{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T15:10:21Z","timestamp":1784214621076,"version":"3.55.0"},"reference-count":64,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T00:00:00Z","timestamp":1596758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","award":["4100112"],"award-info":[{"award-number":["4100112"]}],"id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0236283","type":"journal-article","created":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T13:48:15Z","timestamp":1596808095000},"page":"e0236283","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Plasma biomarkers of the amyloid pathway are associated with geographic atrophy secondary to age-related macular degeneration"],"prefix":"10.1371","volume":"15","author":[{"given":"Kameran","family":"Lashkari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5715-3847","authenticated-orcid":true,"given":"Gianna C.","family":"Teague","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Beattie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Betts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan M.","family":"McLaughlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J.","family":"L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,8,7]]},"reference":[{"issue":"3","key":"pone.0236283.ref001","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1001\/jamaophthalmol.2013.5799","article-title":"Geographic atrophy: a histopathological assessment","volume":"132","author":"AC Bird","year":"2014","journal-title":"JAMA Ophthalmol"},{"issue":"10","key":"pone.0236283.ref002","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1016\/S0161-6420(97)30079-7","article-title":"Visual function abnormalities and prognosis in eyes with age-related geographic atrophy of the macula and good visual acuity","volume":"104","author":"JS Sunness","year":"1997","journal-title":"Ophthalmology"},{"issue":"3","key":"pone.0236283.ref003","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.ophtha.2011.09.027","article-title":"Age and gender variations in age-related macular degeneration prevalence in populations of European ancestry: a meta-analysis","volume":"119","author":"AR Rudnicka","year":"2012","journal-title":"Ophthalmology"},{"issue":"2","key":"pone.0236283.ref004","doi-asserted-by":"crossref","first-page":"e106","DOI":"10.1016\/S2214-109X(13)70145-1","article-title":"Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis","volume":"2","author":"WL Wong","year":"2014","journal-title":"Lancet Glob Health"},{"issue":"5","key":"pone.0236283.ref005","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1097\/IAE.0000000000001392","article-title":"The Pathophysiology of Geographic Atrophy Secondary to Age-Related Macular Degeneration and the Complement Pathway as a Therapeutic Target","volume":"37","author":"DS Boyer","year":"2017","journal-title":"Retina"},{"issue":"23","key":"pone.0236283.ref006","doi-asserted-by":"crossref","first-page":"14682","DOI":"10.1073\/pnas.222551899","article-title":"Drusen proteome analysis: an approach to the etiology of age-related macular degeneration","volume":"99","author":"JW Crabb","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"pone.0236283.ref007","doi-asserted-by":"crossref","first-page":"a017194","DOI":"10.1101\/cshperspect.a017194","article-title":"The proteomics of drusen","volume":"4","author":"JW Crabb","year":"2014","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"2","key":"pone.0236283.ref008","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1167\/iovs.07-1072","article-title":"Complement-associated deposits in the human retina","volume":"49","author":"A Seth","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"Suppl 1","key":"pone.0236283.ref009","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1097\/IAE.0000000000001330","article-title":"Visualizing Retinal Pigment Epithelium Phenotypes in the Transition to Atrophy in Neovascular Age-Related Macular Degeneration","volume":"36","author":"EC Zanzottera","year":"2016","journal-title":"Retina"},{"issue":"6","key":"pone.0236283.ref010","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/j.ophtha.2013.12.034","article-title":"Reticular pseudodrusen: a risk factor for geographic atrophy in fellow eyes of individuals with unilateral choroidal neovascularization","volume":"121","author":"RP