{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T12:32:01Z","timestamp":1792067521918,"version":"4.4.0"},"reference-count":79,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T00:00:00Z","timestamp":1600732800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["NIH T32GM113896 \/ STXMSTP"],"award-info":[{"award-number":["NIH T32GM113896 \/ STXMSTP"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006058","name":"St. Baldrick's Foundation","doi-asserted-by":"publisher","award":["St. Baldrick's Scholar"],"award-info":[{"award-number":["St. Baldrick's Scholar"]}],"id":[{"id":"10.13039\/100006058","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Turn it Gold Foundation","award":["Direct Laboratory Support"],"award-info":[{"award-number":["Direct Laboratory Support"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0238856","type":"journal-article","created":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T18:43:12Z","timestamp":1600800192000},"page":"e0238856","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":48,"title":["Doxorubicin-induced p53 interferes with mitophagy in cardiac fibroblasts"],"prefix":"10.1371","volume":"15","author":[{"given":"T. R.","family":"Mancilla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. R.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2750-6461","authenticated-orcid":true,"given":"G. J.","family":"Aune","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,9,22]]},"reference":[{"key":"pone.0238856.ref001","volume-title":"SEER Cancer Statistics Review, 1975\u20132012.","author":"NA Howlader N","year":"2015"},{"key":"pone.0238856.ref002","article-title":"The cumulative burden of surviving childhood cancer: an initial report from the St Jude Lifetime Cohort Study (SJLIFE).","author":"N Bhakta","journal-title":"The Lancet"},{"issue":"12","key":"pone.0238856.ref003","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1200\/JCO.2013.51.1055","article-title":"Aging and risk of severe, disabling, life-threatening, and fatal events in the childhood cancer survivor study","volume":"32","author":"GT Armstrong","year":"2014","journal-title":"Journal of clinical oncology: official journal of the American Society of Clinical Oncology"},{"issue":"18","key":"pone.0238856.ref004","doi-asserted-by":"crossref","first-page":"3191","DOI":"10.1016\/j.ejca.2006.08.005","article-title":"Clinical heart failure in a cohort of children treated with anthracyclines: a long-term follow-up study","volume":"42","author":"EC van Dalen","year":"2006","journal-title":"European journal of cancer (Oxford, England: 1990)."},{"key":"pone.0238856.ref005","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1155\/2012\/713294","article-title":"Strategies to Prevent Anthracycline-Related Congestive Heart Failure in Survivors of Childhood Cancer","volume":"2012","author":"SH Armenian","year":"2012","journal-title":"Cardiology Research and Practice"},{"issue":"2","key":"pone.0238856.ref006","first-page":"83","article-title":"Childhood and adolescent cancer statistics, 2014.","volume":"64","author":"E Ward","year":"2014","journal-title":"CA: a cancer journal for clinicians."},{"issue":"6","key":"pone.0238856.ref007","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1016\/j.tiv.2010.06.009","article-title":"Enhanced toxicity and ROS generation by doxorubicin in primary cultures of cardiomyocytes from neonatal metallothionein-I\/II null mice","volume":"24","author":"Z Fu","year":"2010","journal-title":"Toxicology in Vitro"},{"issue":"3","key":"pone.0238856.ref008","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1002\/cphy.c180017","article-title":"Doxorubicin-Induced Cardiomyopathy in Children.","volume":"9","author":"TR Mancilla","year":"2019","journal-title":"Compr Physiol."},{"issue":"21","key":"pone.0238856.ref009","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1200\/JCO.2017.76.3920","article-title":"Cardiovascular Disease in Survivors of Childhood Cancer: Insights Into Epidemiology, Pathophysiology, and Prevention.","volume":"36","author":"SH Armenian","year":"2018","journal-title":"Journal of clinical oncology: official journal of the American Society of Clinical Oncology."