{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T01:12:08Z","timestamp":1790471528538,"version":"4.1.0"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T00:00:00Z","timestamp":1600041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007709","name":"Michigan State University","doi-asserted-by":"publisher","award":["Foundation"],"award-info":[{"award-number":["Foundation"]}],"id":[{"id":"10.13039\/100007709","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0238993","type":"journal-article","created":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T17:28:14Z","timestamp":1600104494000},"page":"e0238993","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":13,"title":["Lactobacillus strains vary in their ability to interact with human endometrial stromal cells"],"prefix":"10.1371","volume":"15","author":[{"given":"Megan","family":"Shiroda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9581-0660","authenticated-orcid":true,"given":"Shannon D.","family":"Manning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,9,14]]},"reference":[{"key":"pone.0238993.ref001","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1365-2958.2004.04266.x","article-title":"Molecular pathogenesis of neonatal group B streptococcal infection: No longer in its infancy","author":"KS Doran","year":"2004","journal-title":"Mol Microbiol"},{"key":"pone.0238993.ref002","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/j.1600-065X.2008.00673.x","article-title":"Induction and termination of inflammatory signaling in group B streptococcal sepsis","volume":"225","author":"J Wennekamp","year":"2008","journal-title":"Immunol Rev"},{"key":"pone.0238993.ref003","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/cshperspect.a023051","article-title":"The perinatal microbiome and pregnancy: Moving beyond the vaginal microbiome","volume":"5","author":"AL Prince","year":"2015","journal-title":"Cold Spring Harb Perspect Med"},{"key":"pone.0238993.ref004","doi-asserted-by":"crossref","first-page":"627.e1","DOI":"10.1016\/j.ajog.2016.01.193","article-title":"The placental membrane microbiome is altered among subjects with spontaneous preterm birth with and without chorioamnionitis","volume":"214","author":"AL Prince","year":"2016","journal-title":"Am J Obstet Gynecol"},{"key":"pone.0238993.ref005","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2007.05.044","article-title":"Detection of bacteria in placental tissues obtained from extremely low gestational age neonates","volume":"198","author":"AB Onderdonk","year":"2008","journal-title":"Am J Obstet Gynecol"},{"key":"pone.0238993.ref006","doi-asserted-by":"crossref","first-page":"4680","DOI":"10.1073\/pnas.1002611107","article-title":"Vaginal microbiome of reproductive-age women","volume":"108","author":"J Ravel","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pone.0238993.ref007","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/B978-0-12-814649-1.00014-4","article-title":"Microbiota and the Urogenital Tract, Pathogenesis, and Therapies","author":"B Tungland","year":"2018","journal-title":"Human Microbiota in Health and Disease"},{"key":"pone.0238993.ref008","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/nri3535","article-title":"Microbiota-mediated colonization resistance against intestinal pathogens","author":"CG Buffie","year":"2013","journal-title":"Nature Rev Immunol"},{"key":"pone.0238993.ref009","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.coi.2014.03.003","article-title":"Commensal bacteria mediated defenses against pathogens","author":"MC Abt","year":"2014","journal-title":"Curr Opin Immunol"},{"key":"pone.0238993.ref010","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2017.00906","article-title":"Vaginal Lactobacillus inhibits HIV-1 replication in human tissues ex vivo","volume":"8","author":"RA \u00d1ahui Palomino","year":"2017","journal-title":"Front Microbiol"},{"key":"pone.0238993.ref011","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-019-13468-9","article-title":"Extracellular vesicles from symbiotic vaginal lactobacilli inhibit HIV-1 infection of human tissues","volume":"10","author":"RA \u00d1ahui Palomino","year":"2019","journal-title":"Nat Commun"},{"key":"pone.0238993.ref012","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1139\/m88-063","article-title":"Lactobacillus inhibitor production against Escherichia coli and coaggregation ability with uropathogens","volume":"34","author":"G Reid","year":"1988","journal-title":"Can J Microbiol"},{"key":"pone.0238993.ref013","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1099\/jmm.0.05155-0","article-title":"Growth and lactic acid production by vaginal Lactobacillus acidophilus CRL 1259, and inhibition of uropathogenic Escherichia coli","volume":"52","author":"MSJ Tom\u00e1s","year":"2003","journal-title":"J Med Microbiol"},{"key":"pone.0238993.ref014","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1111\/jam.12739","article-title":"Preventive effect of Lactobacillus reuteri CRL1324 on Group B Streptococcus vaginal colonization in an experimental mouse model","volume":"118","author":"PR De Gregorio","year":"2015","journal-title":"J Appl Microbiol"},{"key":"pone.0238993.ref015","doi-asserted-by":"crossref","first-page":"810","DOI":"10.3390\/nu11040810","article-title":"Rectal and vaginal eradication of