Finger","year":"2014","journal-title":"Ophthalmology"},{"issue":"6","key":"pone.0236283.ref011","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/j.ophtha.2016.02.009","article-title":"Correlation of Histologic Features with In Vivo Imaging of Reticular Pseudodrusen","volume":"123","author":"U Greferath","year":"2016","journal-title":"Ophthalmology"},{"key":"pone.0236283.ref012","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.2147\/OPTH.S130165","article-title":"Spotlight on reticular pseudodrusen","volume":"11","author":"A Rabiolo","year":"2017","journal-title":"Clin Ophthalmol"},{"issue":"5720","key":"pone.0236283.ref013","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1126\/science.1110189","article-title":"Complement factor H polymorphism and age-related macular degeneration","volume":"308","author":"AO Edwards","year":"2005","journal-title":"Science"},{"issue":"3","key":"pone.0236283.ref014","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1586\/17469899.2.3.443","article-title":"Genetic markers and biomarkers for age-related macular degeneration","volume":"2","author":"RJ Ross","year":"2007","journal-title":"Expert Rev Ophthalmol"},{"issue":"2","key":"pone.0236283.ref015","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.ophtha.2011.07.056","article-title":"Risk alleles in CFH and ARMS2 are independently associated with systemic complement activation in age-related macular degeneration","volume":"119","author":"D Smailhodzic","year":"2012","journal-title":"Ophthalmology"},{"issue":"11","key":"pone.0236283.ref016","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1038\/ng.2741","article-title":"Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration","volume":"45","author":"JM Seddon","year":"2013","journal-title":"Nat Genet"},{"issue":"7","key":"pone.0236283.ref017","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/ng.2640","article-title":"A functional variant in the CFI gene confers a high risk of age-related macular degeneration","volume":"45","author":"JP van de Ven","year":"2013","journal-title":"Nat Genet"},{"issue":"1","key":"pone.0236283.ref018","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s12974-016-0548-0","article-title":"Multiallelic copy number variation in the complement component 4A (C4A) gene is associated with late-stage age-related macular degeneration (AMD)","volume":"13","author":"F Grassmann","year":"2016","journal-title":"J Neuroinflammation"},{"issue":"15","key":"pone.0236283.ref019","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.1093\/hmg\/ddy178","article-title":"Functional analyses of rare genetic variants in complement component C9 identified in patients with age-related macular degeneration","volume":"27","author":"M Kremlitzka","year":"2018","journal-title":"Hum Mol Genet"},{"issue":"12","key":"pone.0236283.ref020","doi-asserted-by":"crossref","first-page":"5818","DOI":"10.1167\/iovs.09-3928","article-title":"Plasma complement components and activation fragments: associations with age-related macular degeneration genotypes and phenotypes","volume":"50","author":"R Reynolds","year":"2009","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"6","key":"pone.0236283.ref021","first-page":"8","article-title":"Design Characteristics of Geographic Atrophy Treatment Trials","volume":"2","author":"Cheng QEG Jeffrey","year":"2018","journal-title":"Systemic Review of Registered Trials in ClinicalTrials.gov. Ophthalmology Retina"},{"issue":"395","key":"pone.0236283.ref022","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaf1443","article-title":"Targeting factor D of the alternative complement pathway reduces geographic atrophy progression secondary to age-related macular degeneration","volume":"9","author":"BL Yaspan","year":"2017","journal-title":"Sci Transl Med"},{"issue":"6","key":"pone.0236283.ref023","first-page":"12","article-title":"al. e. Efficacy and safety of lampalizumab for geographic atrophy due to age-related macular degeneration- Chroma and Spectri Phase 3 randomized clinical trials","volume":"136","author":"FG Holz","year":"2018","journal-title":"JAMA Ophthalmol"},{"key":"pone.0236283.ref024","article-title":"APL-2 slows growth of GA in phase II safety and efficacy trial","year":"2018","journal-title":"Modern Retina"},{"issue":"2","key":"pone.0236283.ref025","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.exer.2003.10.011","article-title":"Characterization