},{"issue":"1","key":"pone.0238856.ref010","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S1040-8428(97)10007-5","article-title":"Anthracycline-induced cardiotoxicity in children and young adults","volume":"27","author":"A Giantris","year":"1998","journal-title":"Critical reviews in oncology\/hematology"},{"issue":"10","key":"pone.0238856.ref011","doi-asserted-by":"crossref","first-page":"H1379","DOI":"10.1152\/ajpheart.00099.2014","article-title":"The tell-tale heart: molecular and cellular responses to childhood anthracycline exposure","volume":"307","author":"ML Lindsey","year":"2014","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"50","key":"pone.0238856.ref012","article-title":"Naturally Engineered Maturation of Cardiomyocytes.","volume":"5","author":"GJ Scuderi","year":"2017","journal-title":"Frontiers in Cell and Developmental Biology"},{"key":"pone.0238856.ref013","first-page":"42290","article-title":"Developmental stage-dependent effects of cardiac fibroblasts on function of stem cell-derived engineered cardiac tissues. Scientific Reports","volume":"7","author":"B Liau","year":"2017"},{"issue":"10","key":"pone.0238856.ref014","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1161\/CIRCRESAHA.109.201400","article-title":"Origin of cardiac fibroblasts and the role of periostin","volume":"105","author":"P Snider","year":"2009","journal-title":"Circulation research"},{"issue":"7","key":"pone.0238856.ref015","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1161\/CIRCRESAHA.111.243899","article-title":"Importance of myocyte-nonmyocyte interactions in cardiac development and disease","volume":"110","author":"Y Tian","year":"2012","journal-title":"Circulation research"},{"issue":"1","key":"pone.0238856.ref016","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.actbio.2013.08.037","article-title":"3rd. Young developmental age cardiac extracellular matrix promotes the expansion of neonatal cardiomyocytes in vitro","volume":"10","author":"C Williams","year":"2014","journal-title":"Acta biomaterialia"},{"issue":"7","key":"pone.0238856.ref017","doi-asserted-by":"crossref","first-page":"71001","DOI":"10.1115\/1.4024349","article-title":"The role of cardiac fibroblasts in extracellular matrix-mediated signaling during normal and pathological cardiac development","volume":"135","author":"KE Sullivan","year":"2013","journal-title":"Journal of biomechanical engineering"},{"issue":"2","key":"pone.0238856.ref018","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.pharmthera.2009.05.002","article-title":"Cardiac fibroblasts: at the heart of myocardial remodeling.","volume":"123","author":"KE Porter","year":"2009","journal-title":"Pharmacology & therapeutics"},{"key":"pone.0238856.ref019","doi-asserted-by":"crossref","first-page":"e22847","DOI":"10.7554\/eLife.22847","article-title":"Human cardiac fibroblasts adaptive responses to controlled combined mechanical strain and oxygen changes in vitro.","volume":"6","author":"GS Ugolini","year":"2017","journal-title":"eLife"},{"issue":"2","key":"pone.0238856.ref020","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.molmed.2015.12.006","article-title":"The Living Scar\u2013Cardiac Fibroblasts and the Injured Heart","volume":"22","author":"EA Rog-Zielinska","year":"2016","journal-title":"Trends in molecular medicine"},{"issue":"1","key":"pone.0238856.ref021","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S0008-6363(03)00346-8","article-title":"Human cardiomyocyte hypertrophy induced in vitro by gp130 stimulation","volume":"59","author":"C Ancey","year":"2003","journal-title":"Cardiovascular research"},{"issue":"2","key":"pone.0238856.ref022","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/S0008-6363(98)00121-7","article-title":"Angiotensin II stimulates cardiac myocyte hypertrophy via paracrine release of TGF-beta 1 and endothelin-1 from fibroblasts","volume":"40","author":"MO Gray","year":"1998","journal-title":"Cardiovascular research"},{"issue":"21","key":"pone.0238856.ref023","doi-asserted-by":"crossref","first-page":"12283","DOI":"10.1073\/pnas.211086598","article-title":"The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy","volume":"98","author":"P Liao","year":"2001","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"3","key":"pone.0238856.ref024","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1161\/01.RES.0000258116.60404.ad","article-title":"p38-MAPK induced dephosphorylation of alpha-tropomyosin is associated with depression of myocardial sarcomeric tension and ATPase activity","volume":"100","author":"S Vahebi","year":"2007","journal-title":"Circulation research"},{"issue":"12","key":"pone.0238856.ref025","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1161\/CIRCRESAHA.109.209809","article-title":"Cardiac