{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T07:24:43Z","timestamp":1789025083919,"version":"build-2803163510"},"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T00:00:00Z","timestamp":1604275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0241640","type":"journal-article","created":{"date-parts":[[2020,11,2]],"date-time":"2020-11-02T18:33:46Z","timestamp":1604342026000},"page":"e0241640","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["Blood-brain barrier permeability analysis of plant ceramides"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6930-1846","authenticated-orcid":true,"given":"Koichi","family":"Eguchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Mikami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Tsumita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaori","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuyuki","family":"Mukai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Yuyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyuki","family":"Igarashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,11,2]]},"reference":[{"key":"pone.0241640.ref001","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/nrm2329","article-title":"Principles of bioactive lipid signalling: lessons from sphingolipids","volume":"9","author":"YA Hannun","year":"2008","journal-title":"Nat Rev Mol Cell Biol"},{"key":"pone.0241640.ref002","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1182\/blood.V64.2.534.534","article-title":"Characteristic expression of glycosphingolipid profiles in the bipotential cell differentiation of human promyelocytic leukemia cell line HL-60","volume":"64","author":"H Nojiri","year":"1984","journal-title":"Blood"},{"key":"pone.0241640.ref003","first-page":"303","article-title":"Up-regulation of ceramide glucosyltransferase during the differentiation of U937 cells.","volume":"150","author":"J Aida","year":"2011"},{"key":"pone.0241640.ref004","doi-asserted-by":"crossref","first-page":"15823","DOI":"10.1016\/S0021-9258(18)55472-7","article-title":"Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation","volume":"265","author":"T Okazaki","year":"1990","journal-title":"J Biol Chem"},{"key":"pone.0241640.ref005","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/nature02284","article-title":"Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1","volume":"427","author":"M Matloubian","year":"2004","journal-title":"Nature"},{"key":"pone.0241640.ref006","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.1128\/MCB.00121-12","article-title":"Regulation of cell migration by sphingomyelin synthases: sphingomyelin in lipid rafts decreases responsiveness to signaling by the CXCL12\/CXCR4 pathway","volume":"32","author":"S Asano","year":"2012","journal-title":"Mol Cell Biol"},{"key":"pone.0241640.ref007","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1007\/BF02531119","article-title":"Sphingolipid long chain bases","volume":"5","author":"KA Karlsson","year":"1970","journal-title":"Lipids"},{"key":"pone.0241640.ref008","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1128\/JB.174.8.2575-2581.1992","article-title":"Characterization of enzymatic synthesis of sphingolipid long-chain bases in Saccharomyces cerevisiae: mutant strains exhibiting long-chain-base auxotrophy are deficient in serine palmitoyltransferase activity","volume":"174","author":"WJ Pinto","year":"1992","journal-title":"J Bacteriol"},{"key":"pone.0241640.ref009","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0014-5793(91)80845-T","article-title":"Chemical structure of glycosphingolipids isolated from Sphingomonas paucimobilis","volume":"292","author":"K Kawahara","year":"1991","journal-title":"FEBS Lett"},{"key":"pone.0241640.ref010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1388-1981(03)00033-7","article-title":"Plant sphingolipids: structural diversity, biosynthesis, first genes and functions","volume":"1632","author":"P Sperling","year":"2003","journal-title":"Biochim Biophys Acta"},{"key":"pone.0241640.ref011","doi-asserted-by":"crossref","first-page":"8170","DOI":"10.1016\/S0021-9258(19)43209-2","article-title":"On the identity between the small intestinal enzymes phlorizin hydrolase and glycosylceramidase","volume":"248","author":"HJ Leese","year":"1973","journal-title":"J