{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T19:58:55Z","timestamp":1772308735073,"version":"3.50.1"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T00:00:00Z","timestamp":1601942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Deutsche Gesellschaft f\u00fcr Lymphologie","award":["Fo0315"],"award-info":[{"award-number":["Fo0315"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0239517","type":"journal-article","created":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T17:27:00Z","timestamp":1602005220000},"page":"e0239517","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Short-term molecular and cellular effects of ischemia\/reperfusion on vascularized lymph node flaps in rats"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0904-9591","authenticated-orcid":true,"given":"Florian S.","family":"Frueh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bijan","family":"Jelvani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Scheuer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christina","family":"K\u00f6rbel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bong-Sung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Giovanoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Lindenblatt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Harder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Ampofo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael D.","family":"Menger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias W.","family":"Laschke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2020,10,6]]},"reference":[{"key":"pone.0239517.ref001","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/nature04480","article-title":"Lymphangiogenesis in development and human dis-ease","volume":"438","author":"K Alitalo","year":"2005","journal-title":"Nature"},{"key":"pone.0239517.ref002","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1177\/1358863X10364553","article-title":"Current concepts and future directions in the diagnosis and management of lymphatic vascular disease","volume":"15","author":"SG Rockson","year":"2010","journal-title":"Vasc Med"},{"key":"pone.0239517.ref003","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1038\/nm.2545","article-title":"The lymphatic vasculature in disease","volume":"17","author":"K Alitalo","year":"2011","journal-title":"Nat Med"},{"key":"pone.0239517.ref004","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1172\/JCI71608","article-title":"New developments in clinical aspects of lymphatic disease","volume":"124","author":"PS Mortimer","year":"2014","journal-title":"J Clin Invest"},{"key":"pone.0239517.ref005","doi-asserted-by":"crossref","first-page":"5138","DOI":"10.1002\/cncr.25458","article-title":"Lymphedema beyond breast cancer: a systematic review and meta-analysis of cancer-related secondary lymphedema","volume":"116","author":"JN Cormier","year":"2010","journal-title":"Cancer"},{"key":"pone.0239517.ref006","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/S1470-2045(13)70076-7","article-title":"Incidence of unilateral arm lymphoedema after breast cancer: a systematic review and meta-analysis","volume":"14","author":"T DiSipio","year":"2013","journal-title":"Lancet Oncol"},{"key":"pone.0239517.ref007","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1002\/bjs.9766","article-title":"Global abnormali-ties in lymphatic function following systemic therapy in patients with breast cancer","volume":"102","author":"SK Bains","year":"2015","journal-title":"Br J Surg"},{"key":"pone.0239517.ref008","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1245\/s10434-011-2017-4","article-title":"The surgical treatment of lymphedema: a systematic review of the contemporary literature (2004\u20132010)","volume":"19","author":"JN Cormier","year":"2012","journal-title":"Ann Surg Oncol"},{"key":"pone.0239517.ref009","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1097\/01.sla.0000201258.10304.16","article-title":"Postmastectomy lymphedema: long-term re-sults following microsurgical lymph node transplantation","volume":"243","author":"C Becker","year":"2006","journal-title":"Ann Surg"},{"key":"pone.0239517.ref010","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1002\/bjs.10983","article-title":"Feasibility study of combined dy-namic imaging and lymphaticovenous anastomosis surgery for breast cancer-related lymphoedema","volume":"106","author":"AA Khan","year":"2019","journal-title":"Br J Surg"},{"key":"pone.0239517.ref011","first-page":"34","article-title":"Micro-surgical lymphatic vessel transplantation","volume":"32","author":"RG Baumeister","year":"2016","journal-title":"J Reconstr Microsurg"},{"key":"pone.0239517.ref012","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1097\/PRS.0000000000000383","article-title":"Overview of lymph node transfer for lymphedema treatment","volume":"134","author":"R Ito","year":"2014","journal-title":"Plast Re-constr Surg"},{"key":"pone.0239517.ref013","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.ygyno.2016.01.007","article-title":"Proposed pathway and mechanism of vas-cularized lymph node flaps","volume":"141","author":"R Ito","year":"2016","journal-title":"Gynecol Oncol"},{"key":"pone.0239517.ref014","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1097\/00006534-197963060-00007","article-title":"Successful lymph node transplantation in rats, with restoration of lymphatic function","volume":"63","author":"BF Shesol","year":"1979","journal-title":"Plast Reconstr Surg"},{"key":"pone.0239517.ref015","doi-asserted-by":"crossref","first-page":"192e","DOI":"10.1097\/01.prs.0000437257.78327.5b","article-title":"The mechanism of vascularized lymph node transfer for lymphedema: natural lymphaticovenous drainage","volume":"133","author":"MH Cheng","year":"2014","journal-title":"Plast Reconstr Surg"},{"key":"pone.0239517.ref016","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/micr.22388","article-title":"Quantity of lymph nodes correlates with improvement