{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T17:04:26Z","timestamp":1751562266010,"version":"3.37.3"},"reference-count":68,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T00:00:00Z","timestamp":1603670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["RO1-DK2528"],"award-info":[{"award-number":["RO1-DK2528"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001440","name":"ADA Foundation","doi-asserted-by":"publisher","award":["ADA712BS151"],"award-info":[{"award-number":["ADA712BS151"]}],"id":[{"id":"10.13039\/100001440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","award":["T32-ES007059"],"award-info":[{"award-number":["T32-ES007059"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0241238","type":"journal-article","created":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T18:43:08Z","timestamp":1603737788000},"page":"e0241238","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Specific ablation of the NCoR corepressor \u03b4 splice variant reveals alternative RNA splicing as a key regulator of hepatic metabolism"],"prefix":"10.1371","volume":"15","author":[{"given":"Michael L.","family":"Goodson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trina A.","family":"Knotts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elsie L.","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chelsea A.","family":"Snyder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Briana M.","family":"Young","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0097-6818","authenticated-orcid":true,"given":"Martin L.","family":"Privalsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2020,10,26]]},"reference":[{"issue":"Pt 4","key":"pone.0241238.ref001","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1242\/jcs.115.4.689","article-title":"Biological roles and mechanistic actions of co-repressor complexes","volume":"115","author":"K Jepsen","year":"2002","journal-title":"Journal of cell science"},{"issue":"2","key":"pone.0241238.ref002","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/nrg2736","article-title":"Deconstructing repression: evolving models of co-repressor action","volume":"11","author":"V Perissi","year":"2010","journal-title":"Nature reviews Genetics"},{"issue":"2","key":"pone.0241238.ref003","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.mce.2011.08.033","article-title":"Nuclear hormone receptor co-repressors: structure and function","volume":"348","author":"PJ Watson","year":"2012","journal-title":"Mol Cell Endocrinol"},{"issue":"7","key":"pone.0241238.ref004","doi-asserted-by":"crossref","first-page":"3876","DOI":"10.1016\/j.bbagen.2012.07.001","article-title":"The in vivo role of nuclear receptor corepressors in thyroid hormone action","volume":"1830","author":"I Astapova","year":"2013","journal-title":"Biochim Biophys Acta"},{"issue":"8","key":"pone.0241238.ref005","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1101\/gad.214023.113","article-title":"Emerging roles of the corepressors NCoR1 and SMRT in homeostasis","volume":"27","author":"A Mottis","year":"2013","journal-title":"Genes Dev"},{"key":"pone.0241238.ref006","first-page":"101","article-title":"Corepressors and nuclear hormone receptor function","volume":"254","author":"P Ordentlich","year":"2001","journal-title":"Curr Top Microbiol Immunol"},{"key":"pone.0241238.ref007","first-page":"237","article-title":"N-CoR-HDAC corepressor complexes: roles in transcriptional regulation by nuclear hormone receptors","volume":"274","author":"PL Jones","year":"2003","journal-title":"Curr Top Microbiol Immunol"},{"issue":"2","key":"pone.0241238.ref008","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nsmb.1983","article-title":"Structural basis for the assembly of the SMRT\/NCoR core transcriptional repression machinery","volume":"18","author":"J Oberoi","year":"2011","journal-title":"Nat Struct Mol Biol"},{"issue":"29","key":"pone.0241238.ref009","doi-asserted-by":"crossref","first-page":"18237","DOI":"10.1074\/jbc.M115.661058","article-title":"Insights into the Recruitment of Class IIa Histone Deacetylases (HDACs) to the SMRT\/NCoR Transcriptional Repression Complex","volume":"290","author":"GM Hudson","year":"2015","journal-title":"J Biol Chem"},{"issue":"11","key":"pone.0241238.ref010","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1101\/gad.1424806","article-title":"Sensors and signals: a coactivator\/corepressor\/epigenetic code for integrating signal-dependent programs of transcriptional response","volume":"20","author":"MG