of beta amyloid assemblies in drusen: the deposits associated with aging and age-related macular degeneration","volume":"78","author":"DH Anderson","year":"2004","journal-title":"Exp Eye Res"},{"issue":"1","key":"pone.0236283.ref026","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/jcp.21742","article-title":"Amyloid-beta up-regulates complement factor B in retinal pigment epithelial cells through cytokines released from recruited macrophages\/microglia: Another mechanism of complement activation in age-related macular degeneration","volume":"220","author":"J Wang","year":"2009","journal-title":"J Cell Physiol"},{"issue":"3","key":"pone.0236283.ref027","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1167\/iovs.12-10849","article-title":"Inflammatory mediators induced by amyloid-beta in the retina and RPE in vivo: implications for inflammasome activation in age-related macular degeneration","volume":"54","author":"RT Liu","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"pone.0236283.ref028","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s12035-014-8886-3","article-title":"Beta-Amyloid Precursor Protein (betaAPP) Processing in Alzheimer's Disease (AD) and Age-Related Macular Degeneration (AMD)","volume":"52","author":"Y Zhao","year":"2015","journal-title":"Mol Neurobiol"},{"issue":"24","key":"pone.0236283.ref029","first-page":"14","article-title":"Amyloid B induces early changes in the ribosomal machinery, cytoskeletal organization and oxidative phosphorylation in retinal photoreceptor cells","volume":"12","author":"L. Deng","year":"2019","journal-title":"Frontiers in Molecular Neuroscience"},{"issue":"5","key":"pone.0236283.ref030","doi-asserted-by":"crossref","first-page":"e0195751","DOI":"10.1371\/journal.pone.0195751","article-title":"A monoclonal antibody targeting amyloid \u03b2 (A\u03b2) restores complement factor I bioactivity: Potential implications in age-related macular degeneration and Alzheimer's disease","volume":"13","author":"K Lashkari","year":"2018","journal-title":"PLoS One"},{"issue":"10","key":"pone.0236283.ref031","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.oret.2018.03.001","article-title":"A Randomized Phase 2 Study of an Anti-Amyloid beta Monoclonal Antibody in Geographic Atrophy Secondary to Age-Related Macular Degeneration","volume":"2","author":"PJ Rosenfeld","year":"2018","journal-title":"Ophthalmol Retina"},{"key":"pone.0236283.ref032","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1750-1326-10-2","article-title":"Heteromers of amyloid precursor protein in cerebrospinal fluid","volume":"10","author":"I Cuchillo-Ibanez","year":"2015","journal-title":"Mol Neurodegener"},{"issue":"1","key":"pone.0236283.ref033","doi-asserted-by":"crossref","first-page":"712","DOI":"10.4049\/jimmunol.181.1.712","article-title":"Altered function of factor I caused by amyloid beta: implication for pathogenesis of age-related macular degeneration from Drusen","volume":"181","author":"J Wang","year":"2008","journal-title":"J Immunol"},{"issue":"44","key":"pone.0236283.ref034","doi-asserted-by":"crossref","first-page":"29615","DOI":"10.1074\/jbc.R800019200","article-title":"Amyloid precursor protein trafficking, processing, and function","volume":"283","author":"G Thinakaran","year":"2008","journal-title":"J Biol Chem"},{"issue":"4","key":"pone.0236283.ref035","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/scrt77","article-title":"Soluble amyloid precursor protein: a novel proliferation factor of adult progenitor cells of ectodermal and mesodermal origin","volume":"2","author":"MP Demars","year":"2011","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"pone.0236283.ref036","doi-asserted-by":"crossref","first-page":"311","DOI":"10.3233\/JAD-2010-1221","article-title":"3rd. Alzheimer's disease and the amyloid-beta peptide","volume":"19","author":"MP Murphy","year":"2010","journal-title":"J Alzheimers Dis"},{"issue":"8","key":"pone.0236283.ref037","doi-asserted-by":"crossref","first-page":"4226","DOI":"10.1167\/iovs.09-3910","article-title":"Interferon gamma-inducible protein-10 (IP-10) and eotaxin as biomarkers in age-related macular degeneration","volume":"51","author":"FM Mo","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"9","key":"pone.0236283.ref038","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1358\/dof.2011.036.09.1678338","article-title":"Carboxyethylpyrrole