fibroblast: the renaissance cell.","volume":"105","author":"CA Souders","year":"2009","journal-title":"Circulation research"},{"issue":"2","key":"pone.0238856.ref026","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1002\/jcp.20307","article-title":"Role of interleukin-6 in cardiomyocyte\/cardiac fibroblast interactions during myocyte hypertrophy and fibroblast proliferation","volume":"204","author":"S Fredj","year":"2005","journal-title":"Journal of cellular physiology"},{"issue":"8","key":"pone.0238856.ref027","doi-asserted-by":"crossref","first-page":"5000","DOI":"10.1074\/jbc.M113.536920","article-title":"Defects in Mitochondrial Clearance Predispose Human Monocytes to Interleukin-1\u03b2 Hypersecretion","volume":"289","author":"R van der Burgh","year":"2014","journal-title":"Journal of Biological Chemistry"},{"issue":"10","key":"pone.0238856.ref028","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.4161\/auto.25878","article-title":"Defective quality control mechanisms and accumulation of damaged mitochondria link Gaucher and Parkinson diseases.","volume":"9","author":"LD Osellame","year":"2013","journal-title":"Autophagy."},{"issue":"1","key":"pone.0238856.ref029","doi-asserted-by":"crossref","first-page":"C53","DOI":"10.1152\/ajpcell.2001.280.1.C53","article-title":"Oxidative stress regulates collagen synthesis and matrix metalloproteinase activity in cardiac fibroblasts","volume":"280","author":"DA Siwik","year":"2001","journal-title":"American journal of physiology Cell physiology"},{"issue":"2","key":"pone.0238856.ref030","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3233\/JPD-2011-11025","article-title":"Mitochondrial dysfunction in skin fibroblasts from a Parkinson's disease patient with an alpha-synuclein triplication","volume":"1","author":"SK Mak","year":"2011","journal-title":"Journal of Parkinson's disease"},{"issue":"6","key":"pone.0238856.ref031","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1007\/s11011-018-0308-1","article-title":"Mitochondrial alterations accompanied by oxidative stress conditions in skin fibroblasts of Huntington's disease patients","volume":"33","author":"P Jedrak","year":"2018","journal-title":"Metabolic brain disease"},{"issue":"3","key":"pone.0238856.ref032","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1097\/MPH.0000000000001112","article-title":"Aerobic Exercise During Early Murine Doxorubicin Exposure Mitigates Cardiac Toxicity","volume":"40","author":"F Wang","year":"2018","journal-title":"J Pediatr Hematol Oncol"},{"issue":"3","key":"pone.0238856.ref033","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/echo.12351","article-title":"Cardiac assessment in pediatric mice: strain analysis as a diagnostic measurement.","volume":"31","author":"TG Andrews","year":"2014","journal-title":"Echocardiography."},{"issue":"7","key":"pone.0238856.ref034","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1016\/j.bbamcr.2016.01.021","article-title":"New signal transduction paradigms in anthracycline-induced cardiotoxicity","volume":"1863","author":"A Ghigo","year":"2016","journal-title":"Biochimica et Biophysica Acta (BBA)\u2014Molecular Cell Research."},{"issue":"18","key":"pone.0238856.ref035","doi-asserted-by":"crossref","first-page":"4737","DOI":"10.1158\/1078-0432.CCR-14-0821","article-title":"Twisting and Ironing: Doxorubicin Cardiotoxicity by Mitochondrial DNA Damage","volume":"20","author":"KC Nitiss","year":"2014","journal-title":"Clinical Cancer Research"},{"issue":"12","key":"pone.0238856.ref036","doi-asserted-by":"crossref","first-page":"e1003722","DOI":"10.1371\/journal.ppat.1003722","article-title":"Hepatitis B Virus Disrupts Mitochondrial Dynamics: Induces Fission and Mitophagy to Attenuate Apoptosis.","volume":"9","author":"S-J Kim","year":"2013","journal-title":"PLOS Pathogens"},{"key":"pone.0238856.ref037","doi-asserted-by":"crossref","first-page":"965","DOI":"10.3389\/fnins.2018.00965","article-title":"The Transcription Factor Function of Parkin: Breaking the Dogma.","volume":"12","author":"C Alves da Costa","year":"2019","journal-title":"Front Neurosci."