{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T23:06:10Z","timestamp":1791068770572,"version":"4.1.0"},"reference-count":62,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0237523","type":"journal-article","created":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T18:56:42Z","timestamp":1598986602000},"page":"e0237523","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":23,"title":["Pharmacologic and surgical therapies for patients with Meniere\u2019s disease: A systematic review and network meta-analysis"],"prefix":"10.1371","volume":"15","author":[{"given":"Nadera","family":"Ahmadzai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1475-4079","authenticated-orcid":true,"given":"Wei","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaun","family":"Kilty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Esmaeilisaraji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianna","family":"Wolfe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Bonaparte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Schramm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3422-4507","authenticated-orcid":true,"given":"Elizabeth","family":"Fitzpatrick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8293-9238","authenticated-orcid":true,"given":"Becky","family":"Skidmore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5662-8647","authenticated-orcid":true,"given":"Brian","family":"Hutton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,9,1]]},"reference":[{"key":"pone.0237523.ref001","unstructured":"Canadian Hearing Society. Facts and Figures: Prevalence of hearing loss. [Internet]. https:\/\/www.chs.ca\/facts-and-figures. 2017."},{"key":"pone.0237523.ref002","unstructured":"Mathers C, Stein C, Ma Fat D, Rao C, Inoue M, Tomijima N, et al. Global burden of disease in the year 2000. [Internet]. http:\/\/www.who.int\/healthinfo\/paper50.pdf. 2002."},{"key":"pone.0237523.ref003","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1159\/000439176","article-title":"Single-Sided Deafness: The Effect of Cochlear Implantation on Quality of Life, Quality of Hearing, and Working Performance","volume":"77","author":"K Harkonen","year":"2015","journal-title":"ORLJ Otorhinolaryngol Relat Spec"},{"key":"pone.0237523.ref004","unstructured":"Naude A. Clinical and audiological features of Meniere\u2019s disease: Insight into the diagnostic process [Internet]. 2006. https:\/\/repository.up.ac.za\/handle\/2263\/27851"},{"issue":"6","key":"pone.0237523.ref005","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1097\/00129492-200111000-00030","article-title":"Impact of Meniere\u2019s disease on quality of life","volume":"22","author":"JP Anderson","year":"2001","journal-title":"Otol Neurotol"},{"issue":"2","key":"pone.0237523.ref006","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jpsychores.2008.05.027","article-title":"Cognitions associated with anxiety in Meniere\u2019s disease","volume":"66","author":"SE Kirby","year":"2009","journal-title":"J Psychosom Res"},{"issue":"Suppl 1","key":"pone.0237523.ref007","doi-asserted-by":"crossref","first-page":"S71","DOI":"10.1007\/s00415-015-7930-1","article-title":"What is Meniere\u2019s disease? A contemporary re-evaluation of endolymphatic hydrops","volume":"263","author":"R Gurkov","year":"2016","journal-title":"J Neurol"},{"issue":"3","key":"pone.0237523.ref008","first-page":"287","article-title":"Surgical results and psychological status in patients with intractable Meniere\u2019s disease","volume":"43","author":"Y Yokota","year":"2016","journal-title":"AurisNasusLarynx"},{"issue":"3","key":"pone.0237523.ref009","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0194-5998(95)70102-8","article-title":"Committee on Hearing and Equilibrium guidelines for the diagnosis and evaluation of therapy in Meniere\u2019s disease","volume":"113","year":"1995","journal-title":"American Academy of Otolaryngology-Head and Neck Foundation, Inc. Otolaryngol Head Neck Surg"},{"issue":"8","key":"pone.0237523.ref010","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1097\/MAO.0000000000000831","article-title":"M\u00e9ni\u00e8re\u2019s Syndrome or Disease: Time Trends in Management and Quality of Evidence Over the Last Two Decades","volume":"36","author":"M Syed","year":"2015","journal-title":"Otol Neurotol"},{"issue":"3","key":"pone.0237523.ref011","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S0030-6665(02)00028-2","article-title":"Meniere\u2019s disease: overview, epidemiology, and natural history","volume":"35","author":"SS da Costa","year":"2002","journal-title":"Otolaryngol Clin North Am"},{"key":"pone.0237523.ref012","unstructured":"Higgins J, Green S. