{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T16:47:54Z","timestamp":1772902074483,"version":"3.50.1"},"reference-count":37,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1 CA186107, P01 CA87969, R01 CA49449, R01 HL034594, R01 HL088521, UM1 CA176726, R01 CA67262, UM1 CA167552, and R01 HL35464"],"award-info":[{"award-number":["UM1 CA186107, P01 CA87969, R01 CA49449, R01 HL034594, R01 HL088521, UM1 CA176726, R01 CA67262, UM1 CA167552, and R01 HL35464"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000038","name":"U.S. Food and Drug Administration","doi-asserted-by":"publisher","award":["HHSF223201610080C"],"award-info":[{"award-number":["HHSF223201610080C"]}],"id":[{"id":"10.13039\/100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>The association of body mass index (BMI) and waist circumference (WC) with risk of Guillain-Barr\u00e9 syndrome (GBS) has been inconsistent in previous studies.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>We examined the associations of BMI and WC in relation to risk of GBS among 252,980 participants from the Nurses\u2019 Health Study (NHS), NHS-II, and the Health Professional Follow-up Study (HPFS). BMI and WC were assessed by self-reported questionnaire, and GBS cases were self-reported.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>We documented 328 incident GBS cases during a total of 5,422,788 person years of follow-up. Compared to participants with BMI&lt;25kg\/m<jats:sup>2<\/jats:sup>, the multivariate pooled hazard ratio (HR) of GBS was 1.34 (95% CI: 1.04, 1.73) for overweight participants (25kg\/m<jats:sup>2<\/jats:sup>\u2264BMI&lt;30 kg\/m<jats:sup>2<\/jats:sup>), and 1.68 (95% CI: 1.21, 2.35) for obese participants (BMI\u226530 kg\/m<jats:sup>2<\/jats:sup>) (P for trend = 0.001). Compared to participants with normal WC (&lt;35 inches for women and &lt;40 inches for men), the HR of GBS was 1.55 (95% CI: 1.10, 2.18) for participants with high WC (\u226535 inches for women, and \u226540 inches for men). The positive associations of BMI and WC with risk of GBS were attenuated to null after mutually adjusting for BMI and WC. Joint analysis showed that the HR was 1.84 (95% CI: 1.27, 2.66) for participants with high WC and BMI\u226525 kg\/m<jats:sup>2<\/jats:sup> in comparison to participants with normal WC and BMI&lt;25kg\/m<jats:sup>2<\/jats:sup>.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>These data from large cohorts showed that higher BMI and WC jointly were associated with higher risk of GBS. Our study highlighted the importance of maintaining a normal body weight and waist circumference in prevention of GBS.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0239099","type":"journal-article","created":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T15:25:46Z","timestamp":1606836346000},"page":"e0239099","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Associations of body mass index and waist circumference with risk of Guillain-Barr\u00e9 syndrome in women and men: A prospective analysis of three cohort 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Rimm","year":"1992","journal-title":"American journal of epidemiology"},{"key":"pone.0239099.ref013","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1093\/ije\/18.4.858","article-title":"Food-based validation of a dietary questionnaire: the effects of week-to-week variation in food consumption","volume":"18","author":"S Salvini","year":"1989","journal-title":"International journal of epidemiology"},{"key":"pone.0239099.ref014","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/oxfordjournals.aje.a114086","article-title":"Reproducibility and validity of a semiquantitative food frequency questionnaire","volume":"122","author":"WC Willett","year":"1985","journal-title":"American journal of epidemiology"},{"key":"pone.0239099.ref015","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.3945\/jn.111.157222","article-title":"Alternative dietary indices both strongly predict risk of chronic disease","volume":"142","author":"SE Chiuve","year":"2012","journal-title":"The Journal of nutrition"},{"key":"pone.0239099.ref016","doi-asserted-by":"crossref","first-page":"1220S","DOI":"10.1093\/ajcn\/65.4.1220S","article-title":"Adjustment for total energy intake in epidemiologic studies","volume":"65","author":"WC Willett","year":"1997","journal-title":"Am J Clin Nutr"},{"key":"pone.0239099.ref017","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.1002\/sim.1091","article-title":"Approaches to heterogeneity in meta-analysis","volume":"20","author":"DB Petitti","year":"2001","journal-title":"Statistics in medicine"},{"key":"pone.0239099.ref018","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1093\/ije\/dyu045","article-title":"Body mass index and risk of autoimmune diseases: a study within the Danish National Birth Cohort","volume":"43","author":"MC Harpsoe","year":"2014","journal-title":"International journal of 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Neurologic complications