{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:03:52Z","timestamp":1740146632648,"version":"3.37.3"},"reference-count":57,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T00:00:00Z","timestamp":1597968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Institute of Neurological Diseases and Stroke","award":["R01NS098891"],"award-info":[{"award-number":["R01NS098891"]}]},{"name":"The Fogarty International Center under the Global Brain and Nervous System Disorders Research Across the Lifespan program","award":["R01NS098891"],"award-info":[{"award-number":["R01NS098891"]}]},{"name":"National Institute of Neurological Diseases and Stroke in the U.S.","award":["R21NS077466"],"award-info":[{"award-number":["R21NS077466"]}]},{"name":"The Department of Biotechnology in India under the U.S.-India Bilateral Brain Research Collaborative Partnerships","award":["BT\/MB\/BRCP\/06\/2011"],"award-info":[{"award-number":["BT\/MB\/BRCP\/06\/2011"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0237064","type":"journal-article","created":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T22:09:25Z","timestamp":1598047765000},"page":"e0237064","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Distinguishing patients with idiopathic epilepsy from solitary cysticercus granuloma epilepsy and biochemical phenotype assessment using a serum biomolecule profiling platform"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1922-5333","authenticated-orcid":true,"given":"Jay S.","family":"Hanas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James Randolph Sanders","family":"Hocker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betcy","family":"Evangeline","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasudevan","family":"Prabhakaran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Oommen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vedantam","family":"Rajshekhar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas A.","family":"Drevets","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9l\u00e8ne","family":"Carabin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2020,8,21]]},"reference":[{"issue":"4","key":"pone.0237064.ref001","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1007\/s12031-014-0366-8","article-title":"Concentration of soluble adhesion molecules in cerebrospinal fluid and serum of epilepsy patients","volume":"54","author":"J Luo","year":"2014","journal-title":"J Mol Neurosci"},{"issue":"5","key":"pone.0237064.ref002","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1111\/j.1528-1167.2009.02481.x","article-title":"Estimation of the burden of active and life-time epilepsy: a meta-analytic approach","volume":"51","author":"AK Ngugi","journal-title":"Epilepsia"},{"issue":"9848","key":"pone.0237064.ref003","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/S0140-6736(12)61381-6","article-title":"Epilepsy in poor regions of the world","volume":"380","author":"CR Newton","year":"2012","journal-title":"Lancet"},{"issue":"11","key":"pone.0237064.ref004","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s11908-014-0437-6","article-title":"Neurocysticercosis: an update","volume":"16","author":"CM Coyle","year":"2014","journal-title":"Curr Infect Dis Rep"},{"key":"pone.0237064.ref005","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.nbd.2018.05.007","article-title":"Epilepsy biomarkers\u2014Toward etiology and pathology specificity","volume":"123","author":"A Pitkanen","year":"2019","journal-title":"Neurobiol Dis"},{"issue":"1","key":"pone.0237064.ref006","doi-asserted-by":"crossref","first-page":"29","DOI":"10.31887\/DCNS.2008.10.1\/oksteinlein","article-title":"Genetics and epilepsy","volume":"10","author":"OK Steinlein","year":"2008","journal-title":"Dialogues Clin Neurosci"},{"issue":"156","key":"pone.0237064.ref007","article-title":"Role of Immunological Markers in the Diagnosis, Treatment and Follow-Up of Human Neurocysticercosis","volume":"5","author":"AA Malik","year":"2014","journal-title":"J Neuroinfect Dis"},{"issue":"24","key":"pone.0237064.ref008","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1212\/WNL.0b013e31820202dc","article-title":"A diagnostic and therapeutic scheme for a solitary cysticercus granuloma","volume":"75","author":"G Singh","year":"2010","journal-title":"Neurology"},{"issue":"2","key":"pone.0237064.ref009","first-page":"76","article-title":"Validation of diagnostic criteria for solitary cerebral cysticercus granuloma in patients presenting with seizures","volume":"96","author":"V Rajshekhar","journal-title":"Acta Neurol Scand. 