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Soc"},{"key":"pone.0236568.ref081","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.dadm.2018.01.003","article-title":"Change in retinal structure anatomy during the preclinical stage of Alzheimer's disease","volume":"10","author":"CY Santos","year":"2018","journal-title":"Alzheimer Dement (Amst)"},{"key":"pone.0236568.ref082","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.trci.2019.08.008","article-title":"Ganglion cell layer thinning in prodromal Alzheimer's disease defined by amyloid-PET","volume":"5","author":"A Lopez-de-Eguileta","year":"2019","journal-title":"Alzheimer Dement (NY)"},{"issue":"1","key":"pone.0236568.ref083","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0002-9394(01)01196-5","article-title":"Association of glaucoma with neurodegenerative diseases with apoptotic cell death: Alzheimer's disease and parkinson's disease","volume":"133","author":"AU Bayer","year":"2002","journal-title":"Am J Ophthalmol"},{"issue":"3","key":"pone.0236568.ref084","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1159\/000047976","article-title":"High occurrence rate of glaucoma among patients with Alzheimer's disease","volume":"47","author":"AU Bayer","year":"2002","journal-title":"Eur Neurol"},{"issue":"33","key":"pone.0236568.ref085","doi-asserted-by":"crossref","first-page":"13444","DOI":"10.1073\/pnas.0703707104","article-title":"Targeting amyloid-? in glaucoma treatment","volume":"104","author":"L Guo","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"pone.0236568.ref086","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.neurobiolaging.2009.03.002","article-title":"Tau inclusions in retinal ganglion cells of human P301S tau transgenic mice: effects on axonal viability","volume":"323","author":"L Gasparini","year":"2011","journal-title":"Neurobiol Aging"},{"issue":"8","key":"pone.0236568.ref087","doi-asserted-by":"crossref","first-page":"e0220535","DOI":"10.1371\/journal.pone.0220535","article-title":"Changes in visual function and retinal structure in the progression of Alzheimer's disease","volume":"14","author":"E Salobrar-Garcia","year":"2019","journal-title":"PloS One"},{"issue":"10","key":"pone.0236568.ref088","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1001\/jamaneurol.2018.1563","article-title":"Association of retinal neurodegeneration on optical coherence tomography with dementia","volume":"75","author":"U Mutku","year":"2018","journal-title":"JAMA Neurol"},{"issue":"1","key":"pone.0236568.ref089","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1212\/WNL.45.1.68","article-title":"Visual field loss in senile dementia of the Alzheimer's type","volume":"54","author":"GL Trick","year":"1995","journal-title":"Neurology"},{"key":"pone.0236568.ref090","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.neulet.2010.06.006","article-title":"Retinal nerve fiber layer structure abnormalities in early Alzheimer's disease: evidence in optical coherence tomography","volume":"480","author":"Y Lu","year":"2010","journal-title":"Neurosci Lett"},{"key":"pone.0236568.ref091","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1212\/01.wnl.0000244490.07925.8b","article-title":"Reduction of optic nerve fibers in patients with Alzheimer disease identified by laser imaging","volume":"67","author":"H Danesh-Meyer","year":"2006","journal-title":"Neurology"},{"key":"pone.0236568.ref092","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1167\/iovs.06-1029","article-title":"Retinal abnormalities in early Alzheimer's disease","volume":"48","author":"F Berisha","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"pone.0236568.ref093","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1034\/j.1600-0420.2001.079002187.x","article-title":"An evaluation of the retinal nerve fiber layer thickness by scanning laser polarimetry in individuals with dementia of the Alzheimer type","volume":"79","author":"H Kergoat","year":"2001","journal-title":"Acta Ophthalmol Scand"},{"key":"pone.0236568.ref094","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1007\/s10792-014-0004-z","article-title":"Confocal scanning laser tomography of the optic nerve head on the patients with Alzheimer's disease compared to glaucoma and control","volume":"34","author":"SA Kurna","year":"2014","journal-title":"Int Ophthalmol"},{"key":"pone.0236568.ref095","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1136\/bjophthalmol-2017-310476","article-title":"Evaluation of optical coherence tomography angiographic findings in Alzheimer's type dementia","volume":"102","author":"M Bulut","year":"2018","journal-title":"Br J Ohthalmol"},{"key":"pone.0236568.ref096","doi-asserted-by":"crossref","first-page":"3447","DOI":"10.1167\/iovs.19-27028","article-title":"Comparison of retinal microvasculature in patients with Alzheimer'd disease and primary open-angle glaucoma by optical coherence tomography angiography","volume":"60","author":"P Zabel","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"pone.0236568.ref097","doi-asserted-by":"crossref","first-page":"3079141","DOI":"10.1155\/2017\/3079141","article-title":"Foveal avascular zone in normal tension glaucoma measured by optical coherence tomography angiography","volume":"2017","author":"M Zivkovic","year":"2017","journal-title":"Biomed Res Int"},{"issue":"1","key":"pone.0236568.ref098","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1159\/000499695","article-title":"Correlation between basal macular circulation and following glaucomatous damage in progressed high-tension and normal-tension glaucoma","volume":"62","author":"CY Lee","year":"2019","journal-title":"Ophthalmic Res"},{"key":"pone.0236568.ref099","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1167\/iovs.16-21079","article-title":"Alterations of the foveal avascular zone measured by optical coherence tomography angiography in glaucoma patients with central visual field defects","volume":"58","author":"J Kwon","year":"2017","journal-title":"Invest ophthalmol Vis Sci"},{"key":"pone.0236568.ref100","article-title":"Effect of surgical intraocular pressure lowering on retinal structures\u2014nerve fibre layer, foveal avascular zone, peripapillary and macular vessel density: 1 year results","author":"TW Ch'ng","year":"2019","journal-title":"Eye (Lond)"},{"key":"pone.0236568.ref101","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/cne.903010106","article-title":"Quantitative analysis of a vulnerable subset of pyramidal neurons in Alzheimer's disease: II. 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