Rosenfeld","year":"2006","journal-title":"Genes Dev"},{"issue":"6","key":"pone.0241238.ref011","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.tcb.2007.04.001","article-title":"Transcriptional coregulators in the control of energy homeostasis","volume":"17","author":"JN Feige","year":"2007","journal-title":"Trends in cell biology"},{"issue":"50","key":"pone.0241238.ref012","doi-asserted-by":"crossref","first-page":"20021","DOI":"10.1073\/pnas.0811012105","article-title":"SMRT repression of nuclear receptors controls the adipogenic set point and metabolic homeostasis","volume":"105","author":"RR Nofsinger","year":"2008","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"1","key":"pone.0241238.ref013","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.febslet.2007.11.016","article-title":"Nuclear receptors: decoding metabolic disease","volume":"582","author":"J Sonoda","year":"2008","journal-title":"FEBS letters"},{"issue":"13","key":"pone.0241238.ref014","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/j.addr.2010.09.016","article-title":"Nuclear receptor coregulators as a new paradigm for therapeutic targeting","volume":"62","author":"EY Hsia","year":"2010","journal-title":"Advanced drug delivery reviews"},{"issue":"6","key":"pone.0241238.ref015","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.cmet.2010.11.007","article-title":"Nuclear receptor corepressor SMRT regulates mitochondrial oxidative metabolism and mediates aging-related metabolic deterioration","volume":"12","author":"SM Reilly","year":"2010","journal-title":"Cell Metab"},{"issue":"8","key":"pone.0241238.ref016","doi-asserted-by":"crossref","first-page":"3412","DOI":"10.1073\/pnas.1017707108","article-title":"Corepressor SMRT promotes oxidative phosphorylation in adipose tissue and protects against diet-induced obesity and insulin resistance","volume":"108","author":"S Fang","year":"2011","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"4","key":"pone.0241238.ref017","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.cell.2011.09.050","article-title":"Adipocyte NCoR knockout decreases PPARgamma phosphorylation and enhances PPARgamma activity and insulin sensitivity","volume":"147","author":"P Li","year":"2011","journal-title":"Cell"},{"issue":"6","key":"pone.0241238.ref018","doi-asserted-by":"crossref","first-page":"4236","DOI":"10.1074\/jbc.M110.200964","article-title":"Aberrant corepressor interactions implicated in PML-RAR(alpha) and PLZF-RAR(alpha) leukemogenesis reflect an altered recruitment and release of specific NCoR and SMRT splice variants","volume":"286","author":"BJ Mengeling","year":"2011","journal-title":"J Biol Chem"},{"issue":"4","key":"pone.0241238.ref019","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.cell.2011.10.017","article-title":"NCoR1 is a conserved physiological modulator of muscle mass and oxidative function","volume":"147","author":"H Yamamoto","year":"2011","journal-title":"Cell"},{"issue":"10","key":"pone.0241238.ref020","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/nrendo.2012.100","article-title":"Nuclear receptor coregulators: modulators of pathology and therapeutic targets","volume":"8","author":"DM Lonard","year":"2012","journal-title":"Nat Rev Endocrinol"},{"issue":"3","key":"pone.0241238.ref021","first-page":"169","article-title":"Nuclear receptor corepressor complexes in cancer: mechanism, function and regulation","volume":"2","author":"MM Wong","year":"2014","journal-title":"Am J Clin Exp Urol"},{"key":"pone.0241238.ref022","doi-asserted-by":"crossref","first-page":"411","DOI":"10.3389\/fendo.2019.00411","article-title":"The Nuclear Receptor-Co-repressor Complex in Control of Liver Metabolism and Disease","volume":"10","author":"N Liang","year":"2019","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"12","key":"pone.0241238.ref023","first-page":"1646","article-title":"Two receptor interacting domains in the nuclear hormone receptor corepressor RIP13\/N-CoR","volume":"10","author":"W Seol","year":"1996","journal-title":"Mol Endocrinol"},{"issue":"15","key":"pone.0241238.ref024","doi-asserted-by":"crossref","first-page":"4676","DOI":"10.1093\/nar\/gkh786","article-title":"Alternative splicing generates multiple SMRT transcripts encoding conserved repressor domains linked to variable transcription factor interaction domains","volume":"32","author":"M Malartre","year":"2004","journal-title":"Nucleic acids research"},{"key":"pone.0241238.ref025","doi-asserted-by":"crossref","first-page":"e003","DOI":"10.1621\/nrs.03003","article-title":"Corepressors: custom tailoring and alterations while you wait","volume":"3","author":"M Goodson","year":"2005","journal-title":"Nuclear receptor signaling"},{"issue":"9","key":"pone.0241238.ref026","doi-asserted-by":"crossref","first-page":"7493","DOI":"10.1074\/jbc.M411514200","article-title":"Alternative mRNA splicing of SMRT creates functional diversity by generating corepressor isoforms with different affinities for different nuclear receptors","volume":"280","author":"ML Goodson","year":"2005","journal-title":"J Biol Chem"},{"issue":"3","key":"pone.0241238.ref027","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.bbrc.2005.06.175","article-title":"SMRT has tissue-specific isoform profiles that include a form containing one CoRNR box","volume":"334","author":"S Short","year":"2005","journal-title":"Biochemical and biophysical research communications"},{"issue":"2","key":"pone.0241238.ref028","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.ydbio.2006.01.007","article-title":"Xenopus embryos lacking specific isoforms of the corepressor SMRT develop abnormal heads","volume":"292","author":"M Malartre","year":"2006","journal-title":"Developmental biology"},{"issue":"8","key":"pone.0241238.ref029","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1210\/me.2007-0035","article-title":"Response of SMRT (silencing mediator of retinoic acid and thyroid hormone receptor) and N-CoR (nuclear receptor corepressor) corepressors to mitogen-activated protein kinase kinase kinase cascades is determined by alternative mRNA splicing","volume":"21","author":"BA Jonas","year":"2007","journal-title":"Mol Endocrinol"},{"issue":"3","key":"pone.0241238.ref030","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1042\/BSR20080093","article-title":"Alternative splicing determines the interaction of SMRT isoforms with nuclear receptor-DNA complexes","volume":"29","author":"F Faist","year":"2009","journal-title":"Bioscience reports"},{"issue":"2","key":"pone.0241238.ref031","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.mce.2012.01.006","article-title":"SMRTepsilon, a corepressor variant, interacts with a restricted subset of nuclear receptors, including the retinoic acid receptors alpha and beta","volume":"351","author":"BJ Mengeling","year":"2012","journal-title":"Mol Cell Endocrinol"},{"issue":"1","key":"pone.0241238.ref032","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1158\/0008-5472.CAN-12-2241","article-title":"SpliceArray profiling of breast cancer reveals a novel variant of NCOR2\/SMRT that is associated with tamoxifen resistance and control of ERalpha transcriptional activity","volume":"73","author":"L Zhang","year":"2013","journal-title":"Cancer Res"},{"issue":"8","key":"pone.0241238.ref033","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.150063","article-title":"Short linear motif acquisition, exon formation and alternative splicing determine a pathway to diversity for NCoR-family co-repressors.","volume":"5","author":"S Short","year":"2015","journal-title":"Open Biol"},{"issue":"52","key":"pone.0241238.ref034","doi-asserted-by":"crossref","first-page":"44988","DOI":"10.1074\/jbc.M111.291625","article-title":"Alternative mRNA splicing of corepressors generates variants that play opposing roles in adipocyte differentiation","volume":"286","author":"ML Goodson","year":"2011","journal-title":"J Biol Chem"},{"key":"pone.0241238.ref035","article-title":"Alteration of NCoR corepressor splicing in mice causes increased body weight and hepatosteatosis without glucose intolerance","author":"ML Goodson","year":"2014","journal-title":"Molecular and cellular biology"},{"key":"pone.0241238.ref036","doi-asserted-by":"crossref","first-page":"e002","DOI":"10.1621\/nrs.05002","article-title":"An improved high throughput protein-protein interaction assay for nuclear hormone receptors","volume":"5","author":"ML Goodson","year":"2007","journal-title":"Nuclear receptor signaling"},{"issue":"4","key":"pone.0241238.ref037","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nmeth.4197","article-title":"Salmon provides fast and bias-aware quantification of transcript expression","volume":"14","author":"R Patro","year":"2017","journal-title":"Nat Methods"},{"volume-title":"R: A language and environment for statistical computing","author":"Team RC","key":"pone.0241238.ref038"},{"issue":"12","key":"pone.0241238.ref039","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"MI Love","year":"2014","journal-title":"Genome