{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T04:12:59Z","timestamp":1747195979025,"version":"3.40.5"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T00:00:00Z","timestamp":1604620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objective<\/jats:title>\n<jats:p>Evaluate the performance of QuantiFERON \u00ae -TB Gold In-Tube test (QFT-GIT), to improve the diagnosis of active tuberculosis (TB) in Human Immuno-Deficiency Virus (HIV)-infected children.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Method<\/jats:title>\n<jats:p>Sensitivity, specificity, Positive Predictive Value (PPV), Negative Predictive Value (NPV) of QFT-GIT were assessed in 58\/63 HIV-infected children who were suspected of having TB.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Sensitivity of QFT-GIT was 20.69%, specificity 96.55%, PPV\/NPV respectively 85.71% and 54.90%.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>QFT-GIT appears to be of little contribution to the diagnosis of active TB in children living with HIV in a TB-endemic country.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0241789","type":"journal-article","created":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T18:28:13Z","timestamp":1604687293000},"page":"e0241789","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Performance of a lymphocyte t interferon gamma test (Quantiferon-TB gold in tube) in the 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