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Tadesse","year":"2012","journal-title":"Emerging infectious diseases"},{"key":"pone.0237948.ref019","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.ajic.2004.10.001","article-title":"National Nosocomial Infections Surveillance (NNIS) System Report, data summary from January 1992 through June 2004, issued October 2004","volume":"32","author":"National Nosocomial Infections Surveillance, S","year":"2004","journal-title":"American journal of infection control"},{"key":"pone.0237948.ref020","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1056\/NEJM200105243442102","article-title":"A nosocomial outbreak of fluoroquinolone-resistant salmonella infection","volume":"344","author":"S. J. 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Lortholary","year":"1995","journal-title":"North America"},{"key":"pone.0237948.ref035","first-page":"1811","article-title":"Aminoglycosides: a practical review","volume":"58","author":"L. S. Gonzalez","year":"1998","journal-title":"American family physician"},{"key":"pone.0237948.ref036","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1086\/432803","article-title":"Overview of nosocomial infections caused by gram-negative bacilli. Clinical infectious diseases: an official publication of the","volume":"41","author":"R. Gaynes","year":"2005","journal-title":"Infectious Diseases Society of America"},{"key":"pone.0237948.ref037","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1007\/s11894-008-0079-7","article-title":"Salmonellosis and the GI Tract: More than Just Peanut Butter","volume":"10","author":"N. F. Cianflone","year":"2008","journal-title":"Current Gastroenterology Reports"},{"key":"pone.0237948.ref038","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S1473-3099(13)70190-7","article-title":"Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases","volume":"13","author":"L. S. Munoz-Price","year":"2013","journal-title":"The Lancet. Infectious diseases"},{"key":"pone.0237948.ref039","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s40265-018-0880-z","article-title":"Therapeutic Drug Monitoring of Beta-Lactams and Other Antibiotics in the Intensive Care Unit: Which Agents, Which Patients and Which Infections","volume":"78","author":"A. E. Muller","year":"2018","journal-title":"Drugs"},{"key":"pone.0237948.ref040","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1177\/106002808301700604","article-title":"Gentamicin and tobramycin dosing guidelines: an evaluation","volume":"17","author":"G. R. Matzke","year":"1983","journal-title":"Drug Intell Clin Pharm"},{"key":"pone.0237948.ref041","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1128\/JB.112.2.840-848.1972","article-title":"Reversal of the mannitol-sorbitol diauxie in Escherichia coli","volume":"112","author":"J. Lengeler","year":"1972","journal-title":"J Bacteriol"},{"key":"pone.0237948.ref042","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1056\/NEJM196002252620803","article-title":"Systemic absorption of orally administered neomycin in liver disease","volume":"262","author":"P. M. Last","year":"1960","journal-title":"N Engl J Med"},{"key":"pone.0237948.ref043","doi-asserted-by":"crossref","DOI":"10.1201\/b13787","volume-title":"Kucers' The Use of Antibiotic","author":"M. L. Grayson","year":"2010"},{"key":"pone.0237948.ref044","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.mib.2014.06.016","article-title":"Persistence: a copacetic and parsimonious hypothesis for the existence of non-inherited resistance to antibiotics","volume":"21","author":"B. R. Levin","year":"2014","journal-title":"Current opinion in microbiology"},{"key":"pone.0237948.ref045","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1146\/annurev.micro.112408.134306","article-title":"Persister cells","volume":"64","author":"K. Lewis","year":"2010","journal-title":"Annual review of microbiology"},{"key":"pone.0237948.ref046","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1128\/AAC.44.7.1818-1824.2000","article-title":"Role of antibiotic penetration limitation in Klebsiella pneumoniae biofilm resistance to ampicillin and ciprofloxacin","volume":"44","author":"J. N. Anderl","year":"2000","journal-title":"Antimicrob Agents Chemother"},{"key":"pone.0237948.ref047","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1038\/nature03912","article-title":"Aminoglycoside antibiotics induce bacterial biofilm formation","volume":"436","author":"L. R. Hoffman","year":"2005","journal-title":"Nature"},{"key":"pone.0237948.ref048","first-page":"830","article-title":"Gentamicin susceptibility in Escherichia coli related to the genetic background: problems with breakpoints. Clinical microbiology and infection: the official publication of the","volume":"13","author":"L. Jakobsen","year":"2007","journal-title":"European Society of Clinical Microbiology and Infectious Diseases"},{"key":"pone.0237948.ref049","article-title":"Carbon Sources Tune Antibiotic Susceptibility in Pseudomonas aeruginosa via Tricarboxylic Acid Cycle Control","author":"S. Meylan","year":"2017","journal-title":"Cell chemical biology"},{"key":"pone.0237948.ref050","doi-asserted-by":"crossref","first-page":"6145","DOI":"10.1073\/pnas.0711712105","article-title":"Single-cell protein induction dynamics reveals a period of vulnerability to antibiotics in persister bacteria","volume":"105","author":"O. Gefen","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pone.0237948.ref051","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1093\/toxsci\/kfq267","article-title":"An integrative overview on the mechanisms underlying the renal tubular cytotoxicity of gentamicin","volume":"119","author":"Y. Quiros","year":"2011","journal-title":"Toxicological