{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:48:12Z","timestamp":1790729292280,"version":"4.1.0"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T00:00:00Z","timestamp":1603152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0240012","type":"journal-article","created":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T13:27:07Z","timestamp":1603200427000},"page":"e0240012","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":97,"title":["Proteins associated with neutrophil degranulation are upregulated in nasopharyngeal swabs from SARS-CoV-2 patients"],"prefix":"10.1371","volume":"15","author":[{"given":"Emel","family":"Akgun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mete Bora","family":"Tuzuner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betul","family":"Sahin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meltem","family":"Kilercik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Canan","family":"Kulah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hacer Nur","family":"Cakiroglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7868-7613","authenticated-orcid":true,"given":"Mustafa","family":"Serteser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Unsal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8814-7351","authenticated-orcid":true,"given":"Ahmet Tarik","family":"Baykal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,10,20]]},"reference":[{"key":"pone.0240012.ref001","doi-asserted-by":"crossref","first-page":"613","DOI":"10.2174\/1567205016666190730155926","article-title":"Proteomics Analysis of CA1 Region of the Hippocampus in Pre-, Progression and Pathological Stages in a Mouse Model of the Alzheimer\u2019s Disease","volume":"16","author":"B Gurel","year":"2019","journal-title":"Curr Alzheimer Res"},{"key":"pone.0240012.ref002","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1021\/acs.jproteome.7b00464","article-title":"Scanning Quadrupole Data-Independent Acquisition, Part A: Qualitative and Quantitative Characterization","volume":"17","author":"MA Moseley","year":"2018","journal-title":"J Proteome Res"},{"key":"pone.0240012.ref003","article-title":"A role for neutrophils in viral respiratory disease","volume":"8","author":"J V Camp","year":"2017","journal-title":"Front Immunol"},{"key":"pone.0240012.ref004","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.cca.2020.08.019","article-title":"Laboratory findings in COVID-19 diagnosis and prognosis","volume":"510","author":"PS Atieh","year":"2020","journal-title":"Clin. Chim. Acta"},{"key":"pone.0240012.ref005","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.4049\/jimmunol.150.4.1535","article-title":"Control of exocytosis in early neutrophil activation","volume":"150","author":"H Sengel\u00f8v","year":"1993","journal-title":"J Immunol"},{"key":"pone.0240012.ref006","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.1083\/jcb.109.6.2771","article-title":"The opsonizing ligand on Salmonella typhimurium influences incorporation of specific, but not azurophil, granule constituents into neutrophil phagosomes","volume":"109","author":"KA Joiner","year":"1989","journal-title":"J Cell Biol"},{"key":"pone.0240012.ref007","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.virusres.2012.11.002","article-title":"Neutrophil in viral infections, friend or foe?","volume":"171","author":"B Drescher","journal-title":"Virus Res"},{"key":"pone.0240012.ref008","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1189\/jlb.1204697","article-title":"Myeloperoxidase: friend and foe","volume":"77","author":"SJ Klebanoff","year":"2005","journal-title":"J Leukoc Biol"},{"key":"pone.0240012.ref009","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1073\/pnas.0405193102","article-title":"Myeloperoxidase mediates neutrophil activation by association with CD11b\/CD18 integrins","volume":"102","author":"D Lau","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"pone.0240012.ref010","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s10555-020-09889-4","article-title":"Inflammation resolution: a dual-pronged approach to averting cytokine storms in COVID-19?","volume":"39","author":"D. Panigrahy","year":"2020","journal-title":"Cancer Metastasis Rev"},{"key":"pone.0240012.ref011","first-page":"1","article-title":"Promoting apoptosis of neutrophils and phagocytosis by macrophages: Novel strategies in the resolution of