{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T13:54:08Z","timestamp":1764251648071,"version":"3.37.3"},"reference-count":49,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T00:00:00Z","timestamp":1595548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"swiss national science foundation","doi-asserted-by":"crossref","award":["Special program NCCR Kidney.CH"],"award-info":[{"award-number":["Special program NCCR Kidney.CH"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Association pour l'information et la recherche sur les maladies r\u00e9nales g\u00e9n\u00e9tiques - Suisse","award":["Unrestricted grant"],"award-info":[{"award-number":["Unrestricted grant"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0236361","type":"journal-article","created":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T20:04:17Z","timestamp":1595621057000},"page":"e0236361","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Elevated serum magnesium lowers calcification propensity in Memo1-deficient mice"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7717-651X","authenticated-orcid":true,"given":"Matthias B.","family":"Moor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suresh K.","family":"Ramakrishnan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Finola","family":"Legrand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Bachtler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Koesters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy E.","family":"Hynes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Pasch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4123-4279","authenticated-orcid":true,"given":"Olivier","family":"Bonny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2020,7,24]]},"reference":[{"issue":"329","key":"pone.0236361.ref001","doi-asserted-by":"crossref","first-page":"ra56","DOI":"10.1126\/scisignal.2004870","article-title":"Memo is a copper-dependent redox protein with an essential role in migration and metastasis","volume":"7","author":"G MacDonald","year":"2014","journal-title":"Sci Signal"},{"issue":"1","key":"pone.0236361.ref002","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1096\/fj.13-228320","article-title":"Loss of Memo, a novel FGFR regulator, results in reduced lifespan","volume":"28","author":"B Haenzi","year":"2014","journal-title":"FASEB J"},{"issue":"4","key":"pone.0236361.ref003","doi-asserted-by":"crossref","first-page":"e94114","DOI":"10.1371\/journal.pone.0094114","article-title":"Memo has a novel role in S1P signaling and crucial for vascular development","volume":"9","author":"S Kondo","year":"2014","journal-title":"PLoS One"},{"issue":"4","key":"pone.0236361.ref004","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/jbm4.10034","article-title":"Redox-Dependent Bone Alkaline Phosphatase Dysfunction Drives Part of the Complex Bone Phenotype in Mice Deficient for Memo1","volume":"2","author":"MB Moor","year":"2018","journal-title":"JBMR Plus"},{"issue":"6655","key":"pone.0236361.ref005","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/36285","article-title":"Mutation of the mouse klotho gene leads to a syndrome resembling ageing","volume":"390","author":"M Kuro-o","year":"1997","journal-title":"Nature"},{"issue":"1","key":"pone.0236361.ref006","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1677\/joe.0.1590001","article-title":"Elongation of the epiphyseal trabecular bone in transgenic mice carrying a klotho gene locus mutation that leads to a syndrome resembling aging","volume":"159","author":"T Yamashita","year":"1998","journal-title":"J Endocrinol"},{"issue":"3","key":"pone.0236361.ref007","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1172\/JCI5705","article-title":"Independent impairment of osteoblast and osteoclast differentiation in klotho mouse exhibiting low-turnover osteopenia","volume":"104","author":"H Kawaguchi","year":"1999","journal-title":"J Clin Invest"},{"issue":"4","key":"pone.0236361.ref008","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1172\/JCI200419081","article-title":"Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism","volume":"113","author":"T Shimada","year":"2004","journal-title":"J Clin Invest"},{"issue":"7","key":"pone.0236361.ref009","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1681\/ASN.2006121385","article-title":"Role