Streptococcus agalactiae (GBS) in pregnant women by using Lactobacillus salivarius cect 9145, a target-specific probiotic strain","volume":"11","author":"V Mart\u00edn","year":"2019","journal-title":"Nutrients"},{"key":"pone.0238993.ref016","doi-asserted-by":"crossref","first-page":"103692","DOI":"10.1016\/j.micpath.2019.103692","article-title":"In-vitro effect of vaginal lactobacilli against group B Streptococcus","volume":"136","author":"G Marziali","year":"2019","journal-title":"Microb Pathog"},{"key":"pone.0238993.ref017","doi-asserted-by":"crossref","DOI":"10.1186\/s12866-015-0608-0","article-title":"Lactobacillus crispatus inhibits growth of Gardnerella vaginalis and Neisseria gonorrhoeae on a porcine vaginal mucosa model","volume":"15","author":"LM Breshears","year":"2015","journal-title":"BMC Microbiol"},{"key":"pone.0238993.ref018","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.7150\/ijms.6304","article-title":"Reciprocal interference between Lactobacillus spp. and Gardnerella vaginalis on initial adherence to epithelial cells","volume":"10","author":"J Castro","year":"2013","journal-title":"Int J Med Sci"},{"key":"pone.0238993.ref019","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/j.1574-6968.2009.01887.x","article-title":"Individual and co-operative roles of lactic acid and hydrogen peroxide in the killing activity of enteric strain Lactobacillus johnsonii NCC933 and vaginal strain Lactobacillus gasseri KS120.1 against enteric, uropathogenic and vaginosis-associated pathog","volume":"304","author":"F Atassi","year":"2010","journal-title":"FEMS Microbiol Lett"},{"key":"pone.0238993.ref020","doi-asserted-by":"crossref","first-page":"403S","DOI":"10.1093\/jn\/130.2.403S","article-title":"Probiotic immunomodulation in health and disease","volume":"130","author":"KL Erickson","year":"2000","journal-title":"J Nutr"},{"key":"pone.0238993.ref021","first-page":"1","article-title":"Lactobacillus acidophilus alleviates the inflammatory response to enterotoxigenic Escherichia coli K88 via inhibition of the NF-\u03baB and p38 mitogen-activated protein kinase signaling pathways in piglets","volume":"16","author":"H Li","year":"2016","journal-title":"BMC Microbiol"},{"key":"pone.0238993.ref022","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1177\/1933719113519171","article-title":"Lipopolysaccharide-induced profiles of cytokine, chemokine, and growth factors produced by human decidual cells are altered by Lactobacillus rhamnosus GR-1 supernatant","volume":"21","author":"W Li","year":"2014","journal-title":"Reprod Sci"},{"key":"pone.0238993.ref023","doi-asserted-by":"crossref","first-page":"146.e1","DOI":"10.1016\/j.ajog.2019.04.036","article-title":"Visualization of microbes by 16S in situ hybridization in term and preterm placentas without intraamniotic infection","volume":"221","author":"MD Seferovic","year":"2019","journal-title":"Am J Obstet Gynecol"},{"key":"pone.0238993.ref024","first-page":"1","article-title":"Effectiveness of oral intake of Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 on Group B Streptococcus colonization during pregnancy: a midwifery-led double-blind randomized controlled pilot trial","author":"M Sharpe","year":"2019","journal-title":"J Matern Neonatal Med"},{"key":"pone.0238993.ref025","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.wombi.2017.06.012","article-title":"The impact of oral probiotics on vaginal Group B streptococcal colonisation rates in pregnant women: A pilot randomised control study","volume":"31","author":"P Olsen","year":"2018","journal-title":"Women Birth"},{"key":"pone.0238993.ref026","doi-asserted-by":"crossref","first-page":"237ra65","DOI":"10.1126\/scitranslmed.3008599","article-title":"The placenta harbors a unique microbiome","volume":"6","author":"K Aagaard","year":"2014","journal-title":"Sci Transl Med"},{"key":"pone.0238993.ref027","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1007\/s00431-014-2328-0","article-title":"The efficacy of Lactobacillus reuteri DSM 17938 in infants and children: A review of the current evidence","volume":"173","author":"M Urba\u0144ska","year":"2014","journal-title":"Eur J Pediatr"},{"key":"pone.0238993.ref028","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s12866-016-0704-9","article-title":"Association between genotypic diversity and biofilm production in group B Streptococcus","volume":"16","author":"RE Parker","year":"2016","journal-title":"BMC Microbiol"},{"key":"pone.0238993.ref029","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00729-19","article-title":"Modulation of death and inflammatory signaling in decidual stromal cells following exposure to group B Streptococcus","volume":"87","author":"RA Flaherty","year":"2019","journal-title":"Infect Immun"},{"key":"pone.0238993.ref030","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1111\/j.1600-0463.2007.apm_630.x","article-title":"Quantification of biofilm in microtiter plates: Overview of testing conditions and practical recommendations for assessment of biofilm production by staphylococci","volume":"115","author":"S Stepanovi\u0107","year":"2007","journal-title":"APMIS"},{"key":"pone.0238993.ref031","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1210\/en.2003-1606","article-title":"A novel immortalized human endometrial stromal cell line with normal progestational