inflammation","volume":"145","author":"KR Martin","year":"2015","journal-title":"Swiss Med Wkly"},{"key":"pone.0240012.ref012","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/npjamd.2016.18","article-title":"Macrophages in age-related chronic inflammatory diseases","volume":"2","author":"Y Oishi","year":"2016","journal-title":"npj Aging Mech Dis"},{"key":"pone.0240012.ref013","first-page":"2438","article-title":"Proteinase 3 and neutrophil elastase enhance inflammation in mice by inactivating antiinflammatory progranulin","volume":"118","author":"K Kessenbrock","year":"2008","journal-title":"J Clin Invest"},{"key":"pone.0240012.ref014","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/BOR.0b013e3283331594","article-title":"Interaction of proteinase 3 with its associated partners: Implications in the pathogenesis of Wegener\u2019s granulomatosis","volume":"22","author":"V Witko-Arsat","year":"2010","journal-title":"Curr Opin Rheumatol"},{"key":"pone.0240012.ref015","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.biochi.2007.10.009","article-title":"Neutrophil elastase, proteinase 3 and cathepsin G: physicochemical properties, activity and physiopathological functions","volume":"90","author":"B Korkmaz","year":"2008","journal-title":"Biochimie"},{"key":"pone.0240012.ref016","doi-asserted-by":"crossref","first-page":"3409","DOI":"10.2741\/3462","article-title":"Neutrophil-derived serine proteases modulate innate immune responses","volume":"14","author":"U Meyer-Hoffert","year":"2009","journal-title":"Front Biosci"},{"key":"pone.0240012.ref017","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nri3024","article-title":"Neutrophils in the activation and regulation of innate and adaptive immunity","volume":"11","author":"A Mantovani","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"pone.0240012.ref018","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jdermsci.2008.08.006","article-title":"Cathepsin G increases MMP expression in normal human fibroblasts through fibronectin fragmentation, and induces the conversion of proMMP-1 to active MMP-1","volume":"53","author":"ED Son","year":"2009","journal-title":"J Dermatol Sci"},{"key":"pone.0240012.ref019","first-page":"503","article-title":"O-T, CHAPTER 43\u2014Cytokine Modulation Therapy in Acute Respiratory Failure and ARDS","author":"V Jean-Louis","year":"2008","journal-title":"Mech. Vent"},{"issue":"30","key":"pone.0240012.ref020","doi-asserted-by":"crossref","first-page":"22758","DOI":"10.1074\/jbc.M110.103275","article-title":"Elastase-mediated activation of the severe acute respiratory syndrome coronavirus spike protein at discrete sites within the S2 domain","volume":"285","author":"S Belouzard","year":"2010","journal-title":"J Biol Chem"},{"key":"pone.0240012.ref021","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.00818","article-title":"Proteinase 3 interferes with C1q-mediated clearance of apoptotic cells","volume":"9","author":"P Tacnet-Delorme","year":"2018","journal-title":"Front Immunol"},{"key":"pone.0240012.ref022","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1083\/jcb.200606027","article-title":"Novel cell death program leads to neutrophil extracellular traps","volume":"176","author":"TA Fuchs","year":"2007","journal-title":"J Cell Biol"},{"key":"pone.0240012.ref023","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1183\/09031936.93.04081004","article-title":"Prevention of leukocyte elastase-induced emphysema in mice by heparin fragments","volume":"4","author":"C Lafuma","year":"1991","journal-title":"Eur Respir J"},{"key":"pone.0240012.ref024","doi-asserted-by":"crossref","DOI":"10.1186\/1756-0500-5-401","article-title":"Critical COPD respiratory illness is linked to increased transcriptomic activity of neutrophil proteases genes","volume":"5","author":"R Almansa","year":"2012","journal-title":"BMC Res Notes"},{"key":"pone.0240012.ref025","doi-asserted-by":"crossref","first-page":"4842","DOI":"10.4049\/jimmunol.154.9.4842","article-title":"Cleavage of lymphocyte surface antigens CD2, CD4, and CD8 by polymorphonuclear leukocyte elastase and cathepsin G in patients with cystic fibrosis","volume":"154","author":"G D\u00f6ring","year":"1995","journal-title":"J Immunol"},{"key":"pone.0240012.ref026","first-page":"1","article-title":"\u03b11-Antitrypsin deficiency and chronic respiratory disorders","volume":"29","author":"M Cazzola","journal-title":"Eur