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The role of this growth factor in neuronal plasticity, in health and disease, has been extensively studied. However, mechanisms of epigenetic regulation of <jats:italic>Bdnf<\/jats:italic> gene expression in epilepsy are still elusive. In our previous work, using a rat model of neuronal activation upon kainate-induced seizures, we observed a repositioning of <jats:italic>Bdnf<\/jats:italic> alleles from the nuclear periphery towards the nuclear center. This change of <jats:italic>Bdnf<\/jats:italic> intranuclear position was associated with transcriptional gene activity. In the present study, using the same neuronal activation model, we analyzed the relation between the percentage of the <jats:italic>Bdnf<\/jats:italic> allele at the nuclear periphery and clinical and morphological traits of epilepsy. We observed that the decrease of the percentage of the <jats:italic>Bdnf<\/jats:italic> allele at the nuclear periphery correlates with stronger mossy fiber sprouting\u2014an aberrant form of excitatory circuits formation. Moreover, using <jats:italic>in vitro<\/jats:italic> hippocampal cultures we showed that <jats:italic>Bdnf<\/jats:italic> repositioning is a consequence of transcriptional activity. Inhibition of RNA polymerase II activity in primary cultured neurons with Actinomycin D completely blocked <jats:italic>Bdnf<\/jats:italic> gene transcription and repositioning occurring after neuronal excitation. Interestingly, we observed that histone deacetylases inhibition with Trichostatin A induced a slight increase of <jats:italic>Bdnf<\/jats:italic> gene transcription and its repositioning even in the absence of neuronal excitation. Presented results provide novel insight into the role of BDNF in epileptogenesis. Moreover, they strengthen the statement that this particular gene is a good candidate to search for a new generation of antiepileptic therapies.<\/jats:p>","DOI":"10.1371\/journal.pone.0239111","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T17:43:46Z","timestamp":1622828626000},"page":"e0239111","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["The interplay of seizures-induced axonal sprouting and transcription-dependent Bdnf repositioning in the model of temporal lobe epilepsy"],"prefix":"10.1371","volume":"16","author":[{"given":"Anna","family":"Skupien-Jaroszek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Walczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iwona","family":"Czaban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna Karolina","family":"Pels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1502-3147","authenticated-orcid":true,"given":"Andrzej 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Gall","year":"1993","journal-title":"Exp Neurol"},{"issue":"4","key":"pone.0239111.ref015","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1002\/(SICI)1096-9861(20000320)418:4<411::AID-CNE4>3.0.CO;2-F","article-title":"Altered mRNA expression for brain-derived neurotrophic factor and type II calcium\/calmodulin-dependent protein kinase in the hippocampus of patients with intractable temporal lobe epilepsy","volume":"418","author":"KD Murray","year":"2000","journal-title":"J Comp Neurol"},{"issue":"4","key":"pone.0239111.ref016","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/0306-4522(96)00005-X","article-title":"Short increase of BDNF messenger RNA triggers kainic acid-induced neuronal hypertrophy in adult mice","volume":"72","author":"D Guilhem","year":"1996","journal-title":"Neuroscience"},{"issue":"22","key":"pone.0239111.ref017","doi-asserted-by":"crossref","first-page":"9754","DOI":"10.1523\/JNEUROSCI.22-22-09754.2002","article-title":"Increased 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Martinowich","year":"2003","journal-title":"Science"},{"issue":"42","key":"pone.0239111.ref026","doi-asserted-by":"crossref","first-page":"10576","DOI":"10.1523\/JNEUROSCI.1786-08.2008","article-title":"Epigenetic regulation of BDNF gene transcription in the consolidation of fear memory","volume":"28","author":"FD Lubin","year":"2008","journal-title":"J Neurosci"},{"issue":"24","key":"pone.0239111.ref027","doi-asserted-by":"crossref","first-page":"5603","DOI":"10.1523\/JNEUROSCI.0589-04.2004","article-title":"Histone modifications at gene promoter regions in rat hippocampus after acute and chronic electroconvulsive seizures","volume":"24","author":"NM Tsankova","year":"2004","journal-title":"J Neurosci"},{"issue":"1","key":"pone.0239111.ref028","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.neures.2009.05.002","article-title":"Valproic acid induces up- or down-regulation of gene expression responsible for the neuronal excitation and inhibition in rat cortical neurons through its epigenetic actions","volume":"65","author":"M Fukuchi","year":"2009","journal-title":"Neurosci Res"},{"issue":"12","key":"pone.0239111.ref029","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/s41576-018-0060-8","article-title":"Organizational principles of 3D genome architecture","volume":"19","author":"MJ Rowley","year":"2018","journal-title":"Nat Rev Genet"},{"issue":"3","key":"pone.0239111.ref030","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.ceb.2011.01.001","article-title":"Gene positioning and expression","volume":"23","author":"D Egecioglu","year":"2011","journal-title":"Curr Opin Cell Biol"},{"issue":"7","key":"pone.0239111.ref031","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/nrg2122","article-title":"The nuclear envelope and transcriptional control","volume":"8","author":"A Akhtar","year":"2007","journal-title":"Nat Rev 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Neurosci"},{"issue":"1","key":"pone.0239111.ref035","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0920-1211(98)00017-5","article-title":"Recurrent spontaneous motor seizures after repeated low-dose systemic treatment with kainate: assessment of a rat model of temporal lobe epilepsy","volume":"31","author":"JL Hellier","year":"1998","journal-title":"Epilepsy Res"},{"issue":"Pt 23","key":"pone.0239111.ref036","first-page":"5038","article-title":"CD44 