{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T09:51:35Z","timestamp":1790589095547,"version":"4.1.0"},"reference-count":107,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T00:00:00Z","timestamp":1595980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010221","name":"Higher Education Commision, Pakistan","doi-asserted-by":"publisher","award":["074-0998-Av4-036"],"award-info":[{"award-number":["074-0998-Av4-036"]}],"id":[{"id":"10.13039\/501100010221","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0236319","type":"journal-article","created":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T17:30:36Z","timestamp":1596043836000},"page":"e0236319","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":64,"title":["GC-MS analysis, antimicrobial, antioxidant, antilipoxygenase and cytotoxic activities of Jacaranda mimosifolia methanol leaf extracts and fractions"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2716-2267","authenticated-orcid":true,"given":"Rabia","family":"Naz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3831-3240","authenticated-orcid":true,"given":"Thomas H.","family":"Roberts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asghari","family":"Bano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asia","family":"Nosheen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humaira","family":"Yasmin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Nadeem","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rumana","family":"Keyani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sami","family":"Ullah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wajiha","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahid","family":"Anwar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,7,29]]},"reference":[{"key":"pone.0236319.ref001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/molecules22010070","article-title":"Biological activities of essential oils: From plant chemoecology to traditional healing systems","volume":"22","author":"J Sharifi-Rad","year":"2017","journal-title":"Molecules"},{"key":"pone.0236319.ref002","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1080\/01496395.2015.1014054","article-title":"Aqueous two-phase system as an effective tool for purification of phenolic compounds from fig fruits (Ficus carica L","volume":"50","author":"YC Feng","year":"2015","journal-title":"Sep Sci Technol"},{"key":"pone.0236319.ref003","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.3390\/molecules22122145","article-title":"Plants of the genus zingiber as a source of bioactive phytochemicals: From tradition to pharmacy","volume":"22","author":"M Sharifi-Rad","year":"2017","journal-title":"Molecules"},{"key":"pone.0236319.ref004","doi-asserted-by":"crossref","first-page":"609","DOI":"10.4067\/S0717-95022007000300023","article-title":"Toxic effects of methanolic exract of Aspilia africana leaf on the estrous cycle and uterine tissues of Wistar rats","volume":"25","author":"KA Oluyemi","year":"2007","journal-title":"Int J Morphol"},{"issue":"3","key":"pone.0236319.ref005","doi-asserted-by":"crossref","DOI":"10.17795\/jjnpp-31129","article-title":"Cytotoxic and Antioxidant Activities of Alstonia scholaris, Alstonia venenata and Moringa oleifera Plants from India","volume":"11","author":"G Bagheri","year":"2016","journal-title":"Jundishapur J Nat Pharm Prod"},{"key":"pone.0236319.ref006","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1046\/j.1440-1681.2000.03322.x","article-title":"Time\u2010course of changes in hepatic lipid peroxidation and glutathione metabolism in rats with carbon tetrachloride\u2010induced cirrhosis","volume":"27","author":"M Cabre","year":"2000","journal-title":"Clin. Exp Pharmacol Physiol"},{"key":"pone.0236319.ref007","first-page":"123","article-title":"Antioxidant properties of methanolic extract and fatty acid composition of Centaurea urvillei DC. subsp. hayekiana Wagenitz","volume":"5","author":"G Zengin","year":"2011","journal-title":"Rec Nat Prod"},{"key":"pone.0236319.ref008","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cbi.2010.10.013","article-title":"beta-Lapachone-induced reactive oxygen species (ROS) generation mediates autophagic cell death in glioma U87 MG cells","volume":"189","author":"EJ Park","year":"2011","journal-title":"Chem Biol Interact"},{"key":"pone.0236319.ref009","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbi.2005.12.009","article-title":"Free radicals, metals and antioxidants in oxidative stress-induced cancer","volume":"160","author":"M Valko","year":"2006","journal-title":"Chem Biol Interact"},{"key":"pone.0236319.ref010","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.fct.2011.12.025","article-title":"Changes in the phenolic and lipophilic composition: in the enzyme inhibition and antiproliferative activity of Ficus carica L. cultivar Dottato fruits during maturation","volume":"50","author":"M Marrelli","year":"2012","journal-title":"Food Chem Toxicol"},{"issue":"1","key":"pone.0236319.ref011","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/s13197-015-1983-0","article-title":"Antioxidant and antimicrobial properties of grape and papaya seed extracts and their application on the preservation of Indian mackerel (Rastrelliger kanagurta) during ice storage","volume":"53","author":"FR Sofi","year":"2016","journal-title":"J Food Sci Technol"},{"issue":"4","key":"pone.0236319.ref012","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.foodchem.2005.04.028","article-title":"Antioxidant activity of some Algerian medicinal plants extracts containing phenolic compounds","volume":"97","author":"A Djeridane","year":"2006","journal-title":"Food Chem"},{"issue":"5","key":"pone.0236319.ref013","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1016\/j.fct.2010.03.002","article-title":"Antioxidant activities of the essential oil and methanol extracts from myrtle (Myrtus communis var. italica L.) leaf, stem and flower","volume":"48","author":"WA Wannes","year":"2010","journal-title":"Food Chem Toxicol"},{"issue":"2","key":"pone.0236319.ref014","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1039\/C5FO01036E","article-title":"Rutin protects against aging-related metabolic dysfunction","volume":"7","author":"T Li","year":"2015","journal-title":"Food Funct"},{"issue":"10","key":"pone.0236319.ref015","doi-asserted-by":"crossref","first-page":"3296","DOI":"10.1039\/C5FO00500K","article-title":"Rutin inhibits amylin-induced neurocytotoxicity and oxidative stress","volume":"6","author":"XL Yu","year":"2015","journal-title":"Food Funct"},{"key":"pone.0236319.ref016","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s12906-015-0580-0","article-title":"Antibiotic additive and synergistic action of rutin, morin and quercetin against methicillin resistant Staphylococcus aureus","volume":"15","author":"MU Amin","year":"2015","journal-title":"BMC Comp Alter Med"},{"issue":"3","key":"pone.0236319.ref017","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1021\/acs.jnatprod.5b01055","article-title":"Natural products as sources of new drugs from 1981 to 2014","volume":"79","author":"DJ Newman","year":"2016","journal-title":"J Nat Prod"},{"issue":"11","key":"pone.0236319.ref018","doi-asserted-by":"crossref","first-page":"e112748","DOI":"10.1371\/journal.pone.0112748","article-title":"Antioxidant and Cytotoxic Activity of Hydroethanolic Extract from Jacaranda decurrens Leaves","volume":"9","author":"JC Casagrande","year":"2014","journal-title":"PLoS ONE"},{"issue":"1","key":"pone.0236319.ref019","article-title":"Cytotoxic and apoptogenic effect of Swietenia mahagoni (L.) Jacq. leaf extract in human leukemic cell lines U937, K562 and HL-60","volume":"37","author":"S Roy","year":"2014","journal-title":"Environ Toxicol Pharmacol"},{"key":"pone.0236319.ref020","doi-asserted-by":"crossref","first-page":"912484","DOI":"10.1155\/2015\/912484","article-title":"Antibacterial and Cytotoxic Activity of Compounds Isolated from Flourensia oolepis","volume":"2015","author":"MB Joray","year":"2015","journal-title":"Evid Based Complement Alternat Med"},{"key":"pone.0236319.ref021","doi-asserted-by":"crossref","first-page":"641","DOI":"10.4049\/jimmunol.178.2.641","article-title":"Arachidonic acid metabolism as a potential mediator of cardiac fibrosis associated with inflammation","volume":"178","author":"SP Levick","year":"2007","journal-title":"J Immunol"},{"key":"pone.0236319.ref022","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/1-4020-5688-5_1","article-title":"Anti-inflammatory