Biol"},{"issue":"3","key":"pone.0241238.ref040","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/ng1180","article-title":"PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes","volume":"34","author":"VK Mootha","year":"2003","journal-title":"Nat Genet"},{"issue":"43","key":"pone.0241238.ref041","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"A Subramanian","year":"2005","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"pone.0241238.ref042","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-319-24277-4","volume-title":"ggplot2: Elegant Graphics for Data Analysis","author":"H. Wickham","year":"2016"},{"issue":"6757","key":"pone.0241238.ref043","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/47069","article-title":"The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors","volume":"402","author":"X Hu","year":"1999","journal-title":"Nature"},{"issue":"2","key":"pone.0241238.ref044","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1210\/me.2002-0310","article-title":"Determination of nuclear receptor corepressor interactions with the thyroid hormone receptor","volume":"17","author":"A Makowski","year":"2003","journal-title":"Mol Endocrinol"},{"issue":"3","key":"pone.0241238.ref045","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.jmb.2009.12.008","article-title":"Molecular determinants required for selective interactions between the thyroid hormone receptor homodimer and the nuclear receptor corepressor N-CoR","volume":"396","author":"JY Kim","year":"2010","journal-title":"J Mol Biol"},{"issue":"12","key":"pone.0241238.ref046","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1089\/thy.2017.0551","article-title":"Pathological Interactions Between Mutant Thyroid Hormone Receptors and Corepressors and Their Modulation by a Thyroid Hormone Analogue with Therapeutic Potential","volume":"28","author":"D Harrus","year":"2018","journal-title":"Thyroid"},{"issue":"58","key":"pone.0241238.ref047","first-page":"3041","article-title":"The diabetic disease (M.D.). Clinical picture and complications","volume":"65","author":"G. Lenti","year":"1974","journal-title":"Minerva Med"},{"issue":"10","key":"pone.0241238.ref048","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.2174\/138920012803762710","article-title":"Nuclear receptors and transcription factors in the development of fatty liver disease","volume":"13","author":"A Vluggens","year":"2012","journal-title":"Curr Drug Metab"},{"issue":"7","key":"pone.0241238.ref049","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1002\/hep4.1203","article-title":"Nuclear receptors and liver disease: Summary of the 2017 basic research symposium.","volume":"2","author":"M Tran","year":"2018","journal-title":"Hepatol Commun"},{"issue":"4","key":"pone.0241238.ref050","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1172\/JCI88893","article-title":"Nutrient-sensing nuclear receptors PPARalpha and FXR control liver energy balance","volume":"127","author":"GA Preidis","year":"2017","journal-title":"J Clin Invest"},{"issue":"1","key":"pone.0241238.ref051","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.biochi.2004.11.008","article-title":"Carbohydrate responsive element binding protein (ChREBP) and sterol regulatory element binding protein-1c (SREBP-1c): two key regulators of glucose metabolism and lipid synthesis in liver","volume":"87","author":"R Dentin","year":"2005","journal-title":"Biochimie"},{"key":"pone.0241238.ref052","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.mce.2015.06.036","article-title":"Regulation of corepressor alternative mRNA splicing by hormonal and metabolic signaling","volume":"413","author":"CA Snyder","year":"2015","journal-title":"Mol Cell Endocrinol"},{"issue":"6","key":"pone.0241238.ref053","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/nm.2744","article-title":"Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration","volume":"18","author":"Z Sun","year":"2012","journal-title":"Nat Med"},{"issue":"3","key":"pone.0241238.ref054","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1210\/me.2008-0311","article-title":"Distinct dysregulation of lipid metabolism by unliganded thyroid hormone receptor isoforms","volume":"23","author":"O Araki","year":"2009","journal-title":"Mol Endocrinol"},{"issue":"2","key":"pone.0241238.ref055","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1210\/en.2011-1793","article-title":"Thyroid hormone receptor-alpha gene knockout mice are protected from diet-induced hepatic insulin resistance","volume":"153","author":"FR