{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T19:36:40Z","timestamp":1777664200691,"version":"3.51.4"},"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T00:00:00Z","timestamp":1596672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0237143","type":"journal-article","created":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T19:13:24Z","timestamp":1596741204000},"page":"e0237143","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Gene expression regulated by abatacept associated with methotrexate and correlation with disease activity in rheumatoid arthritis"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6722-5955","authenticated-orcid":true,"given":"C\u00e9line","family":"Derambure","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4607-0931","authenticated-orcid":true,"given":"Gaelle","family":"Dzangue-Tchoupou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Antonietta","family":"D\u2019Agostino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Lequerr\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Vittecoq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2020,8,6]]},"reference":[{"issue":"3","key":"pone.0237143.ref001","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/35105024","article-title":"T-cell regulation by CD28 and CTLA-4","volume":"1","author":"ML Alegre","year":"2001","journal-title":"Nat Rev Immunol"},{"issue":"3","key":"pone.0237143.ref002","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.coi.2004.03.006","article-title":"The regulation of lymphocyte activation by inhibitory receptors","volume":"16","author":"PJ Leibson","year":"2004","journal-title":"Curr Opin Immunol"},{"issue":"5","key":"pone.0237143.ref003","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/1074-7613(94)90071-X","article-title":"CTLA-4 can function as a negative regulator of T cell activation","volume":"1","author":"TL Walunas","year":"1994","journal-title":"Immunity"},{"issue":"3","key":"pone.0237143.ref004","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/art.37787","article-title":"Abatacept (CTLA-4IG) treatment reduces the migratory capacity of monocytes in patients with rheumatoid arthritis","volume":"65","author":"M Bonelli","year":"2012","journal-title":"Arthritis Rheum"},{"issue":"4","key":"pone.0237143.ref005","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1093\/rheumatology\/kev403","article-title":"Abatacept (CTLA-4Ig) treatment reduces T cell apoptosis and regulatory T cell suppression in patients with rheumatoid arthritis","volume":"55","author":"M Bonelli","journal-title":"Rheumatology (Oxford)"},{"issue":"1","key":"pone.0237143.ref006","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.autrev.2008.07.035","article-title":"Co-stimulatory modulation in rheumatoid arthritis: the role of (CTLA4-Ig) abatacept","volume":"8","author":"U Fiocco","year":"2008","journal-title":"Autoimmun Rev"},{"issue":"3","key":"pone.0237143.ref007","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/art.39470","article-title":"Abatacept Inhibition of T Cell Priming in Mice by Induction of a Unique Transcriptional Profile That Reduces Their Ability to Activate Antigen-Presenting Cells","volume":"68","author":"A Patakas","year":"2015","journal-title":"Arthritis Rheumatol"},{"issue":"7","key":"pone.0237143.ref008","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1136\/ard.2008.091876","article-title":"Mode of action of abatacept in rheumatoid arthritis patients having failed tumour necrosis factor blockade: a histological, gene expression and dynamic magnetic resonance imaging pilot study","volume":"68","author":"MH Buch","year":"2009","journal-title":"Ann Rheum Dis"},{"issue":"10","key":"pone.0237143.ref009","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1002\/art.22139","article-title":"CTLA-4IG suppresses reactive oxygen species by preventing synovial adherent cell-induced inactivation of Rap1, a Ras family GTPASE mediator of oxidative stress in rheumatoid arthritis T cells","volume":"54","author":"PH Remans","year":"2006","journal-title":"Arthritis Rheum"},{"issue":"1","key":"pone.0237143.ref010","doi-asserted-by":"crossref","first-page":"e000237","DOI":"10.1136\/rmdopen-2015-000237","article-title":"Exploring a new ultrasound score as a clinical predictive tool in patients with rheumatoid arthritis starting abatacept: results from the APPRAISE study","volume":"2","author":"MA D\u2019Agostino","year":"2016","journal-title":"RMD Open"},{"issue":"10","key":"pone.0237143.ref011","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1136\/annrheumdis-2015-207709","article-title":"Value of ultrasonography as a marker of early response to abatacept in patients with rheumatoid arthritis and an inadequate response to methotrexate: results from the APPRAISE study","volume":"75","author":"MA D\u2019Agostino","year":"2016","journal-title":"Ann Rheum Dis"},{"issue":"3","key":"pone.0237143.ref012","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/art.1780310302","article-title":"The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis","volume":"31","author":"FC Arnett","year":"1988","journal-title":"Arthritis Rheum"},{"issue":"11","key":"pone.0237143.ref013","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1136\/ard.49.11.916","article-title":"Judging disease activity in clinical practice in rheumatoid arthritis: first step in the development of a disease activity score","volume":"49","author":"DM van der Heijde","year":"1990","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"pone.0237143.ref014","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s13075-017-1319-8","article-title":"Pre-silencing of genes involved in the electron transport chain (ETC) pathway is associated with responsiveness to abatacept in rheumatoid arthritis","volume":"19","author":"C Derambure","year":"2017","journal-title":"Arthritis Res