{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T06:06:54Z","timestamp":1788242814976,"version":"build-2803163510"},"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T00:00:00Z","timestamp":1596412800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National research foundation of Korea","doi-asserted-by":"crossref","award":["2017R1E1A1A01078409"],"award-info":[{"award-number":["2017R1E1A1A01078409"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0236784","type":"journal-article","created":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T17:36:45Z","timestamp":1596476205000},"page":"e0236784","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["A computational study to model the effect of electrode-to-auditory nerve fiber distance on spectral resolution in cochlear implant"],"prefix":"10.1371","volume":"15","author":[{"given":"Hyejin","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Ho","family":"Won","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inyong","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2227-5948","authenticated-orcid":true,"given":"Jihwan","family":"Woo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,8,3]]},"reference":[{"key":"pone.0236784.ref001","doi-asserted-by":"crossref","first-page":"3586","DOI":"10.1121\/1.423941","article-title":"Effects of noise and spectral resolution on vowel and consonant recognition: Acoustic and electric hearing","volume":"104","author":"Q-J Fu","year":"1998","journal-title":"J Acoust Soc Am"},{"key":"pone.0236784.ref002","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1121\/1.428449","article-title":"Place-pitch sensitivity and its relation to consonant recognition by cochlear implant listeners using the MPEAK and SPEAK speech processing strategies","volume":"107","author":"GS Donaldson","year":"2000","journal-title":"J Acoust Soc Am"},{"key":"pone.0236784.ref003","article-title":"Frequency resolving power measured by rippled noise","author":"AY Supin","year":"1994","journal-title":"Hear Res"},{"key":"pone.0236784.ref004","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1121\/1.1561900","article-title":"The resolution of complex spectral patterns by cochlear implant and normal-hearing listeners","volume":"113","author":"BA Henry","year":"2003","journal-title":"J Acoust Soc Am"},{"key":"pone.0236784.ref005","article-title":"Spectral peak resolution and speech recognition in quiet: Normal hearing, hearing impaired, and cochlear implant listeners","author":"BA Henry","year":"2005","journal-title":"J Acoust Soc Am"},{"key":"pone.0236784.ref006","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1007\/s10162-007-0085-8","article-title":"Spectral-ripple resolution correlates with speech reception in noise in cochlear implant users","volume":"8","author":"JH Won","year":"2007","journal-title":"JARO\u2014J Assoc Res Otolaryngol"},{"key":"pone.0236784.ref007","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1121\/1.4932020","article-title":"Cochlear implant users\u2019 spectral ripple resolution","volume":"138","author":"EK Jeon","year":"2015","journal-title":"J Acoust Soc Am"},{"key":"pone.0236784.ref008","article-title":"Speech perception of children using Nucleus, Clarion or Med-El cochlear implants","author":"R Taitelbaum-Swead","year":"2005","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"pone.0236784.ref009","article-title":"Impact of electrode design and surgical approach on scalar location and cochlear implant outcomes","author":"GB Wanna","year":"2014","journal-title":"Laryngoscope"},{"key":"pone.0236784.ref010","article-title":"Effect of residual hearing prior to cochlear implantation on speech perception in children","author":"KA Gordon","year":"2001","journal-title":"J Otolaryngol"},{"key":"pone.0236784.ref011","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1097\/00129492-200405000-00015","article-title":"Degree of modiolar coiling, electrical thresholds, and speech perception after cochlear implantation","author":"MS Marrinan","year":"2004","journal-title":"Otology and Neurotology"},{"key":"pone.0236784.ref012","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1097\/AUD.0b013e3182741aa7","article-title":"Factors affecting open-set word recognition in adults with cochlear implants","volume":"34","author":"LK Holden","year":"2013","journal-title":"Ear Hear"},{"key":"pone.0236784.ref013","article-title":"Pre-, Per- and Postoperative Factors Affecting Performance of Postlinguistically Deaf Adults Using Cochlear Implants: A New Conceptual Model over Time","author":"DS Lazard","year":"2012","journal-title":"PLoS One"},{"key":"pone.0236784.ref014","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1097\/MAO.0000000000001241","article-title":"Factors affecting outcomes in cochlear implant recipients implanted with a perimodiolar electrode array located in scala tympani","volume":"37","author":"LK