{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T02:57:45Z","timestamp":1789786665985,"version":"4.0.1"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T00:00:00Z","timestamp":1602115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science KAKENHI","doi-asserted-by":"crossref","award":["17K17350"],"award-info":[{"award-number":["17K17350"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science KAKENHI","doi-asserted-by":"crossref","award":["17K17907"],"award-info":[{"award-number":["17K17907"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science KAKENHI","doi-asserted-by":"crossref","award":["18K10746"],"award-info":[{"award-number":["18K10746"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science KAKENHI","doi-asserted-by":"crossref","award":["20K16579"],"award-info":[{"award-number":["20K16579"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0239773","type":"journal-article","created":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T17:53:33Z","timestamp":1602179613000},"page":"e0239773","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["Association between periodontal disease due to Campylobacter rectus and cerebral microbleeds in acute stroke patients"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7881-570X","authenticated-orcid":true,"given":"Yuji","family":"Shiga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naohisa","family":"Hosomi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohisa","family":"Nezu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Nishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5348-5783","authenticated-orcid":true,"given":"Shiro","family":"Aoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Nakamori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoto","family":"Kinoshita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Imamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Ueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoaki","family":"Shintani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Ohge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Kawaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidemi","family":"Kurihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Wakabayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Maruyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,10,8]]},"reference":[{"issue":"9499","key":"pone.0239773.ref001","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1016\/S0140-6736(05)67728-8","article-title":"Periodontal diseases","volume":"366","author":"BL Pihlstrom","year":"2005","journal-title":"Lancet"},{"issue":"1","key":"pone.0239773.ref002","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.atherosclerosis.2014.06.002","article-title":"Association between periodontal disease and its treatment, flow-mediated dilatation and carotid intima-media thickness: a systematic review and meta-analysis","volume":"236","author":"M Orlandi","year":"2014","journal-title":"Atherosclerosis"},{"issue":"9","key":"pone.0239773.ref003","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1111\/ene.12415","article-title":"Periodontal disease and stroke: a meta-analysis of cohort studies","volume":"21","author":"A Lafon","year":"2014","journal-title":"Eur J Neurol"},{"issue":"2","key":"pone.0239773.ref004","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1161\/STROKEAHA.117.018990","article-title":"Periodontal Disease, Regular Dental Care Use, and Incident Ischemic Stroke","volume":"49","author":"S Sen","year":"2018","journal-title":"Stroke"},{"issue":"1","key":"pone.0239773.ref005","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1902\/annals.1996.1.1.216","article-title":"Consensus report. Periodontal diseases: epidemiology and diagnosis","volume":"1","year":"1996","journal-title":"Ann Periodontol"},{"issue":"1","key":"pone.0239773.ref006","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.atherosclerosis.2006.06.027","article-title":"Systemic exposure to Porphyromonas gingivalis predicts incident stroke","volume":"193","author":"PJ Pussinen","year":"2007","journal-title":"Atherosclerosis"},{"issue":"5\u20136","key":"pone.0239773.ref007","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1159\/000343659","article-title":"Association of serum anti-periodontal pathogen antibody with ischemic stroke","volume":"34","author":"N Hosomi","year":"2012","journal-title":"Cerebrovasc Dis"},{"key":"pone.0239773.ref008","article-title":"Serum IgG antibody titer to Fusobacterium nucleatum is