{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:04:41Z","timestamp":1740146681776,"version":"3.37.3"},"reference-count":36,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T00:00:00Z","timestamp":1595376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["GM 085793"],"award-info":[{"award-number":["GM 085793"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100013779","name":"Retina Research Foundation","doi-asserted-by":"publisher","award":["Mary Ellen Wilson Research Project"],"award-info":[{"award-number":["Mary Ellen Wilson Research Project"]}],"id":[{"id":"10.13039\/100013779","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006784","name":"Golfers Against Cancer","doi-asserted-by":"publisher","award":["Award"],"award-info":[{"award-number":["Award"]}],"id":[{"id":"10.13039\/100006784","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0236175","type":"journal-article","created":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T17:30:30Z","timestamp":1595439030000},"page":"e0236175","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Inhibitors of metalloprotease, \u03b3-sectretase, protein kinase C and Rho kinase inhibit wild-type adenoviral replication"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3988-212X","authenticated-orcid":true,"given":"Alice","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6179-720X","authenticated-orcid":true,"given":"Cristhian J.","family":"Ildefonso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9715-0336","authenticated-orcid":true,"given":"Wesley S.","family":"Bond","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2940-9083","authenticated-orcid":true,"given":"Mary Y.","family":"Hurwitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard L.","family":"Hurwitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2020,7,22]]},"reference":[{"issue":"31","key":"pone.0236175.ref001","doi-asserted-by":"crossref","first-page":"7927","DOI":"10.1200\/JCO.2004.00.1883","article-title":"Response of retinoblastoma with vitreous tumor seeding to adenovirus-mediated delivery of thymidine kinase followed by ganciclovir.","volume":"23","author":"P Chevez-Barrios","year":"2005","journal-title":"J Clin Oncol"},{"issue":"10097","key":"pone.0236175.ref002","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0140-6736(17)31868-8","article-title":"Efficacy and safety of voretigene neparvovec (AAV2-hRPE65v2) in patients with RPE65-mediated inherited retinal dystrophy: a randomised, controlled, open-label, phase 3 trial.","volume":"390","author":"S Russell","year":"2017","journal-title":"Lancet"},{"issue":"10","key":"pone.0236175.ref003","first-page":"1885","article-title":"Absence of systemic immune response to adenovectors after intraocular administration to children with retinoblastoma.","volume":"18","author":"CJ Ildefonso","year":"2010","journal-title":"MolTher."},{"issue":"3","key":"pone.0236175.ref004","first-page":"566","article-title":"Modulation of Adenoviral Transduction In Vitro and In Vivo by Hyaluronan and its Receptor CD44.","volume":"15","author":"SR Chaudhuri","year":"2007","journal-title":"MolTher."},{"issue":"39","key":"pone.0236175.ref005","doi-asserted-by":"crossref","first-page":"32697","DOI":"10.1074\/jbc.M112.347369","article-title":"The liberation of CD44 intracellular domain modulates adenoviral vector transgene expression","volume":"287","author":"CJ Ildefonso","year":"2012","journal-title":"J Biol Chem"},{"issue":"35","key":"pone.0236175.ref006","doi-asserted-by":"crossref","first-page":"14381","DOI":"10.1074\/jbc.M116.773549","article-title":"Versican G1 domain enhances adenoviral-mediated transgene expression and can be modulated by inhibitors of the Janus kinase (JAK)\/STAT and Src family kinase pathways.","volume":"292","author":"PY Akinfenwa","year":"2017","journal-title":"J Biol Chem"},{"key":"pone.0236175.ref007","unstructured":"Diseases ACoI. Red Book (2018). Kimberlin DW, Brady MT, Jackson MA, editors2018. 1153 p."},{"issue":"1","key":"pone.0236175.ref008","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1556\/EuJMI.4.2014.1.2","article-title":"Human adenovirus: Viral pathogen with increasing importance.","volume":"4","author":"B Ghebremedhin","year":"2014","journal-title":"European journal of microbiology & immunology"},{"issue":"3","key":"pone.0236175.ref009","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1128\/CMR.5.3.262","article-title":"Adenoviruses in the immunocompromised host","volume":"5","author":"JC Hierholzer","year":"1992","journal-title":"Clin Microbiol Rev"},{"issue":"6","key":"pone.0236175.ref010","doi-asserted-by":"crossref","first-page":"421","DOI":"10.2174\/1566523213666131125095046","article-title":"Adenovirus vectors for gene therapy, vaccination and cancer gene therapy.","volume":"13","author":"WSM Wold","year":"2013","journal-title":"Current gene therapy."