{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:39:32Z","timestamp":1793158772976,"version":"4.5.0"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T00:00:00Z","timestamp":1600387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0239228","type":"journal-article","created":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T17:37:11Z","timestamp":1600450631000},"page":"e0239228","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":48,"title":["Tolerability of daily intermittent or continuous short-arm centrifugation during 60-day 6o head down bed rest (AGBRESA study)"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5572-1177","authenticated-orcid":true,"given":"Timo","family":"Frett","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Andrew","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin","family":"Mulder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Noppe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Arz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Willi","family":"Pustowalow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Petrat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Tegtbur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Jordan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,9,18]]},"reference":[{"key":"pone.0239228.ref001","author":"G. Cl\u00e9ment","year":"2007"},{"key":"pone.0239228.ref002","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41526-017-0013-0","article-title":"Towards human exploration of space: the THESEUS review series on muscle and bone research priorities","volume":"3","author":"T. Lang","year":"2017","journal-title":"NPJ Microgravity"},{"key":"pone.0239228.ref003","author":"E Arnauld","year":"2016","journal-title":"Space Physiology and Medicine: From Evidence to Practice"},{"issue":"24","key":"pone.0239228.ref004","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1097\/BRS.0000000000001873","article-title":"Lumbar spine paraspinal muscle and intervertebral disc height changes in astronauts after long-duration spaceflight on the International Space Station","volume":"41","author":"D.G. Chang","year":"2016","journal-title":"Spine"},{"issue":"3","key":"pone.0239228.ref005","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1152\/japplphysiol.01251.2013","article-title":"Peak exercise oxygen uptake during and following long-duration spaceflight","volume":"117","author":"A.D. Moore","year":"2014","journal-title":"J Appl Physiol (1985)"},{"issue":"7","key":"pone.0239228.ref006","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1038\/s41433-018-0070-y","article-title":"Space flight-associated neuro-ocular syndrome (SANS)","volume":"32","author":"A.G. Lee","year":"2018","journal-title":"Eye"},{"issue":"18","key":"pone.0239228.ref007","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1056\/NEJMoa1705129","article-title":"Effects of Spaceflight on Astronaut Brain Structure as Indicated on MRI","volume":"377","author":"D.R. Roberts","year":"2017","journal-title":"New England Journal of Medicine"},{"issue":"1","key":"pone.0239228.ref008","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1152\/jappl.1996.81.1.7","article-title":"Orthostatic intolerance after spaceflight","volume":"81","author":"J.C. Buckey","year":"1996","journal-title":"Journal of Applied Physiology"},{"key":"pone.0239228.ref009","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1161\/STROKEAHA.110.610576","article-title":"Impairment of cerebral blood flow regulation in astronauts with post flight orthostatic intolerance","volume":"42","author":"A.P. Blaber","year":"2011","journal-title":"Stroke"},{"issue":"12","key":"pone.0239228.ref010","doi-asserted-by":"crossref","first-page":"3531","DOI":"10.1519\/JSC.0000000000001191","article-title":"The Astronaut-Athlete: Optimizing Human Performance in Space","volume":"29","author":"K.J. Hackney","year":"2015","journal-title":"The Journal of Strength & Conditioning Research"},{"key":"pone.0239228.ref011","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13728-016-0050-4","article-title":"Exercise in space: the European Space Agency approach to in-flight exercise countermeasures for long-duration missions on ISS","volume":"5","author":"N. Petersen","year":"2016","journal-title":"Extreme Physiology & Medicine"},{"issue":"3\u201310","key":"pone.0239228.ref012","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0094-5765(01)00100-X","article-title":"Artificial gravity: head movements during short-radius centrifugation","volume":"49","author":"L.R. Young","year":"2001","journal-title":"Acta Astronaut"},{"issue":"1","key":"pone.0239228.ref013","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41526-017-0013-0","article-title":"Towards