associated with unfavorable outcome after stroke","author":"H Nishi","year":"2020","journal-title":"Clin Exp Immunol"},{"issue":"7","key":"pone.0239773.ref009","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/S1474-4422(10)70104-6","article-title":"Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges","volume":"9","author":"L Pantoni","year":"2010","journal-title":"Lancet Neurol"},{"issue":"7","key":"pone.0239773.ref010","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1161\/STROKEAHA.107.508135","article-title":"Biomarkers of Inflammation and MRI-Defined Small Vessel Disease of the Brain: The Cardiovascular Health Study","volume":"39","author":"M Fornage","year":"2008","journal-title":"Stroke"},{"issue":"6","key":"pone.0239773.ref011","doi-asserted-by":"crossref","first-page":"e434","DOI":"10.1161\/STROKEAHA.109.569855","article-title":"A systematic review of dynamic cerebral and peripheral endothelial function in lacunar stroke versus controls","volume":"41","author":"SF Stevenson","year":"2010","journal-title":"Stroke"},{"issue":"4","key":"pone.0239773.ref012","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/hr.2015.4","article-title":"Endothelial dysfunction is associated with the severity of cerebral small vessel disease","volume":"38","author":"T Nezu","year":"2015","journal-title":"Hypertens Res"},{"issue":"2","key":"pone.0239773.ref013","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1161\/STROKEAHA.115.009627","article-title":"Emerging Evidence for Pathogenesis of Sporadic Cerebral Small Vessel Disease","volume":"47","author":"M Ihara","year":"2016","journal-title":"Stroke"},{"issue":"1","key":"pone.0239773.ref014","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1161\/01.STR.24.1.35","article-title":"Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment","volume":"24","author":"HP Adams","year":"1993","journal-title":"Stroke"},{"issue":"6","key":"pone.0239773.ref015","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1053\/j.ajkd.2008.12.034","article-title":"Revised equations for estimated GFR from serum creatinine in Japan","volume":"53","author":"S Matsuo","year":"2009","journal-title":"Am J Kidney Dis"},{"issue":"2","key":"pone.0239773.ref016","doi-asserted-by":"crossref","first-page":"351","DOI":"10.2214\/ajr.149.2.351","article-title":"MR signal abnormalities at 1.5 T in Alzheimer\u2019s dementia and normal aging","volume":"149","author":"F Fazekas","year":"1987","journal-title":"AJR Am J Roentgenol"},{"issue":"2","key":"pone.0239773.ref017","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s00535-017-1368-4","article-title":"Involvement of Porphyromonas gingivalis in the progression of non-alcoholic fatty liver disease","volume":"53","author":"T Nakahara","year":"2018","journal-title":"J Gastroenterol"},{"issue":"Pt 11","key":"pone.0239773.ref018","doi-asserted-by":"crossref","first-page":"3384","DOI":"10.1093\/brain\/awr252","article-title":"Genetic variants of the NOTCH3 gene in the elderly and magnetic resonance imaging correlates of age-related cerebral small vessel disease","volume":"134","author":"H Schmidt","year":"2011","journal-title":"Brain"},{"issue":"3","key":"pone.0239773.ref019","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1161\/01.STR.0000058480.77236.B3","article-title":"Is breakdown of the blood-brain barrier responsible for lacunar stroke, leukoaraiosis, and dementia?","volume":"34","author":"JM Wardlaw","year":"2003","journal-title":"Stroke"},{"issue":"10","key":"pone.0239773.ref020","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1111\/ene.13080","article-title":"Chronic periodontitis is associated with lacunar infarct: a case-control study","volume":"23","author":"Y Leira","year":"2016","journal-title":"Eur J Neurol"},{"issue":"6","key":"pone.0239773.ref021","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1159\/000353707","article-title":"Association between oral health and the risk of lacunar infarction in Japanese adults","volume":"59","author":"A Taguchi","year":"2013","journal-title":"Gerontology"},{"issue":"6","key":"pone.0239773.ref022","doi-asserted-by":"crossref","first-page":"929","DOI":"10.3346\/jkms.2013.28.6.929","article-title":"Tooth loss is associated with brain white matter change and silent infarction among adults without dementia and stroke","volume":"28","author":"YK Minn","year":"2013","journal-title":"J Korean Med Sci"},{"issue":"3\u20134","key":"pone.0239773.ref023","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1159\/000448839","article-title":"The