},{"issue":"32","key":"pone.0236175.ref011","first-page":"29420","article-title":"Hyaluronan-mediated CD44 interaction with RhoGEF and Rho kinase promotes Grb2-associated binder-1 phosphorylation and phosphatidylinositol 3-kinase signaling leading to cytokine (macrophage-colony stimulating factor) production and breast tumor progression.","volume":"278","author":"LY Bourguignon","year":"2003","journal-title":"JBiolChem."},{"issue":"39","key":"pone.0236175.ref012","first-page":"26533","article-title":"Hyaluronan-CD44 interaction with protein kinase C(epsilon) promotes oncogenic signaling by the stem cell marker Nanog and the Production of microrna-21, leading to down-regulation of the tumor suppressor protein PDCD4, anti-apoptosis, and chemotherapy resistance in breast tumor cells.","volume":"284","author":"LY Bourguignon","year":"2009","journal-title":"JBiolChem"},{"issue":"2","key":"pone.0236175.ref013","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/jmv.10382","article-title":"Rapid and quantitative detection of human adenovirus DNA by real-time PCR","volume":"70","author":"A Heim","year":"2003","journal-title":"J Med Virol"},{"issue":"6","key":"pone.0236175.ref014","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/sj.bmt.1703798","article-title":"Cidofovir for adenovirus infections after allogeneic hematopoietic stem cell transplantation: a survey by the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation","volume":"31","author":"P Ljungman","year":"2003","journal-title":"Bone Marrow Transplant"},{"issue":"9","key":"pone.0236175.ref015","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.healun.2007.06.009","article-title":"Treatment of adenovirus pneumonia with cidofovir in pediatric lung transplant recipients","volume":"26","author":"ML Doan","year":"2007","journal-title":"J Heart Lung Transplant"},{"issue":"3","key":"pone.0236175.ref016","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.bbmt.2016.12.621","article-title":"Brincidofovir for Asymptomatic Adenovirus Viremia in Pediatric and Adult Allogeneic Hematopoietic Cell Transplant Recipients: A Randomized Placebo-Controlled Phase II Trial.","volume":"23","author":"MS Grimley","year":"2017","journal-title":"Biol Blood Marrow Transplant"},{"issue":"1","key":"pone.0236175.ref017","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.bbmt.2006.08.040","article-title":"Treatment of adenovirus disease in stem cell transplant recipients with cidofovir","volume":"13","author":"D Neofytos","year":"2007","journal-title":"Biol Blood Marrow Transplant"},{"issue":"10","key":"pone.0236175.ref018","first-page":"1160","article-title":"Monoculture-derived T lymphocytes specific for multiple viruses expand and produce clinically relevant effects in immunocompromised individuals.","volume":"12","author":"AM Leen","year":"2006","journal-title":"NatMed"},{"issue":"4","key":"pone.0236175.ref019","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1097\/CJI.0000000000000034","article-title":"First-in-man clinical results with good manufacturing practice (GMP)-compliant polypeptide-expanded adenovirus-specific T cells after haploidentical hematopoietic stem cell transplantation.","volume":"37","author":"R Geyeregger","year":"2014","journal-title":"J Immunother"},{"issue":"6","key":"pone.0236175.ref020","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1158\/1078-0432.CCR-1183-02","article-title":"A phase I study of oral BMS-275291, a novel nonhydroxamate sheddase-sparing matrix metalloproteinase inhibitor, in patients with advanced or metastatic cancer","volume":"10","author":"NA Rizvi","year":"2004","journal-title":"Clin Cancer Res"},{"issue":"9","key":"pone.0236175.ref021","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1097\/01.cad.0000176504.86551.5c","article-title":"A phase I and pharmacokinetic study of the selective, non-peptidic inhibitor of matrix metalloproteinase BAY 12\u20139566 in combination with etoposide and carboplatin.","volume":"16","author":"JR Molina","year":"2005","journal-title":"Anticancer Drugs."