{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T17:05:40Z","timestamp":1770915940851,"version":"3.50.1"},"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T00:00:00Z","timestamp":1602720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0240491","type":"journal-article","created":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T18:37:43Z","timestamp":1602787063000},"page":"e0240491","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["The absence of orthostatic heart rate increase is associated with cognitive impairment in Parkinson\u2019s disease"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3158-1955","authenticated-orcid":true,"given":"Ryota","family":"Tanaka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Yamashiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Genko","family":"Oyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenya","family":"Nishioka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Umemura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Shimo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobutaka","family":"Hattori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2020,10,15]]},"reference":[{"issue":"3","key":"pone.0240491.ref001","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1136\/jnnp.55.3.181","article-title":"Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases","volume":"55","author":"AJ Hughes","year":"1992","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"4","key":"pone.0240491.ref002","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1136\/jnnp-2012-303455","article-title":"Parkinson's disease subtypes: lost in translation?","volume":"84","author":"C Marras","year":"2013","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"7","key":"pone.0240491.ref003","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1002\/mds.26632","article-title":"Orthostatic hypotension and cognitive impairment in Parkinson's disease: Causation or association?","volume":"31","author":"C McDonald","year":"2016","journal-title":"Mov Disord"},{"issue":"10","key":"pone.0240491.ref004","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1002\/mds.20527","article-title":"A systematic review of prevalence studies of dementia in Parkinson's disease","volume":"20","author":"D Aarsland","year":"2005","journal-title":"Mov Disord"},{"issue":"9","key":"pone.0240491.ref005","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/S1474-4422(16)30079-5","article-title":"Neurogenic orthostatic hypotension and supine hypertension in Parkinson's disease and related synucleinopathies: prioritisation of treatment targets","volume":"15","author":"AJ Espay","year":"2016","journal-title":"Lancet Neurol"},{"issue":"5","key":"pone.0240491.ref006","doi-asserted-by":"crossref","first-page":"423","DOI":"10.5114\/ninp.2013.38222","article-title":"Causes and consequences of falls in Parkinson disease patients in a prospective study","volume":"47","author":"M Rudzi\u0144ska","year":"2013","journal-title":"Neurol Neurochir Pol"},{"issue":"5","key":"pone.0240491.ref007","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1097\/WNF.0000000000000168","article-title":"Droxidopa and Reduced Falls in a Trial of Parkinson Disease Patients With Neurogenic Orthostatic Hypotension","volume":"39","author":"RA Hauser","year":"2016","journal-title":"Clin Neuropharmacol"},{"issue":"18","key":"pone.0240491.ref008","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1212\/WNL.0000000000002086","article-title":"Survival in synucleinopathies: A prospective cohort study","volume":"85","author":"DS Goldstein","year":"2015","journal-title":"Neurology"},{"issue":"8","key":"pone.0240491.ref009","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1001\/jamaneurol.2017.1125","article-title":"Association of Autonomic Dysfunction With Disease Progression and Survival in Parkinson Disease","volume":"74","author":"E De Pablo-Fernandez","year":"2017","journal-title":"JAMA Neurol"},{"issue":"10","key":"pone.0240491.ref010","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.parkreldis.2014.07.004","article-title":"Severity of mild cognitive impairment in early Parkinson's disease contributes to poorer quality of life","volume":"20","author":"RA Lawson","year":"2014","journal-title":"Parkinsonism Relat Disord"},{"issue":"6","key":"pone.0240491.ref011","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.parkreldis.2015.03.024","article-title":"Neuropsychiatric symptoms and caregiver's burden in Parkinson's disease","volume":"21","author":"P Martinez-Martin","year":"2015","journal-title":"Parkinsonism Relat Disord"},{"issue":"8","key":"pone.0240491.ref012","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/S1474-4422(12)70152-7","article-title":"Cognitive impairment in patients with Parkinson's disease: diagnosis, biomarkers, and treatment","volume":"11","author":"P Svenningsson","year":"2012","journal-title":"Lancet Neurol"},{"issue":"2","key":"pone.0240491.ref013","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s10286-011-0119-5","article-title":"Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome","volume":"21","author":"R Freeman","year":"2011","journal-title":"Clin Auton Res"},{"issue":"12","key":"pone.0240491.ref014","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1212\/01.wnl.0000187889.17253.b1","article-title":"Consortium on DLB, Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium","volume":"65","author":"IG McKeith","year":"2005","journal-title":"Neurology"},{"issue":"12","key":"pone.0240491.ref015","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1002\/mds.21507","article-title":"Clinical diagnostic criteria for dementia associated with Parkinson's disease","volume":"22","author":"M Emre","year":"2007","journal-title":"Mov