Influence of Age in the Relationship between Cerebral Small Vessel Disease and Edentulism. The Atahualpa Project","volume":"76","author":"OH Del Brutto","year":"2016","journal-title":"Eur Neurol"},{"issue":"9","key":"pone.0239773.ref024","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1161\/STROKEAHA.114.004286","article-title":"Cerebral microbleeds: is antithrombotic therapy safe to administer?","volume":"45","author":"Z Wang","year":"2014","journal-title":"Stroke"},{"issue":"11","key":"pone.0239773.ref025","doi-asserted-by":"crossref","first-page":"2916","DOI":"10.1161\/STROKEAHA.112.658369","article-title":"Different impacts of blood pressure variability on the progression of cerebral microbleeds and white matter lesions","volume":"43","author":"W Liu","year":"2012","journal-title":"Stroke"},{"key":"pone.0239773.ref026","doi-asserted-by":"crossref","first-page":"20074","DOI":"10.1038\/srep20074","article-title":"Intracerebral hemorrhage and deep microbleeds associated with cnm-positive Streptococcus mutans; a hospital cohort study","volume":"6","author":"S Tonomura","year":"2016","journal-title":"Sci Rep"},{"issue":"4","key":"pone.0239773.ref027","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/j.1399-302X.1993.tb00565.x","article-title":"Campylobacter rectus in human periodontitis","volume":"8","author":"TE Rams","year":"1993","journal-title":"Oral Microbiol Immunol"},{"issue":"3","key":"pone.0239773.ref028","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1128\/JCM.01590-08","article-title":"Oral abscess caused by Campylobacter rectus: case report and literature review","volume":"47","author":"SD Mahlen","year":"2009","journal-title":"J Clin Microbiol"},{"issue":"2","key":"pone.0239773.ref029","doi-asserted-by":"crossref","first-page":"189","DOI":"10.4103\/0970-9290.159164","article-title":"Prevalence of eight putative periodontal pathogens in atherosclerotic plaque of coronary artery disease patients and comparing them with noncardiac subjects: A case-control study","volume":"26","author":"J Mahendra","year":"2015","journal-title":"Indian J Dent Res"},{"issue":"22","key":"pone.0239773.ref030","doi-asserted-by":"crossref","first-page":"3325","DOI":"10.2169\/internalmedicine.1025-18","article-title":"Clival Osteomyelitis with Cavernous Sinus Thrombosis Due to Fusobacterium nucleatum and Campylobacter rectus Induced by Tooth Extraction","volume":"57","author":"K Oka","year":"2018","journal-title":"Intern Med"},{"key":"pone.0239773.ref031","article-title":"Septic cavernous sinus thrombosis due to Campylobacter rectus infection","volume":"2014","author":"QJ Leo","year":"2014","journal-title":"BMJ Case Rep"},{"issue":"2","key":"pone.0239773.ref032","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1159\/000487103","article-title":"Campylobacter rectus in the Oral Cavity Correlates with Proteinuria in Immunoglobulin A Nephropathy Patients","volume":"139","author":"T Misaki","year":"2018","journal-title":"Nephron"},{"issue":"1","key":"pone.0239773.ref033","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/jcbfm.2015.116","article-title":"Circulating biologic markers of endothelial dysfunction in cerebral small vessel disease: A review","volume":"36","author":"A Poggesi","year":"2016","journal-title":"J Cereb Blood Flow Metab"},{"issue":"8","key":"pone.0239773.ref034","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1161\/STROKEAHA.115.010001","article-title":"Interleukin-1 in Stroke: From Bench to Bedside","volume":"47","author":"OA Sobowale","year":"2016","journal-title":"Stroke"},{"issue":"2","key":"pone.0239773.ref035","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1161\/STROKEAHA.107.513259","article-title":"Lipoprotein-associated phospholipase A2 and high-sensitivity C-reactive protein improve the stratification of ischemic stroke risk in the Atherosclerosis Risk in Communities (ARIC) study","volume":"40","author":"V Nambi","year":"2009","journal-title":"Stroke"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0239773","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T17:54:44Z","timestamp":1602179684000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0239773"}},"subtitle":[],"editor":[{"given":"Hansel McClear","family":"Fletcher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,10,8]]},"references-count":35,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2020,10,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0239773","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,8]]}}}