plasma biomarkers in age-related macular degeneration","volume":"36","author":"D Ardeljan","year":"2011","journal-title":"Drugs Future"},{"key":"pone.0236283.ref039","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.preteyeres.2016.04.003","article-title":"Risk factors and biomarkers of age-related macular degeneration","volume":"54","author":"NG Lambert","year":"2016","journal-title":"Prog Retin Eye Res"},{"issue":"1","key":"pone.0236283.ref040","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1167\/iovs.12-10655","article-title":"NLRP3 inflammasome activation in retinal pigment epithelial cells by lysosomal destabilization: implications for age-related macular degeneration","volume":"54","author":"WA Tseng","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"11","key":"pone.0236283.ref041","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1001\/archopht.123.11.1484","article-title":"The Age-Related Eye Disease Study severity scale for age-related macular degeneration: AREDS Report No. 17","volume":"123","author":"MD Davis","year":"2005","journal-title":"Arch Ophthalmol"},{"issue":"9","key":"pone.0236283.ref042","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1128\/CVI.00115-07","article-title":"Validation of a Microsphere-Based Immunoassay for Detection of Anti-West Nile Virus and Anti-St. Louis Encephalitis Virus Immunoglobulin M Antibodies","volume":"14","author":"AJ Johnson","year":"2007","journal-title":"Clinical and Vaccine Immunology"},{"issue":"9","key":"pone.0236283.ref043","doi-asserted-by":"crossref","first-page":"e75302","DOI":"10.1371\/journal.pone.0075302","article-title":"High-throughput profiling of anti-glycan humoral responses to SIV vaccination and challenge","volume":"8","author":"JC Campbell","year":"2013","journal-title":"PLOS One"},{"issue":"11","key":"pone.0236283.ref044","doi-asserted-by":"crossref","first-page":"6523","DOI":"10.1167\/iovs.15-16793","article-title":"Angiogenic and Inflammatory Vitreous Biomarkers Associated With Increasing Levels of Retinal Ischemia","volume":"56","author":"K Kovacs","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"2","key":"pone.0236283.ref045","first-page":"42","article-title":"An analysis of transformations","volume":"26","author":"GEP Box","year":"1964","journal-title":"Journal of the Royal Statistical Society Series B (Methodological)"},{"issue":"3","key":"pone.0236283.ref046","first-page":"5","article-title":"Correcting inhomogeneity of variance with power transformation weighting","volume":"16","author":"GEPH Box","year":"1974","journal-title":"Technometrics"},{"issue":"4","key":"pone.0236283.ref047","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1214\/aos\/1013699998","article-title":"The control of the false discovery rate in multiple testing under dependency","volume":"29","author":"Y Benjamini","year":"2001","journal-title":"Ann Statist"},{"key":"pone.0236283.ref048","volume-title":"A language and enviroment for statistical computing","author":"T. RC","year":"2013"},{"key":"pone.0236283.ref049","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.dadm.2017.07.004","article-title":"Plasma amyloid beta 42\/40 ratios as biomarkers for amyloid beta cerebral deposition in cognitively normal individuals","volume":"8","author":"N Fandos","year":"2017","journal-title":"Alzheimers Dement (Amst)"},{"issue":"10","key":"pone.0236283.ref050","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1097\/IAE.0000000000001283","article-title":"Clinical Endpoints for the Study of Geographic Atrophy Secondary to Age-Related Macular Degeneration","volume":"36","author":"SR Sadda","year":"2016","journal-title":"Retina"},{"issue":"7","key":"pone.0236283.ref051","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.celrep.2017.10.075","article-title":"CRISPR Transcriptional Activation Analysis Unmasks an Occult gamma-Secretase Processivity Defect in Familial Alzheimer's Disease Skin Fibroblasts","volume":"21","author":"K Inoue","year":"2017","journal-title":"Cell Reports"},{"issue":"2","key":"pone.0236283.ref052","first-page":"6","article-title":"Pancreatic secretory trypsin inhibitor: More than a trypsin inhibitor","volume":"1","author":"C.