{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:01:12Z","timestamp":1787022072993,"version":"build-2736575974"},"reference-count":64,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T00:00:00Z","timestamp":1605744000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>\n                    The poultry red mite (PRM),\n                    <jats:italic>Dermanyssus gallinae<\/jats:italic>\n                    , a potential vector of pathogens to animals and humans, causes impaired bird welfare. A study investigated changes in behavioural variables, physiological biomarkers, and health parameters following acaricidal treatment of PRM infestation of laying hens on a commercial farm. Mite traps determined the challenge to 12,700 hens before and after drinking water administration of the acaricide, fluralaner (Exzolt\n                    <jats:sup>\u00ae<\/jats:sup>\n                    , 0.5 mg\/kg; Weeks 0 and 1). Weekly daytime direct observations and night-time video recordings monitored bird behaviours from Weeks -6 through +6. Blood samples were collected from randomly-selected birds (Weeks -6, -1, and +6). Following treatment, mite count reductions (&gt;99%) were statistically significant (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.0001), as were night-time reductions in the percent of hens showing activity, preening, head scratching (all\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.0001), and head shaking (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.0007). Significant daytime reductions were observed in preening and head scratching (both\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.0001), head shaking (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.0389), severe feather pecking (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.0002), and aggressive behaviour (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.0165). Post-treatment, comb wounds were significantly reduced (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.0127), and comb colour was significantly improved (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.0001). Heterophil\/lymphocyte ratio was significantly reduced at Weeks 1 and 6 (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.0009 and\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.0001, respectively). At Week 6, blood corticosterone (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.0041) and total oxidant status (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.0001) were significantly reduced, and haemoglobin and mean corpuscular haemoglobin significantly increased (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.0001). Farm production records indicated that those post-treatment improvements were accompanied by significant reductions in weekly mortality rate (\n                    <jats:italic>P<\/jats:italic>\n                    = 0.0169), and significant recovery in mean weekly egg weights (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.0001) and laying rate (P &lt; 0.0001). The improvements in behavioural variables, physiological biomarkers, and health parameters that were observed following the elimination of PRM on a commercial farm indicate that infestations can be a cause of reduced hen welfare.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0241608","type":"journal-article","created":{"date-parts":[[2020,11,19]],"date-time":"2020-11-19T14:11:27Z","timestamp":1605795087000},"page":"e0241608","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Assessment of laying-bird welfare following acaricidal treatment of a commercial flock naturally infested with the poultry red mite (Dermanyssus gallinae)"],"prefix":"10.1371","volume":"15","author":[{"given":"D\u00e9borah","family":"Temple","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Manteca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dami\u00e1n","family":"Escribano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Salas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Mainau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Zschiesche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roser","family":"Dolz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9532-8161","authenticated-orcid":true,"given":"Emmanuel","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,11,19]]},"reference":[{"key":"pone.0241608.ref001","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1146\/annurev-ento-011613-162101","article-title":"Significance and control of the poultry red mite Dermanyssus gallinae","volume":"59","author":"OA Sparagano","year":"2014","journal-title":"Annu Rev Entomol"},{"key":"pone.0241608.ref002","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1017\/S0043933909000403","article-title":"Control methods for Dermanyssus gallinae in systems for laying hens: results of an international seminar","volume":"6","author":"M Mul","year":"2009","journal-title":"World Poult Sci J"},{"key":"pone.0241608.ref003","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1186\/s13071-015-0768-7","article-title":"Should the poultry red mite Dermanyssus gallinae be of wider concern for veterinary medical science","volume":"8","author":"DR George","year":"2015","journal-title":"Parasit Vectors"},{"key":"pone.0241608.ref004","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1186\/s13071-017-2292-4","article-title":"Poultry red mite (Dermanyssus gallinae) infestation: a broad impact parasitological disease that still remains a significant challenge for the egg-laying industry in Europe","volume":"10","author":"A Sigognault Flochlay","year":"2017","journal-title":"Parasit Vectors"},{"key":"pone.0241608.ref005","unstructured":"Mul M. 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