},{"issue":"3","key":"pone.0236175.ref022","doi-asserted-by":"crossref","first-page":"207","DOI":"10.2174\/156720510791050920","article-title":"Discovery of notch-sparing gamma-secretase inhibitors.","volume":"7","author":"CE Augelli-Szafran","year":"2010","journal-title":"Curr Alzheimer Res"},{"issue":"1","key":"pone.0236175.ref023","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1167\/iovs.05-0757","article-title":"Inhibition of PKC beta by oral administration of ruboxistaurin is well tolerated and ameliorates diabetes-induced retinal hemodynamic abnormalities in patients","volume":"47","author":"LP Aiello","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"10","key":"pone.0236175.ref024","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1097\/IAE.0b013e3182111669","article-title":"Oral protein kinase c beta inhibition using ruboxistaurin: efficacy, safety, and causes of vision loss among 813 patients (1,392 eyes) with diabetic retinopathy in the Protein Kinase C beta Inhibitor-Diabetic Retinopathy Study and the Protein Kinase C beta Inhibitor-Diabetic Retinopathy Study 2.","volume":"31","author":"LP Aiello","year":"2011","journal-title":"Retina"},{"issue":"3","key":"pone.0236175.ref025","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1167\/iovs.12-11055","article-title":"The effect of the oral PKC beta inhibitor ruboxistaurin on vision loss in two phase 3 studies","volume":"54","author":"MJ Sheetz","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"pone.0236175.ref026","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1136\/bjophthalmol-2018-312244","article-title":"Intravitreal injection of a Rho-kinase inhibitor (fasudil) combined with bevacizumab versus bevacizumab monotherapy for diabetic macular oedema: a pilot randomised clinical trial.","volume":"103","author":"H Ahmadieh","year":"2019","journal-title":"Br J Ophthalmol"},{"issue":"5","key":"pone.0236175.ref027","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1083\/jcb.200108159","article-title":"Proteolytic release of CD44 intracellular domain and its role in the CD44 signaling pathway","volume":"155","author":"I Okamoto","year":"2001","journal-title":"J Cell Biol"},{"key":"pone.0236175.ref028","article-title":"Identification of a function for the CD44-Intracytoplasmic Domain (CD44-ICD): Modulation of MMP-9 transcription via a novel promoter response element.","author":"KE Miletti-Gonzalez","year":"2012","journal-title":"JBiolChem"},{"issue":"2\u20133","key":"pone.0236175.ref029","first-page":"123","article-title":"Anterior chamber associated immune deviation (ACAID): regulation, biological relevance, and implications for therapy.","volume":"21","author":"J Stein-Streilein","year":"2002","journal-title":"IntRevImmunol"},{"issue":"3","key":"pone.0236175.ref030","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1111\/j.1365-2567.2005.02239.x","article-title":"The analysis of systemic tolerance elicited by antigen inoculation into the vitreous cavity: vitreous cavity-associated immune deviation","volume":"116","author":"KH Sonoda","year":"2005","journal-title":"Immunology"},{"key":"pone.0236175.ref031","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0021-9258(18)75338-6","article-title":"The Polysaccharide of the Vitreous Humor","volume":"107","author":"K Meyer","year":"1934","journal-title":"J Biol Chem"},{"key":"pone.0236175.ref032","first-page":"1","volume-title":"Vitreous biochemistry, morphology, and clinical examination.","author":"J Sebag","year":"1992"},{"issue":"3","key":"pone.0236175.ref033","first-page":"387","article-title":"Involvement of CD44 in matrix metalloproteinase-2 regulation in human melanoma cells.","volume":"80","author":"K Takahashi","year":"1999"},{"issue":"5","key":"pone.0236175.ref034","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1083\/jcb.153.5.893","article-title":"Membrane-type 1 matrix metalloproteinase cleaves CD44 and promotes cell migration.","volume":"153","author":"M Kajita","year":"2001","journal-title":"JCell Biol."},{"issue":"10","key":"pone.0236175.ref035","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1038\/sj.onc.1206298","article-title":"Presenilin-dependent gamma-secretase activity mediates the intramembranous cleavage of CD44","volume":"22","author":"D Murakami","year":"2003","journal-title":"Oncogene"},{"issue":"10","key":"pone.0236175.ref036","first-page":"7327","article-title":"CD44 interaction with c-Src kinase promotes cortactin-mediated cytoskeleton function and hyaluronic acid-dependent ovarian tumor cell migration","volume":"276","author":"LY Bourguignon","year":"2001","journal-title":"JBiolChem"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0236175","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T13:30:37Z","timestamp":1616765437000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0236175"}},"subtitle":[],"editor":[{"given":"Ilya","family":"Ulasov","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,7,22]]},"references-count":36,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2020,7,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0236175","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2020,7,22]]}}}