drugs in the 21st century","volume":"42","author":"KD Rainsford","year":"2007","journal-title":"Subcell Biochem"},{"key":"pone.0236319.ref023","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.tips.2007.07.005","article-title":"Treatment of inflammatory diseases by selective eicosanoid inhibition: A double-edged sword?","volume":"28","author":"S Yedgar","year":"2007","journal-title":"Trends Pharmacol Sci"},{"key":"pone.0236319.ref024","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1084\/jem.20051310","article-title":"Prostacyclin-IP signaling and prostaglandin E2-EP2\/EP4 signaling both mediate joint inflammation in mouse collagen-induced arthritis","volume":"203","author":"T Honda","year":"2006","journal-title":"J Exp Med"},{"key":"pone.0236319.ref025","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1097\/01.wnr.0000129372.89000.31","article-title":"Membrane-associated prostaglandin E synthase-1 is required for neuropathic pain","volume":"15","author":"T Mabuchi","year":"2004","journal-title":"Neuroreport"},{"key":"pone.0236319.ref026","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1097\/00005373-200012000-00033","article-title":"Prostaglandin E2 synthesis and metabolism in burn injury and trauma","volume":"49","author":"EL Hahn","year":"2000","journal-title":"J Trauma"},{"key":"pone.0236319.ref027","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1159\/000086629","article-title":"Mechanisms for the prevention of gastrointestinal cancer: The role of prostaglandin E2","volume":"69","author":"MG Backlund","year":"2005","journal-title":"Oncology"},{"key":"pone.0236319.ref028","doi-asserted-by":"crossref","first-page":"12647","DOI":"10.1074\/jbc.M312972200","article-title":"Microsomal prostaglandin E synthase-1 is overexpressed in inflammatory bowel disease. Evidence for involvement of the transcription factor E-1","volume":"279","author":"K Subbaramaiah","year":"2004","journal-title":"J Biol Chem"},{"issue":"4","key":"pone.0236319.ref029","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.joim.2018.04.009","article-title":"In vitro antioxidant, antilipoxygenase and antimicrobial activities of extracts from seven climbing plants belonging to the Bignoniaceae","volume":"16","author":"CA Torres","year":"2018","journal-title":"J Integr Med"},{"key":"pone.0236319.ref030","first-page":"17","article-title":"Constituents of Jacaranda mimosaefolia","volume":"19","author":"V Gambaro","year":"1988","journal-title":"Rev. Latinoam. Quim"},{"key":"pone.0236319.ref031","first-page":"98","article-title":"Phytochemical and antimicrobial study of Jacaranda mimosifolia D. Don grown in Egypt","volume":"30","author":"GH Mahran","year":"1991","journal-title":"Herb Hung"},{"key":"pone.0236319.ref032","first-page":"48","article-title":"Preliminary Ethnopharmacological Survey of Plants Used in Mexico for the Treatment of Hypertension","volume":"3","author":"P Castillo-Espa\u00f1a","year":"2009","journal-title":"Pharmacog Reviews"},{"key":"pone.0236319.ref033","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1021\/jo01056a037","article-title":"Isolation and structure of a new conjugated triene fatty acid","volume":"27","author":"MJ Chisholm","year":"1962","journal-title":"J Org Chem"},{"key":"pone.0236319.ref034","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1080\/14786419.2012.717290","article-title":"A new phenylethanoid glucoside from Jacaranda mimosifolia","volume":"27","author":"A Rana","year":"2013","journal-title":"Natl Prod Res.: Formerly Natl Prod Lett"},{"key":"pone.0236319.ref035","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-662-02398-3","volume-title":"Plant drug analysis","author":"H Wagner","year":"1984"},{"key":"pone.0236319.ref036","first-page":"453","volume-title":"Pharmacognosy","author":"GE Trease","year":"1985","edition":"12"},{"key":"pone.0236319.ref037","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.lwt.2011.11.009","article-title":"Total phenolic and total flavonoid content, antioxidant activity and sensory evaluation of pseudocereal breads","volume":"46","author":"J Chlopicka","year":"2012","journal-title":"LWT-Food Sci Technol"},{"key":"pone.0236319.ref038","first-page":"178","article-title":"Estimation of total flavonoid content in propolis by two