Biol Chem"},{"key":"pone.0241640.ref012","doi-asserted-by":"crossref","first-page":"7768","DOI":"10.1016\/S0021-9258(18)43343-1","article-title":"The glycosylceramidase in the murine intestine. Purification and substrate specificity","volume":"256","author":"T Kobayashi","year":"1981","journal-title":"J Biol Chem"},{"key":"pone.0241640.ref013","doi-asserted-by":"crossref","first-page":"7324","DOI":"10.1074\/jbc.M508382200","article-title":"Neutral ceramidase encoded by the Asah2 gene is essential for the intestinal degradation of sphingolipids","volume":"281","author":"M Kono","year":"2006","journal-title":"J Biol Chem"},{"key":"pone.0241640.ref014","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1194\/jlr.M002204","article-title":"Intestinal absorption of dietary maize glucosylceramide in lymphatic duct cannulated rats","volume":"51","author":"T Sugawara","year":"2010","journal-title":"J Lipid Res"},{"key":"pone.0241640.ref015","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0005-2760(69)90138-6","article-title":"Metabolism of cerebroside in the intestinal tract of the rat","volume":"187","author":"\u00c5 Nilsson","year":"1969","journal-title":"Biochim Biophys Acta"},{"key":"pone.0241640.ref016","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.jdermsci.2009.09.002","article-title":"Dietary glucosylceramide is absorbed into the lymph and increases levels of epidermal sphingolipids","volume":"56","author":"J Ishikawa","year":"2009","journal-title":"J Dermatol Sci"},{"key":"pone.0241640.ref017","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1159\/000177035","article-title":"Prevalence of dementia in the rural island town of Ama-cho, Japan.","volume":"32","author":"K Wada-Isoe","year":"2009","journal-title":"Neuroepidemiology"},{"key":"pone.0241640.ref018","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1126\/science.1197623","article-title":"Decreased clearance of CNS beta-amyloid in Alzheimer's disease","volume":"330","author":"KG Mawuenyega","year":"2010","journal-title":"Science"},{"key":"pone.0241640.ref019","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jalz.2011.03.003","article-title":"Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease.","volume":"7","author":"RA Sperling","year":"2011","journal-title":"Alzheimers Dement."},{"key":"pone.0241640.ref020","doi-asserted-by":"crossref","first-page":"24488","DOI":"10.1074\/jbc.M114.577213","article-title":"Decreased amyloid-\u03b2 pathologies by intracerebral loading of glycosphingolipid-enriched exosomes in Alzheimer model mice","volume":"289","author":"K Yuyama","year":"2014","journal-title":"J Biol Chem"},{"key":"pone.0241640.ref021","doi-asserted-by":"crossref","first-page":"16827","DOI":"10.1038\/s41598-019-53394-w","article-title":"Plant sphingolipids promote extracellular vesicle release and alleviate amyloid-\u03b2 pathologies in a mouse model of Alzheimer's disease.","volume":"9","author":"K Yuyama","year":"2019","journal-title":"Sci Rep"},{"key":"pone.0241640.ref022","doi-asserted-by":"crossref","first-page":"10977","DOI":"10.1074\/jbc.M111.324616","article-title":"Sphingolipid-modulated exosome secretion promotes clearance of amyloid-\u03b2 by microglia","volume":"287","author":"K Yuyama","year":"2012","journal-title":"J Biol Chem"},{"key":"pone.0241640.ref023","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.febslet.2014.11.027","article-title":"A potential function for neuronal exosomes: sequestering intracerebral amyloid-\u03b2 peptide","volume":"589","author":"K Yuyama","year":"2015","journal-title":"FEBS Lett"},{"key":"pone.0241640.ref024","first-page":"879","article-title":"Biochemistry of the spingolipides. IX. Configuration of cerebrosides","volume":"221","author":"HE Carter","year":"1956","journal-title":"J Biol Chem"},{"issue":"11","key":"pone.0241640.ref025","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1038\/nn.2946","article-title":"Central nervous system pericytes in health and disease","volume":"14","author":"EA Winkler","year":"2011","journal-title":"Nat Neurosci"},{"issue":"1","key":"pone.0241640.ref026","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nbd.2003.12.016","article-title":"The blood-brain barrier: an overview: structure, regulation, and clinical implications","volume":"16","author":"P