sciences: an official journal of the Society of Toxicology"},{"key":"pone.0237948.ref052","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1093\/toxsci\/56.1.229","article-title":"Gentamicin-induced apoptosis in renal cell lines and embryonic rat fibroblasts","volume":"56","author":"M. El Mouedden","year":"2000","journal-title":"Toxicological sciences: an official journal of the Society of Toxicology"},{"key":"pone.0237948.ref053","first-page":"213","article-title":"Experimental aminoglycoside nephrotoxicity","volume":"86","author":"F. C. Luft","year":"1975","journal-title":"J Lab Clin Med"},{"key":"pone.0237948.ref054","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1093\/jac\/dkm318","article-title":"Mortality and delay in effective therapy associated with extended-spectrum beta-lactamase production in Enterobacteriaceae bacteraemia: a systematic review and meta-analysis","volume":"60","author":"M. J. Schwaber","year":"2007","journal-title":"The Journal of antimicrobial chemotherapy"},{"key":"pone.0237948.ref055","first-page":"671","article-title":"A Study on the Usage Pattern of Antimicrobial Agents for the Prevention of Surgical Site Infections (SSIs) in a Tertiary Care Teaching Hospital","volume":"7","author":"A. K. A. Khan","year":"2013","journal-title":"Journal of clinical and diagnostic research: JCDR"},{"key":"pone.0237948.ref056","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1128\/AAC.43.5.1003","article-title":"Aminoglycosides: nephrotoxicity","volume":"43","author":"M. P. Mingeot-Leclercq","year":"1999","journal-title":"Antimicrob Agents Chemother"},{"key":"pone.0237948.ref057","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1159\/000071059","article-title":"A cochlear cell line as an in vitro system for drug ototoxicity screening","volume":"8","author":"G. M. Kalinec","year":"2003","journal-title":"Audiology & neuro-otology"},{"key":"pone.0237948.ref058","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1093\/jac\/26.5.713","article-title":"Aminoglycoside toxicity following antibiotic prophylaxis in cardiac surgery","volume":"26","author":"A. P. Wilson","year":"1990","journal-title":"The Journal of antimicrobial chemotherapy"},{"key":"pone.0237948.ref059","doi-asserted-by":"crossref","first-page":"289","DOI":"10.3949\/ccjm.69.4.289","article-title":"How to prevent, recognize, and treat drug-induced nephrotoxicity","volume":"69","author":"X. Guo","year":"2002","journal-title":"Cleveland Clinic journal of medicine"},{"key":"pone.0237948.ref060","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1227\/00006123-199303000-00017","article-title":"Mannitol, intracranial pressure, and vasogenic edema","volume":"32","author":"R. C. Hartwell","year":"1993","journal-title":"Neurosurgery"},{"key":"pone.0237948.ref061","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/00005792-199005000-00003","article-title":"Mannitol-induced acute renal failure","volume":"69","author":"H. R. Dorman","year":"1990","journal-title":"Medicine"},{"key":"pone.0237948.ref062","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.jcf.2012.11.002","article-title":"Pooled analysis of two large randomised phase III inhaled mannitol studies in cystic fibrosis","volume":"12","author":"D. Bilton","year":"2013","journal-title":"J Cyst Fibros"},{"key":"pone.0237948.ref063","doi-asserted-by":"crossref","first-page":"e84220","DOI":"10.1371\/journal.pone.0084220","article-title":"Mannitol enhances antibiotic sensitivity of persister bacteria in Pseudomonas aeruginosa biofilms","volume":"8","author":"N. Barraud","year":"2013","journal-title":"PloS one"},{"key":"pone.0237948.ref064","doi-asserted-by":"crossref","first-page":"e0141192","DOI":"10.1371\/journal.pone.0141192","article-title":"Mannitol Does Not Enhance Tobramycin Killing of Pseudomonas aeruginosa in a Cystic Fibrosis Model System of Biofilm Formation","volume":"10","author":"K. E. 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Neidhardt","year":"1974","journal-title":"J Bacteriol"},{"key":"pone.0237948.ref075","doi-asserted-by":"crossref","first-page":"612","DOI":"10.7326\/0003-4819-89-5-612","article-title":"Amikacin serum concentrations: prediction of levels and dosage guidelines","volume":"89","author":"F. A. Sarubbi","year":"1978","journal-title":"Ann Intern Med"},{"key":"pone.0237948.ref076","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1128\/AAC.33.6.973","article-title":"Serial trough and peak amikacin levels in plasma as predictors of nephrotoxicity","volume":"33","author":"A. M. Contreras","year":"1989","journal-title":"Antimicrob Agents Chemother"},{"key":"pone.0237948.ref077","article-title":"Microtiter dish biofilm formation assay","author":"G. A. O'Toole","year":"2011","journal-title":"Journal of visualized experiments: JoVE"},{"key":"pone.0237948.ref078","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1074\/jbc.M109959200","article-title":"Megalin deficiency offers protection from renal aminoglycoside accumulation","volume":"277","author":"C. Schmitz","year":"2002","journal-title":"The Journal of biological chemistry"},{"key":"pone.0237948.ref079","first-page":"38","article-title":"Assessment of different permeabilization methods of minimizing damage to the adherent cells for detection of intracellular RNA by flow cytometry","volume":"6","author":"Z. Amidzadeh","year":"2014","journal-title":"Avicenna journal of medical biotechnology"},{"key":"pone.0237948.ref080","first-page":"135","article-title":"Genetic mechanisms of antimicrobial resistance identified in Salmonella enterica, Escherichia coli, and","volume":"4","author":"J. G. Frye","year":"2013","journal-title":"Enteroccocus spp. isolated from U.S. food animals. 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