{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:51:56Z","timestamp":1790704316043,"version":"4.1.0"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T00:00:00Z","timestamp":1605052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006387","name":"Fondation Leenaards","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006387","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Aim<\/jats:title>\n<jats:p>We aimed to identify variables associated with gestational age at full oral feeding in a cohort of very preterm infants.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>In this retrospective study, all infants born below 32 weeks of gestation and admitted to a level III neonatal unit in 2015 were included. We dichotomized our population of 122 infants through the median age at full oral feeding, and explored which variables were statistically different between the two groups. We then used linear regression analysis to study the association between variables known from the literature and variables we had identified and age at full oral feeding.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>The median postnatal age at full oral feeding was 36 6\/7weeks post menstrual age (Q1-Q3 35 6\/7-392\/7), and was associated with the duration of hospital of stay. In the univariable linear regression, the variables significantly associated with full oral feeding were gestational age, socioeconomic status, sepsis, patent ductus arteriosus, duration of supplementary oxygen, of non-invasive and invasive ventilation, and bronchopulmonary dysplasia. In the multivariable regression analysis, duration of non-invasive ventilation and oxygen therapy, bronchopulmonary dysplasia, and patent ductus arteriosus were associated with an older age at full oral feeding, with bronchopulmonary dysplasia the single most potent predictor.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Discussion<\/jats:title>\n<jats:p>Lung disease severity is a major determinant of age at full oral feeding and thus length of stay in this population. Other factors associated with FOF include socioeconomic status and patent ductus arteriosus, There is a need for research addressing evidence-based bundles of care for these infants at risk of long-lasting feeding and neurodevelopmental impairments.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0241769","type":"journal-article","created":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T18:42:15Z","timestamp":1605120135000},"page":"e0241769","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["Factors associated with postmenstrual age at full oral feeding in very preterm infants"],"prefix":"10.1371","volume":"15","author":[{"given":"Gr\u00e9goire","family":"Brun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line J.","family":"Fischer Fumeaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Giannoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2733-3588","authenticated-orcid":true,"given":"Myriam","family":"Bickle Graz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,11,11]]},"reference":[{"issue":"Suppl 1","key":"pone.0241769.ref001","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1186\/1742-4755-10-S1-S2","article-title":"Born Too Soon: The global epidemiology of 15 million preterm births.","volume":"10","author":"H Blencowe","year":"2013","journal-title":"Reproductive Health."},{"issue":"3","key":"pone.0241769.ref002","first-page":"e20172169","volume":"141","author":"J Schneider","year":"2018","journal-title":"Nutrient Intake in the First Two Weeks of Life and Brain Growth in Preterm Neonates"},{"key":"pone.0241769.ref003","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.earlhumdev.2016.08.006","article-title":"Does parental involvement affect the development of feeding skills in preterm infants? 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