{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:32:22Z","timestamp":1790872342626,"version":"4.1.0"},"reference-count":36,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T00:00:00Z","timestamp":1606694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Since Marine sponge <jats:italic>Dysidea avara<\/jats:italic> is regarded as a source of anti-inflammatory compounds, we decided to evaluate its potential anti-psoriatic activity in a psoriasis Imiquimod-induced in the mouse model. Psoriatic mice were treated with three different methanolic extracts of <jats:italic>Dysidea avara<\/jats:italic> compared with betamethasone-treated mice in in- vivo studies. Clinical skin severity was assessed with the psoriasis area index (PASI), whilst ELISA detected the expression of TNF-\u03b1, IL-17A, and IL-22. <jats:italic>Dysidea avara<\/jats:italic> activity was studied by employing GC-MS (to distinguish compounds), HPTLC (for skin permeation and accumulation), and SEA DOCK to predict single compound potential anti-inflammatory activity. After 7 days of treatment, mice treated with <jats:italic>Dysidea avara<\/jats:italic> displayed a dose-dependent, statistically significant improvement compared to controls (<jats:italic>p<\/jats:italic>&lt; 0.001). In line with the clinical results, ELISA revealed a statistically significant decrease in IL-22, IL-17A, and TNF-\u03b1 after treatment; the same SEA DOCK analysis suggests a possible anti-psoriatic activity of the extracts.<\/jats:p>","DOI":"10.1371\/journal.pone.0241582","type":"journal-article","created":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T13:31:24Z","timestamp":1606743084000},"page":"e0241582","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Chemical profiling and anti-psoriatic activity of marine sponge (Dysidea avara) in induced imiquimod-psoriasis-skin 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