complementary colorimetric methods","volume":"10","author":"CC Chang","year":"2002","journal-title":"J Food Drug Anal"},{"key":"pone.0236319.ref039","first-page":"63","article-title":"Total phenolic content, flavonoid concentration and antioxidant activity of Marrubium peregrinum L. extracts","volume":"33","author":"MS Stankovi\u0107","year":"2011","journal-title":"Kragujevac J Sci"},{"key":"pone.0236319.ref040","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s00580-010-1008-3","article-title":"Therapeutic potential of Dendrophthoe falcata (Lf) Ettingsh on 7, 12-dimethylbenz (a) anthracene-induced mammary tumorigenesis in female rats: effect on antioxidant system, lipid peroxidation, and hepatic marker enzymes","volume":"20","author":"SP Pattanayak","year":"2011","journal-title":"Comp Clinical Pathol"},{"key":"pone.0236319.ref041","doi-asserted-by":"crossref","first-page":"33","DOI":"10.22270\/jddt.v3i4.546","article-title":"Estimation of total flavonoids content (TFC) and antioxidant activities of methanolic whole plant extract of Biophytum sensitivum Linn","volume":"3","author":"P Kalita","year":"2013","journal-title":"J. Drug Delivery Therap"},{"key":"pone.0236319.ref042","doi-asserted-by":"crossref","first-page":"4267","DOI":"10.1021\/jf980366j","article-title":"Critical factors of vanillin assay for catechins and proanthocyanidins","volume":"46","author":"B Sun","year":"1998","journal-title":"J Agric Food Chem"},{"key":"pone.0236319.ref043","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1002\/jsfa.1122","article-title":"L-Phenylalanine ammonia-lyase activity and concentration of phenolics in developing olive (Olea europaea L. cv Arbequina) fruit grown under different irrigation regimes","volume":"82","author":"MJ Tovar","year":"2002","journal-title":"J Sci Food Agric"},{"key":"pone.0236319.ref044","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0023-6438(02)00226-8","article-title":"Determination of in vitro antioxidant activity of fennel (Foeniculum vulgare) seed extracts","volume":"36","author":"M Oktay","year":"2003","journal-title":"Lebensmittel-Wissenchaft und Technologie"},{"key":"pone.0236319.ref045","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1093\/carcin\/10.6.1003","article-title":"Prevention of cytotoxicity and inhibition of intracellular communication by antioxidant catechins isolated from Chinese green tea","volume":"10","author":"RJ Ruch","year":"1989","journal-title":"Carcinogenesis"},{"key":"pone.0236319.ref046","first-page":"70","article-title":"Anti-inflammation and antioxidant activities of Cassia fistula Linn. bark extracts","volume":"2","author":"R Ilavarasan","year":"2005","journal-title":"Afr J Trad Compl Altern Med"},{"key":"pone.0236319.ref047","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/0003-2697(71)90370-8","article-title":"Superoxide dismutase: improved assays and an assay applicable to acrylamide gels","volume":"44","author":"C Beauchamp","year":"1971","journal-title":"Anal Biochem"},{"key":"pone.0236319.ref048","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0378-8741(99)00171-3","article-title":"In vitro antioxidant activity of Anthriscus cerefolium L. (Hoffm.) extracts","volume":"69","author":"S Fejes","year":"2000","journal-title":"J Ethnopharmacol"},{"key":"pone.0236319.ref049","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0263-7855(97)00006-4","article-title":"Affecting the activity of soybean lipoxygenase-1","volume":"14","author":"H Wu","year":"1996","journal-title":"J Mol Graph"},{"key":"pone.0236319.ref050","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1590\/S1517-83822007000200034","article-title":"Screening methods to determine antibacterial activity of natural products","volume":"38","author":"C Valgas","year":"2007","journal-title":"Braz J Microbial"},{"key":"pone.0236319.ref051","volume-title":"Methods for Dilution Antimicrobial Susceptibility Tests","author":"Clinical and Laboratory Standards Institute (CLSI)","year":"2008","edition":"4"},{"key":"pone.0236319.ref052","first-page":"453","volume-title":"Manual of clinical microbiology","author":"JAU Washington","year":"1980","edition":"3"},{"key":"pone.0236319.ref053","first-page":"82","author":"P Skehan","year":"1990","journal-title":"Journal of the National Cancer