1997 Aug"},{"issue":"4","key":"pone.0237064.ref010","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/epi.12550","article-title":"ILAE official report: a practical clinical definition of epilepsy","volume":"55","author":"RS Fisher","year":"2014","journal-title":"Epilepsia"},{"key":"pone.0237064.ref011","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.seizure.2017.10.004","article-title":"Neurocysticercosis as an infectious acquired epilepsy worldwide","volume":"52","author":"DS Reddy","year":"2017","journal-title":"Seizure"},{"issue":"9","key":"pone.0237064.ref012","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1111\/epi.12739","article-title":"Enhanced steroid dosing reduces seizures during antiparasitic treatment for cysticercosis and early after","volume":"55","author":"HH Garcia","year":"2014","journal-title":"Epilepsia"},{"key":"pone.0237064.ref013","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.exppara.2018.07.015","article-title":"Distinguishing neurocysticercosis epilepsy from epilepsy of unknown etiology using a minimal serum mass profiling platform","volume":"192","author":"JS Hanas","year":"2018","journal-title":"Exp Parasitol"},{"issue":"3","key":"pone.0237064.ref014","doi-asserted-by":"crossref","first-page":"319","DOI":"10.4103\/0971-5916.198686","article-title":"Neurocysticercosis: Diagnostic problems & current therapeutic strategies","volume":"144","author":"V Rajshekhar","year":"2016","journal-title":"Indian J Med Res"},{"issue":"10","key":"pone.0237064.ref015","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S1474-4422(05)70194-0","article-title":"Cysticercosis Working Group in P. Neurocysticercosis: updated concepts about an old disease","volume":"4","author":"HH Garcia","year":"2005","journal-title":"Lancet Neurol"},{"issue":"6","key":"pone.0237064.ref016","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.trstmh.2006.10.001","article-title":"Conformation-sensitive immunoassays improve the serodiagnosis of solitary cysticercus granuloma in Indian patients","volume":"101","author":"V Prabhakaran","year":"2007","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"1","key":"pone.0237064.ref017","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1021\/pr800545q","article-title":"Standard operating procedures for serum and plasma collection: early detection research network consensus statement standard operating procedure integration working group","volume":"8","author":"MK Tuck","journal-title":"J Proteome Res"},{"issue":"4","key":"pone.0237064.ref018","doi-asserted-by":"crossref","first-page":"e0215762","DOI":"10.1371\/journal.pone.0215762","article-title":"Distinguishing and phenotype monitoring of traumatic brain injury and post-concussion syndrome including chronic migraine in serum of Iraq and Afghanistan war veterans","volume":"14","author":"JS Hanas","year":"2019","journal-title":"PLoS One"},{"issue":"4","key":"pone.0237064.ref019","doi-asserted-by":"crossref","first-page":"136","DOI":"10.3109\/07357907.2014.883528","article-title":"Distinguishing patients with stage I lung cancer versus control individuals using serum mass profiling","volume":"32","author":"JS Hanas","year":"2014","journal-title":"Cancer Invest"},{"issue":"2","key":"pone.0237064.ref020","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.canlet.2015.01.035","article-title":"Discriminating patients with early-stage pancreatic cancer or chronic pancreatitis using serum electrospray mass profiling","volume":"359","author":"JR Hocker","year":"2015","journal-title":"Cancer Lett"},{"issue":"4","key":"pone.0237064.ref021","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1093\/bioinformatics\/btt703","article-title":"Causal analysis approaches in Ingenuity Pathway Analysis","volume":"30","author":"A Kramer","year":"2014","journal-title":"Bioinformatics"},{"key":"pone.0237064.ref022","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1471-2288-2-4","article-title":"Markers for early detection of cancer: statistical guidelines for nested case-control studies","volume":"2","author":"SG Baker","year":"2002","journal-title":"BMC Med Res Methodol"},{"key":"pone.0237064.ref023","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1186\/1471-2105-10-259","article-title":"Ovarian cancer detection from metabolomic liquid chromatography\/mass spectrometry data by support vector machines","volume":"10","author":"W Guan","year":"2009","journal-title":"BMC Bioinformatics"},{"issue":"4","key":"pone.0237064.ref024","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nrc1322","article-title":"Rules of evidence for cancer molecular-marker discovery and validation","volume":"4","author":"DF Ransohoff","year":"2004","journal-title":"Nat Rev Cancer"},{"issue":"1\u20132","key":"pone.0237064.ref025","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0378-1119(88)90161-8","article-title":"Synthesis of phosphorothioate analogues of oligodeoxyribonucleotides and their antiviral activity against human immunodeficiency virus (HIV)","volume":"72","author":"M Matsukura","year":"1988","journal-title":"Gene"},{"journal-title":"Post-hoc Statistical Power Calculator for a Student t-Test","year":"2018","author":"DS Soper","key":"pone.0237064.ref026"},{"issue":"6947","key":"pone.0237064.ref027","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1136\/bmj.309.6947.102","article-title":"Diagnostic-Tests-2\u2014Predictive Values .4","volume":"309","author":"DG Altman","year":"1994","journal-title":"Brit Med J"},{"issue":"6943","key":"pone.0237064.ref028","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1136\/bmj.308.6943.1552","article-title":"Diagnostic tests. 