{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T10:47:10Z","timestamp":1767178030180,"version":"build-2238731810"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T00:00:00Z","timestamp":1605657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007382","name":"Universidade Federal do Par\u00e1","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007382","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Centro Nacional de Primatas"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>ABH antigens are histo-antigens, but were first described on the surface of human erythrocytes. They are found in those cells only in great apes and humans, while in more primitive animals they are found in tissues and body fluids. ABH antigens are mainly distributed in tissues that are in contact with the external environment and may serve as ligands for pathogens in tissues or block their connection. Description of the distribution of these molecules in non-human primate tissues is restricted to a few tissues and species. This paper describes the expression of human A, B and H type antigens in different organs from four species of New World Primates, obtained from the Centro Nacional de Primatas, as well as comparing that expression with what has been described for humans. In this study, although the tissue description of the antigens is similar to the genetic model for humans, some differences in expression between some organs from those species and those of humans were found. The differences occurred mainly in endodermal organs that have secretory functions and are probably under the control of the human-type FUT-2 enzyme. In the mesodermal-origin organs there was a reduction or absence of A and B antigen marking, particularly in the H precursor substance, indicating that those organs are under the control of the human-type FUT-1 enzyme. These findings have demonstrated that there is similar ABH antigen reactivity in tissue distribution between the species, although there are some species-specific cases.<\/jats:p>","DOI":"10.1371\/journal.pone.0241487","type":"journal-article","created":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T13:39:34Z","timestamp":1605706774000},"page":"e0241487","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Tissue expression of antigens of ABH blood groups in species of New World Monkeys (Aotus infulatus, Callithrix jacchus, Sapajus apella and Saimiri sciureus)"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9075-9947","authenticated-orcid":true,"given":"D\u00e9lia Cristina Figueira","family":"Aguiar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Washington Luiz Assun\u00e7\u00e3o","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gyselly de C\u00e1ssia Bastos","family":"de Matos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5996-490X","authenticated-orcid":true,"given":"Klena Sarges","family":"Marruaz da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosane do Socorro Pompeu","family":"de Loiola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tereza Cristina Oliveira","family":"Corvelo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2020,11,18]]},"reference":[{"key":"pone.0241487.ref001","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/vox.12786","article-title":"Biologic roles of the ABH and Lewis histo-blood group antigens Part I: infection and immunity","volume":"114","author":"CP Stowell","year":"2019","journal-title":"Vox Sang"},{"key":"pone.0241487.ref002","first-page":"28","article-title":"Genetic regulation of the expression of ABH and Lewis antigens in tissues","volume":"27","author":"R Oriol","year":"1992","journal-title":"APMIS Suppl"},{"key":"pone.0241487.ref003","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1034\/j.1600-0463.2000.d01-1.x","article-title":"Tissue distribution of histo-blood group antigens","volume":"108","author":"V Ravn","year":"2000","journal-title":"APMIS"},{"key":"pone.0241487.ref004","first-page":"64","article-title":"Blood group antigens in primate animals and their relation to human blood groups","volume":"3","author":"J Moor-Jankowski","year":"1969","journal-title":"Primates Med"},{"key":"pone.0241487.ref005","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/j.1600-0684.1995.tb00182.x","article-title":"Red cell polymorphisms in nonhuman primates: a review","volume":"4","author":"WW Socha","year":"1995","journal-title":"J Med Primatol"},{"key":"pone.0241487.ref006","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1093\/oxfordjournals.molbev.a026314","article-title":"Evolution of alpha 2-fucosyltransferase genes in primates: relation between an intronic Alu-Y element and red cell expression of ABH antigens","volume":"17","author":"PA Apoil","year":"2000","journal-title":"Mol Biol Evol"},{"key":"pone.0241487.ref007","doi-asserted-by":"crossref","first-page":"29721","DOI":"10.1074\/jbc.272.47.29721","article-title":"Evolution of fucosyltransferase genes in vertebrates","volume":"272","author":"M Costache","year":"1997","journal-title":"J Biol Chem"},{"key":"pone.0241487.ref008","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1093\/glycob\/10.6.611","article-title":"Three bovine \u03b12-fucosyltransferase genes encode enzymes that preferentially transfer fucose on Galb1-3GalNAc acceptor