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. [Internet] http:\/\/handbook.cochrane.org\/. 2011."},{"issue":"11","key":"pone.0237523.ref013","doi-asserted-by":"crossref","first-page":"777","DOI":"10.7326\/M14-2385","article-title":"The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: checklist and explanations","volume":"162","author":"B Hutton","year":"2015","journal-title":"Ann Intern Med"},{"key":"pone.0237523.ref014","unstructured":"National Institute for Health Research. PROSPERO: International prospective register of systematic reviews. [Internet]. https:\/\/www.crd.york.ac.uk\/prospero\/"},{"key":"pone.0237523.ref015","article-title":"Pharmacologic and surgical therapies for patients with Meniere\u2019s disease: A protocol for a systematic review and meta-analysis","author":"N Ahmadzai","year":"2019","journal-title":"Appear Syst Rev"},{"issue":"1","key":"pone.0237523.ref016","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s11739-016-1583-7","article-title":"Network meta-analysis: an introduction for clinicians","volume":"12","author":"B Rouse","year":"2017","journal-title":"Intern Emerg Med"},{"issue":"1","key":"pone.0237523.ref017","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.jid.2018.10.028","article-title":"Research Techniques Made Simple: Network Meta-Analysis","volume":"139","author":"J Watt","year":"2019","journal-title":"J Invest Dermatol"},{"issue":"11","key":"pone.0237523.ref018","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1007\/s00296-014-2994-2","article-title":"Network meta-analysis for comparing treatment effects of multiple interventions: an introduction","volume":"34","author":"F Catal\u00e1-L\u00f3pez","year":"2014","journal-title":"Rheumatol Int"},{"issue":"2","key":"pone.0237523.ref019","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1136\/eb-2015-102088","article-title":"A primer on network meta-analysis with emphasis on mental health","volume":"18","author":"D Mavridis","year":"2015","journal-title":"Evid Based Ment Health"},{"issue":"7521","key":"pone.0237523.ref020","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1136\/bmj.331.7521.897","article-title":"Simultaneous comparison of multiple treatments: combining direct and indirect evidence","volume":"331","author":"DM Caldwell","year":"2005","journal-title":"BMJ"},{"key":"pone.0237523.ref021","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jclinepi.2016.01.021","article-title":"PRESS Peer Review of Electronic Search Strategies: 2015 Guideline Statement","volume":"75","author":"J McGowan","year":"2016","journal-title":"J Clin Epidemiol"},{"issue":"sup497","key":"pone.0237523.ref022","doi-asserted-by":"crossref","first-page":"141","DOI":"10.3109\/00016489209136849","article-title":"VIII: The AAOO 1972 and AAO-HNS 1985 guidelines for reporting treatment results in Meni\u00e8re\u2019s disease","volume":"112","year":"1992","journal-title":"Acta Otolaryngol (Stockh)"},{"key":"pone.0237523.ref023","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/2046-4053-1-10","article-title":"Evidence summaries: the evolution of a rapid review approach","volume":"1","author":"S Khangura","year":"2012","journal-title":"Syst Rev"},{"key":"pone.0237523.ref024","doi-asserted-by":"crossref","first-page":"d5928","DOI":"10.1136\/bmj.d5928","article-title":"The Cochrane Collaboration\u2019s tool for assessing risk of bias in randomised trials","volume":"343","author":"JP Higgins","year":"2011","journal-title":"BMJ"},{"issue":"12","key":"pone.0237523.ref025","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1016\/j.jclinepi.2011.03.017","article-title":"GRADE guidelines: 7. Rating the quality of evidence\u2014inconsistency","volume":"64","author":"GH Guyatt","year":"2011","journal-title":"J Clin Epidemiol"},{"key":"pone.0237523.ref026","unstructured":"Review Manager (RevMan). 