{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:38:07Z","timestamp":1787319487619,"version":"build-2736575974"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T00:00:00Z","timestamp":1600992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0239453","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T18:03:40Z","timestamp":1601057020000},"page":"e0239453","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Cerebrospinal fluid oligoclonal bands in Neuroborreliosis are specific for Borrelia burgdorferi"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2755-2043","authenticated-orcid":true,"given":"Klaus","family":"Berek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Hegen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Auer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Zinganell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franziska","family":"Di Pauli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Deisenhammer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,9,25]]},"reference":[{"issue":"6","key":"pone.0239453.ref001","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1007\/s00415-016-8346-2","article-title":"Neuroborreliosis","volume":"264","author":"JJ Halperin","year":"2017","journal-title":"J Neurol"},{"key":"pone.0239453.ref002","doi-asserted-by":"crossref","first-page":"16090","DOI":"10.1038\/nrdp.2016.90","article-title":"Lyme borreliosis","volume":"2","author":"AC Steere","year":"2016","journal-title":"Nat Rev Dis Primers"},{"issue":"10146","key":"pone.0239453.ref003","first-page":"452","article-title":"Introducing EU-wide surveillance of Lyme neuroborreliosis","volume":"392","author":"The Lancet","year":"2018","journal-title":"Lancet"},{"issue":"10","key":"pone.0239453.ref004","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1212\/WNL.41.10.1571","article-title":"Central nervous system abnormalities in Lyme neuroborreliosis","volume":"41","author":"JJ Halperin","year":"1991","journal-title":"Neurology"},{"issue":"1","key":"pone.0239453.ref005","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1468-1331.2009.02862.x","article-title":"EFNS guidelines on the diagnosis and management of European Lyme neuroborreliosis","volume":"17","author":"A Mygland","year":"2010","journal-title":"Eur J Neurol"},{"issue":"4","key":"pone.0239453.ref006","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1007\/s00415-011-6221-8","article-title":"Cerebrospinal fluid findings in adults with acute Lyme neuroborreliosis","volume":"259","author":"M Djukic","year":"2012","journal-title":"J Neurol"},{"issue":"8","key":"pone.0239453.ref007","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1136\/jnnp.57.8.897","article-title":"Cerebrospinal fluid in the diagnosis of multiple sclerosis: a consensus report","volume":"57","author":"M Andersson","year":"1994","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"6","key":"pone.0239453.ref008","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1001\/archneur.62.6.865","article-title":"Recommended standard of cerebrospinal fluid analysis in the diagnosis of multiple sclerosis: a consensus statement","volume":"62","author":"MS Freedman","year":"2005","journal-title":"Arch Neurol"},{"issue":"3","key":"pone.0239453.ref009","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1002\/ana.22508","article-title":"Revised McDonald criteria: the persisting importance of cerebrospinal fluid analysis","volume":"70","author":"H Tumani","year":"2011","journal-title":"Ann Neurol"},{"issue":"2","key":"pone.0239453.ref010","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/ana.22366","article-title":"Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria","volume":"69","author":"CH Polman","year":"2011","journal-title":"Ann Neurol"},{"issue":"2","key":"pone.0239453.ref011","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S1474-4422(17)30470-2","article-title":"Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria","volume":"17","author":"AJ Thompson","year":"2018","journal-title":"Lancet Neurol"},{"issue":"6","key":"pone.0239453.ref012","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1111\/j.1468-1331.2007.01802.x","article-title":"Antigen-specific oligoclonal bands in cerebrospinal fluid and serum from patients with anti-amphiphysin- and anti-CV2\/CRMP5 associated paraneoplastic neurological syndromes","volume":"14","author":"O Stich","year":"2007","journal-title":"Eur J Neurol"},{"issue":"1\u20132","key":"pone.0239453.ref013","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0165-5728(00)00391-X","article-title":"Demonstration of anti-HuD specific oligoclonal bands in the cerebrospinal fluid from patients with paraneoplastic neurological syndromes. Qualitative evidence of anti-HuD specific IgG-synthesis in the central nervous system","volume":"111","author":"S Rauer","year":"2000","journal-title":"J Neuroimmunol"},{"issue":"1\u20132","key":"pone.0239453.ref014","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0165-5728(03)00257-1","article-title":"Qualitative evidence of anti-Yo-specific intrathecal antibody synthesis in patients with paraneoplastic cerebellar degeneration","volume":"141","author":"O Stich","year":"2003","journal-title":"J Neuroimmunol"},{"issue":"2","key":"pone.0239453.ref015","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1136\/jnnp.2005.062489","article-title":"Qualitative evidence of anti-Ri specific intrathecal antibody synthesis and quantification of anti-Ri antibodies in serial samples from a patient with anti-Ri syndrome","volume":"77","author":"O Stich","year":"2006","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"3","key":"pone.0239453.ref016","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/BF00314301","article-title":"Intrathecal production of HIV antibodies in suspected AIDS encephalopathy","volume":"235","author":"R Biniek","year":"1988","journal-title":"J Neurol"},{"issue":"6","key":"pone.0239453.ref017","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1093\/infdis\/161.6.1194","article-title":"Oligoclonal Borrelia burgdorferi-specific IgG antibodies in cerebrospinal fluid in Lyme neuroborreliosis","volume":"161","author":"K Hansen","year":"1990","journal-title":"J Infect Dis"},{"issue":"4","key":"pone.0239453.ref018","doi-asserted-by":"crossref","first-page":"e0215410","DOI":"10.1371\/journal.pone.0215410","article-title":"The clinical significance of single or double bands in cerebrospinal fluid isoelectric focusing. A retrospective study and systematic review","volume":"14","author":"H Hegen","year":"2019","journal-title":"PLoS One"},{"issue":"3","key":"pone.0239453.ref019","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1515\/CCLM.2003.053","article-title":"Quality assurance for cerebrospinal fluid protein analysis: international consensus by an Internet-based group discussion","volume":"41","author":"H Reiber","year":"2003","journal-title":"Clin Chem Lab Med"},{"issue":"1","key":"pone.0239453.ref020","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1186\/s12859-017-1934-z","article-title":"ImageJ2: ImageJ for the next generation of scientific image data","volume":"18","author":"CT Rueden","year":"2017","journal-title":"BMC Bioinformatics"},{"key":"pone.0239453.ref021","unstructured":"Rasband WS. ImageJ: US National Institutes of Health, Bethseda, Maryland,; 1997\u20132005 [17.12.2019]. Available from: https:\/\/imagej.net\/."},{"issue":"2","key":"pone.0239453.ref022","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-510X(94)90298-4","article-title":"Flow rate of cerebrospinal fluid (CSF)\u2014a concept common to normal blood-CSF barrier function and to dysfunction in neurological diseases","volume":"122","author":"H. Reiber","year":"1994","journal-title":"J Neurol Sci"},{"issue":"4","key":"pone.0239453.ref023","first-page":"229","article-title":"Detection of oligoclonal IgG bands in cerebrospinal fluid and serum: comparison between commercial immunofixation method and home-made affinity immunoblotting method and evaluation of interobserver agreement","volume":"19","author":"L Novackova","year":"2011","journal-title":"Klin Biochem Metab"},{"issue":"1","key":"pone.0239453.ref024","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1373\/clinchem.2004.042218","article-title":"Between-laboratory variability in oligoclonal IgG band numbering","volume":"51","author":"D Franciotta","year":"2005","journal-title":"Clin Chem"},{"issue":"3","key":"pone.0239453.ref025","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.pathol.2016.02.004","article-title":"Concordance of four commercial enzyme immunoassay and three immunoblot formats for the detection of Lyme borreliosis antibodies in human serum: the two-tier approach remains","volume":"48","author":"DJ Dickeson","year":"2016","journal-title":"Pathology"},{"issue":"1","key":"pone.0239453.ref026","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.clim.2011.06.005","article-title":"Epitope mapping of antibodies to VlsE protein of Borrelia burgdorferi in post-Lyme disease syndrome","volume":"141","author":"A Chandra","year":"2011","journal-title":"Clin Immunol"},{"issue":"1\u20132","key":"pone.0239453.ref027","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jneuroim.2011.06.012","article-title":"Intrathecal human herpesvirus 6 antibodies in multiple sclerosis and other demyelinating diseases presenting as oligoclonal bands in cerebrospinal fluid","volume":"237","author":"JO Virtanen","year":"2011","journal-title":"J Neuroimmunol"},{"issue":"8","key":"pone.0239453.ref028","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1373\/clinchem.2007.089052","article-title":"Interlaboratory reproducibility of isoelectric focusing in oligoclonal band detection","volume":"53","author":"D Franciotta","year":"2007","journal-title":"Clin Chem"},{"issue":"11","key":"pone.0239453.ref029","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1002\/elps.200800720","article-title":"Quantifying Western blots: pitfalls of densitometry","volume":"30","author":"M Gassmann","year":"2009","journal-title":"Electrophoresis"},{"issue":"10","key":"pone.0239453.ref030","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1212\/01.wnl.0000269672.17807.e0","article-title":"Relevance of the antibody index to diagnose Lyme neuroborreliosis among seropositive patients","volume":"69","author":"F Blanc","year":"2007","journal-title":"Neurology"},{"issue":"12","key":"pone.0239453.ref031","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/j.cmi.2018.04.007","article-title":"Diagnostic value of cerebrospinal fluid CXCL13 for acute Lyme neuroborreliosis. A systematic review and meta-analysis","volume":"24","author":"TA Rupprecht","year":"2018","journal-title":"Clin Microbiol Infect"},{"issue":"1","key":"pone.0239453.ref032","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1186\/s12974-019-1601-6","article-title":"Cytokine and immune cell profiling in the cerebrospinal fluid of patients with neuro-inflammatory diseases","volume":"16","author":"G Lepennetier","year":"2019","journal-title":"J Neuroinflammation"},{"key":"pone.0239453.ref033","doi-asserted-by":"crossref","first-page":"116843","DOI":"10.1016\/j.jns.2020.116843","article-title":"Sensitivity and specificity of cerebrospinal fluid CXCL13 for diagnosing Lyme neuroborreliosis\u2014a study on 1410 patients and review of the literature","volume":"414","author":"H Lintner","year":"2020","journal-title":"J Neurol Sci"},{"issue":"4","key":"pone.0239453.ref034","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1097\/00007435-198610000-00005","article-title":"Evaluation of sera from patients with Lyme disease in the fluorescent treponemal antibody-absorption test for syphilis","volume":"13","author":"EF Hunter","year":"1986","journal-title":"Sex Transm Dis"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0239453","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T18:04:28Z","timestamp":1601057068000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0239453"}},"subtitle":[],"editor":[{"given":"Edgar","family":"Meinl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,9,25]]},"references-count":34,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2020,9,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0239453","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,25]]}}}