Respir Rev. 2020"},{"key":"pone.0240012.ref027","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1159\/000088439","article-title":"Matrix metalloproteinase-12 and Cathepsin D expression in pulmonary macrophages and dendritic cells of cigarette smoke-exposed mice","volume":"138","author":"K Bracke","year":"2005","journal-title":"Int Arch Allergy Immunol"},{"key":"pone.0240012.ref028","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1111\/j.1365-2222.2004.02030.x","article-title":"Cellular and molecular mechanisms in chronic obstructive pulmonary disease: An overview","volume":"34","author":"A Di Stefano","year":"2004","journal-title":"Clin Exp Allergy"},{"key":"pone.0240012.ref029","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1348-0421.2011.00424.x","article-title":"Contribution of neutrophil-derived myeloperoxidase in the early phase of fulminant acute respiratory distress syndrome induced by influenza virus infection","volume":"56","author":"R Sugamata","year":"2012","journal-title":"Microbiol Immunol"},{"key":"pone.0240012.ref030","doi-asserted-by":"crossref","first-page":"3316","DOI":"10.1073\/pnas.0511206103","article-title":"Proteinase 3 is an IL-32 binding protein","volume":"103","author":"D Novick","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pone.0240012.ref031","doi-asserted-by":"crossref","first-page":"3642","DOI":"10.1002\/art.24959","article-title":"Caspase 1-independent activation of interleukin-1\u03b2 in neutrophil-predominant inflammation","volume":"60","author":"M Guma","year":"2009","journal-title":"Arthritis Rheum"},{"key":"pone.0240012.ref032","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/humu.22169","article-title":"Naturally Occurring Genetic Variants of Human Caspase-1 Differ Considerably in Structure and the Ability to Activate Interleukin-1\u03b2","volume":"34","author":"H Luksch","year":"2013","journal-title":"Hum Mutat"},{"key":"pone.0240012.ref033","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a022459","article-title":"Interaction of mycobacterium tuberculosis with host cell death pathways","volume":"4","author":"L Srinivasan","year":"2014","journal-title":"Cold Spring Harb Perspect Med"},{"key":"pone.0240012.ref034","first-page":"1","article-title":"Interleukin-1 beta converting enzyme is necessary for development of depression-like behavior following intracerebroventricular administration of lipopolysaccharide to mice","volume":"10","author":"MA Lawson","year":"2013","journal-title":"J Neuroinflammation"},{"key":"pone.0240012.ref035","first-page":"10","article-title":"Induction of pro-inflammatory cytokines (IL-1 and IL-6) and lung inflammation by Coronavirus-19 (COVI-19 or SARS-CoV-2): anti-inflammatory strategies","volume":"34","author":"P Conti","year":"2020","journal-title":"J Biol Regul Homeost Agents"},{"key":"pone.0240012.ref036","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1126\/science.1092385","article-title":"Neutrophil Extracellular Traps Kill Bacteria","volume":"303","author":"V Brinkmann","year":"2004","journal-title":"Science"},{"issue":"3","key":"pone.0240012.ref037","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.celrep.2014.06.044","article-title":"A myeloperoxidase-containing complex regulates neutrophil elastase release and actin dynamics during NETosis","volume":"8","author":"DM Kathleen","year":"2014","journal-title":"Cell Rep"},{"key":"pone.0240012.ref038","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2020.00525","article-title":"Animal Models of ANCA Associated Vasculitis","volume":"11","author":"L Shochet","year":"2020","journal-title":"Front Immunol"},{"key":"pone.0240012.ref039","article-title":"Excessive Neutrophils and Neutrophil Extracellular Traps in COVID-19","author":"W Jun","year":"2020","journal-title":"Front. Ummunol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0240012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T02:21:13Z","timestamp":1696904473000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0240012"}},"subtitle":[],"editor":[{"given":"Nades","family":"Palaniyar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,10,20]]},"references-count":39,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2020,10,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0240012","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.05.14.20102558","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,20]]}}}