5.3 ed. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration; 2014."},{"key":"pone.0237523.ref027","unstructured":"Dias S, Sutton A, Welton N, Ades A. NICE DSU Technical Support Document 3: Heterogeneity: subgroups, meta-regression, bias and bias-adjustment. [Internet]. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK395886\/. 2012."},{"key":"pone.0237523.ref028","unstructured":"Dias S, Welton N, Sutton A, Ades A. NICE DSU Technical Support Document 2: A Generalised Linear Modelling Framework for Pairwise and Network Meta-Analysis of Randomised Controlled Trials. [Internet]. https:\/\/www.ncbi.nlm.nih.gov\/books\/n\/nicedsutsd2\/pdf\/. 2014."},{"key":"pone.0237523.ref029","unstructured":"Dias S, Welton N, Sutton A, Caldwell DM, Lu G, Ades A. NICE DSU Technical Support Document 4: Inconsistency in Networks of Evidence Based on Randomised Controlled Trials. [Internet]. https:\/\/www.ncbi.nlm.nih.gov\/pubmedhealth\/n\/nicedsutsd4\/pdf\/. 2014."},{"issue":"4","key":"pone.0237523.ref030","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/1467-9868.00353","article-title":"Bayesian measures of model complexity and fit","volume":"64","author":"DJ Spiegelhalter","year":"2002","journal-title":"J R Stat Soc B"},{"key":"pone.0237523.ref031","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jclinepi.2010.03.016","article-title":"Graphical methods and numerical summaries for presenting results from multiple-treatment meta-analysis: an overview and tutorial","volume":"64","author":"G Salanti","year":"2011","journal-title":"J Clin Epidemiol"},{"issue":"10","key":"pone.0237523.ref032","doi-asserted-by":"crossref","first-page":"e76654","DOI":"10.1371\/journal.pone.0076654","article-title":"Graphical Tools for Network Meta-Analysis in STATA","volume":"8","author":"A Chaimani","year":"2013","journal-title":"PLOS ONE"},{"key":"pone.0237523.ref033","unstructured":"Spiegelhalter D, Thomas A, Best N, Dave L. Manuals\u2014OpenBUGS [Internet]. [cited 2018 Jul 19]. http:\/\/www.openbugs.net\/w\/Manuals."},{"issue":"3","key":"pone.0237523.ref034","first-page":"1","article-title":"R2WinBUGS: A Package for Running WinBUGS from R","volume":"12","author":"S Sturtz","journal-title":"Stat Softw"},{"issue":"5","key":"pone.0237523.ref035","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1097\/MAO.0000000000001810","article-title":"Endolymphatic Sac Decompression With Intra-Sac Dexamethasone Injection in Meniere\u2019s Disease","volume":"39","author":"DI Bojrab","year":"2018","journal-title":"Otol Neurotol"},{"issue":"95","key":"pone.0237523.ref036","first-page":"341","article-title":"Methylprednisolone versus Dexamethasone for Control of Vertigo in Patients with Definite Meniere\u2019s disease","volume":"29","author":"E Masoumi","year":"2017","journal-title":"Iran J Otorhinolaryngol"},{"issue":"1","key":"pone.0237523.ref037","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/BF02907620","article-title":"Intratympanic dexamethasone application in Meniere\u2019s disease-Is it superior to conventional therapy?","volume":"57","author":"G Paragache","year":"2005","journal-title":"Indian J Otolaryngol Head Neck Surg"},{"issue":"10061","key":"pone.0237523.ref038","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1016\/S0140-6736(16)31461-1","article-title":"Intratympanic methylprednisolone versus gentamicin in patients with unilateral Meniere\u2019s disease: a randomised, double-blind, comparative effectiveness trial","volume":"388","author":"M Patel","year":"2016","journal-title":"Lancet"},{"issue":"6","key":"pone.0237523.ref039","doi-asserted-by":"crossref","first-page":"e0158309","DOI":"10.1371\/journal.pone.0158309","article-title":"A Two-Year Randomized Trial of Interventions to Decrease Stress Hormone Vasopressin Production in Patients with Meniere\u2019s Disease-A Pilot Study","volume":"11","author":"T