},{"issue":"8","key":"pone.0238856.ref038","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1093\/emboj\/20.8.1863","article-title":"Perinuclear, perigranular and sub-plasmalemmal mitochondria have distinct functions in the regulation of cellular calcium transport","volume":"20","author":"MK Park","year":"2001","journal-title":"The EMBO journal"},{"issue":"231","key":"pone.0238856.ref039","first-page":"ra47","article-title":"Perinuclear mitochondrial clustering creates an oxidant-rich nuclear domain required for hypoxia-induced transcription","volume":"5","author":"A-B Al-Mehdi","year":"2012","journal-title":"Sci Signal"},{"key":"pone.0238856.ref040","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.yjmcc.2016.03.005","article-title":"Myocyte-Fibroblast Communication in Cardiac Fibrosis and Arrhythmias: Mechanisms and Model Systems","volume":"94","author":"J Pellman","year":"2016","journal-title":"Journal of molecular and cellular cardiology"},{"issue":"4 Suppl","key":"pone.0238856.ref041","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jelectrocard.2005.06.096","article-title":"Electrical coupling of fibroblasts and myocytes: relevance for cardiac propagation","volume":"38","author":"P Kohl","year":"2005","journal-title":"Journal of electrocardiology"},{"key":"pone.0238856.ref042","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1755-1536-5-15","article-title":"Cardiac fibroblasts, fibrosis and extracellular matrix remodeling in heart disease","volume":"5","author":"D Fan","year":"2012","journal-title":"Fibrogenesis & Tissue Repair"},{"issue":"6","key":"pone.0238856.ref043","first-page":"1113","article-title":"Myofibroblasts and the extracellular matrix network in post-myocardial infarction cardiac remodeling","volume":"466","author":"Y Ma","year":"2014","journal-title":"Pfl\u00fcgers Archiv\u2014European Journal of Physiology"},{"key":"pone.0238856.ref044","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.ijbiomac.2014.02.028","article-title":"Intercalation of antitumor drug doxorubicin and its analogue by DNA duplex: structural features and biological implications","volume":"66","author":"D Agudelo","year":"2014","journal-title":"International journal of biological macromolecules"},{"issue":"5","key":"pone.0238856.ref045","first-page":"421","article-title":"DNA Topoisomerases and Their Poisoning by Anticancer and Antibacterial Drugs. Chemistry &","volume":"17","author":"Y Pommier","year":"2010","journal-title":"Biology"},{"issue":"6","key":"pone.0238856.ref046","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s00005-009-0051-8","article-title":"Cardiomyocyte death in doxorubicin-induced cardiotoxicity.","volume":"57","author":"Y-W Zhang","year":"2009","journal-title":"Archivum immunologiae et therapiae experimentalis."},{"issue":"1","key":"pone.0238856.ref047","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1172\/JCI109642","article-title":"Enzymatic defenses of the mouse heart against reactive oxygen metabolites: alterations produced by doxorubicin","volume":"65","author":"JH Doroshow","year":"1980","journal-title":"The Journal of clinical investigation"},{"key":"pone.0238856.ref048","first-page":"3405","author":"S Harkey Shirley","year":"2009","journal-title":"Transcriptional Regulation of Estrogen Receptor- by p53 in Human Breast Cancer Cells"},{"issue":"1\u20132","key":"pone.0238856.ref049","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s11010-005-5905-8","article-title":"Targeted disruption of p53 attenuates doxorubicin-induced cardiac toxicity in mice","volume":"273","author":"Y Shizukuda","year":"2005","journal-title":"Molecular and cellular biochemistry"},{"issue":"10","key":"pone.0238856.ref050","doi-asserted-by":"crossref","first-page":"e3130","DOI":"10.1038\/cddis.2017.492","article-title":"p53 dynamics orchestrates with binding affinity to target genes for cell fate decision.","volume":"8","author":"M Wu","year":"2017","journal-title":"Cell Death & Disease."},{"issue":"4","key":"pone.0238856.ref051","doi-asserted-by":"crossref","first-page":"e0231223","DOI":"10.1371\/journal.pone.0231223","article-title":"Doxorubicin induces large-scale and differential H2A and H2B redistribution in live cells.","volume":"15","author":"P Nanasi","year":"2020","journal-title":"PLoS One."},{"key":"pone.0238856.ref052","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1038\/ncomms2921","article-title":"Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin.","volume":"4","author":"B Pang","year":"2013","journal-title":"Nat Commun."