after surgery for obesity","volume":"33","author":"BM Koffman","year":"2006","journal-title":"Muscle & nerve"},{"key":"pone.0239099.ref020","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.orcp.2015.02.001","article-title":"Guillain-Barre syndrome (demyelinating) six weeks after bariatric surgery: A case report and literature review","volume":"9","author":"N Ishaque","year":"2015","journal-title":"Obesity research & clinical practice"},{"key":"pone.0239099.ref021","article-title":"Postoperative Guillain-Barre syndrome, a neurological complication that must not be overlooked: a literature review","author":"Z Yu-Xin","year":"2019","journal-title":"World neurosurgery"},{"key":"pone.0239099.ref022","doi-asserted-by":"crossref","first-page":"139239","DOI":"10.1155\/2013\/139239","article-title":"Adipose tissue in obesity-related inflammation and insulin resistance: cells, cytokines, and chemokines","volume":"2013","author":"K Makki","year":"2013","journal-title":"ISRN inflammation"},{"key":"pone.0239099.ref023","doi-asserted-by":"crossref","first-page":"4286364","DOI":"10.1155\/2018\/4286364","article-title":"Beneficial or Harmful Role of Macrophages in Guillain-Barre Syndrome and Experimental Autoimmune Neuritis","volume":"2018","author":"D Shen","year":"2018","journal-title":"Mediators of inflammation"},{"key":"pone.0239099.ref024","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1093\/ije\/dyx181","article-title":"Early predictors of Guillain-Barre syndrome in the life course of women","volume":"47","author":"N Auger","year":"2018","journal-title":"International journal of epidemiology"},{"key":"pone.0239099.ref025","doi-asserted-by":"crossref","first-page":"232","DOI":"10.3389\/fneur.2018.00232","article-title":"Association of Pre-Disease Body Mass Index With Multiple Sclerosis Prognosis","volume":"9","author":"A Manouchehrinia","year":"2018","journal-title":"Frontiers in neurology"},{"key":"pone.0239099.ref026","doi-asserted-by":"crossref","first-page":"e1002053","DOI":"10.1371\/journal.pmed.1002053","article-title":"Obesity and Multiple Sclerosis: A Mendelian Randomization Study","volume":"13","author":"LE Mokry","year":"2016","journal-title":"PLoS medicine"},{"key":"pone.0239099.ref027","first-page":"162","article-title":"Causal Effect of Genetic Variants Associated With Body Mass Index on Multiple Sclerosis Susceptibility","volume":"185","author":"MA Gianfrancesco","year":"2017","journal-title":"American journal of epidemiology"},{"key":"pone.0239099.ref028","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1097\/MIB.0000000000000283","article-title":"Measures of obesity and risk of Crohn's disease and ulcerative colitis","volume":"21","author":"H Khalili","year":"2015","journal-title":"Inflammatory bowel diseases"},{"key":"pone.0239099.ref029","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1097\/MED.0000000000000170","article-title":"Obesity, insulin resistance, and type 1 diabetes mellitus","volume":"22","author":"S Polsky","year":"2015","journal-title":"Current opinion in endocrinology, diabetes, and obesity"},{"key":"pone.0239099.ref030","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1186\/s13075-016-1171-2","article-title":"Abdominal obesity, gender and the risk of rheumatoid arthritis\u2014a nested case-control study","volume":"18","author":"L Ljung","year":"2016","journal-title":"Arthritis research & therapy"},{"key":"pone.0239099.ref031","doi-asserted-by":"crossref","first-page":"e2859","DOI":"10.1097\/MD.0000000000002859","article-title":"Body Mass Index and Risk of Rheumatoid Arthritis: A Meta-Analysis of Observational Studies","volume":"95","author":"J Feng","year":"2016","journal-title":"Medicine"},{"key":"pone.0239099.ref032","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1016\/j.cgh.2016.01.016","article-title":"Association Between Circulating Levels of C-Reactive Protein and Interleukin-6 and Risk of Inflammatory Bowel Disease","volume":"14","author":"P Lochhead","year":"2016","journal-title":"Clinical gastroenterology and hepatology: the official clinical practice journal of the American Gastroenterological Association"},{"key":"pone.0239099.ref033","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/art.24350","article-title":"Biomarkers of inflammation and development of rheumatoid arthritis in women from two prospective cohort studies","volume":"60","author":"EW Karlson","year":"2009","journal-title":"Arthritis and rheumatism"},{"key":"pone.0239099.ref034","doi-asserted-by":"crossref","first-page":"852195","DOI":"10.1155\/2013\/852195","article-title":"Role of Campylobacter jejuni infection in the pathogenesis of Guillain-Barre syndrome: an update","volume":"2013","author":"KK Nyati","year":"2013","journal-title":"BioMed research international"},{"key":"pone.0239099.ref035","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/S1473-3099(06)70523-0","volume":"6","author":"ME Falagas","year":"2006","journal-title":"Obesity and infection. 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