"4","key":"pone.0235702.ref031","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1084\/jem.187.4.461","article-title":"Interleukin 6 is required for the development of collagen-induced arthritis","volume":"187","author":"T Alonzi","year":"1998","journal-title":"J Exp Med"},{"issue":"12","key":"pone.0235702.ref032","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1177\/1535370213505961","article-title":"Muscle wasting in collagen-induced arthritis and disuse atrophy","volume":"238","author":"V de Oliveira Nunes Teixeira","year":"2013","journal-title":"Exp Biol Med"},{"issue":"Pt 8","key":"pone.0235702.ref033","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1113\/jphysiol.2009.183699","article-title":"Low-dose dexamethasone prevents endotoxaemia-induced muscle protein loss and impairment of carbohydrate oxidation in rat skeletal muscle","volume":"588","author":"H Crossland","year":"2010","journal-title":"J Physiol"},{"issue":"12","key":"pone.0235702.ref034","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1242\/jcs.163774","article-title":"Autocrine VEGF maintains endothelial survival through regulation of metabolism and autophagy","volume":"128","author":"CK Domigan","year":"2015","journal-title":"J Cell Sci"},{"issue":"9","key":"pone.0235702.ref035","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1136\/annrheumdis-2013-203416","article-title":"Augmented pain behavioural responses to intra-articular injection of nerve growth factor in two animal models of osteoarthritis","volume":"73","author":"S Ashraf","year":"2014","journal-title":"Ann Rheum Dis"},{"issue":"8","key":"pone.0235702.ref036","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/S0736-5748(00)00041-1","article-title":"Nerve growth factor (NGF) influences differentiation and proliferation of myogenic cells in vitro via TrKA","volume":"18","author":"M Rende","year":"2000","journal-title":"Int J Dev Neurosci"},{"issue":"3","key":"pone.0235702.ref037","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0092-8674(04)00400-3","article-title":"Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy","volume":"117","author":"M Sandri","year":"2004","journal-title":"Cell"},{"issue":"1","key":"pone.0235702.ref038","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1096\/fj.03-0610com","article-title":"Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression","volume":"18","author":"SH Lecker","year":"2004","journal-title":"FASEB journal: official publication of the Federation of American Societies for Experimental Biology"},{"issue":"1","key":"pone.0235702.ref039","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.mce.2009.05.017","article-title":"IGF-I system, atrogenes and myogenic regulatory factors in arthritis induced muscle wasting","volume":"309","author":"E Castillero","year":"2009","journal-title":"Mol Cell Endocrinol"},{"issue":"13","key":"pone.0235702.ref040","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1042\/CS20170958","article-title":"Peroxisome proliferator-activated receptor gamma agonism attenuates endotoxaemia-induced muscle protein loss and lactate accumulation in rats","volume":"131","author":"H Crossland","year":"2017","journal-title":"Clin Sci (Lond)"},{"issue":"1","key":"pone.0235702.ref041","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0300-483X(00)00273-0","article-title":"Metallothioneins, oxidative stress and the cardiovascular system","volume":"155","author":"R Nath","year":"2000","journal-title":"Toxicol"},{"issue":"9","key":"pone.0235702.ref042","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S0899-9007(97)00185-8","article-title":"Cytokines and cachexia","volume":"13","author":"P Matthys","year":"1997","journal-title":"Nutrition (Burbank, Los Angeles County, Calif)"},{"issue":"14","key":"pone.0235702.ref043","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1242\/jeb.017640","article-title":"Scaling of muscle architecture and fiber types in the rat hindlimb","volume":"211","author":"CM Eng","year":"2008","journal-title":"J Exp Biol"},{"issue":"1","key":"pone.0235702.ref044","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1748-1716.1983.tb07185.x","article-title":"Distribution of different fibre types in human skeletal muscles 2. A study of cross-sections of whole m. vastus lateralis","volume":"117","author":"J LEXELL","year":"1983","journal-title":"Acta Physiol Scand"},{"issue":"Suppl 1","key":"pone.0235702.ref045","first-page":"S39","article-title":"Of mice and men. When it comes to studying ageing and the means to slow it down, mice are not just small humans","volume":"6","author":"L Demetrius","year":"2005","journal-title":"EMBO Rep"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0235702","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T13:03:24Z","timestamp":1723208604000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0235702"}},"subtitle":[],"editor":[{"given":"Aldrin V.","family":"Gomes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,7,7]]},"references-count":45,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2020,7,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0235702","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,7]]}}}