},{"issue":"1","key":"pone.0238856.ref053","doi-asserted-by":"crossref","first-page":"13672","DOI":"10.1038\/s41598-018-31939-9","article-title":"Doxorubicin induces an extensive transcriptional and metabolic rewiring in yeast cells","volume":"8","author":"H Taymaz-Nikerel","year":"2018","journal-title":"Sci Rep"},{"issue":"1","key":"pone.0238856.ref054","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1080\/21691401.2019.1593854","article-title":"Alantolactone induces apoptosis through ROS-mediated AKT pathway and inhibition of PINK1-mediated mitophagy in human HepG2 cells.","volume":"47","author":"X Kang","year":"2019","journal-title":"Artif Cells Nanomed Biotechnol."},{"issue":"6","key":"pone.0238856.ref055","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1007\/s12192-018-0937-7","article-title":"Matrine promotes liver cancer cell apoptosis by inhibiting mitophagy and PINK1\/Parkin pathways","volume":"23","author":"R Wei","year":"2018","journal-title":"Cell Stress Chaperones"},{"issue":"38","key":"pone.0238856.ref056","doi-asserted-by":"crossref","first-page":"14891","DOI":"10.1074\/jbc.RA117.001469","article-title":"Mitochondria-targeted drugs stimulate mitophagy and abrogate colon cancer cell proliferation","volume":"293","author":"KA Boyle","year":"2018","journal-title":"J Biol Chem"},{"key":"pone.0238856.ref057","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.etap.2016.06.006","article-title":"Mitophagy inhibits proliferation by decreasing cyclooxygenase-2 (COX-2) in arsenic trioxide-treated HepG2 cells.","volume":"45","author":"Z Niu","year":"2016","journal-title":"Environ Toxicol Pharmacol"},{"issue":"1","key":"pone.0238856.ref058","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1093\/cvr\/cvw032","article-title":"Ataxia telangiectasia mutated in cardiac fibroblasts regulates doxorubicin-induced cardiotoxicity","volume":"110","author":"H Zhan","year":"2016","journal-title":"Cardiovascular research"},{"key":"pone.0238856.ref059","first-page":"2308","article-title":"Cytosolic p53 inhibits Parkin-mediated mitophagy and promotes mitochondrial dysfunction in the mouse heart.","volume":"4","author":"A Hoshino","year":"2013"},{"issue":"7","key":"pone.0238856.ref060","doi-asserted-by":"crossref","first-page":"e22801","DOI":"10.1371\/journal.pone.0022801","article-title":"Cardiomyocyte Specific Ablation of p53 Is Not Sufficient to Block Doxorubicin Induced Cardiac Fibrosis and Associated Cytoskeletal Changes.","volume":"6","author":"T Feridooni","year":"2011","journal-title":"PLOS ONE."},{"issue":"2","key":"pone.0238856.ref061","first-page":"617","article-title":"Dual Role of Mitophagy in Cancer Drug Resistance","volume":"38","author":"C Yan","year":"2018","journal-title":"Anticancer Research"},{"issue":"51","key":"pone.0238856.ref062","doi-asserted-by":"crossref","first-page":"E5537","DOI":"10.1073\/pnas.1414665111","article-title":"Bnip3 mediates doxorubicin-induced cardiac myocyte necrosis and mortality through changes in mitochondrial signaling","volume":"111","author":"R Dhingra","year":"2014","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"41","key":"pone.0238856.ref063","doi-asserted-by":"crossref","first-page":"21616","DOI":"10.1074\/jbc.M116.733410","article-title":"BNIP3 Protein Suppresses PINK1 Kinase Proteolytic Cleavage to Promote Mitophagy","volume":"291","author":"T Zhang","year":"2016","journal-title":"Journal of Biological Chemistry"},{"issue":"26","key":"pone.0238856.ref064","doi-asserted-by":"crossref","first-page":"15182","DOI":"10.1073\/pnas.1922072117","article-title":"Uncoupling DNA damage from chromatin damage to detoxify doxorubicin","volume":"117","author":"X Qiao","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"pone.0238856.ref065","doi-asserted-by":"crossref","first-page":"109475","DOI":"10.1016\/j.biopha.2019.109475","article-title":"Inhibition of CACNA1H attenuates doxorubicin-induced acute cardiotoxicity by affecting endoplasmic reticulum stress.","volume":"120","author":"J Hu","year":"2019","journal-title":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie."},{"issue":"10","key":"pone.0238856.ref066","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18102121","article-title":"Cardiotoxic Effects of Short-Term Doxorubicin Administration: Involvement of Connexin 43 in Calcium Impairment","volume":"18","author":"M Pecoraro","year":"2017","journal-title":"International journal of molecular sciences"},{"issue":"10","key":"pone.0238856.ref067","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1177\/1947601911436199","article-title":"Prevention of Doxorubicin cardiopathic changes by a benzyl styryl sulfone in mice","volume":"2","author":"M Lu","year":"2011","journal-title":"Genes & cancer"},{"issue":"5","key":"pone.0238856.ref068","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1161\/CIRCRESAHA.115.307604","article-title":"Chemical Endoplasmic Reticulum Chaperone Alleviates Doxorubicin-Induced Cardiac Dysfunction","volume":"118","author":"HY Fu","year":"2016","journal-title":"Circulation research"},{"issue":"10","key":"pone.0238856.ref069","doi-asserted-by":"crossref","first-page":"e26441","DOI":"10.1371\/journal.pone.0026441","article-title":"S-diclofenac Protects against Doxorubicin-Induced Cardiomyopathy in Mice via Ameliorating Cardiac Gap Junction Remodeling.","volume":"6","author":"H Zhang","year":"2011","journal-title":"PLOS ONE."