Holden","year":"2016","journal-title":"Otol Neurotol"},{"key":"pone.0236784.ref015","article-title":"Investigation of the effects of temporal and spatial interactions on speech-recognition skills in cochlear-implant subjects","author":"CS Throckmorton","year":"1999","journal-title":"J Acoust Soc Am"},{"key":"pone.0236784.ref016","article-title":"Forward masked excitation patterns in multielectrode electrical stimulation","author":"M Chatterjee","year":"1998","journal-title":"J Acoust Soc Am"},{"key":"pone.0236784.ref017","article-title":"Loudness summation for pulsatile electrical stimulation of the cochlea: Effects of rate, electrode separation, level, and mode of stimulation","author":"CM McKay","year":"2001","journal-title":"J Acoust Soc Am"},{"key":"pone.0236784.ref018","article-title":"Response properties of the refractory auditory nerve fiber","author":"CA Miller","year":"2001","journal-title":"JARO\u2014J Assoc Res Otolaryngol"},{"key":"pone.0236784.ref019","unstructured":"Dynes SBC. Discharge Characteristics of Auditory Nerve Fibers for Pulsatile Electrical Stimuli. PhD thesis. Massachusetts Institute of Technology. 1996."},{"key":"pone.0236784.ref020","article-title":"Evaluation of a model of the cochlear neural membrane. I. Physiological measurement of membrane characteristics in response to intrameatal electrical stimulation","author":"LA Cartee","year":"2000","journal-title":"Hear Res"},{"key":"pone.0236784.ref021","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1097\/00003446-200012000-00008","article-title":"Speech perception as a function of electrical stimulation rate: Using the nucleus 24 cochlear implant system","volume":"21","author":"AE Vandali","year":"2000","journal-title":"Ear Hear"},{"key":"pone.0236784.ref022","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1109\/TBME.2009.2023978","article-title":"Biophysical model of an auditory nerve fiber with a novel adaptation component","volume":"56","author":"J Woo","year":"2009","journal-title":"IEEE Trans Biomed Eng"},{"key":"pone.0236784.ref023","doi-asserted-by":"crossref","DOI":"10.1016\/j.specom.2016.10.005","article-title":"Prediction of vowel identification for cochlear implant using a computational model","volume":"85","author":"H Yang","year":"2016","journal-title":"Speech Commun"},{"key":"pone.0236784.ref024","article-title":"Changes across time in the temporal responses of auditory nerve fibers stimulated by electric pulse trains","author":"CA Miller","year":"2008","journal-title":"JARO\u2014J Assoc Res Otolaryngol"},{"key":"pone.0236784.ref025","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s10162-009-0199-2","article-title":"The dependence of auditory nerve rate adaptation on electric stimulus parameters, electrode position, and fiber diameter: A computer model study","volume":"11","author":"J Woo","year":"2010","journal-title":"JARO\u2014J Assoc Res Otolaryngol"},{"key":"pone.0236784.ref026","article-title":"Cochlear implants: audiologic management and considerations for implantable hearing devices","author":"Wolfe Jace","year":"2017","journal-title":"Plural Pub"},{"key":"pone.0236784.ref027","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0378-5955(98)00061-6","article-title":"Spatial resolution of cochlear implants: The electrical field and excitation of auditory afferents","volume":"121","author":"A Kral","year":"1998","journal-title":"Hear Res"},{"key":"pone.0236784.ref028","article-title":"Stochastic versions of the Hodgkin-Huxley equations","author":"RF Fox","year":"1997","journal-title":"Biophys J"},{"key":"pone.0236784.ref029","article-title":"Comparison of algorithms for the simulation of action potentials with stochastic sodium channels","author":"H Mino","year":"2002","journal-title":"Ann Biomed Eng"},{"key":"pone.0236784.ref030","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1109\/TBME.2008.2005782","article-title":"Simulation of the electrically stimulated cochlear neuron: Modeling adaptation to trains of electric pulses","volume":"56","author":"J Woo","year":"2009","journal-title":"IEEE Trans Biomed Eng"},{"key":"pone.0236784.ref031","article-title":"Dimensions of the scala tympani in the human and cat with reference to cochlear implants","author":"SI Hatsushika","year":"1990","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"pone.0236784.ref032","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.specom.2011.09.004","article-title":"Speech intelligibility prediction using a Neurogram Similarity Index Measure","volume":"54","author":"A Hines","year":"2012","journal-title":"Speech Commun"},{"key":"pone.0236784.ref033","unstructured":"Bruce IC, L\u00e9ger AC, Wirtzfeld MR, Moore BC, Lorenzi C. Spike-time coding and auditory-nerve degeneration best explain speech intelligibility in noise for normal and near-normal low-frequency hearing. 38th ARO Midwinter Research Meeting. 2015."