1: Sensitivity and specificity","volume":"308","author":"DG Altman","year":"1994","journal-title":"BMJ"},{"issue":"3","key":"pone.0237064.ref029","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1177\/002215540305100305","article-title":"DNA ploidy and markovian analysis of neoplastic progression in experimental pancreatic cancer","volume":"51","author":"RG Postier","year":"2003","journal-title":"J Histochem Cytochem"},{"issue":"16","key":"pone.0237064.ref030","doi-asserted-by":"crossref","first-page":"6095","DOI":"10.1523\/JNEUROSCI.21-16-06095.2001","article-title":"Ducky mouse phenotype of epilepsy and ataxia is associated with mutations in the Cacna2d2 gene and decreased calcium channel current in cerebellar Purkinje cells","volume":"21","author":"J Barclay","year":"2001","journal-title":"Journal of Neuroscience"},{"issue":"11","key":"pone.0237064.ref031","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1111\/epi.13898","article-title":"Alterations in the alpha2 delta ligand, thrombospondin-1, in a rat model of spontaneous absence epilepsy and in patients with idiopathic\/genetic generalized epilepsies","volume":"58","author":"I Santolini","year":"2017","journal-title":"Epilepsia"},{"issue":"10","key":"pone.0237064.ref032","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1177\/0883073809332696","article-title":"Mutations in VLDLR as a cause for autosomal recessive cerebellar ataxia with mental retardation (dysequilibrium syndrome)","volume":"24","author":"KM Boycott","year":"2009","journal-title":"J Child Neurol"},{"issue":"1","key":"pone.0237064.ref033","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000486945","article-title":"TOP3B: A Novel Candidate Gene in Juvenile Myoclonic Epilepsy?","volume":"154","author":"M Daghsni","year":"2018","journal-title":"Cytogenet Genome Res"},{"issue":"9","key":"pone.0237064.ref034","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1161\/ATVBAHA.113.301362","article-title":"Endothelial Von Willebrand factor promotes blood-brain barrier flexibility and provides protection from hypoxia and seizures in mice","volume":"33","author":"GL Suidan","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"7","key":"pone.0237064.ref035","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1111\/jth.13696","article-title":"von Willebrand factor and inflammation","volume":"15","author":"C Kawecki","year":"2017","journal-title":"J Thromb Haemost"},{"issue":"1","key":"pone.0237064.ref036","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.neuroscience.2010.01.056","article-title":"Loss of synaptotagmin IV results in a reduction in synaptic vesicles and a distortion of the Golgi structure in cultured hippocampal neurons","volume":"167","author":"CP Arthur","year":"2010","journal-title":"Neuroscience"},{"key":"pone.0237064.ref037","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.brainres.2010.02.007","article-title":"Abnormal expression and spatiotemporal change of Slit2 in neurons and astrocytes in temporal lobe epileptic foci: A study of epileptic patients and experimental animals","volume":"1324","author":"M Fang","year":"2010","journal-title":"Brain Res"},{"issue":"12","key":"pone.0237064.ref038","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1002\/humu.22445","article-title":"Whole-exome sequencing identifies a variant of the mitochondrial MT-ND1 gene associated with epileptic encephalopathy: west syndrome evolving to Lennox-Gastaut syndrome","volume":"34","author":"A Delmiro","year":"2013","journal-title":"Hum Mutat"},{"issue":"6","key":"pone.0237064.ref039","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1111\/epi.12645","article-title":"Towards the identification of a genetic basis for Landau-Kleffner syndrome","volume":"55","author":"J Conroy","year":"2014","journal-title":"Epilepsia"},{"issue":"12","key":"pone.0237064.ref040","first-page":"3115","article-title":"Beyond Epilepsy and Autism: Disruption of GABRB3","volume":"17","author":"RJ Delahanty","year":"2016","journal-title":"Causes Ocular Hypopigmentation. Cell Rep"},{"issue":"12","key":"pone.0237064.ref041","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1002\/jbmr.2913","article-title":"Novel Genetic Variants Associated With Increased Vertebral Volumetric BMD, Reduced Vertebral Fracture Risk, and Increased Expression of SLC1A3 and EPHB2","volume":"31","author":"CM Nielson","year":"2016","journal-title":"J Bone Miner Res"},{"issue":"4","key":"pone.0237064.ref042","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.mcn.2009.09.008","article-title":"LGI1-associated epilepsy through altered ADAM23-dependent neuronal morphology","volume":"42","author":"K