Institute"},{"key":"pone.0236319.ref054","volume-title":"Statistical Procedure for Agricultural Research","author":"KA Gomez","year":"1984"},{"key":"pone.0236319.ref055","first-page":"110","article-title":"Bioactivity of Jacaranda mimosifolia and Bougainvillea spectabilis Leaves powder against Acanthoscelides obtectus","volume":"5","author":"WR Waweru","year":"2017","journal-title":"J Ent Zoo Studies"},{"key":"pone.0236319.ref056","first-page":"106","article-title":"Phytochemical evaluation of Bignoniaceae flowers","volume":"5","author":"J Joselin","year":"2013","journal-title":"J. Chem. Pharma.Res"},{"key":"pone.0236319.ref057","doi-asserted-by":"crossref","first-page":"3482","DOI":"10.1016\/j.fct.2008.08.025","article-title":"Antioxidant properties, total phenols and pollen analysis of propolis samples from Portugal","volume":"46","author":"L Moreira","year":"2008","journal-title":"Food Chem.Toxicol"},{"key":"pone.0236319.ref058","doi-asserted-by":"crossref","first-page":"3954","DOI":"10.1021\/jf990146l","article-title":"Antioxidant activity of plant extracts containing phenolic compounds","volume":"47","author":"MP K\u00e4hk\u00f6nen","year":"1999","journal-title":"J Agri Food Chem"},{"key":"pone.0236319.ref059","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.foodcont.2007.09.007","article-title":"Evaluation of antioxidant and antibacterial activities of Ficus microcarpa L. fill extract","volume":"19","author":"C Ao","year":"2008","journal-title":"Food Contrl"},{"key":"pone.0236319.ref060","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1186\/s12906-017-1815-z","article-title":"Antimicrobial activity, toxicity and antiinflammatory potential of methanolic extracts of four ethnomedicinal plant species from Punjab, Pakistan","volume":"17","author":"R Naz","year":"2007","journal-title":"BMC Complement Altern Med"},{"key":"pone.0236319.ref061","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/2191-2858-2-12","article-title":"Plant polyphenols as electron donors for erythrocyte plasma membrane redox system: validation through in silico approach","volume":"2","author":"RK Kesharwani","year":"2012","journal-title":"Org Med Chem Lett"},{"key":"pone.0236319.ref062","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1186\/s12906-015-0835-9","article-title":"The antibacterial, phytochemicals and antioxidants evaluation of the root extracts of Hydnora africanaThunb. used as antidysenteric in Eastern Cape Province, South Africa","volume":"15","author":"OA Wintola","year":"2015","journal-title":"BMC Complementary and Alternative Medicine"},{"issue":"11","key":"pone.0236319.ref063","doi-asserted-by":"crossref","first-page":"e112748","DOI":"10.1371\/journal.pone.0112748","article-title":"Antioxidant and Cytotoxic Activity of Hydroethanolic Extract from Jacaranda decurrens Leaves","volume":"9","author":"JC Casagrande","year":"2014","journal-title":"PLoS ONE"},{"issue":"11","key":"pone.0236319.ref064","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.3109\/13880209.2014.1001407","article-title":"Stem bark and flower extracts of Vismia cauliflora are highly effective antioxidants to human blood cells by preventing oxidative burst in neutrophils and oxidative damage in erythrocytes","volume":"53","author":"AB Ribeiro","year":"2015","journal-title":"Pharm Biol"},{"key":"pone.0236319.ref065","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1007\/s11130-013-0375-8","article-title":"Antioxidant properties and preliminary evaluation of phytochemical composition of different anatomical parts of amaranth","volume":"68","author":"P. Kraujalis","year":"2013","journal-title":"Plant Foods Hum Nutr"},{"key":"pone.0236319.ref066","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jfca.2014.09.003","article-title":"Characterization of phenolics, betacyanins and antioxidant activities of the seed, leaf, sprout, flower and stalk extracts of three Amaranthus species","volume":"37","author":"H Li","year":"2015","journal-title":"J Food Compos Anal"},{"issue":"8","key":"pone.0236319.ref067","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1517\/13543784.2013.805744","article-title":"Rutin: therapeutic potential and recent advances in drug delivery","volume":"22","author":"S Sharma","year":"2013","journal-title":"Expert