in lymphatic drainage in treatment of hind limb lymphedema with lymph node flap transfer in rats","volume":"36","author":"DH Nguyen","year":"2016","journal-title":"Microsurgery"},{"key":"pone.0239517.ref017","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1097\/SLA.0b013e3182426757","article-title":"Microvascu-lar breast reconstruction and lymph node transfer for postmastectomy lymphedema pa-tients","volume":"255","author":"AM Saaristo","year":"2012","journal-title":"Ann Surg"},{"key":"pone.0239517.ref018","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1679\/aohc.71.69","article-title":"Structure and function of rat lymph nodes","volume":"71","author":"O Ohtani","year":"2008","journal-title":"Arch Histol Cytol"},{"key":"pone.0239517.ref019","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1038\/nm1689","article-title":"Thera-peutic differentiation and maturation of lymphatic vessels after lymph node dissection and transplantation","volume":"13","author":"T Tammela","year":"2007","journal-title":"Nat Med"},{"key":"pone.0239517.ref020","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1161\/CIRCULATIONAHA.110.965384","article-title":"Growth factor therapy and autologous lymph node transfer in lymphedema","volume":"123","author":"M L\u00e4hteenvuo","year":"2011","journal-title":"Circulation"},{"key":"pone.0239517.ref021","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1097\/01.prs.0000436840.69752.7e","article-title":"Lymph node transplantation results in spontaneous lymphatic reconnection and restora-tion of lymphatic flow","volume":"133","author":"SZ Aschen","year":"2014","journal-title":"Plast Reconstr Surg"},{"key":"pone.0239517.ref022","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.jss.2015.02.031","article-title":"Growth factor therapy and lymph node graft for lymphedema","volume":"196","author":"TV Tervala","year":"2015","journal-title":"J Surg Res"},{"key":"pone.0239517.ref023","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/GOX.0b013e318293a532","article-title":"Lymphatic vessel function and lymphatic growth factor secretion after microvascular lymph node transfer in lymphedema patients","volume":"1","author":"TP Viitanen","year":"2013","journal-title":"Plast Reconstr Surg Glob Open"},{"key":"pone.0239517.ref024","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.jss.2015.04.041","article-title":"Anti-inflammatory effects of flap and lymph node transfer","volume":"199","author":"TP Viitanen","year":"2015","journal-title":"J Surg Res"},{"key":"pone.0239517.ref025","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/s10456-015-9461-x","article-title":"Large-scale time series microscopy of neovessel growth during angiogenesis","volume":"18","author":"U Utzinger","year":"2015","journal-title":"Angiogenesis"},{"key":"pone.0239517.ref026","doi-asserted-by":"crossref","first-page":"1128e","DOI":"10.1097\/PRS.0000000000003271","article-title":"Adipose Tissue Drives Response to Ischemia-Reperfusion Injury in a Murine Pressure Sore Model","volume":"139","author":"MJ Gust","year":"2017","journal-title":"Plast Reconstr Surg"},{"key":"pone.0239517.ref027","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1097\/PRS.0b013e3181f4468b","article-title":"Adipose tissue remodeling under is-chemia: death of adipocytes and activation of stem\/progenitor cells","volume":"126","author":"H Suga","year":"2010","journal-title":"Plast Reconstr Surg"},{"key":"pone.0239517.ref028","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1097\/PRS.0000000000004673","article-title":"Critical ischemia time, perfusion, and drainage function of vascularized lymph nodes","volume":"142","author":"CY Yang","year":"2018","journal-title":"Plast Reconstr Surg"},{"key":"pone.0239517.ref029","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/jso.25518","article-title":"Impacts of arterial ischemia or venous occlusion on vascularized groin lymph nodes in a rat model","volume":"121","author":"IE Tinhofer","year":"2020","journal-title":"J Surg Oncol"},{"key":"pone.0239517.ref030","doi-asserted-by":"crossref","first-page":"e0227599","DOI":"10.1371\/journal.pone.0227599","article-title":"Ischemia and reperfusion injury in superficial inferior epigastric artery-based vascularized lymph node flaps","volume":"15","author":"DP Perrault","year":"2020","journal-title":"PLoS One"},{"key":"pone.0239517.ref031","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1002\/micr.22472","article-title":"Vascularized axil-lary lymph node transfer: A novel model in the rat","volume":"35","author":"GJ Kwiecien","year":"2015","journal-title":"Microsurgery"},{"key":"pone.0239517.ref032","doi-asserted-by":"crossref","first-page":"R67","DOI":"10.1088\/0031-9155\/46\/5\/201","article-title":"Three-dimensional ultrasound imaging","volume":"46","author":"A Fenster","year":"2001","journal-title":"Phys Med Biol"},{"key":"pone.0239517.ref033","doi-asserted-by":"crossref","first-page":"289","DOI":"10.7150\/thno.10155","article-title":"Prediction of tumor recur-rence and therapy monitoring using ultrasound-guided photoacoustic imaging","volume":"5","author":"S Mallidi","year":"2015","journal-title":"Theranostics"},{"key":"pone.0239517.ref034","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1148\/radiol.14140654","article-title":"Photoacoustic imaging of vascular hemodynamics: validation with blood oxygenation level-dependent MR imaging","volume":"275","author":"LJ Rich","year":"2015","journal-title":"Radiology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0239517","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T04:26:56Z","timestamp":1696825616000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0239517"}},"subtitle":[],"editor":[{"given":"Zhejun","family":"Cai","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,10,6]]},"references-count":34,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2020,10,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0239517","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,6]]}}}