{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:47:22Z","timestamp":1790138842726,"version":"4.0.1"},"reference-count":44,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T00:00:00Z","timestamp":1595548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP17K10410"],"award-info":[{"award-number":["JP17K10410"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP20K08111"],"award-info":[{"award-number":["JP20K08111"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0236512","type":"journal-article","created":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T17:23:39Z","timestamp":1595611419000},"page":"e0236512","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["A voxel-based analysis of cerebral blood flow abnormalities in obsessive-compulsive disorder using pseudo-continuous arterial spin labeling MRI"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9846-8693","authenticated-orcid":true,"given":"Daichi","family":"Momosaka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Togao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Hiwatashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazufumi","family":"Kikuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Tomiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Nakao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keitaro","family":"Murayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuriko","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Honda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,7,24]]},"reference":[{"issue":"3","key":"pone.0236512.ref001","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.neubiorev.2004.11.006","article-title":"The neuropsychology of obsessive compulsive disorder: the importance of failures in cognitive and behavioural inhibition as candidate endophenotypic markers","volume":"29","author":"SR Chamberlain","year":"2005","journal-title":"Neurosci Biobehav Rev"},{"key":"pone.0236512.ref002","first-page":"370","volume-title":"Diagnostic criteria from DSM-IV-TR","author":"American Psychiatric Association","year":"2000"},{"issue":"3","key":"pone.0236512.ref003","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.neubiorev.2007.09.005","article-title":"Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: the orbitofronto-striatal model revisited","volume":"32","author":"L Menzies","year":"2008","journal-title":"Neurosci Biobehav Rev"},{"issue":"9","key":"pone.0236512.ref004","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1001\/archpsyc.1992.01820090023004","article-title":"Regional xenon 133 cerebral blood flow and cerebral technetium 99m HMPAO uptake in unmedicated patients with obsessive-compulsive disorder and matched normal control subjects. Determination by high-resolution single-photon emission computed tomography","volume":"49","author":"RT Rubin","year":"1992","journal-title":"Archives of general psychiatry"},{"issue":"4","key":"pone.0236512.ref005","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/hbm.460010403","article-title":"Mapping of SPECT regional cerebral perfusion abnormalities in obsessive-compulsive disorder","volume":"1","author":"GJ Harris","year":"1994","journal-title":"Human brain mapping"},{"issue":"5","key":"pone.0236512.ref006","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1192\/bjp.167.5.629","article-title":"Regional cerebral blood flow in obsessive-compulsive disordered patients at rest. Differential correlates with obsessive-compulsive and anxious-avoidant dimensions","volume":"167","author":"JV Lucey","year":"1995","journal-title":"The British journal of psychiatry: the journal of mental science"},{"issue":"1","key":"pone.0236512.ref007","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0925-4927(00)00050-0","article-title":"A voxel-based investigation of regional cerebral blood flow abnormalities in obsessive-compulsive disorder using single photon emission computed tomography (SPECT)","volume":"99","author":"GF Busatto","year":"2000","journal-title":"Psychiatry Res"},{"issue":"1","key":"pone.0236512.ref008","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0925-4927(01)00086-5","article-title":"Tc-99m HMPAO brain perfusion SPECT in drug-free obsessive-compulsive patients without depression","volume":"107","author":"K Alptekin","year":"2001","journal-title":"Psychiatry Res"},{"issue":"2","key":"pone.0236512.ref009","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0925-4927(03)00061-1","article-title":"Elevated thalamic and prefrontal regional cerebral blood flow in obsessive-compulsive disorder: a SPECT study","volume":"123","author":"AL Lacerda","year":"2003","journal-title":"Psychiatry Res"},{"issue":"2","key":"pone.0236512.ref010","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0925-4927(03)00069-6","article-title":"Effects of behavior therapy on regional cerebral blood flow in obsessive-compulsive disorder","volume":"124","author":"E Nakatani","year":"2003","journal-title":"Psychiatry Res"},{"issue":"1","key":"pone.0236512.ref011","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3349\/ymj.2004.45.1.90","article-title":"Pharmacotherapy and regional cerebral blood flow in children with obsessive compulsive disorder","volume":"45","author":"RS Diler","year":"2004","journal-title":"Yonsei medical journal"},{"issue":"2","key":"pone.0236512.ref012","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.pscychresns.2012.07.005","article-title":"The comparison of pre- and post-treatment (99m)Tc HMPAO brain SPECT images in patients with