response","volume":"145","author":"G Krikun","year":"2004","journal-title":"Endocrinology"},{"key":"pone.0238993.ref032","doi-asserted-by":"crossref","first-page":"4587","DOI":"10.1128\/IAI.02181-14","article-title":"Association and virulence gene expression vary among serotype III group B Streptococcus isolates following exposure to decidual and lung epithelial cells","volume":"82","author":"ML Korir","year":"2014","journal-title":"Infect Immun"},{"key":"pone.0238993.ref033","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1128\/MMBR.00031-10","article-title":"Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases","volume":"75","author":"M Cargnello","year":"2011","journal-title":"Microbiol Mol Biol Rev"},{"key":"pone.0238993.ref034","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.4014\/jmb.1905.05066","article-title":"Heat-Killed Lactobacillus plantarum KCTC 13314BP Enhances phagocytic activity and immunomodulatory effects via activation of MAPK and STAT3 pathways","volume":"29","author":"M Jeong","year":"2019","journal-title":"J Microbiol Biotechnol"},{"key":"pone.0238993.ref035","article-title":"Lactobacillus reuteri ZJ617 culture supernatant attenuates acute liver injury induced in mice by lipopolysaccharide","author":"Y Cui","year":"2019","journal-title":"J Nutr"},{"key":"pone.0238993.ref036","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/biof.1475","article-title":"Functional capabilities of probiotic strains on attenuation of intestinal epithelial cell inflammatory response induced by TLR4 stimuli","volume":"45","author":"P Kanmani","year":"2019","journal-title":"BioFactors"},{"key":"pone.0238993.ref037","doi-asserted-by":"crossref","first-page":"3211","DOI":"10.1039\/C6FO00510A","article-title":"Lactobacillus casei triggers a TLR mediated RACK-1 dependent p38 MAPK pathway in Caenorhabditis elegans to resist Klebsiella pneumoniae infection","volume":"7","author":"A Kamaladevi","year":"2016","journal-title":"Food Funct"},{"key":"pone.0238993.ref038","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.tjog.2016.06.003","article-title":"Oral Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 to reduce Group B Streptococcus colonization in pregnant women: A randomized controlled trial","volume":"55","author":"M Ho","year":"2016","journal-title":"Taiwan J Obstet Gynecol"},{"key":"pone.0238993.ref039","first-page":"41","article-title":"In vitro antagonistic effect of Lactobacillus on organisms associated with bacterial vaginosis","volume":"47","author":"M Strus","year":"2002","journal-title":"J Reprod Med Obstet Gynecol"},{"key":"pone.0238993.ref040","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1210\/endo.137.6.8641169","article-title":"Human endometrial fibroblasts immortalized by simian virus 40 large T antigen differentiate in response to a decidualization stimulus","volume":"137","author":"JJ Brosens","year":"1996","journal-title":"Endocrinology"},{"key":"pone.0238993.ref041","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1128\/AEM.65.1.351-354.1999","article-title":"Persistence of colonization of human colonic mucosa by a probiotic strain, Lactobacillus rhamnosus GG, after oral consumption","volume":"65","author":"M Alander","year":"1999","journal-title":"Appl Environ Microbiol"},{"key":"pone.0238993.ref042","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1080\/14728222.2016.1216980","article-title":"p38 Mitogen activated protein kinase (MAPK): a new therapeutic target for reducing the risk of adverse pregnancy outcomes","volume":"20","author":"R Menon","year":"2016","journal-title":"Expert Opin Ther Targets"},{"key":"pone.0238993.ref043","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.01745","article-title":"Cell signaling of Caenorhabditis elegans in response to enterotoxigenic Escherichia coli infection and Lactobacillus zeae protection","volume":"9","author":"M Zhou","year":"2018","journal-title":"Front Immunol"},{"key":"pone.0238993.ref044","first-page":"1","article-title":"Characterization of the immunomodulatory and anti-Helicobacter pylori properties of the human gastric isolate Lactobacillus rhamnosus UCO-25A","author":"V Garcia-Castillo","year":"2019","journal-title":"Biofouling"},{"key":"pone.0238993.ref045","doi-asserted-by":"crossref","first-page":"e0223913","DOI":"10.1371\/journal.pone.0223913","article-title":"Isolation and characterization of five novel probiotic strains from Korean infant and children faeces","volume":"14","author":"S-Y Kook","year":"2019","journal-title":"PLoS One"},{"key":"pone.0238993.ref046","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.placenta.2013.02.010","article-title":"Antimicrobial peptide response to Group B Streptococcus in human extraplacental membranes in culture","volume":"34","author":"E Boldenow","year":"2013","journal-title":"Placenta"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0238993","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T17:28:31Z","timestamp":1600104511000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0238993"}},"subtitle":[],"editor":[{"given":"Matthew","family":"Payne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,9,14]]},"references-count":46,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2020,9,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0238993","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,14]]}}}