substrates","volume":"10","author":"JP Barreaud","year":"2000","journal-title":"Glycobiology"},{"key":"pone.0241487.ref009","doi-asserted-by":"crossref","first-page":"663","DOI":"10.4238\/vol7-3gmr452","article-title":"Evolution of the SEC1 gene in New World monkey lineages (Primates, Platyrrhini)","volume":"7","author":"BN Borges","year":"2008","journal-title":"Genet Mol Res"},{"key":"pone.0241487.ref010","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1084\/jem.42.6.853","article-title":"Serological studies on the blood of the primates: II. The blood groups in anthropoid apes","volume":"42","author":"K Landsteiner","year":"1925","journal-title":"J Exp Med"},{"key":"pone.0241487.ref011","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1423-0410.1986.tb01946.x","article-title":"Genetics of ABO, H, Lewis and related antigens","volume":"51","author":"R Oriol","year":"1986","journal-title":"Vox Sang"},{"key":"pone.0241487.ref012","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1423-0410.1989.tb03040.x","article-title":"ABH and related histo-blood group antigens; immunochemical differences in carrier isotypes and their distribution","volume":"56","author":"H Clausen","year":"1989","journal-title":"Vox Sang"},{"key":"pone.0241487.ref013","first-page":"4448","article-title":"Primate animal model for the study of ABO incompatibility in organ transplantation","volume":"19","author":"WW Socha","year":"1987","journal-title":"Transplant Proc"},{"key":"pone.0241487.ref014","first-page":"514","article-title":"ABH antigens in vascular endothelium and some epithelial tissues of baboons","volume":"50","author":"R Oriol","year":"1984","journal-title":"Lab Invest"},{"key":"pone.0241487.ref015","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/BF01885790","article-title":"Relationship between lectin binding properties and the expression of blood group ABH antigens in vascular endothelia and red blood cells from 18 primate species","volume":"22","author":"N Ito","year":"1990","journal-title":"Histochem J"},{"issue":"8","key":"pone.0241487.ref016","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1590\/S0074-02762011000800007","article-title":"Immunodetection of Helicobacter sp. and the associated expression of ABO blood group antigens in the gastric mucosa of captive and free-living New World primates in the Amazon region","volume":"106","author":"DC Aguiar","year":"2011","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"pone.0241487.ref017","unstructured":"Pedal I, Reichert W, Oliveira Corvelo TC. Das Samenbl\u00e4schenepithel Lewis-positiver Individuen sezerniert Lea in sialyerter Form. Beitr\u00e4ge zur Gerichtlichen Medizin. Band XLVII. Verlag Franz Deuticcke, Wies, 1989; pp 153\u20138."},{"key":"pone.0241487.ref018","unstructured":"Ayres M, Ayres M Jr, Ayres DL, dos Santos AAS. BIOESTAT\u2013aplica\u00e7\u00f5es estat\u00edsticas nas \u00e1reas das Ci\u00eancias Bio-M\u00e9dicas. Edition: 4th. CNPq. Editor: Sociedade Civil Mamirau\u00e1."},{"issue":"3","key":"pone.0241487.ref019","first-page":"531","article-title":"ABO blood groups in natural populations of callitrichidae (Platyrrhini, primates)","volume":"13","author":"RM Rocha","year":"1990","journal-title":"Rev Bras Genetica"},{"key":"pone.0241487.ref020","first-page":"697","article-title":"ABO blood groups in capuchin monkeys (Cebus apella)","volume":"8","author":"H Schneider","year":"1985","journal-title":"Rev Bras Genet"},{"issue":"3","key":"pone.0241487.ref021","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1034\/j.1600-0684.2002.00035.x","article-title":"ABO blood groups in the primate species of Cebidae from the Amazon region","volume":"31","author":"TC Corvelo","year":"2002","journal-title":"J Med Primatol"},{"key":"pone.0241487.ref022","volume-title":"Blood Groups of Primates: Theory, Practice, Evolutionary Meaning","author":"WW Socha","year":"1983"},{"key":"pone.0241487.ref023","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/BF02381130","article-title":"Human-type ABO blood groups as genetic markers for the management of a squirrel monkey (Saimiri sciureus) breeding colony","volume":"29","author":"K Terao","year":"1988","journal-title":"Primates"},{"key":"pone.0241487.ref024","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1084\/jem.111.6.785","article-title":"The histological distribution of blood group substances A and B in man","volume":"111","author":"AE Szulman","year":"1960","journal-title":"J Exp Med"},{"key":"pone.0241487.ref025","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1084\/jem.115.5.977","article-title":"The histological distribution of the blood group substances in man as disclosed by immunofluorescence II. The H antigen and its relation to A and B antigens","volume":"115","author":"AE Szulman","year":"1962","journal-title":"J Exp Med"},{"key":"pone.0241487.ref026","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1177\/154405910508400103","article-title":"ABO blood-group antigens in oral cancer","volume":"84","author":"E Dabelsteen","year":"2005","journal-title":"J Dent Res"},{"key":"pone.0241487.ref027","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1590\/S0004-28032002000400004","article-title":"Expression of ABH and Lewis antigens in chronic gastritis and pre-neoplasic alterations in