Opin. Investig. Drugs"},{"key":"pone.0236319.ref068","first-page":"407","article-title":"Antioxidant and cytotoxic activities and phytochemical screening of four Philippine medicinal plants","volume":"4","author":"NP Peteros","year":"2010","journal-title":"J Medicinal Plants Res"},{"issue":"2","key":"pone.0236319.ref069","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3109\/15376516.2014.1003359","article-title":"Rutin potentially attenuates fluorideinduced oxidative stress-mediated cardiotoxicity, blood toxicity and dyslipidemia in rats","volume":"25","author":"V Umarani","year":"2015","journal-title":"Toxicol Mech Methods"},{"issue":"1","key":"pone.0236319.ref070","doi-asserted-by":"crossref","first-page":"52","DOI":"10.5581\/1516-8484.20130015","article-title":"Protective effect of flavonoids against reactive oxygen species production in sickle cell anemia patients treated with hydroxyurea","volume":"35","author":"R Henneberg","year":"2013","journal-title":"Rev Bras Hematol Hemoter"},{"key":"pone.0236319.ref071","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1080\/14786410701875686","article-title":"Antioxidant activities of extracts and flavonoid compounds from Oxytropis falcate Bunge","volume":"22","author":"H Jiang","year":"2008","journal-title":"Nat Prod Res"},{"key":"pone.0236319.ref072","first-page":"151","article-title":"The modulatory effect of Cochlospermum tinctorium a rich aqueous root extract on liver damage induced by carbon tetrachloride in rats. Afric","volume":"3","author":"EU Etuk","year":"2009","journal-title":"J. Pharm. Pharmacol"},{"key":"pone.0236319.ref073","first-page":"143","article-title":"Antioxidant activity of Jacaranda acutifolia flower","volume":"17","author":"YF Chen","year":"2006","journal-title":"J Chin Med"},{"issue":"6","key":"pone.0236319.ref074","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/S2222-1808(13)60104-8","article-title":"Phytochemical screening, antioxidants and antimicrobial potential of Lantana camara in different solvents","volume":"3","author":"R Naz","year":"2013","journal-title":"Asian Pac J Trop Dis"},{"key":"pone.0236319.ref075","first-page":"2202","article-title":"Methods for determination of in vitro antioxidant activity for extracts and organic compounds","volume":"33","author":"CQ Alves","year":"2010","journal-title":"Qu\u00edmica Nova"},{"key":"pone.0236319.ref076","doi-asserted-by":"crossref","first-page":"438","DOI":"10.9734\/BJMMR\/2015\/16284","article-title":"Free Radicals: Health Implications and their Mitigation by Herbals","volume":"7","author":"S Kumar","year":"2015","journal-title":"British J Med Medic Res"},{"key":"pone.0236319.ref077","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/S0924-2244(00)89140-2","article-title":"Application of enzymes as food antioxidants","volume":"6","author":"AS Meyer","year":"1995","journal-title":"Trends Food Sci. Tech"},{"key":"pone.0236319.ref078","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1186\/1472-6882-12-221","article-title":"Antioxidant activity, total phenolic and total flavonoid contents of whole plant extracts Torilis leptophylla L","volume":"12","author":"N Saeed","year":"2012","journal-title":"BMC Comp Alter Med"},{"key":"pone.0236319.ref079","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.indcrop.2012.12.011","article-title":"Extracts from Quercus sp: acorns exhibit in vitro neuroprotective features through inhibition of cholinesterase and protection of the human dopaminergic cell line SH-SY5Y from hydrogen peroxide-induced cytotoxicity","volume":"45","author":"L Custodio","year":"2013","journal-title":"Ind Crops Prod"},{"key":"pone.0236319.ref080","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.foodchem.2015.08.086","article-title":"Effect of carob (Ceratonia siliqua L.) flour on the antioxidant potential nutritional quality, and sensory characteristics of fortified durum wheat pasta","volume":"194","author":"L S\u0229czyk","year":"2016","journal-title":"Food Chem"},{"key":"pone.0236319.ref081","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.indcrop.2016.10.007","article-title":"Bioactive metabolites involved in the antioxidant, anticancer and anticalpain activities of Ficus carica L., Ceratonia siliqua L. and Quercus ilex