Owuor","year":"2009","journal-title":"Mol Cell Neurosci"},{"issue":"9","key":"pone.0237064.ref043","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.braindev.2011.06.014","article-title":"Disorders of amino acid metabolism associated with epilepsy","volume":"33","author":"WT Lee","year":"2011","journal-title":"Brain Dev"},{"year":"1993","author":"IA Meijer","key":"pone.0237064.ref044"},{"issue":"6","key":"pone.0237064.ref045","first-page":"458","article-title":"Pathogenic gene variants and clinical phenotype features of 26 children with progressive myoclonic epilepsy","volume":"57","author":"J Zhang","year":"2019","journal-title":"Zhonghua Er Ke Za Zhi"},{"issue":"4","key":"pone.0237064.ref046","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S2215-0366(18)30049-X","article-title":"Five novel loci associated with antipsychotic treatment response in patients with schizophrenia: a genome-wide association study","volume":"5","author":"H Yu","year":"2018","journal-title":"Lancet Psychiatry"},{"issue":"2\u20133","key":"pone.0237064.ref047","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.psychres.2010.08.002","article-title":"No association between schizophrenia and rs27388 of the MEGF10 gene in Chinese case-control sample","volume":"186","author":"L Yun","year":"2011","journal-title":"Psychiatry Res"},{"issue":"9","key":"pone.0237064.ref048","doi-asserted-by":"crossref","first-page":"e6875","DOI":"10.1371\/journal.pone.0006875","article-title":"Apoptotic engulfment pathway and schizophrenia","volume":"4","author":"X Chen","year":"2009","journal-title":"PLoS One"},{"issue":"4","key":"pone.0237064.ref049","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.cell.2006.03.032","article-title":"A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration","volume":"125","author":"J Lim","year":"2006","journal-title":"Cell"},{"issue":"6","key":"pone.0237064.ref050","doi-asserted-by":"crossref","first-page":"e0005664","DOI":"10.1371\/journal.pntd.0005664","article-title":"Comparison of monocyte gene expression among patients with neurocysticercosis-associated epilepsy, Idiopathic Epilepsy and idiopathic headaches in India","volume":"11","author":"V Prabhakaran","year":"2017","journal-title":"PLOS Neglected Tropical Diseases"},{"issue":"4","key":"pone.0237064.ref051","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1097\/JTO.0000000000000447","article-title":"Validation of a multiprotein plasma classifier to identify benign lung nodules","volume":"10","author":"A Vachani","year":"2015","journal-title":"J Thorac Oncol"},{"issue":"9","key":"pone.0237064.ref052","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1080\/07357907.2017.1373120","article-title":"Serum Monitoring and Phenotype Identification of Stage I Non-Small Cell Lung Cancer Patients","volume":"35","author":"JR Hocker","year":"2017","journal-title":"Cancer Investigation"},{"issue":"1","key":"pone.0237064.ref053","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1172\/JCI26022","article-title":"Differential exoprotease activities confer tumor-specific serum peptidome patterns","volume":"116","author":"J Villanueva","year":"2006","journal-title":"J Clin Invest"},{"issue":"1","key":"pone.0237064.ref054","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1189\/jlb.0306164","article-title":"DAMPs, PAMPs and alarmins: all we need to know about danger","volume":"81","author":"ME Bianchi","year":"2007","journal-title":"J Leukoc Biol"},{"issue":"12","key":"pone.0237064.ref055","doi-asserted-by":"crossref","first-page":"e82154","DOI":"10.1371\/journal.pone.0082154","article-title":"A novel null homozygous mutation confirms CACNA2D2 as a gene mutated in epileptic encephalopathy","volume":"8","author":"T Pippucci","year":"2013","journal-title":"PLoS One"},{"key":"pone.0237064.ref056","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.neulet.2016.08.013","article-title":"Transgenic over-expression of slit2 enhances disruption of blood-brain barrier and increases cell death after traumatic brain injury in mice","volume":"631","author":"S Li","year":"2016","journal-title":"Neurosci Lett"},{"issue":"5","key":"pone.0237064.ref057","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1111\/j.1601-183X.2009.00509.x","article-title":"Szt2, a novel gene for seizure threshold in mice","volume":"8","author":"WN Frankel","year":"2009","journal-title":"Genes Brain Behav"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0237064","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T01:15:15Z","timestamp":1616980515000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0237064"}},"subtitle":[],"editor":[{"given":"Ugo","family":"de Grazia","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,8,21]]},"references-count":57,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2020,8,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0237064","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2020,8,21]]}}}