{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T11:32:38Z","timestamp":1773660758932,"version":"3.50.1"},"reference-count":21,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T00:00:00Z","timestamp":1597276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0236882","type":"journal-article","created":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T18:29:44Z","timestamp":1597343384000},"page":"e0236882","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Mutations in m6A consensus motifs are suppressed in the m6A modified genes in human cancer cells"],"prefix":"10.1371","volume":"15","author":[{"given":"Mingzi","family":"An","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiyun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2458-3162","authenticated-orcid":true,"given":"Yingqian","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2020,8,13]]},"reference":[{"issue":"7632","key":"pone.0236882.ref001","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1038\/nature20577","article-title":"m(6)A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination","volume":"540","author":"IU Haussmann","year":"2016","journal-title":"Nature"},{"issue":"3","key":"pone.0236882.ref002","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/s41556-018-0045-z","article-title":"Recognition of RNA N(6)-methyladenosine by IGF2BP proteins enhances mRNA stability and translation","volume":"20","author":"H Huang","year":"2018","journal-title":"Nat Cell Biol"},{"key":"pone.0236882.ref003","doi-asserted-by":"crossref","first-page":"15737","DOI":"10.1038\/ncomms15737","article-title":"The m(6)A pathway facilitates sex determination in Drosophila","volume":"8","author":"L Kan","year":"2017","journal-title":"Nat Commun"},{"issue":"7632","key":"pone.0236882.ref004","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/nature20568","article-title":"m(6)A modulates neuronal functions and sex determination in Drosophila","volume":"540","author":"T Lence","year":"2016","journal-title":"Nature"},{"issue":"7481","key":"pone.0236882.ref005","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nature12730","article-title":"N6-methyladenosine-dependent regulation of messenger RNA stability","volume":"505","author":"X Wang","year":"2014","journal-title":"Nature"},{"issue":"6","key":"pone.0236882.ref006","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.cell.2015.05.014","article-title":"-methyladenosine Modulates Messenger RNA Translation Efficiency","volume":"161","author":"X Wang","year":"2015","journal-title":"Cell"},{"issue":"9","key":"pone.0236882.ref007","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1038\/cr.2017.100","article-title":"Mettl3-mediated m(6)A regulates spermatogonial differentiation and meiosis initiation","volume":"27","author":"K Xu","year":"2017","journal-title":"Cell Res"},{"key":"pone.0236882.ref008","article-title":"m6AVar: a database of functional variants involved in m6A modification","author":"Y Zheng","year":"2017","journal-title":"Nucleic Acids Res"},{"issue":"7574","key":"pone.0236882.ref009","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/nature15377","article-title":"Dynamic m(6)A mRNA methylation directs translational control of heat shock response","volume":"526","author":"J Zhou","year":"2015","journal-title":"Nature"},{"issue":"3","key":"pone.0236882.ref010","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.molcel.2016.03.021","article-title":"The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells","volume":"62","author":"S Lin","year":"2016","journal-title":"Mol Cell"},{"key":"pone.0236882.ref011","article-title":"Reduced C-to-U RNA editing rates might play a regulatory role in stress response of Arabidopsis","volume":"244","author":"D Chu","year":"2020","journal-title":"J Plant Physiol"},{"key":"pone.0236882.ref012","article-title":"Most m6A RNA modifications in protein-coding regions are evolutionarily unconserved and likely nonfunctional","author":"Z Liu","year":"2017","journal-title":"Mol Biol Evol"},{"key":"pone.0236882.ref013","article-title":"Human C-to-U coding RNA editing is largely nonadaptive","author":"Z Liu","year":"2018","journal-title":"Mol Biol Evol"},{"issue":"9","key":"pone.0236882.ref014","doi-asserted-by":"crossref","first-page":"e00169","DOI":"10.1002\/pld3.169","article-title":"The chloroplast and mitochondrial C-to-U RNA editing in Arabidopsis thaliana shows signals of adaptation","volume":"3","author":"D Chu","year":"2019","journal-title":"Plant Direct"},{"issue":"5924","key":"pone.0236882.ref015","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1126\/science.1168978","article-title":"Genome-wide analysis in vivo of translation with nucleotide resolution using ribosome profiling","volume":"324","author":"NT Ingolia","year":"2009","journal-title":"Sci"},{"issue":"6","key":"pone.0236882.ref016","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1101\/gr.229102","article-title":"The human genome browser at UCSC","volume":"12","author":"WJ Kent","year":"2002","journal-title":"Genome Res"},{"issue":"1","key":"pone.0236882.ref017","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"A Dobin","year":"2013","journal-title":"Bioinformatics"},{"issue":"2","key":"pone.0236882.ref018","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq\u2014a Python framework to work with high-throughput sequencing data","volume":"31","author":"S Anders","year":"2015","journal-title":"Bioinformatics"},{"key":"pone.0236882.ref019","doi-asserted-by":"crossref","first-page":"11194","DOI":"10.1038\/ncomms11194","article-title":"Genome-wide assessment of differential translations with ribosome profiling data","volume":"7","author":"Z Xiao","year":"2016","journal-title":"Nat Commun"},{"issue":"16","key":"pone.0236882.ref020","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The Sequence Alignment\/Map format and SAMtools","volume":"25","author":"H Li","year":"2009","journal-title":"Bioinformatics"},{"issue":"4","key":"pone.0236882.ref021","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.cell.2015.10.012","article-title":"5 ' UTR m(6)A Promotes Cap-Independent Translation","volume":"163","author":"KD Meyer","year":"2015","journal-title":"Cell"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0236882","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T18:30:28Z","timestamp":1597343428000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0236882"}},"subtitle":[],"editor":[{"given":"Alexander F.","family":"Palazzo","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,8,13]]},"references-count":21,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2020,8,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0236882","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,13]]}}}