obsessive-compulsive disorder","volume":"213","author":"F Karadag","year":"2013","journal-title":"Psychiatry Res"},{"issue":"1","key":"pone.0236512.ref013","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1590\/0004-282X20130205","article-title":"Regional cerebral blood flow and cognitive function in patients with obsessive-compulsive disorder","volume":"72","author":"H Guo","year":"2014","journal-title":"Arq Neuropsiquiatr"},{"issue":"1","key":"pone.0236512.ref014","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0925-4927(93)90024-C","article-title":"MRI-guided region of interest placement on emission computed tomograms","volume":"50","author":"GJ Harris","year":"1993","journal-title":"Psychiatry Res"},{"issue":"6 Pt 1","key":"pone.0236512.ref015","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1006\/nimg.2000.0582","article-title":"Voxel-based morphometry\u2014the methods","volume":"11","author":"J Ashburner","year":"2000","journal-title":"NeuroImage"},{"issue":"6","key":"pone.0236512.ref016","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.mri.2013.03.016","article-title":"Abnormalities of cerebral blood flow in multiple sclerosis: a pseudocontinuous arterial spin labeling MRI study","volume":"31","author":"M Ota","year":"2013","journal-title":"Magnetic resonance imaging"},{"issue":"2","key":"pone.0236512.ref017","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.pscychresns.2010.01.009","article-title":"Chronic and treatment-resistant depression: a study using arterial spin labeling perfusion MRI at 3Tesla","volume":"182","author":"B Duhameau","year":"2010","journal-title":"Psychiatry Res"},{"issue":"1","key":"pone.0236512.ref018","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.pscychresns.2011.06.013","article-title":"Resting quantitative cerebral blood flow in schizophrenia measured by pulsed arterial spin labeling perfusion MRI","volume":"194","author":"A Pinkham","year":"2011","journal-title":"Psychiatry Res"},{"issue":"11","key":"pone.0236512.ref019","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1001\/archpsyc.1989.01810110048007","article-title":"The Yale-Brown Obsessive Compulsive Scale. I. Development, use, and reliability","volume":"46","author":"WK Goodman","year":"1989","journal-title":"Archives of general psychiatry"},{"issue":"1","key":"pone.0236512.ref020","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1002\/mrm.25197","article-title":"Recommended implementation of arterial spin-labeled perfusion MRI for clinical applications: A consensus of the ISMRM perfusion study group and the European consortium for ASL in dementia","volume":"73","author":"DC Alsop","year":"2015","journal-title":"Magnetic resonance in medicine"},{"issue":"1412","key":"pone.0236512.ref021","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1098\/rstb.2001.0915","article-title":"A probabilistic atlas and reference system for the human brain: International Consortium for Brain Mapping (ICBM)","volume":"356","author":"J Mazziotta","year":"2001","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"issue":"2","key":"pone.0236512.ref022","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/nprot.2015.014","article-title":"A 12-step user guide for analyzing voxel-wise gray matter asymmetries in statistical parametric mapping (SPM)","volume":"10","author":"F Kurth","year":"2015","journal-title":"Nature protocols"},{"issue":"1","key":"pone.0236512.ref023","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/hbm.1058","article-title":"Nonparametric permutation tests for functional neuroimaging: a primer with examples","volume":"15","author":"TE Nichols","year":"2002","journal-title":"Human brain mapping"},{"issue":"1","key":"pone.0236512.ref024","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.neuroimage.2008.08.045","article-title":"Issues with threshold masking in voxel-based morphometry of atrophied brains","volume":"44","author":"GR Ridgway","year":"2009","journal-title":"NeuroImage"},{"issue":"4","key":"pone.0236512.ref025","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.clinph.2007.10.026","article-title":"Human brain mapping: Hemodynamic response and electrophysiology","volume":"119","author":"H Shibasaki","year":"2008","journal-title":"Clinical Neurophysiology"},{"issue":"2","key":"pone.0236512.ref026","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/ana.20742","article-title":"Functional role of the basal ganglia in the planning and execution of actions","volume":"59","author":"O Monchi","year":"2006","journal-title":"Annals of neurology"},{"issue":"5","key":"pone.0236512.ref027","doi-asserted-by":"crossref","first-page":"378","DOI":"10.3109\/15622975.2015.1102323","article-title":"Executive functions in obsessive-compulsive disorder: An activation likelihood estimate meta-analysis of fMRI studies","volume":"17","author":"A Del Casale","year":"2016","journal-title":"The world journal of biological psychiatry: the official journal of the World Federation of Societies of Biological Psychiatry"},{"issue":"5","key":"pone.0236512.ref028","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.pneurobio.2004.09.004","article-title":"Mesolimbic dopaminergic pathways in fear conditioning","volume":"74","author":"MA Pezze","year":"2004","journal-title":"Progress in neurobiology"},{"key":"pone.0236512.ref029","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1093\/oso\/9780198566960.001.0001","volume-title":"Cingulate neurobiology and disease","author":"BA