of hyperphosphatemia and 1,25-dihydroxyvitamin D in vascular calcification and mortality in fibroblastic growth factor 23 null mice","volume":"18","author":"JR Stubbs","year":"2007","journal-title":"J Am Soc Nephrol"},{"issue":"12","key":"pone.0236361.ref010","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1210\/me.2003-0048","article-title":"Klotho, a gene related to a syndrome resembling human premature aging, functions in a negative regulatory circuit of vitamin D endocrine system","volume":"17","author":"H Tsujikawa","year":"2003","journal-title":"Mol Endocrinol"},{"issue":"11","key":"pone.0236361.ref011","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1038\/ki.2009.24","article-title":"Reversal of mineral ion homeostasis and soft-tissue calcification of klotho knockout mice by deletion of vitamin D 1alpha-hydroxylase","volume":"75","author":"M Ohnishi","year":"2009","journal-title":"Kidney Int"},{"issue":"6","key":"pone.0236361.ref012","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1096\/fj.05-5432fje","article-title":"Premature aging-like phenotype in fibroblast growth factor 23 null mice is a vitamin D-mediated process","volume":"20","author":"MS Razzaque","year":"2006","journal-title":"FASEB J"},{"issue":"2","key":"pone.0236361.ref013","doi-asserted-by":"crossref","first-page":"e31376","DOI":"10.1371\/journal.pone.0031376","article-title":"Klotho lacks a vitamin D independent physiological role in glucose homeostasis, bone turnover, and steady-state PTH secretion in vivo","volume":"7","author":"R Anour","year":"2012","journal-title":"PLoS One"},{"issue":"2","key":"pone.0236361.ref014","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.matbio.2006.10.003","article-title":"Ablation of vitamin D signaling rescues bone, mineral, and glucose homeostasis in Fgf-23 deficient mice","volume":"26","author":"M Hesse","year":"2007","journal-title":"Matrix Biol"},{"issue":"3","key":"pone.0236361.ref015","first-page":"229","article-title":"FGF23 promotes renal calcium reabsorption through the TRPV5 channel","volume":"33","author":"O Andrukhova","year":"2014","journal-title":"EMBO J"},{"issue":"12","key":"pone.0236361.ref016","doi-asserted-by":"crossref","first-page":"3182","DOI":"10.1093\/jn\/131.12.3182","article-title":"The progression of aging in klotho mutant mice can be modified by dietary phosphorus and zinc","volume":"131","author":"K Morishita","year":"2001","journal-title":"J Nutr"},{"issue":"9","key":"pone.0236361.ref017","doi-asserted-by":"crossref","first-page":"3562","DOI":"10.1096\/fj.09-152488","article-title":"Dietary and genetic evidence for phosphate toxicity accelerating mammalian aging","volume":"24","author":"M Ohnishi","year":"2010","journal-title":"FASEB J"},{"issue":"9","key":"pone.0236361.ref018","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/nm.1865","article-title":"An efficient and versatile system for acute and chronic modulation of renal tubular function in transgenic mice","volume":"14","author":"M Traykova-Brauch","year":"2008","journal-title":"Nat Med"},{"issue":"23","key":"pone.0236361.ref019","doi-asserted-by":"crossref","first-page":"e134","DOI":"10.1093\/nar\/gnf134","article-title":"Stringent doxycycline dependent control of CRE recombinase in vivo","volume":"30","author":"K Schonig","year":"2002","journal-title":"Nucleic Acids Res"},{"issue":"10","key":"pone.0236361.ref020","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1681\/ASN.2012030240","article-title":"Nanoparticle-based test measures overall propensity for calcification in serum","volume":"23","author":"A Pasch","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"pone.0236361.ref021","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/j.1749-6632.2002.tb04763.x","article-title":"Immunohistochemical detection of the sodium-calcium exchanger in rat hippocampus cultures using subtype-specific antibodies","volume":"976","author":"T Thurneysen","year":"2002","journal-title":"Ann N Y Acad Sci"},{"issue":"11","key":"pone.0236361.ref022","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1007\/s00424-014-1470-x","article-title":"Coordinated regulation of TRPV5-mediated Ca(2)(+) transport in primary distal convolution cultures","volume":"466","author":"EA van der Hagen","year":"2014","journal-title":"Pflugers Arch"},{"issue":"5 Pt 