{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T07:50:42Z","timestamp":1768722642736,"version":"3.49.0"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T00:00:00Z","timestamp":1597276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23-HL136688"],"award-info":[{"award-number":["K23-HL136688"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0237613","type":"journal-article","created":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T18:56:28Z","timestamp":1597344988000},"page":"e0237613","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Nordihydroguaiaretic acid reduces secondary organ injury in septic rats after cecal ligation and puncture"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5216-4803","authenticated-orcid":true,"given":"Michael E.","family":"Zubrow","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3615-7902","authenticated-orcid":true,"given":"Susan S.","family":"Margulies","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadir","family":"Yehya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2020,8,13]]},"reference":[{"issue":"9","key":"pone.0237613.ref001","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1097\/PCC.0000000000000254","article-title":"Pediatric severe sepsis: current trends and outcomes from the Pediatric Health Information Systems database","volume":"15","author":"A Ruth","year":"2014","journal-title":"Ped Crit Care Med"},{"issue":"7","key":"pone.0237613.ref002","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1097\/PCC.0b013e3182917fad","article-title":"Trends in the epidemiology of pediatric severe sepsis","volume":"14","author":"ME Hartman","year":"2013","journal-title":"Ped Crit Care Med"},{"key":"pone.0237613.ref003","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1097\/00003246-199609000-00004","article-title":"Increased interleukin-8 concentrations in the pulmonary edema fluid of patients with acute respiratory distress syndrome from sepsis","volume":"24","author":"EJ Miller","year":"1996","journal-title":"Crit Care Med"},{"issue":"4","key":"pone.0237613.ref004","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1097\/00024382-199504000-00001","article-title":"Interleukin-1 and interleukin-1 antagonism in sepsis, systemic inflammatory response syndrome, and septic shock","volume":"3","author":"JH Pruitt","year":"1995","journal-title":"Shock."},{"issue":"8848","key":"pone.0237613.ref005","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/0140-6736(93)90558-X","article-title":"Serum antioxidants as predictors of adult respiratory distress syndrome in patients with sepsis","volume":"341","author":"JA Leff","year":"1993","journal-title":"Lancet"},{"key":"pone.0237613.ref006","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.thromres.2016.11.007","article-title":"Coagulation and sepsis","volume":"149","author":"M Levi","year":"2017","journal-title":"Thromb Res"},{"issue":"5","key":"pone.0237613.ref007","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1097\/00024382-199905000-00006","article-title":"Impaired energy metabolism in hearts of septic baboons: diminished activities of Complex I and Complex II of the mitochondrial respiratory chain","volume":"11","author":"FN Gellerich","year":"1999","journal-title":"Shock"},{"issue":"7","key":"pone.0237613.ref008","doi-asserted-by":"crossref","first-page":"E552","DOI":"10.21037\/jtd.2016.05.37","article-title":"Metabolic resuscitation in sepsis: a necessary step beyond the hemodynamic?","volume":"8","author":"HP Leite","year":"2016","journal-title":"J Thorac Dis"},{"key":"pone.0237613.ref009","doi-asserted-by":"crossref","first-page":"R290","DOI":"10.1186\/cc13155","article-title":"Sustained high serum malondialdehyde levels are associated with severity and mortality in septic patients","volume":"17","author":"L Lorente","year":"2013","journal-title":"Crit Care"},{"issue":"18","key":"pone.0237613.ref010","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1056\/NEJMoa1401602","article-title":"A randomized trial of protocol-based care for early septic shock","volume":"370","author":"ProCESS Investigators","year":"2014","journal-title":"N Engl J Med"},{"key":"pone.0237613.ref011","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jss.2019.04.011","article-title":"Risk