Kitahara","year":"2016","journal-title":"PLoS One"},{"issue":"3","key":"pone.0237523.ref040","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.amjoto.2015.12.007","article-title":"Treatment of Meniere\u2019s disease with intratympanic dexamethazone plus high dosage of betahistine","volume":"37","author":"S Albu","year":"2016","journal-title":"Am J Otolaryngol"},{"key":"pone.0237523.ref041","doi-asserted-by":"crossref","first-page":"h6816","DOI":"10.1136\/bmj.h6816","article-title":"Efficacy and safety of betahistine treatment in patients with Meniere\u2019s disease: primary results of a long term, multicentre, double blind, randomised, placebo controlled, dose defining trial (BEMED trial)","volume":"352","author":"C Adrion","year":"2016","journal-title":"BMJ"},{"issue":"2","key":"pone.0237523.ref042","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.amjoto.2014.10.032","article-title":"Intratympanic dexamethasone versus high dosage of betahistine in the treatment of intractable unilateral Meniere disease","volume":"36","author":"S Albu","year":"2015","journal-title":"Am J Otolaryngol"},{"key":"pone.0237523.ref043","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1186\/1745-6215-15-328","article-title":"Intratympanic gentamicin treatment for Meniere\u2019s disease: a randomized, double-blind, placebo-controlled trial on dose efficacy\u2014results of a prematurely ended study","volume":"15","author":"HG Bremer","year":"2014","journal-title":"Trials"},{"issue":"3","key":"pone.0237523.ref044","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1177\/0194599811429432","article-title":"Intratympanic treatment of intractable unilateral Meniere disease: gentamicin or dexamethasone? A randomized controlled trial","volume":"146","author":"AP Casani","year":"2012","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"5","key":"pone.0237523.ref045","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1080\/00016480802273082","article-title":"Comparable efficacy and tolerability between twice daily and three times daily betahistine for Meniere\u2019s disease","volume":"129","author":"MM Gananca","year":"2009","journal-title":"Acta Otolaryngol"},{"issue":"8","key":"pone.0237523.ref046","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1080\/00016480701762458","article-title":"Intratympanic gentamicin therapy for control of vertigo in unilateral Meniere\u2019s disease: a prospective, double-blind, randomized, placebo-controlled trial","volume":"128","author":"RJ Postema","year":"2008","journal-title":"Acta Otolaryngol"},{"issue":"5","key":"pone.0237523.ref047","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1097\/MLG.0b013e3181651c4a","article-title":"Effects of endolymphatic sac drainage with steroids for intractable Meniere\u2019s disease: a long-term follow-up and randomized controlled study","volume":"118","author":"T Kitahara","year":"2008","journal-title":"Laryngoscope"},{"issue":"5","key":"pone.0237523.ref048","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1097\/01.mao.0000185057.81962.51","article-title":"Oral administration of prednisone to control refractory vertigo in Meniere\u2019s disease: a pilot study","volume":"26","author":"E Morales-Luckie","year":"2005","journal-title":"Otol Neurotol"},{"issue":"2","key":"pone.0237523.ref049","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.otohns.2005.05.010","article-title":"Dexamethasone inner ear perfusion by intratympanic injection in unilateral Meniere\u2019s disease: a two-year prospective, placebo-controlled, double-blind, randomized trial","volume":"133","author":"MA Garduno-Anaya","year":"2005","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"2","key":"pone.0237523.ref050","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1080\/00016480410016621","article-title":"Selective vestibular ablation by intratympanic gentamicin in patients with unilateral active Meniere\u2019s disease: a prospective, double-blind, placebo-controlled, randomized clinical trial","volume":"124","author":"R Stokroos","year":"2004","journal-title":"Acta