Ther"},{"issue":"6","key":"pone.0237143.ref015","doi-asserted-by":"crossref","first-page":"4077","DOI":"10.4049\/jimmunol.0804351","article-title":"Expression of tolerance associated gene-1, a mitochondrial protein inhibiting T cell activation, can be used to predict response to immune modulating therapies","volume":"183","author":"K Keeren","year":"2009","journal-title":"J Immunol"},{"issue":"23","key":"pone.0237143.ref016","doi-asserted-by":"crossref","first-page":"3763","DOI":"10.1016\/j.febslet.2013.09.049","article-title":"Delineation of the TRAK binding regions of the kinesin-1 motor proteins","volume":"587","author":"TS Randall","year":"2013","journal-title":"FEBS Lett"},{"key":"pone.0237143.ref017","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1471-2121-6-35","article-title":"The novel protein KBP regulates mitochondria localization by interaction with a kinesin-like protein","volume":"6","author":"MJ Wozniak","year":"2005","journal-title":"BMC Cell Biol"},{"issue":"46","key":"pone.0237143.ref018","doi-asserted-by":"crossref","first-page":"13063","DOI":"10.1073\/pnas.1613701113","article-title":"Complex I assembly into supercomplexes determines differential mitochondrial ROS production in neurons and astrocytes","volume":"113","author":"I Lopez-Fabuel","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pone.0237143.ref019","doi-asserted-by":"crossref","first-page":"13821","DOI":"10.1038\/ncomms13821","article-title":"CCT complex restricts neuropathogenic protein aggregation via autophagy","volume":"7","author":"M Pavel","year":"2016","journal-title":"Nat Commun"},{"issue":"331","key":"pone.0237143.ref020","doi-asserted-by":"crossref","first-page":"331ra338","DOI":"10.1126\/scitranslmed.aad7151","article-title":"Restoring oxidant signaling suppresses proarthritogenic T cell effector functions in rheumatoid arthritis","volume":"8","author":"Z Yang","year":"2016","journal-title":"Sci Transl Med"},{"key":"pone.0237143.ref021","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/s13075-016-1052-8","article-title":"Identification of baseline gene expression signatures predicting therapeutic responses to three biologic agents in rheumatoid arthritis: a retrospective observational study","volume":"18","author":"S Nakamura","year":"2016","journal-title":"Arthritis Res Ther"},{"issue":"7","key":"pone.0237143.ref022","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.4049\/jimmunol.1501764","article-title":"Grb2 Is Important for T Cell Development, Th Cell Differentiation, and Induction of Experimental Autoimmune Encephalomyelitis","volume":"196","author":"D Radtke","year":"2016","journal-title":"J Immunol"},{"issue":"8","key":"pone.0237143.ref023","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1016\/j.cellsig.2012.03.022","article-title":"NEMO differentially regulates TCR and TNF-alpha induced NF-kappaB pathways and has an inhibitory role in TCR-induced NF-kappaB activation","volume":"24","author":"K Wang","journal-title":"Cell Signal"},{"issue":"2","key":"pone.0237143.ref024","doi-asserted-by":"crossref","first-page":"695","DOI":"10.4049\/jimmunol.1403187","article-title":"The Importance of IL-6 in the Development of LAT-Mediated Autoimmunity","volume":"195","author":"SA O\u2019Brien","year":"2015","journal-title":"J Immunol"},{"issue":"6","key":"pone.0237143.ref025","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.4049\/jimmunol.159.6.2973","article-title":"Defective TCR-mediated signaling in synovial T cells in rheumatoid arthritis","volume":"159","author":"MM Maurice","year":"1997","journal-title":"J Immunol"},{"issue":"6965","key":"pone.0237143.ref026","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/nature02119","article-title":"Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice","volume":"426","author":"N Sakaguchi","year":"2003","journal-title":"Nature"},{"issue":"7","key":"pone.0237143.ref027","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/ni0702-611","article-title":"CTLA-4: new insights into its biological function and use in tumor immunotherapy","volume":"3","author":"JG Egen","year":"2002","journal-title":"Nat Immunol"},{"issue":"5","key":"pone.0237143.ref028","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.semcdb.2012.02.006","article-title":"Regulation of gene expression by the ubiquitin-proteasome system","volume":"23","author":"T Yao","year":"2012","journal-title":"Semin Cell Dev Biol"},{"issue":"16","key":"pone.0237143.ref029","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1038\/sj.onc.1207523","article-title":"Toxic proteins released from mitochondria in cell death","volume":"23","author":"X Saelens","year":"2004","journal-title":"Oncogene"},{"issue":"11","key":"pone.0237143.ref030","doi-asserted-by":"crossref","first-page":"7437","DOI":"10.1074\/jbc.272.11.7437","article-title":"Monocyte cells and cancer cells express novel paxillin isoforms with different binding properties to focal adhesion proteins","volume":"272","author":"Y Mazaki","year":"1997","journal-title":"J Biol Chem"},{"issue":"1","key":"pone.0237143.ref031","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s13046-017-0524-2","article-title":"Elevated Gab2 induces tumor growth and angiogenesis in colorectal cancer through upregulating VEGF levels","volume":"36","author":"C Ding","year":"2017","journal-title":"J Exp Clin Cancer Res"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0237143","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T10:45:52Z","timestamp":1696502752000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0237143"}},"subtitle":[],"editor":[{"given":"Masataka","family":"Kuwana","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,8,6]]},"references-count":31,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2020,8,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0237143","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,6]]}}}