Jornayvaz","year":"2012","journal-title":"Endocrinology"},{"issue":"7","key":"pone.0241238.ref056","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1136\/gutjnl-2015-310798","article-title":"Liver PPARalpha is crucial for whole-body fatty acid homeostasis and is protective against NAFLD","volume":"65","author":"A Montagner","year":"2016","journal-title":"Gut"},{"issue":"5","key":"pone.0241238.ref057","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1210\/en.2018-00115","article-title":"Divergent Role of Estrogen-Related Receptor alpha in Lipid- and Fasting-Induced Hepatic Steatosis in Mice","volume":"159","author":"W B'Chir","year":"2018","journal-title":"Endocrinology"},{"issue":"1","key":"pone.0241238.ref058","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.cmet.2013.04.021","article-title":"Reciprocal regulation of hepatic and adipose lipogenesis by liver X receptors in obesity and insulin resistance","volume":"18","author":"SW Beaven","year":"2013","journal-title":"Cell Metab"},{"issue":"5","key":"pone.0241238.ref059","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1172\/JCI59817","article-title":"Liver LXRalpha expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice","volume":"122","author":"Y Zhang","year":"2012","journal-title":"J Clin Invest"},{"issue":"6242","key":"pone.0241238.ref060","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1126\/science.aab3021","article-title":"GENE REGULATION. Discrete functions of nuclear receptor Rev-erbalpha couple metabolism to the clock","volume":"348","author":"Y Zhang","year":"2015","journal-title":"Science"},{"key":"pone.0241238.ref061","article-title":"Transcriptional Control of Circadian Rhythms and Metabolism: A Matter of Time and Space","author":"Y Hoon Kim","year":"2020","journal-title":"Endocr Rev"},{"issue":"8","key":"pone.0241238.ref062","doi-asserted-by":"crossref","first-page":"4920","DOI":"10.1074\/jbc.M510101200","article-title":"A novel principle for partial agonism of liver X receptor ligands. Competitive recruitment of activators and repressors","volume":"281","author":"M Albers","year":"2006","journal-title":"J Biol Chem"},{"issue":"9","key":"pone.0241238.ref063","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1128\/MCB.00129-14","article-title":"Thyroid hormone signaling in vivo requires a balance between coactivators and corepressors","volume":"34","author":"KR Vella","year":"2014","journal-title":"Molecular and cellular biology"},{"issue":"37","key":"pone.0241238.ref064","doi-asserted-by":"crossref","first-page":"34182","DOI":"10.1074\/jbc.M204887200","article-title":"Stimulation of lipogenesis by pharmacological activation of the liver X receptor leads to production of large, triglyceride-rich very low density lipoprotein particles","volume":"277","author":"A Grefhorst","year":"2002","journal-title":"J Biol Chem"},{"issue":"5","key":"pone.0241238.ref065","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S0092-8674(00)81432-4","article-title":"Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha","volume":"93","author":"DJ Peet","year":"1998","journal-title":"Cell"},{"issue":"1","key":"pone.0241238.ref066","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.cell.2013.08.054","article-title":"NCoR repression of LXRs restricts macrophage biosynthesis of insulin-sensitizing omega 3 fatty acids","volume":"155","author":"P Li","year":"2013","journal-title":"Cell"},{"issue":"6","key":"pone.0241238.ref067","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.molcel.2013.10.022","article-title":"Deacetylase-independent function of HDAC3 in transcription and metabolism requires nuclear receptor corepressor","volume":"52","author":"Z Sun","year":"2013","journal-title":"Mol Cell"},{"issue":"1","key":"pone.0241238.ref068","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1186\/s12862-016-0781-2","article-title":"Corepressor diversification by alternative mRNA splicing is species specific","volume":"16","author":"ML Privalsky","year":"2016","journal-title":"BMC Evol Biol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0241238","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,24]],"date-time":"2022-11-24T20:45:24Z","timestamp":1669322724000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0241238"}},"subtitle":[],"editor":[{"given":"Aijun","family":"Qiao","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,10,26]]},"references-count":68,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2020,10,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0241238","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2020,10,26]]}}}