Disord"},{"issue":"2","key":"pone.0240491.ref016","doi-asserted-by":"crossref","first-page":"351","DOI":"10.2214\/ajr.149.2.351","article-title":"MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging","volume":"149","author":"F Fazekas","year":"1987","journal-title":"Am J Roentgenol"},{"issue":"10","key":"pone.0240491.ref017","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.parkreldis.2011.04.016","article-title":"Prevalence of orthostatic hypotension in Parkinson's disease: a systematic review and meta-analysis","volume":"17","author":"DC Velseboer","year":"2011","journal-title":"Parkinsonism Relat Disord"},{"issue":"12","key":"pone.0240491.ref018","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1002\/gps.4964","volume":"33","author":"M Min","year":"2018","journal-title":"Int J Geriatr Psychiatry"},{"issue":"12","key":"pone.0240491.ref019","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1136\/jnnp-2016-314123","article-title":"'Under pressure': is there a link between orthostatic hypotension and cognitive impairment in \u03b1-synucleinopathies?","volume":"87","author":"SJ Udow","year":"2016","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"pone.0240491.ref020","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.nicl.2017.05.012","article-title":"Loss of integrity and atrophy in cingulate structural covariance networks in Parkinson's disease","volume":"15","author":"LJ de Schipper","year":"2017","journal-title":"Neuroimage Clin"},{"issue":"3","key":"pone.0240491.ref021","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/nrn2573","article-title":"locus coeruleus and noradrenergic modulation of cognition","volume":"10","author":"SJ Sara","year":"2009","journal-title":"Nat Rev Neurosci"},{"issue":"2","key":"pone.0240491.ref022","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1093\/brain\/awx348","article-title":"Evaluation of the noradrenergic system in Parkinson's disease: an 11C-MeNER PET and neuromelanin MRI study","volume":"141","author":"M Sommerauer","year":"2018","journal-title":"Brain"},{"issue":"1","key":"pone.0240491.ref023","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/jcbfm.2015.164","article-title":"The neuropathology and cerebrovascular mechanisms of dementia","volume":"36","author":"L Raz","year":"2016","journal-title":"J Cereb Blood Flow Metab"},{"issue":"3","key":"pone.0240491.ref024","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/jcbfm.2010.170","article-title":"Alpha-synuclein aggregation induced by brief ischemia negatively impacts neuronal survival in vivo: a study in [A30P]alpha-synuclein transgenic mouse","volume":"31","author":"I Unal-Cevik","year":"2011","journal-title":"J Cereb Blood Flow Metab"},{"issue":"13","key":"pone.0240491.ref025","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1212\/WNL.0b013e31826c1acd","article-title":"Association of cognitive dysfunction with neurocirculatory abnormalities in early Parkinson disease","volume":"79","author":"Joong-Seok Kim","year":"2012","journal-title":"Neurology"},{"issue":"9","key":"pone.0240491.ref026","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1016\/j.parkreldis.2015.06.019","article-title":"The prevalence and riskof cerebral microbleeds in patients with Parkinson's disease","volume":"21","author":"K Yamashiro","year":"2015","journal-title":"Parkinsonism Relat Disord"},{"key":"pone.0240491.ref027","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jns.2018.08.009","article-title":"The presence of cerebral microbleeds is associated with cognitive impairment in Parkinson's disease","volume":"393","author":"K Daida","year":"2018","journal-title":"J Neurol Sci"},{"key":"pone.0240491.ref028","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.ensci.2017.12.002","article-title":"Cerebral microbleeds and blood pressure abnormalities in Parkinson's disease","volume":"10","author":"K Yamashiro","year":"2017","journal-title":"eNeurologicalSci"},{"issue":"10","key":"pone.0240491.ref029","doi-asserted-by":"crossref","first-page":"e1002143","DOI":"10.1371\/journal.pmed.1002143","article-title":"Orthostatic Hypotension and the Long-Term Risk of Dementia: A Population-Based Study","volume":"13","author":"Heart Brain Connection Collaborative Research Group","year":"2016","journal-title":"PLoS Med"},{"key":"pone.0240491.ref030","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1212\/WNL.0b013e3182a351d4","article-title":"White LR; Antihypertensive medication use and risk of cognitive impairment: the Honolulu-Asia Aging Study","volume":"81","author":"RP Gelber","year":"2013","journal-title":"Neurology"},{"key":"pone.0240491.ref031","doi-asserted-by":"crossref","first-page":"106649","DOI":"10.1016\/j.vph.2020.106649","article-title":"Beta-blocker therapy and risk of vascular dementia: A population-based prospective study","volume":"125\u2013126","author":"H Holm","year":"2020","journal-title":"Vascul Pharmacol"},{"key":"pone.0240491.ref032","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1111\/jgs.14225","article-title":"Etiology of Syncope and Unexplained Falls in Elderly Adults with Dementia: Syncope and Dementia (SYD) Study","volume":"64","author":"A Ungar","year":"2016","journal-title":"J Am Geriatr Soc"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0240491","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T18:38:01Z","timestamp":1602787081000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0240491"}},"subtitle":[],"editor":[{"given":"Pasquale","family":"Abete","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,10,15]]},"references-count":32,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2020,10,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0240491","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,15]]}}}