human exploration of space: the THESEUS review series on muscle and bone research priorities","volume":"3","author":"T. Lang","year":"2017","journal-title":"npj Microgravity"},{"issue":"12","key":"pone.0239228.ref014","doi-asserted-by":"crossref","first-page":"A54","DOI":"10.3357\/AMHP.EC08.2015","article-title":"Orthostatic Intolerance After ISS and Space Shuttle Missions","volume":"86","author":"S.M.C. Lee","year":"2015","journal-title":"Aerospace Medicine and Human Performance"},{"issue":"173","key":"pone.0239228.ref015","article-title":"Introduction to the Frontiers Research Topic: Optimization of Exercise Countermeasures for Human Space Flight\u2013Lessons From Terrestrial Physiology and Operational Considerations","volume":"10","author":"J.P.R. Scott","year":"2019","journal-title":"Frontiers in Physiology"},{"key":"pone.0239228.ref016","first-page":"1090","author":"Y.L. Kaderka J","year":"2010","journal-title":"critical benefit analysis of artificial gravity as a microgravity countermeasure, in Acta Astronautica"},{"issue":"8","key":"pone.0239228.ref017","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1152\/japplphysiol.00935.2015","article-title":"Long-duration bed rest as an analog to microgravity","volume":"120","author":"A.R. Hargens","year":"2016","journal-title":"J Appl Physiol (1985)"},{"issue":"1","key":"pone.0239228.ref018","first-page":"60","article-title":"Effects of five days of bed rest with intermittent centrifugation on neurovestibular function","volume":"15","author":"G. Clement","year":"2015","journal-title":"J Musculoskelet Neuronal Interact"},{"issue":"2","key":"pone.0239228.ref019","first-page":"84","article-title":"Centrifugation as a countermeasure during bed rest and dry immersion: What has been learned?","volume":"16","author":"G. Cl\u00e9ment","year":"2016","journal-title":"Journal of musculoskeletal & neuronal interactions"},{"issue":"1\/2","key":"pone.0239228.ref020","first-page":"29","article-title":"Effects of graded load of artificial gravity on cardiovascular functions in humans","volume":"46","author":"S. Iwase","year":"2002","journal-title":"ENVIRONMENTAL MEDICINE-NAGOYA"},{"issue":"6","key":"pone.0239228.ref021","doi-asserted-by":"crossref","first-page":"R1909","DOI":"10.1152\/ajpregu.1998.275.6.R1909","article-title":"Gender differences in autonomic functions associated with blood pressure regulation","volume":"275","author":"V.A. Convertino","year":"1998","journal-title":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"},{"issue":"5","key":"pone.0239228.ref022","doi-asserted-by":"crossref","first-page":"e0125780","DOI":"10.1371\/journal.pone.0125780","article-title":"Effects of individualized centrifugation training on orthostatic tolerance in men and women.","volume":"10","author":"N. Goswami","year":"2015","journal-title":"PLoS One"},{"issue":"10","key":"pone.0239228.ref023","first-page":"850","article-title":"Centrifuge training increases presyncopal orthostatic tolerance in ambulatory men","volume":"75","author":"J.M. Evans","year":"2004","journal-title":"Aviation, space, and environmental medicine"},{"key":"pone.0239228.ref024","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3389\/fneur.2016.00014","article-title":"Moving in a Moving World: A Review on Vestibular Motion Sickness","volume":"7","author":"G. Bertolini","year":"2016","journal-title":"Front Neurol"},{"issue":"3","key":"pone.0239228.ref025","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s13304-018-0574-9","article-title":"Telemedicine and telerobotics: from science fiction to reality","volume":"70","author":"C.R. Evans","year":"2018","journal-title":"Updates Surg"},{"issue":"6","key":"pone.0239228.ref026","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1152\/jappl.2001.91.6.2611","article-title":"Gender differences in autonomic cardiovascular regulation: spectral, hormonal, and hemodynamic indexes","volume":"91","author":"J.M. Evans","year":"2001","journal-title":"J Appl Physiol (1985)"},{"issue":"1","key":"pone.0239228.ref027","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1152\/physrev.00006.2018","article-title":"Lower Body Negative Pressure: Physiological Effects, Applications, and","volume":"99","author":"N. Goswami","year":"2019","journal-title":"Implementation. Physiological reviews"},{"issue":"1","key":"pone.0239228.ref028","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1475-097X.1990.tb00085.x","article-title":"The venous pump of the human foot","volume":"10","author":"J. Styf","year":"1990","journal-title":"Clin Physiol"},{"issue":"2","key":"pone.0239228.ref029","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.paid.2006.01.012","article-title":"Predicting