2","key":"pone.0236361.ref023","first-page":"F767","article-title":"Expression of Na-P(i) cotransport in rat kidney: localization by RT-PCR and immunohistochemistry","volume":"266","author":"M Custer","year":"1994","journal-title":"Am J Physiol"},{"issue":"8","key":"pone.0236361.ref024","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1172\/JCI31680","article-title":"Impaired basolateral sorting of pro-EGF causes isolated recessive renal hypomagnesemia","volume":"117","author":"WM Groenestege","year":"2007","journal-title":"J Clin Invest"},{"key":"pone.0236361.ref025","doi-asserted-by":"crossref","first-page":"874","DOI":"10.3389\/fphys.2018.00874","article-title":"Renal Memo1 Differentially Regulates the Expression of Vitamin D-Dependent Distal Renal Tubular Calcium Transporters","volume":"9","author":"MB Moor","year":"2018","journal-title":"Front Physiol"},{"issue":"Pt 6","key":"pone.0236361.ref026","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1242\/jcs.032094","article-title":"Memo is a cofilin-interacting protein that influences PLCgamma1 and cofilin activities, and is essential for maintaining directionality during ErbB2-induced tumor-cell migration","volume":"122","author":"M Meira","year":"2009","journal-title":"J Cell Sci"},{"issue":"6","key":"pone.0236361.ref027","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/ncb1134","article-title":"Memo mediates ErbB2-driven cell motility","volume":"6","author":"R Marone","year":"2004","journal-title":"Nat Cell Biol"},{"key":"pone.0236361.ref028","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/srep00146","article-title":"Phosphatidylinositol 4,5-bisphosphate (PIP(2)) controls magnesium gatekeeper TRPM6 activity","volume":"1","author":"J Xie","year":"2011","journal-title":"Sci Rep"},{"issue":"5","key":"pone.0236361.ref029","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.13176","article-title":"Antibody-mediated inhibition of EGFR reduces phosphate excretion and induces hyperphosphatemia and mild hypomagnesemia in mice","volume":"5","author":"B Ortega","year":"2017","journal-title":"Physiol Rep"},{"issue":"2 Pt 2","key":"pone.0236361.ref030","first-page":"F309","article-title":"Epidermal growth factor inhibits Na-Pi cotransport and mRNA in OK cells","volume":"268","author":"M Arar","year":"1995","journal-title":"Am J Physiol"},{"issue":"1","key":"pone.0236361.ref031","first-page":"F72","article-title":"Epidermal growth factor inhibits Na-Pi cotransport in weaned and suckling rats","volume":"276","author":"M Arar","year":"1999","journal-title":"Am J Physiol"},{"issue":"6","key":"pone.0236361.ref032","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.ceca.2011.09.003","article-title":"EGF enhances the migration of cancer cells by up-regulation of TRPM7","volume":"50","author":"H Gao","year":"2011","journal-title":"Cell Calcium"},{"issue":"6","key":"pone.0236361.ref033","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1089\/ars.2010.3648","article-title":"Role of reactive oxygen species and redox in regulating the function of transient receptor potential channels","volume":"15","author":"MY Song","year":"2011","journal-title":"Antioxid Redox Signal"},{"issue":"34","key":"pone.0236361.ref034","doi-asserted-by":"crossref","first-page":"26081","DOI":"10.1074\/jbc.M110.103655","article-title":"Methionine sulfoxide reductase B1 (MsrB1) recovers TRPM6 channel activity during oxidative stress","volume":"285","author":"G Cao","year":"2010","journal-title":"J Biol Chem"},{"issue":"3","key":"pone.0236361.ref035","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S1016-8478(23)10727-8","article-title":"Regulation of transient receptor potential melastatin 7 (TRPM7) currents by mitochondria","volume":"23","author":"BJ Kim","year":"2007","journal-title":"Mol Cells"},{"issue":"30","key":"pone.0236361.ref036","doi-asserted-by":"crossref","first-page":"E6079","DOI":"10.1073\/pnas.1707380114","article-title":"TRPM7 senses oxidative stress to release Zn2+ from unique intracellular vesicles","volume":"114","author":"SA Abiria","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"pone.0236361.ref037","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1093\/jn\/113.10.2041","article-title":"Impairment of ascorbic acid synthesis in liver extracts of magnesium-deficient rats","volume":"113","author":"JM Hsu","year":"1983","journal-title":"J