Otolaryngol"},{"issue":"3","key":"pone.0237523.ref051","doi-asserted-by":"crossref","first-page":"171","DOI":"10.7123\/01.EJO.0000418018.88180.0c","article-title":"Intratympanic injection in Meniere\u2019s disease; symptomatic and audiovestibular; comparative, prospective randomized 1-year control study","volume":"28","author":"YF ElBeltagy","year":"2012","journal-title":"Egypt J Otolaryngol"},{"key":"pone.0237523.ref052","unstructured":"Garduno-Anaya M, Couthino De Toledo H, Pane C, Pane C. Four years of prospective evaluation of dexamethasone inner ear perfussion in unilateral Meniere\u2019s disease. In 2005. https:\/\/www.cochranelibrary.com\/central\/doi\/10.1002\/central\/CN-00614717\/full."},{"issue":"Sippl1","key":"pone.0237523.ref053","first-page":"S259","article-title":"Betahistidine 16mg tid or 24 mg bid in Meniere\u2019s disease","volume":"264","author":"M Gananca","year":"2007","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"pone.0237523.ref054","doi-asserted-by":"crossref","unstructured":"Kitahara T, Okumura SI, Kubo T, Kitahara M. Effects of intra-endolymphatic sac application of large doses of steroids for intractable Meniere\u2019s Disease: a randomized controlled trial. 2007; https:\/\/www.cochranelibrary.com\/central\/doi\/10.1002\/central\/CN-00624671\/full.","DOI":"10.1097\/MLG.0b013e3181651c4a"},{"issue":"2","key":"pone.0237523.ref055","volume":"129","author":"MA Garduno-Anaya","year":"2003","journal-title":"Intratympanic dexamethasone in unilateral Meniere?s disease: a two-year prospective trial"},{"issue":"SUPPL. 2","key":"pone.0237523.ref056","doi-asserted-by":"crossref","first-page":"P97","DOI":"10.1177\/0194599811416318a177","article-title":"Meniere\u2019s disease: Intratympanic gentamicin or dexamethasone","volume":"145","author":"AP Casani","year":"2011","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"1","key":"pone.0237523.ref057","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1177\/0194599814555840","article-title":"Endolymphatic duct blockage: a randomized controlled trial of a novel surgical technique for Meniere\u2019s disease treatment","volume":"152","author":"I Saliba","year":"2015","journal-title":"Otolaryngol Head Neck Surg"},{"key":"pone.0237523.ref058","doi-asserted-by":"crossref","first-page":"617","DOI":"10.3109\/00016489109131486","article-title":"Treatment of vestibular disorders","volume":"481","author":"A Itoh","year":"1991","journal-title":"Acta Oto-Laryngol Suppl"},{"key":"pone.0237523.ref059","first-page":"CD008234","article-title":"Intratympanic gentamicin for Meniere\u2019s disease or syndrome","volume":"3","author":"B Pullens","year":"2011","journal-title":"Cochrane Database Syst Rev"},{"issue":"4","key":"pone.0237523.ref060","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1111\/coa.13350","article-title":"Different medications for the treatment of M\u00e9ni\u00e8re\u2019s disease by intratympanic injection: A systematic review and network meta-analysis","volume":"44","author":"Z Cao","year":"2019","journal-title":"Clin Otolaryngol"},{"key":"pone.0237523.ref061","doi-asserted-by":"crossref","unstructured":"Hao W, Yu H, Li H. Effects of Intratympanic Gentamicin and Intratympanic Glucocorticoids in M\u00e9ni\u00e8re\u2019s Disease: A Network Meta-Analysis of Randomized, Controlled Trials [Internet]. Rochester, NY: Social Science Research Network; 2019 Apr [cited 2019 Oct 7]. Report No.: ID 3371077. https:\/\/papers.ssrn.com\/abstract=3371077.","DOI":"10.2139\/ssrn.3371077"},{"key":"pone.0237523.ref062","first-page":"505","article-title":"Meniere\u2019s disease","volume":"11","author":"T Wright","year":"2015","journal-title":"BMJ Clin Evid"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0237523","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T17:48:01Z","timestamp":1696614481000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0237523"}},"subtitle":[],"editor":[{"given":"Ivan D.","family":"Florez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,9,1]]},"references-count":62,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2020,9,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0237523","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,1]]}}}