regulates dendrite morphogenesis through Src tyrosine kinase-dependent positioning of the Golgi","volume":"127","author":"A Skupien","year":"2014","journal-title":"J Cell Sci"},{"key":"pone.0239111.ref037","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/978-1-59745-406-3_15","article-title":"Multicolor 3D fluorescence in situ hybridization for imaging interphase chromosomes","volume":"463","author":"M Cremer","year":"2008","journal-title":"Methods Mol Biol"},{"issue":"5","key":"pone.0239111.ref038","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1083\/jcb.200708213","article-title":"Important role of matrix metalloproteinase 9 in epileptogenesis","volume":"180","author":"GM Wilczynski","year":"2008","journal-title":"J Cell Biol"},{"issue":"1","key":"pone.0239111.ref039","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0006-8993(96)01387-X","article-title":"Fluoro-Jade: a novel fluorochrome for the sensitive and reliable histochemical localization of neuronal degeneration","volume":"751","author":"LC Schmued","year":"1997","journal-title":"Brain Res"},{"key":"pone.0239111.ref040","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3389\/fnana.2019.00081","article-title":"Three-Dimensional Segmentation and Reconstruction of Neuronal Nuclei in Confocal Microscopic Images","volume":"13","author":"B Ruszczycki","year":"2019","journal-title":"Front 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Rep"},{"issue":"5","key":"pone.0239111.ref050","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.semcdb.2007.08.007","article-title":"Three-dimensional genome organization in interphase and its relation to genome function","volume":"18","author":"S Goetze","year":"2007","journal-title":"Semin Cell Dev Biol"},{"issue":"12","key":"pone.0239111.ref051","doi-asserted-by":"crossref","first-page":"4475","DOI":"10.1128\/MCB.00208-07","article-title":"The three-dimensional structure of human interphase chromosomes is related to the transcriptome map","volume":"27","author":"S Goetze","year":"2007","journal-title":"Mol Cell Biol"},{"key":"pone.0239111.ref052","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1101\/sqb.2010.75.046","article-title":"Transcription factories and nuclear organization of the genome","volume":"75","author":"CH Eskiw","year":"2010","journal-title":"Cold Spring Harb Symp Quant 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Forsberg","year":"2001","journal-title":"Bioessays"},{"issue":"Pt 17","key":"pone.0239111.ref075","doi-asserted-by":"crossref","first-page":"4017","DOI":"10.1242\/jcs.02521","article-title":"The nuclear-envelope protein and transcriptional repressor LAP2beta interacts with HDAC3 at the nuclear periphery, and induces histone H4 deacetylation","volume":"118","author":"R Somech","year":"2005","journal-title":"J Cell Sci"},{"issue":"5","key":"pone.0239111.ref076","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20051109","article-title":"HDAC Inhibitors Induce BDNF Expression and Promote Neurite Outgrowth in Human Neural Progenitor Cells-Derived Neurons","volume":"20","author":"A Bagheri","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"9","key":"pone.0239111.ref077","doi-asserted-by":"crossref","first-page":"4691","DOI":"10.1007\/s00429-016-1196-y","article-title":"A role for histone acetylation mechanisms in adolescent alcohol exposure-induced deficits in hippocampal brain-derived neurotrophic factor expression and neurogenesis markers in adulthood","volume":"221","author":"AJ Sakharkar","year":"2016","journal-title":"Brain Struct Funct"},{"issue":"1","key":"pone.0239111.ref078","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1590\/1516-4446-2013-1094","article-title":"Histone deacetylase activity and brain-derived neurotrophic factor (BDNF) levels in a pharmacological model of mania","volume":"36","author":"L Stertz","year":"2014","journal-title":"Braz J Psychiatry"},{"key":"pone.0239111.ref079","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.neuropharm.2013.07.015","article-title":"Differential regulation of Bdnf expression in cortical neurons by class-selective histone deacetylase inhibitors","volume":"75","author":"I 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Guarda","year":"2009","journal-title":"Exp Cell Res"},{"issue":"9","key":"pone.0239111.ref083","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1093\/hmg\/9.9.1377","article-title":"MECP2 mutations account for most cases of typical forms of Rett syndrome","volume":"9","author":"T Bienvenu","year":"2000","journal-title":"Hum Mol Genet"},{"key":"pone.0239111.ref084","doi-asserted-by":"crossref","first-page":"28460","DOI":"10.1038\/srep28460","article-title":"A Role for Nuclear Actin in HDAC 1 and 2 Regulation","volume":"6","author":"LA Serebryannyy","year":"2016","journal-title":"Sci Rep"},{"issue":"5","key":"pone.0239111.ref085","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1176\/ajp.141.5.651","article-title":"Varieties of aggressive behavior in temporal lobe epilepsy","volume":"141","author":"O Devinsky","year":"1984","journal-title":"The American journal of psychiatry"},{"issue":"9","key":"pone.0239111.ref086","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1002\/1097-0142(19810501)47:9<2302::AID-CNCR2820470933>3.0.CO;2-K","article-title":"The treatment of Wilms\u2019 tumor: results of the Second National Wilms\u2019 Tumor Study","volume":"47","author":"GJ D\u2019Angio","year":"1981","journal-title":"Cancer"},{"issue":"11","key":"pone.0239111.ref087","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1097\/00043426-200411000-00020","article-title":"Immune-mediated thrombocytopenia following dactinomycin therapy in a child with alveolar rhabdomyosarcoma: the unresolved issues","volume":"26","author":"S Khatua","year":"2004","journal-title":"J Pediatr Hematol Oncol"},{"issue":"3","key":"pone.0239111.ref088","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/BF00254018","article-title":"Actinomycin D in the treatment of advanced breast cancer","volume":"4","author":"RA 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