Vogt","year":"2009"},{"issue":"6","key":"pone.0236512.ref030","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1001\/archpsyc.61.6.564","article-title":"Distinct neural correlates of washing, checking, and hoarding symptom dimensions in obsessive-compulsive disorder","volume":"61","author":"D Mataix-Cols","year":"2004","journal-title":"Archives of general psychiatry"},{"issue":"3","key":"pone.0236512.ref031","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1097\/00004583-200103000-00015","article-title":"Regional cerebral blood flow abnormalities in early-onset obsessive-compulsive disorder: an exploratory SPECT study","volume":"40","author":"GF Busatto","year":"2001","journal-title":"Journal of the American Academy of Child and Adolescent Psychiatry"},{"issue":"9","key":"pone.0236512.ref032","doi-asserted-by":"crossref","first-page":"e1230","DOI":"10.1038\/tp.2017.192","article-title":"Mechanisms of cognitive-behavioral therapy for obsessive-compulsive disorder involve robust and extensive increases in brain network connectivity","volume":"7","author":"TD Moody","year":"2017","journal-title":"Translational psychiatry"},{"key":"pone.0236512.ref033","doi-asserted-by":"crossref","first-page":"134449","DOI":"10.1016\/j.neulet.2019.134449","article-title":"Abnormalities within and beyond the cortico-striato-thalamo-cortical circuitry in medication-free patients with OCD revealed by the fractional amplitude of low-frequency fluctuations and resting-state functional connectivity","volume":"712","author":"J Gao","year":"2019","journal-title":"Neurosci Lett"},{"issue":"2","key":"pone.0236512.ref034","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/brb3.212","article-title":"Brain microstructural changes and cognitive correlates in patients with pure obsessive compulsive disorder","volume":"4","author":"G Spalletta","year":"2014","journal-title":"Brain Behav"},{"issue":"1","key":"pone.0236512.ref035","first-page":"777","article-title":"The Temporal Pole Top-Down Modulates the Ventral Visual Stream During Social Cognition","volume":"27","author":"C Pehrs","year":"2017","journal-title":"Cereb Cortex"},{"issue":"8","key":"pone.0236512.ref036","doi-asserted-by":"crossref","first-page":"e1224","DOI":"10.1038\/tp.2017.189","article-title":"The neural correlates of obsessive-compulsive disorder: a multimodal perspective","volume":"7","author":"PS Moreira","year":"2017","journal-title":"Translational psychiatry"},{"issue":"2","key":"pone.0236512.ref037","doi-asserted-by":"crossref","first-page":"e01201","DOI":"10.1002\/brb3.1201","article-title":"Abnormalities of white matter microstructure in unmedicated patients with obsessive-compulsive disorder: Changes after cognitive behavioral therapy","volume":"9","author":"Z Zhong","year":"2019","journal-title":"Brain and behavior"},{"key":"pone.0236512.ref038","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jpsychires.2014.03.006","article-title":"Diffusion tensor imaging (DTI) studies in patients with obsessive-compulsive disorder (OCD): A review","volume":"54","author":"K Koch","year":"2014","journal-title":"Journal of psychiatric research"},{"issue":"2","key":"pone.0236512.ref039","doi-asserted-by":"crossref","first-page":"e56733","DOI":"10.1371\/journal.pone.0056733","article-title":"The relationship between cortical blood flow and sub-cortical white-matter health across the adult age span","volume":"8","author":"JJ Chen","year":"2013","journal-title":"PloS one"},{"issue":"1","key":"pone.0236512.ref040","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.pscychresns.2010.06.011","article-title":"Regional gray and white matter volume abnormalities in obsessive-compulsive disorder: a voxel-based morphometry study","volume":"184","author":"O Togao","year":"2010","journal-title":"Psychiatry Res"},{"issue":"7","key":"pone.0236512.ref041","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/pcn.12269","article-title":"Biological heterogeneity of obsessive-compulsive disorder: A voxel-based morphometric study based on dimensional assessment","volume":"69","author":"K Okada","year":"2015","journal-title":"Psychiatry Clin Neurosci"},{"key":"pone.0236512.ref042","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.cortex.2013.01.016","article-title":"Widespread structural brain changes in OCD: a systematic review of voxel-based morphometry studies","volume":"62","author":"F Piras","year":"2015","journal-title":"Cortex"},{"issue":"1","key":"pone.0236512.ref043","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.psychres.2010.08.001","article-title":"Distinct neuropsychological profiles of three major symptom dimensions in obsessive\u2013compulsive disorder","volume":"187","author":"N Hashimoto","year":"2011","journal-title":"Psychiatry Research"},{"issue":"10","key":"pone.0236512.ref044","doi-asserted-by":"crossref","first-page":"384","DOI":"10.4329\/wjr.v2.i10.384","article-title":"Arterial spin labeling in neuroimaging","volume":"2","author":"S Petcharunpaisan","year":"2010","journal-title":"World J Radiol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0236512","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T19:23:49Z","timestamp":1723317829000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0236512"}},"subtitle":[],"editor":[{"given":"Xi","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,7,24]]},"references-count":44,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2020,7,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0236512","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,24]]}}}