},{"key":"pone.0236784.ref034","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1109\/TBME.2003.820383","article-title":"Effects of Electrode-to-Fiber Distance on Temporal Neural Response with Electrical Stimulation","volume":"51","author":"H Mino","year":"2004","journal-title":"IEEE Trans Biomed Eng"},{"key":"pone.0236784.ref035","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.heares.2010.05.005","article-title":"Modeling the electrode-neuron interface of cochlear implants: Effects of neural survival, electrode placement, and the partial tripolar configuration","volume":"268","author":"JH Goldwyn","year":"2010","journal-title":"Hear Res"},{"key":"pone.0236784.ref036","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s10162-016-0557-9","article-title":"Assessing the Electrode-Neuron Interface with the Electrically Evoked Compound Action Potential, Electrode Position, and Behavioral Thresholds","volume":"17","author":"L DeVries","year":"2016","journal-title":"JARO\u2014J Assoc Res Otolaryngol"},{"key":"pone.0236784.ref037","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1748-1716.1965.tb04037.x","article-title":"Accommodation in Myelinated Nerve Fibres of Xenopus Laevis as Computed on the Basis of Voltage Clamp Data","volume":"63","author":"B Frankenhaeuser","year":"1965","journal-title":"Acta Physiol Scand"},{"key":"pone.0236784.ref038","article-title":"Deactivating stimulation sites based on low-rate thresholds improves spectral ripple and speech reception thresholds in cochlear implant users","author":"N. Zhou","year":"2017","journal-title":"J Acoust Soc Am"},{"key":"pone.0236784.ref039","article-title":"A model of the electrically excited human cochlear neuronI. Contribution of neural substructures to the generation and propagation of spikes","author":"F Rattay","year":"2001","journal-title":"Hear Res"},{"key":"pone.0236784.ref040","article-title":"Comparative anatomy of the cochlea and auditory nerve in mammals","author":"JB Nadol","year":"1988","journal-title":"Hear Res"},{"key":"pone.0236784.ref041","article-title":"Morphometry of intracellularly labeled neurons of the auditory nerve: Correlations with functional properties","author":"MC Liberman","year":"1984","journal-title":"J Comp Neurol"},{"key":"pone.0236784.ref042","article-title":"Changes across time in spike rate and spike amplitude of auditory nerve fibers stimulated by electric pulse trains","author":"F Zhang","year":"2007","journal-title":"JARO\u2014J Assoc Res Otolaryngol"},{"key":"pone.0236784.ref043","article-title":"Auditory nerve responses to monophasic and biphasic electric stimuli","author":"CA Miller","year":"2001","journal-title":"Hear Res"},{"key":"pone.0236784.ref044","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/934382","article-title":"Effects of electrode position on spatiotemporal auditory nerve fiber responses: A 3D computational model study","volume":"2015","author":"S Kang","year":"2015","journal-title":"Comput Math Methods Med"},{"key":"pone.0236784.ref045","article-title":"The development of a modified spectral ripple test","author":"JM Aronoff","year":"2013","journal-title":"J Acoust Soc Am"},{"key":"pone.0236784.ref046","doi-asserted-by":"crossref","DOI":"10.1121\/1.5079636","article-title":"Development and validation of a spectro-temporal processing test for cochlear-implant listeners","author":"AW Archer-Boyd","year":"2018","journal-title":"J Acoust Soc Am"},{"key":"pone.0236784.ref047","article-title":"Modeling Axon Membranes for Functional Electrical Stimulation","author":"F Rattay","year":"1993","journal-title":"IEEE Trans Biomed Eng"},{"key":"pone.0236784.ref048","article-title":"Higher sensitivity of human auditory nerve fibers to positive electrical currents","author":"O Macherey","year":"2008","journal-title":"JARO\u2014J Assoc Res Otolaryngol"},{"key":"pone.0236784.ref049","article-title":"Spread of excitation varies for different electrical pulse shapes and stimulation modes in cochlear implants","author":"JA Undurraga","year":"2012","journal-title":"Hear Res"},{"key":"pone.0236784.ref050","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1007\/s101620020013","article-title":"CT-derived estimation of cochlear morphology and electrode array position in relation to word recognition in nucleus-22 recipients","volume":"3","author":"MW Skinner","year":"2002","journal-title":"JARO\u2014J Assoc Res Otolaryngol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0236784","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T17:37:04Z","timestamp":1596476224000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0236784"}},"subtitle":[],"editor":[{"given":"Paul Hinckley","family":"Delano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,8,3]]},"references-count":50,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2020,8,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0236784","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,3]]}}}