L. extracts","volume":"95","author":"N Amessis-Ouchemoukh","year":"2017","journal-title":"Ind Crops Prod"},{"key":"pone.0236319.ref082","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/1472-6882-14-112","article-title":"Medicinal attributes of Solanum xanthocarpum fruit consumed by several tribal communities as food: an in vitro antioxidant, anticancer and anti HIV perspective","volume":"14","author":"S Kumar","year":"2014","journal-title":"BMC Comp Alter Med"},{"key":"pone.0236319.ref083","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.arabjc.2011.01.007","article-title":"A study on the total phenols content and antioxidant activity of essential oil and different solvent extracts of endemic plant Merremia borneensis","volume":"8","author":"MA Hossain","year":"2015","journal-title":"Arab J Chem"},{"key":"pone.0236319.ref084","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.foodchem.2006.09.025","article-title":"Antioxidant properties of different cultivars of Portulaca oleracea","volume":"103","author":"YY Lim","year":"2007","journal-title":"Food Chem"},{"key":"pone.0236319.ref085","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.foodchem.2007.04.038","article-title":"Antioxidant activity and phenolic compounds in 32 selected herbs","volume":"105","author":"A Wojdylo","year":"2007","journal-title":"Food Chem"},{"issue":"5","key":"pone.0236319.ref086","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/S1734-1140(12)70914-3","article-title":"Evaluation of the antioxidative properties of lipoxygenase inhibitors","volume":"64","author":"GA Czapski","year":"2012","journal-title":"Pharmacol Rep"},{"key":"pone.0236319.ref087","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0006-2952(02)01621-0","article-title":"Inhibition of 15-lipoxygenases by flavonoids: structure-activity relations and mode of action","volume":"65","author":"CD Sadik","year":"2003","journal-title":"Biochem Pharmacol"},{"issue":"25","key":"pone.0236319.ref088","first-page":"1542","article-title":"Anticancer, Antioxidant and Anti-Inflammatory Activities of Chloroform Extracts from Some Centaurea Species","volume":"2","author":"T Sekerler","year":"2018","journal-title":"In Multidisciplinary Digital Publishing Institute Proceedings"},{"key":"pone.0236319.ref089","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1089\/jmf.2010.0251","article-title":"Jacaranda cuspidifolia Mart. (Bignoniaceae) as an antibacterial agent","volume":"14","author":"AL Arruda","year":"2011","journal-title":"J Med Food"},{"key":"pone.0236319.ref090","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1021\/np900528m","article-title":"Jacaranone-derived glucosidic esters from Jacaranda glabra and their activity against Plasmodium falciparum","volume":"73","author":"MS Gachet","year":"2010","journal-title":"J Nat Prod"},{"key":"pone.0236319.ref091","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1080\/14786419.2010.511217","article-title":"Phenylpropanoids from the stem bark of Jacaranda mimosaefolia","volume":"25","author":"AM Zaghloul","year":"2011","journal-title":"Nat Prod Res"},{"issue":"1","key":"pone.0236319.ref092","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.3390\/molecules17011113","article-title":"Phenolic enriched extract of Baccharis trimera presents anti-inflammatory and antioxidant activities","volume":"17","author":"CB de Oliveira","year":"2012","journal-title":"Molecules"},{"issue":"2","key":"pone.0236319.ref093","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.jep.2013.09.019","article-title":"Inhibition of the human neutrophil oxidative metabolism by Baccharis dracunculifolia DC (Asteraceae) is influenced by seasonality and the ratio of caffeic acid to other phenolic compounds","volume":"150","author":"ASG Figueiredo-Rinhel","year":"2013","journal-title":"J Ethnopharmacol"},{"issue":"7","key":"pone.0236319.ref094","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.3390\/molecules14072466","article-title":"Identification and quantification of flavonoids and phenolic acids in burr parsley (Caucalis platycarpos L.), using high-performance liquid chromatography with diode array detection and electrospray ionization mass spectrometry","volume":"14","author":"A