-S. Wang G-PX","year":"2010","journal-title":"World Journal of Gastrointestinal Pathophysiology"},{"issue":"1","key":"pone.0236283.ref053","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.bbamcr.2009.07.004","article-title":"Matrix metalloproteinases: evolution, gene regulation and functional analysis in mouse models","volume":"1803","author":"M Fanjul-Fernandez","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"pone.0236283.ref054","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.brainres.2011.06.042","article-title":"Serine proteases, serine protease inhibitors, and protease-activated receptors: roles in synaptic function and behavior","volume":"1407","author":"AG Almonte","year":"2011","journal-title":"Brain Res"},{"issue":"7","key":"pone.0236283.ref055","doi-asserted-by":"crossref","first-page":"e0132800","DOI":"10.1371\/journal.pone.0132800","article-title":"Systemic and Ocular Long Pentraxin 3 in Patients with Age-Related Macular Degeneration","volume":"10","author":"HB Juel","year":"2015","journal-title":"PLoS One"},{"issue":"2","key":"pone.0236283.ref056","doi-asserted-by":"crossref","first-page":"e0149269","DOI":"10.1371\/journal.pone.0149269","article-title":"Release of matrix metalloproteinases-2 and 9 by S-nitrosylated caveolin-1 contributes to degradation of extracellular matrix in tPA-treated hypoxic endothelial cells","volume":"11","author":"H Song","year":"2016","journal-title":"PLOS One"},{"issue":"1","key":"pone.0236283.ref057","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/imr.12476","article-title":"Pentraxins in the activation and regulation of innate immunity","volume":"274","author":"K Daigo","year":"2016","journal-title":"Immunol Rev"},{"key":"pone.0236283.ref058","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.12659\/MSM.889887","article-title":"Age-related macular degeneration and changes in the extracellular matrix","volume":"20","author":"M Nita","year":"2014","journal-title":"Med Sci Monit"},{"key":"pone.0236283.ref059","doi-asserted-by":"crossref","first-page":"8374647","DOI":"10.1155\/2018\/8374647","article-title":"Age-Related Macular Degeneration: New Paradigms for Treatment and Management of AMD","volume":"2018","author":"LF Hernandez-Zimbron","year":"2018","journal-title":"Oxid Med Cell Longev"},{"key":"pone.0236283.ref060","first-page":"7","article-title":"Imbalances in tissue inhibitors of metalloproteinases differentiate choroidal neovascularization from geographic atrophy","volume":"97","author":"M.K. SY Nielsen","year":"2019","journal-title":"Acta Ophthalmologica"},{"issue":"10","key":"pone.0236283.ref061","doi-asserted-by":"crossref","first-page":"7038","DOI":"10.1167\/iovs.13-12730","article-title":"Comparative analysis of aqueous humor cytokine levels between patients with exudative age-related macular degeneration and normal controls","volume":"54","author":"DM Cha","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"pone.0236283.ref062","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s13287-015-0098-x","article-title":"Osteopontin mediates survival, proliferation and migration of neural stem cells through the chemokine receptor CXCR4","volume":"6","author":"M Rabenstein","year":"2015","journal-title":"Stem Cell Res Ther"},{"key":"pone.0236283.ref063","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3389\/fnmol.2016.00058","article-title":"Increased Expression of Osteopontin in Retinal Degeneration Induced by Blue Light-Emitting Diode Exposure in Mice","volume":"9","author":"SW Chang","year":"2016","journal-title":"Front Mol Neurosci"},{"key":"pone.0236283.ref064","first-page":"54","article-title":"Osteopontin (OPN) is present in drusen and basal deposits in human eyes with age-related macular degeneration","author":"A Bednar","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0236283","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,27]],"date-time":"2021-03-27T20:42:10Z","timestamp":1616877730000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0236283"}},"subtitle":[],"editor":[{"given":"Simon J.","family":"Clark","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,8,7]]},"references-count":64,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2020,8,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0236283","relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.17504\/protocols.io.bhwuj7ew","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,7]]}}}