individual differences in motion sickness susceptibility by questionnaire","volume":"41","author":"J.F. Golding","year":"2006","journal-title":"Personality and Individual Differences"},{"issue":"2\u20133","key":"pone.0239228.ref030","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3233\/VES-2003-132-302","article-title":"Adaptation of the vestibulo-ocular reflex, subjective tilt, and motion sickness to head movements during short-radius centrifugation","volume":"13","author":"L.R. Young","year":"2003","journal-title":"J Vestib Res"},{"key":"pone.0239228.ref031","first-page":"104","volume-title":"Borg's perceived exertion and pain scales","author":"G. Borg","year":"1998"},{"issue":"2","key":"pone.0239228.ref032","first-page":"115","article-title":"A Questionnaire for the Assessment of the Multiple Dimensions of Motion Sickness","volume":"72","author":"P.J. Gianaros","year":"2001","journal-title":"Aviation, space, and environmental medicine"},{"issue":"8","key":"pone.0239228.ref033","first-page":"873","article-title":"Sopite syndrome: a sometimes sole manifestation of motion sickness","volume":"47","author":"A. Graybiel","year":"1976","journal-title":"Aviat Space Environ Med"},{"issue":"3\u20136","key":"pone.0239228.ref034","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0094-5765(98)00153-2","article-title":"The sopite syndrome revisited: drowsiness and mood changes during real or apparent motion","volume":"43","author":"B.D. Lawson","year":"1998","journal-title":"Acta Astronaut"},{"issue":"3","key":"pone.0239228.ref035","doi-asserted-by":"crossref","first-page":"189","DOI":"10.3109\/14992027.2015.1111526","article-title":"Motion sickness and sopite syndrome associated with parabolic flights: a case report","volume":"55","author":"A. Van Ombergen","year":"2016","journal-title":"Int J Audiol"},{"key":"pone.0239228.ref036","doi-asserted-by":"crossref","first-page":"712","DOI":"10.3389\/fphys.2018.00712","article-title":"Comparison of Autonomic Control of Blood Pressure During Standing and Artificial Gravity Induced via Short-Arm Human Centrifuge","volume":"9","author":"A.K. Verma","year":"2018","journal-title":"Front Physiol"},{"key":"pone.0239228.ref037","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.3389\/fphys.2019.01061","article-title":"Effects of prolonged head-down bed rest on cardiac and vascular baroreceptor modulation and orthostatic tolerance in healthy individuals","volume":"10","author":"F. Barbic","year":"2019","journal-title":"Frontiers in physiology"},{"issue":"6","key":"pone.0239228.ref038","doi-asserted-by":"crossref","first-page":"599","DOI":"10.3357\/ASEM.2558.2011","article-title":"Cardiac arrhythmias during aerobatic flight and its simulation on a centrifuge","volume":"82","author":"E.K. Zawadzka-Bartczak","year":"2011","journal-title":"Aviat Space Environ Med"},{"issue":"11","key":"pone.0239228.ref039","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.3357\/AMHP.4910.2017","article-title":"Dysrhythmias in Laypersons During Centrifuge-Simulated Suborbital Spaceflight.","volume":"88","author":"R. Suresh","year":"2017","journal-title":"Aerosp Med Hum Perform"},{"issue":"11","key":"pone.0239228.ref040","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1177\/014107687807101109","article-title":"Motion sickness adaptation: a neural mismatch model","volume":"71","author":"J.T. Reason","year":"1978","journal-title":"J R Soc Med"},{"key":"pone.0239228.ref041","first-page":"310","volume-title":"Motion sickness","author":"J.T. Reason","year":"1975"},{"issue":"5","key":"pone.0239228.ref042","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0361-9230(98)00115-4","article-title":"Motion sickness: only one provocative conflict?","volume":"47","author":"W. Bles","year":"1998","journal-title":"Brain Res Bull"},{"issue":"2","key":"pone.0239228.ref043","doi-asserted-by":"crossref","first-page":"104","DOI":"10.3357\/ASEM.3170.2013","article-title":"Motion sickness adaptation to Coriolis-inducing head movements in a sustained G flight simulator","volume":"84","author":"M.C. Newman","year":"2013","journal-title":"Aviat Space Environ Med"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0239228","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,19]],"date-time":"2022-11-19T04:49:49Z","timestamp":1668833389000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0239228"}},"subtitle":[],"editor":[{"given":"Shigehiko","family":"Ogoh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,9,18]]},"references-count":43,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2020,9,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0239228","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,18]]}}}