gastric mucosa","volume":"39","author":"DC Aguiar","year":"2002","journal-title":"Arq Gastroenterol"},{"key":"pone.0241487.ref028","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.3748\/wjg.v12.i7.1120","article-title":"ABH and Lewis antigen distributions in blood, saliva and gastric mucosa and H pylori infection in gastric ulcer patients","volume":"12","author":"LC Martins","year":"2006","journal-title":"World J Gastroenterol"},{"key":"pone.0241487.ref029","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1172\/JCI113256","article-title":"Glycoconjugate Expression in Normal, Metaplastic and Neoplastic Human Upper Gastrointestinal Mucosa","volume":"80","author":"C Shimamoto","year":"1987","journal-title":"The Journal of Clinical Investigation"},{"key":"pone.0241487.ref030","first-page":"4499","article-title":"Distribution of blood group antigens A, B, H, Lewis a, and Lewis b in human normal, fetal, and malignant colonic tissue","volume":"45","author":"M Yuan","year":"1985","journal-title":"Cancer Res"},{"key":"pone.0241487.ref031","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1177\/002215540004801208","article-title":"Distribution of H type 1\u20134 chains of the ABO(H) system in different cell types of human respiratory epithelium","volume":"48","author":"N Fujitani","year":"2000","journal-title":"The Journal of Histochemistry & Cytochemistry"},{"key":"pone.0241487.ref032","first-page":"4113","article-title":"Blood group-related antigens in human urothelium: enhanced expression of precursor, LeX, and LeY determinants in urothelial carcinoma","volume":"48","author":"C Cordon-Cardo","year":"1988","journal-title":"Cancer Res"},{"key":"pone.0241487.ref033","first-page":"42","article-title":"Expression of blood group antigens by normal bronchopulmonary tissues and common forms of pulmonary carcinomas","volume":"115","author":"E Alvarez-Fernandez","year":"1991","journal-title":"Arch Pathol Lab Med"},{"key":"pone.0241487.ref034","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1177\/32.9.6379041","article-title":"Histochemical evaluation of secretory glycoproteins in human salivary glands with lectin-horseradish peroxidase conjugates","volume":"32","author":"SA Laden","year":"1984","journal-title":"J Histochem Cytochem"},{"key":"pone.0241487.ref035","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1002\/hep.1840200219","article-title":"Profiles of expression of carbohydrate chain structures during human intrahepatic bile duct development and maturation: a lectin-histochemical and immunohistochemical study","volume":"20","author":"T Terada","year":"1994","journal-title":"Hepatology"},{"key":"pone.0241487.ref036","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1097\/00000478-199009000-00002","article-title":"Blood group antigen expression in dysplasia and adenocarcinoma of the prostate","volume":"14","author":"EJ Perlman","year":"1990","journal-title":"Am J Surg Pathol"},{"key":"pone.0241487.ref037","first-page":"411","article-title":"Expression of type -2 histo-blood group carbohydrate antigens (Lex, Ley and H) in normal and malignant human endometrium","volume":"424","author":"V Ravn","year":"1994","journal-title":"Virchows Archiv"},{"key":"pone.0241487.ref038","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1006\/gyno.1996.0198","article-title":"Expression of A, B, and H blood group antigens in epithelial ovarian cancer: relationship to tumor grade and patient survival","volume":"62","author":"M Welshinger","year":"1996","journal-title":"Gynecol Oncol"},{"key":"pone.0241487.ref039","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/BF02340827","article-title":"ABH-related antigens in human male genital tract. A histochemical examination","volume":"105","author":"K Nishi","year":"1992","journal-title":"I nt J Legal Med"},{"key":"pone.0241487.ref040","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1600-0463.2001.tb00011.x","article-title":"ABH and Lewis histo-blood group antigens in cancer","volume":"1091","author":"J Le Pendu","year":"2001","journal-title":"APMIS"},{"key":"pone.0241487.ref041","first-page":"444","article-title":"Immunoanatomic distribution of blood group antigens in the human urinary tract. Influence of secretor status","volume":"55","author":"C Cordon-Cardo","year":"1986","journal-title":"Lab Invest"},{"key":"pone.0241487.ref042","first-page":"553","volume":"23","author":"P Rouger","year":"1980","journal-title":"Developmental aspects A, B, H, Lewis, I, i and Pr antigens in human kidney Revue Francaise de Transfusion et Immuno-h\u00e9matologie"}],"updated-by":[{"DOI":"10.1371\/journal.pone.0259504","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2021,10,28]],"date-time":"2021-10-28T00:00:00Z","timestamp":1635379200000}}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0241487","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T06:43:59Z","timestamp":1606200239000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0241487"}},"subtitle":[],"editor":[{"given":"Bi-Song","family":"Yue","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,11,18]]},"references-count":42,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020,11,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0241487","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,18]]}}}