{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T18:16:10Z","timestamp":1761156970323,"version":"3.37.3"},"reference-count":8,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T00:00:00Z","timestamp":1597104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2017\/12725-0"],"award-info":[{"award-number":["2017\/12725-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0236297","type":"journal-article","created":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T17:36:00Z","timestamp":1597167360000},"page":"e0236297","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Simultaneous separation of naproxen and 6-O-desmethylnaproxen metabolite in saliva samples by liquid chromatography\u2013tandem mass spectrometry: Pharmacokinetic study of naproxen alone and associated with esomeprazole"],"prefix":"10.1371","volume":"15","author":[{"given":"Thiago Jos\u00e9","family":"Dion\u00edsio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0990-7106","authenticated-orcid":true,"given":"Gabriela Moraes","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Morettin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavio Cardoso","family":"Faria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Ferreira","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2876-0955","authenticated-orcid":true,"given":"Adriana Maria","family":"Calvo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2020,8,11]]},"reference":[{"key":"pone.0236297.ref001","first-page":"e122","article-title":"Efficacy of naproxen with or without esomeprazole for pain and inflammation in patients after bilateral third molar extractions: a double blinded crossover study","volume":"22","author":"GM Weckwerth","year":"2017","journal-title":"Medicina Oral, Patologia Oral y Cirugia Bucal"},{"key":"pone.0236297.ref002","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1517\/17425250902970998","article-title":"Genetically based impairment in CYP2C8- and CYP2C9-dependent NSAID metabolism as a risk factor for gastrointestinal bleeding: is a combination of pharmacogenomics and metabolomics required to improve personalized medicine?","volume":"5","author":"JA Agundez","year":"2009","journal-title":"Expert Opinion on Drug Metabolism & Toxicology"},{"key":"pone.0236297.ref003","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/S1130-6343(06)73982-4","article-title":"Clinical pharmacogenomics for CYP2C8 and CYP2C9: general concepts and application to the use of NSAIDs","volume":"30","author":"C Martinez","year":"2006","journal-title":"Farmacia Hospitalaria: Organo Oficial de Expresion Cientifica de la Sociedad Espanola de Farmacia Hospitalaria"},{"key":"pone.0236297.ref004","unstructured":"NCIt. https:\/\/ncit.nci.nih.gov\/ncitbrowser"},{"key":"pone.0236297.ref005","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.clinthera.2014.11.004","article-title":"Pharmacokinetic comparison study of a combination containing 500 mg of naproxen and 20 mg of esomeprazole: a randomized, single-dose, 2-way crossover, open-label study in healthy Korean men","volume":"37","author":"HG Choi","year":"2015","journal-title":"Clinical Therapeutics"},{"key":"pone.0236297.ref006","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1002\/bmc.2878","article-title":"Development and validation of a sensitive and high-throughput LC-MS\/MS method for the simultaneous determination of esomeprazole and naproxen in human plasma","volume":"27","author":"S Gopinath","year":"2013","journal-title":"Biomedical Chromatography: BMC"},{"key":"pone.0236297.ref007","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.jpba.2015.12.042","article-title":"Quantification of piroxicam and 5'-hydroxypiroxicam in human plasma and saliva using liquid chromatography-tandem mass spectable 1trometry following oral administration","volume":"120","author":"AM Calvo","year":"2016","journal-title":"Journal of Pharmaceutical and Biomedical Analysis"},{"key":"pone.0236297.ref008","doi-asserted-by":"crossref","DOI":"10.1590\/1807-3107BOR-2016.vol30.0058","article-title":"Effective method for the detection of piroxicam in human plasma using HPLC","volume":"30","author":"AM Calvo","year":"2016","journal-title":"Brazilian Oral Research"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0236297","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T17:36:04Z","timestamp":1597167364000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0236297"}},"subtitle":[],"editor":[{"given":"Joseph","family":"Banoub","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,8,11]]},"references-count":8,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2020,8,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0236297","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2020,8,11]]}}}