Factors for Mortality in Pediatric Postsurgical versus Medical Severe Sepsis","volume":"242","author":"RK Thakkar","year":"2019","journal-title":"J Surg Res"},{"key":"pone.0237613.ref012","doi-asserted-by":"crossref","first-page":"461","DOI":"10.3858\/emm.2008.40.4.461","article-title":"Regulation of pro-inflammatory responses by lipoxygenases via intracellular reactive oxygen species in vitro and in vivo","volume":"40","author":"SY Kim","year":"2008","journal-title":"Exp Mol Med"},{"key":"pone.0237613.ref013","doi-asserted-by":"crossref","first-page":"G528","DOI":"10.1152\/ajpgi.00189.2003","article-title":"Linoleic acid induces interleukin-8 production by Crohn's human intestinal smooth muscle cells via arachidonic acid metabolites","volume":"286","author":"MA Alzoghaibi","year":"2004","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"pone.0237613.ref014","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1172\/JCI113168","article-title":"Relative contribution of leukotriene B4 to the neutrophil chemotactic activity produced by the resident human alveolar macrophage","volume":"80","author":"TR Martin","year":"1987","journal-title":"J Clin Invest"},{"key":"pone.0237613.ref015","doi-asserted-by":"crossref","first-page":"4616","DOI":"10.1074\/jbc.273.8.4616","article-title":"Role of activating protein-1 in the regulation of the vascular cell adhesion molecule-1 gene expression by tumor necrosis factor-alpha","volume":"273","author":"M Ahmad","year":"1998","journal-title":"J Biol Chem"},{"issue":"4","key":"pone.0237613.ref016","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s00401-010-0788-5","article-title":"Modulation of lipid peroxidation and mitochondrial function by nordihydroguaiaretic acid (NDGA) improves neuropathology in Huntington\u2019s disease mice","volume":"121","author":"J Lee","year":"2011","journal-title":"Acta Neuropathol"},{"key":"pone.0237613.ref017","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1080\/10715760500419365","article-title":"Nordihydroguaiaretic acid is a potent in vitro scavenger of peroxynitrite, singlet oxygen, hydroxyl radical, superoxide anion and hypochlorous acid and prevents in vivo ozone-induced tyrosine nitration in lungs","volume":"40","author":"E Floriano-Sanchez","year":"2006","journal-title":"Free Radic Res"},{"key":"pone.0237613.ref018","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1016\/S0041-0101(02)00203-9","article-title":"Nordihydroguaiaretic acid: hepatotoxicity and detoxification in the mouse","volume":"40","author":"JD Lambert","year":"2002","journal-title":"Toxicon"},{"key":"pone.0237613.ref019","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1165\/rcmb.2009-0210ST","article-title":"An Official American Thoracic Society Workshop Report: Features and Measurements of Experimental Acute Lung Injury in Animals","volume":"44","author":"G Matute-Bello","year":"2011","journal-title":"Am J Respir Cell Mol Biol"},{"key":"pone.0237613.ref020","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s40560-017-0222-3","article-title":"The clinical practice guideline for the management of ARDS in Japan","volume":"5","author":"S Hashimoto","year":"2017","journal-title":"J Intensive Care"},{"key":"pone.0237613.ref021","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1001\/jama.283.15.1995","article-title":"The Acute Respiratory Distress Syndrome Network. Ketoconazole for early treatment of acute lung injury and acute respiratory distress syndrome: a randomized controlled trial","volume":"283","year":"2000","journal-title":"JAMA"},{"key":"pone.0237613.ref022","doi-asserted-by":"crossref","first-page":"e90983","DOI":"10.1371\/journal.pone.0090983","article-title":"Recombinant Human Activated Protein C in the Treatment of Acute Respiratory Distress Syndrome: A Randomized Clinical Trial","volume":"9","author":"AD Cornet","year":"2014","journal-title":"PLOS One"},{"key":"pone.0237613.ref023","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1378\/chest.105.1.190","article-title":"N-acetylcysteine enhances recovery from acute lung injury in man. A randomized, double-blind, placebo-controlled clinical study","volume":"105","author":"PM