Ballabh","year":"2004","journal-title":"Neurobiol Dis"},{"key":"pone.0241640.ref027","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.jconrel.2020.03.001","article-title":"Novel cyclic peptides facilitating transcellular blood-brain barrier transport of macromolecules in vitro and in vivo","volume":"321","author":"S Yamaguchi","year":"2020","journal-title":"J Control Release"},{"issue":"2","key":"pone.0241640.ref028","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1007\/s11418-020-01388-8","article-title":"Accelerative effects of carbazole-type alkaloids from Murraya koenigii on neurite outgrowth and their derivative's in vivo study for spatial memory","volume":"74","author":"M Yano","year":"2020","journal-title":"J Nat Med"},{"issue":"1","key":"pone.0241640.ref029","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1007\/s11418-019-01368-7","article-title":"BBB-permeable aporphine-type alkaloids in Nelumbo nucifera flowers with accelerative effects on neurite outgrowth in PC-12 cells","volume":"74","author":"M Yano","year":"2020","journal-title":"J Nat Med"},{"issue":"16","key":"pone.0241640.ref030","doi-asserted-by":"crossref","first-page":"16943","DOI":"10.1021\/acsomega.9b02307","article-title":"Brain Targeting of Acyl-CoA:Cholesterol O-Acyltransferase-1 Inhibitor K-604 via the Intranasal Route Using a Hydroxycarboxylic Acid Solution.","volume":"4","author":"K Shibuya","year":"2019","journal-title":"ACS Omega."},{"issue":"20","key":"pone.0241640.ref031","doi-asserted-by":"crossref","first-page":"3650","DOI":"10.1038\/sj.onc.1207430","article-title":"Mitochondrial ceramide increases in UV-irradiated HeLa cells and is mainly derived from hydrolysis of sphingomyelin","volume":"23","author":"Q Dai","year":"2004","journal-title":"Oncogene"},{"issue":"3","key":"pone.0241640.ref032","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1091\/mbc.e04-07-0594","article-title":"Golgi fragmentation is associated with ceramide-induced cellular effects","volume":"16","author":"W Hu","year":"2005","journal-title":"Mol Biol Cell"},{"issue":"2","key":"pone.0241640.ref033","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1124\/pr.57.2.4","article-title":"The blood-brain barrier\/neurovascular unit in health and disease.","volume":"57","author":"BT Hawkins","year":"2005","journal-title":"Pharmacol Rev."},{"key":"pone.0241640.ref034","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1093\/jn\/124.5.702","article-title":"Uptake and metabolism of sphingolipids in isolated intestinal loops of mice","volume":"124","author":"EM Schmelz","year":"1994","journal-title":"J Nutr"},{"key":"pone.0241640.ref035","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.neuron.2017.07.030","article-title":"The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease","volume":"96","author":"C Iadecola","year":"2017","journal-title":"Neuron"},{"key":"pone.0241640.ref036","doi-asserted-by":"crossref","first-page":"e49405","DOI":"10.7554\/eLife.49405","article-title":"Apolipoprotein M-bound sphingosine-1-phosphate regulates blood-brain barrier paracellular permeability and transcytosis.","volume":"8","author":"M Mathiesen Janiurek","year":"2019","journal-title":"Elife"},{"key":"pone.0241640.ref037","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/nature13241","article-title":"Mfsd2a is a transporter for the essential omega-3 fatty acid docosahexaenoic acid","volume":"509","author":"LN Nguyen","year":"2014","journal-title":"Nature"},{"key":"pone.0241640.ref038","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/nature10742","article-title":"Molecular recognition of a single sphingolipid species by a protein's transmembrane domain","volume":"481","author":"FX Contreras","year":"2012","journal-title":"Nature"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0241640","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,11]],"date-time":"2021-04-11T19:46:36Z","timestamp":1618170396000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0241640"}},"subtitle":[],"editor":[{"given":"M\u00e1ria A.","family":"Deli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,11,2]]},"references-count":38,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020,11,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0241640","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,2]]}}}