Plazonic","year":"2009","journal-title":"Molecules"},{"issue":"6","key":"pone.0236319.ref095","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1111\/j.1439-0507.2008.01647.x","article-title":"Evaluation of the antifungal potential of Brazilian Cerrado medicinal plants","volume":"52","author":"FM Silva","year":"2009","journal-title":"Mycoses"},{"issue":"1","key":"pone.0236319.ref096","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3923\/jas.2011.157.162","article-title":"Antioxidant and antibacterial activities of three species of Lannea from Burkina Faso","volume":"11","author":"L Ouattara","year":"2011","journal-title":"J Appl Sci"},{"key":"pone.0236319.ref097","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0956-7135(03)00083-5","article-title":"Total phenolic contents and antibacterial activities of grape (Vitis vinifera L.) extracts","volume":"15","author":"NG Baydar","year":"2004","journal-title":"Food Control"},{"key":"pone.0236319.ref098","doi-asserted-by":"crossref","first-page":"181","DOI":"10.2478\/v10007-012-0014-1","article-title":"The isolation of bioactive flavonoids from Jacaranda obtusifolia HBK ssp. rhombifolia (GFW Meijer) Gentry","volume":"62","author":"S Khamsan","year":"2012","journal-title":"Acta Pharm"},{"key":"pone.0236319.ref099","doi-asserted-by":"crossref","first-page":"73","DOI":"10.14715\/cmb\/2017.63.6.15","article-title":"Pharmacological activities of cinnamaldehyde and eugenol: antioxidant, cytotoxic and anti-leishmanial studies","volume":"63","author":"UK Sharma","year":"2017","journal-title":"Cell Mol Biol (Noisy-le-grand)"},{"key":"pone.0236319.ref100","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/j.1747-0285.2012.01418.x","article-title":"Anti-inflammatory property of n-hexadecanoic acid: Structural evidence and kinetic assessment","volume":"80","author":"V Aparna","year":"2012","journal-title":"Chem Biol Drug Des"},{"key":"pone.0236319.ref101","first-page":"191","article-title":"Screening of antioxidant activity, total phenolics and GC-MS study of Vitex negundo","volume":"4","author":"PP Kumar","year":"2010","journal-title":"Afr J Biochem Res"},{"key":"pone.0236319.ref102","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0367-326X(00)00164-7","article-title":"Effect of Feronia limonia on mosquito larvae","volume":"71","author":"AA Rahuman","year":"2000","journal-title":"Fitoterapia"},{"issue":"6","key":"pone.0236319.ref103","doi-asserted-by":"crossref","first-page":"598","DOI":"10.5530\/pj.2016.6.14","article-title":"Comparative Biochemical Studies on Indian Sedges Cyperus scariosus R.Br and Cyperus rotundus L\u201d","volume":"8","author":"L Kakarla","year":"2016","journal-title":"Pharmacogn J"},{"key":"pone.0236319.ref104","first-page":"279","article-title":"GC\u2013MS determination of bioactive components of Wedelia chinensis (Osbeck) Merrill","volume":"5","author":"BH Rehana","year":"2013","journal-title":"J Chem Pharm Res"},{"issue":"1","key":"pone.0236319.ref105","doi-asserted-by":"crossref","first-page":"e2617","DOI":"10.1371\/journal.pntd.0002617","article-title":"Phytol, a diterpene alcohol from chlorophyll, as a drug against neglected tropical disease Schistosomiasis Mansoni","volume":"8","author":"J De Moraes","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"issue":"7","key":"pone.0236319.ref106","first-page":"609","article-title":"Antinociceptive and antioxidant activities of phytol in vivo and in vitro models","volume":"18","author":"CCMP Santos","year":"2013","journal-title":"Neuroscience J"},{"key":"pone.0236319.ref107","unstructured":"Department of Agriculture, Agricultural Research Service (1992\u20132016) Dr. Duke\u2019s Phytochemical and Ethnobotanical Databases. http:\/\/phytochem.nal.usda.gov\/. Accessed 16 Mar 2017"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0236319","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,5]],"date-time":"2022-11-05T02:35:29Z","timestamp":1667615729000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0236319"}},"subtitle":[],"editor":[{"given":"Walid","family":"Elfalleh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,7,29]]},"references-count":107,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2020,7,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0236319","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,29]]}}}