Suter","year":"1994","journal-title":"Chest"},{"key":"pone.0237613.ref024","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0883-9441(97)90029-0","article-title":"Treatment with N-acetylcysteine during acute respiratory distress syndrome: a randomized, double-blind, placebo-controlled clinical study","volume":"12","author":"G Domenighetti","year":"1997","journal-title":"J Crit Care"},{"key":"pone.0237613.ref025","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0140-6736(02)09459-X","article-title":"Association between mitochondrial dysfunction and severity and outcome of septic shock","volume":"360","author":"D Brealey","year":"2002","journal-title":"Lancet"},{"key":"pone.0237613.ref026","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/2110-5820-1-41","article-title":"Mitochondrial dysfunction and biogenesis: do ICU patients die from mitochondrial failure?","volume":"1","author":"AV Kozlov","year":"2011","journal-title":"Ann Intensive Care"},{"key":"pone.0237613.ref027","doi-asserted-by":"crossref","first-page":"766","DOI":"10.3389\/fimmu.2017.00766","article-title":"Regulation of Lung Epithelial Sodium Channels by Cytokines and Chemokines","volume":"8","author":"BM Wynne","year":"2017","journal-title":"Front Immunol."},{"key":"pone.0237613.ref028","doi-asserted-by":"crossref","first-page":"2808","DOI":"10.1529\/biophysj.105.073106","article-title":"Reactive oxygen species inactivation of surfactant involves structural and functional alterations to surfactant proteins SP-B and SP-C","volume":"90","author":"K Rodr\u00edguez-Capote","year":"2006","journal-title":"Biophys J."},{"key":"pone.0237613.ref029","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1164\/ajrccm\/145.2_Pt_1.388","article-title":"Polyethylene glycolconjugated superoxide dismutase attenuates septic lung injury in guinea pigs","volume":"145","author":"Y Suzuki","year":"1992","journal-title":"Am Rev Respir Dis"},{"key":"pone.0237613.ref030","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1152\/jappl.1993.74.6.2641","article-title":"Effects of recombinant human superoxide dismutase on tumor necrosis factor-induced lung injury in awake sheep","volume":"74","author":"T Amari","year":"1993","journal-title":"J Appl Physiol"},{"key":"pone.0237613.ref031","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1152\/jappl.1988.64.3.929","article-title":"Catalase prevents increased lung permeability during air emboli in unanesthetized sheep","volume":"64","author":"MR Flick","year":"1988","journal-title":"J Appl Physiol"},{"key":"pone.0237613.ref032","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1165\/rcmb.4899","article-title":"Vitamin E reduces transendothelial migration of neutrophils and prevents lung injury in endotoxin-induced airway inflammation","volume":"28","author":"D Rocks\u00e9n","year":"2003","journal-title":"Am J Respir Cell Mol Biol."},{"issue":"4","key":"pone.0237613.ref033","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1097\/01.shk.0000248595.17130.24","article-title":"Isoflurane Improves Survival and Protects Against Renal and Hepatic Injury in Murine Septic Peritonitis","volume":"27","author":"HT Lee","year":"2007","journal-title":"Shock"},{"key":"pone.0237613.ref034","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1097\/00004836-199004000-00021","article-title":"Herbal hepatitis: subacute hepatic necrosis secondary to chaparral leaf","volume":"12","author":"M Katz","year":"1990","journal-title":"J Clin Gastroenterol"},{"key":"pone.0237613.ref035","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1159\/000085103","article-title":"Inhibition of Influenza-Virus-Induced Apoptosis in Chorion Cells of Human Fetal Membranes by Nordihydroguaiaretic Acid","volume":"48","author":"N Uchide","year":"2005","journal-title":"Intervirology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0237613","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T18:56:50Z","timestamp":1597345010000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0237613"}},"subtitle":[],"editor":[{"given":"Shama","family":"Ahmad","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,8,13]]},"references-count":35,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2020,8,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0237613","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,13]]}}}