Nutr"},{"issue":"3","key":"pone.0236361.ref038","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/glia.20923","article-title":"Sodium-dependent vitamin C transporter 2 (SVCT2) is necessary for the uptake of L-ascorbic acid into Schwann cells","volume":"58","author":"B Gess","year":"2010","journal-title":"Glia"},{"issue":"4","key":"pone.0236361.ref039","doi-asserted-by":"crossref","first-page":"20","DOI":"10.7603\/s40681-016-0020-6","article-title":"Magnesium deficiency and oxidative stress: an update","volume":"6","author":"AA Zheltova","year":"2016","journal-title":"Biomedicine (Taipei)"},{"issue":"4","key":"pone.0236361.ref040","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1042\/bj0600573","article-title":"Some properties of alkaline phosphatase of cow's milk and calf intestinal mucosa","volume":"60","author":"RK Morton","year":"1955","journal-title":"Biochem J"},{"issue":"3","key":"pone.0236361.ref041","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1172\/JCI17202","article-title":"The serum protein alpha 2-Heremans-Schmid glycoprotein\/fetuin-A is a systemically acting inhibitor of ectopic calcification","volume":"112","author":"C Schafer","year":"2003","journal-title":"J Clin Invest"},{"issue":"316","key":"pone.0236361.ref042","article-title":"Tissue transcriptome-driven identification of epidermal growth factor as a chronic kidney disease biomarker","volume":"7","author":"W Ju","year":"2015","journal-title":"Sci Transl Med"},{"issue":"5","key":"pone.0236361.ref043","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/j.kint.2017.04.011","article-title":"Dietary magnesium supplementation prevents and reverses vascular and soft tissue calcifications in uremic rats","volume":"92","author":"JM Diaz-Tocados","year":"2017","journal-title":"Kidney Int"},{"issue":"4","key":"pone.0236361.ref044","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/ki.2015.165","article-title":"Magnesium modifies the association between serum phosphate and the risk of progression to end-stage kidney disease in patients with non-diabetic chronic kidney disease","volume":"88","author":"Y Sakaguchi","year":"2015","journal-title":"Kidney Int"},{"issue":"6","key":"pone.0236361.ref045","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1681\/ASN.2018111150","article-title":"A Randomized Trial of Magnesium Oxide and Oral Carbon Adsorbent for Coronary Artery Calcification in Predialysis CKD","volume":"30","author":"Y Sakaguchi","year":"2019","journal-title":"J Am Soc Nephrol"},{"key":"pone.0236361.ref046","doi-asserted-by":"crossref","first-page":"14471","DOI":"10.1038\/srep14471","article-title":"Renoprotective effect of long acting thioredoxin by modulating oxidative stress and macrophage migration inhibitory factor against rhabdomyolysis-associated acute kidney injury","volume":"5","author":"K Nishida","year":"2015","journal-title":"Sci Rep"},{"issue":"2","key":"pone.0236361.ref047","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1172\/JCI77632","article-title":"Sirtuin 3-dependent mitochondrial dynamic improvements protect against acute kidney injury","volume":"125","author":"M Morigi","year":"2015","journal-title":"J Clin Invest"},{"issue":"4","key":"pone.0236361.ref048","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1172\/JCI41563","article-title":"Sirt1 activation protects the mouse renal medulla from oxidative injury","volume":"120","author":"W He","year":"2010","journal-title":"J Clin Invest"},{"issue":"6","key":"pone.0236361.ref049","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1038\/ki.2012.439","article-title":"Targeting the transcription factor Nrf2 to ameliorate oxidative stress and inflammation in chronic kidney disease","volume":"83","author":"S Ruiz","year":"2013","journal-title":"Kidney Int"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0236361","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T19:29:17Z","timestamp":1723318157000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0236361"}},"subtitle":[],"editor":[{"given":"Peter A.","family":"Friedman","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,7,24]]},"references-count":49,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2020,7,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0236361","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2020,7,24]]}}}