{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:18:59Z","timestamp":1790349539290,"version":"4.1.0"},"reference-count":77,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T00:00:00Z","timestamp":1609113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Our previous study showed that long-term practitioners of Sahaja Yoga Meditation (SYM) had around 7% larger grey matter volume (GMV) in the whole brain compared with healthy controls; however, when testing individual regions, only 5 small brain areas were statistically different between groups. Under the hypothesis that those results were statistically conservative, with the same dataset, we investigated in more detail the regional differences in GMV associated with the practice of SYM, with a different statistical approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Twenty-three experienced practitioners of SYM and 23 healthy non-meditators matched on age, sex and education level, were scanned using structural magnetic resonance imaging (MRI). Their GMV were extracted and compared using Voxel-Based Morphometry (VBM). Using a novel ad-hoc general linear model, statistical comparisons were made to observe if the GMV differences between meditators and controls were statistically significant.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the 16 lobe area subdivisions, GMV was statistically significantly different in 4 out of 16 areas: in right hemispheric temporal and frontal lobes, left frontal lobe and brainstem. In the 116 AAL area subdivisions, GMV difference was statistically significant in 11 areas. The GMV differences were statistically more significant in right hemispheric brain areas.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The study shows that long-term practice of SYM is associated with larger GMV overall, and with significant differences mainly in temporal and frontal areas of the right hemisphere and the brainstem. These neuroplastic changes may reflect emotional and attentional control mechanisms developed with SYM. On the other hand, our statistical ad-hoc method shows that there were more brain areas with statistical significance compared to the traditional methodology which we think is susceptible to conservative Type II errors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0237552","type":"journal-article","created":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T13:41:19Z","timestamp":1609162879000},"page":"e0237552","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Larger whole brain grey matter associated with long-term Sahaja Yoga Meditation: A detailed area by area comparison"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5043-1341","authenticated-orcid":true,"given":"Sergio El\u00edas","family":"Hern\u00e1ndez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Dorta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Suero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Barros-Loscertales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Luis","family":"Gonz\u00e1lez-Mora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katya","family":"Rubia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,12,28]]},"reference":[{"issue":"6","key":"pone.0237552.ref001","first-page":"96","article-title":"The Yoga Sutra of Patanjali","volume":"139","author":"A Kokodoko","year":"2014","journal-title":"Library Journal"},{"issue":"1","key":"pone.0237552.ref002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biopsycho.2009.04.003","article-title":"The neurobiology of Meditation and its clinical effectiveness in psychiatric disorders","volume":"82","author":"K Rubia","year":"2009","journal-title":"Biological Psychology"},{"key":"pone.0237552.ref003","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2011\/960583","article-title":"A Randomized, Controlled Trial of Meditation for Work Stress, Anxiety and Depressed Mood in Full-Time Workers","author":"R Manocha","year":"2011","journal-title":"Evidence-Based Complementary and Alternative Medicine"},{"issue":"4","key":"pone.0237552.ref004","first-page":"479","article-title":"Sahaja Yoga Meditation as a family treatment program for attention deficit hyperactivity disorder children","volume":"9","author":"L Harrison","year":"2004","journal-title":"Journal of Clinical Psychology and Psychiatry"},{"issue":"3","key":"pone.0237552.ref005","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1080\/09297040600770761","article-title":"Performance of children with attention deficit hyperactivity disorder (ADHD) on a test battery of impulsiveness","volume":"13","author":"K Rubia","year":"2007","journal-title":"Child Neuropsychology"},{"issue":"6","key":"pone.0237552.ref006","article-title":"Effect of Sahaja Yoga Meditation on Quality of Life, Anxiety, and Blood Pressure Control","volume":"18","author":"S-C Chung","year":"2012","journal-title":"Journal of Alternative and Complementary Medicine"},{"key":"pone.0237552.ref007","unstructured":"Morgan A. 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