},{"issue":"3","key":"pone.0238856.ref070","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.bbadis.2014.12.012","article-title":"Mitochondrial dysfunction in primary human fibroblasts triggers an adaptive cell survival program that requires AMPK-\u03b1.","volume":"1852","author":"F Distelmaier","year":"2015","journal-title":"Biochimica et Biophysica Acta (BBA)\u2014Molecular Basis of Disease."},{"key":"pone.0238856.ref071","doi-asserted-by":"crossref","first-page":"4396368","DOI":"10.1155\/2016\/4396368","article-title":"The CXCL10\/CXCR3 Axis and Cardiac Inflammation: Implications for Immunotherapy to Treat Infectious and Noninfectious Diseases of the Heart","volume":"2016","author":"R Altara","year":"2016","journal-title":"Journal of Immunology Research"},{"issue":"7","key":"pone.0238856.ref072","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1042\/CS20150666","article-title":"Emerging importance of chemokine receptor CXCR3 and its ligands in cardiovascular diseases","volume":"130","author":"R Altara","year":"2016","journal-title":"Clinical Science"},{"issue":"12","key":"pone.0238856.ref073","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.4161\/cbt.11.12.15540","article-title":"Doxorubicin and daunorubicin induce processing and release of interleukin-1beta through activation of the NLRP3 inflammasome","volume":"11","author":"KA Sauter","year":"2011","journal-title":"Cancer biology & therapy"},{"issue":"3","key":"pone.0238856.ref074","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1177\/1535370217746383","article-title":"Immune response proteins as predictive biomarkers of doxorubicin-induced cardiotoxicity in breast cancer patients","volume":"243","author":"LR Yu","year":"2018","journal-title":"Experimental biology and medicine"},{"issue":"Pt 8","key":"pone.0238856.ref075","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.1242\/jcs.115.8.1623","article-title":"Remodeling the intercalated disc leads to cardiomyopathy in mice misexpressing cadherins in the heart","volume":"115","author":"MC Ferreira-Cornwell","year":"2002","journal-title":"Journal of cell science"},{"issue":"9","key":"pone.0238856.ref076","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.prp.2010.05.007","article-title":"Apoptosis-related factors p53, bcl-2 and the defects of force transmission in dilated cardiomyopathy.","volume":"206","author":"A Tsipis","year":"2010","journal-title":"Pathology\u2014Research and Practice"},{"key":"pone.0238856.ref077","volume-title":"Investigation of docetaxel and doxorubicin resistance in mcf-7 breast carcinoma cell line","author":"O. Darcansoy iseri","year":"2009"},{"issue":"3","key":"pone.0238856.ref078","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.bbrc.2005.03.153","article-title":"Prospective therapeutic applications of p53 inhibitors","volume":"331","author":"AV Gudkov","year":"2005","journal-title":"Biochemical and biophysical research communications"},{"issue":"7","key":"pone.0238856.ref079","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/j.molonc.2016.04.001","article-title":"Mutant p53 proteins counteract autophagic mechanism sensitizing cancer cells to mTOR inhibition","volume":"10","author":"M Cordani","year":"2016","journal-title":"Molecular Oncology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0238856","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,19]],"date-time":"2022-11-19T19:02:07Z","timestamp":1668884527000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0238856"}},"subtitle":[],"editor":[{"given":"Partha","family":"Mukhopadhyay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,9,22]]},"references-count":79,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2020,9,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0238856","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/674309","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,22]]}}}