{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T09:38:44Z","timestamp":1784367524591,"version":"3.55.0"},"reference-count":55,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T00:00:00Z","timestamp":1605657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2016-04620"],"award-info":[{"award-number":["RGPIN-2016-04620"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2015-06219"],"award-info":[{"award-number":["RGPIN-2015-06219"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Pain induces deficits in appreciation of rewards (i.e. anhedonia) and variation in response to pain may be partly explained by individual differences in general expectations (i.e. optimism). Dairy calves are routinely subjected to painful procedures such as hot-iron disbudding. We tested if female Holstein calves (n = 17) display signs of anhedonia (as evidenced by reduced consumption of a sweet solution) after hot-iron disbudding (performed under general and local anesthesia), and whether individual differences in optimism explain the variation in this response. Individual variation in optimism was measured using responses to two judgment bias tests (performed when calves were 25 d old), and anhedonia was measured by comparing consumption of a sweet solution before and after hot-iron disbudding. We found that intake of the sweet solution declined (by mean \u00b1 SD: 48.4 \u00b1 44.3%) on the day after disbudding, and that more pessimistic calves were more affected. Sweet solution consumption did not return to baseline for the duration of the study (i.e. 5 days). Calves reduced their intake of a sweet solution after hot-iron disbudding, consistent with pain-induced anhedonia, and more pessimistic calves showed stronger evidence of anhedonia, suggesting that they were more affected by the procedure. However, our results cannot rule out the possibility that calf responses were driven by anorexia.<\/jats:p>","DOI":"10.1371\/journal.pone.0242100","type":"journal-article","created":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T18:46:08Z","timestamp":1605725168000},"page":"e0242100","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["Pessimistic dairy calves are more vulnerable to pain-induced anhedonia"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5973-7152","authenticated-orcid":true,"given":"Benjamin","family":"Lecorps","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emeline","family":"Nogues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina A. G.","family":"von Keyserlingk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0917-3982","authenticated-orcid":true,"given":"Daniel M.","family":"Weary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,11,18]]},"reference":[{"key":"pone.0242100.ref001","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1097\/j.pain.0000000000000613","article-title":"Updating the definition of pain","volume":"157","author":"ACDC Williams","year":"2016","journal-title":"Pain"},{"key":"pone.0242100.ref002","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.anbehav.2014.09.007","article-title":"Defining and assessing animal pain","author":"LU Sneddon","year":"2014","journal-title":"Anim Behav"},{"key":"pone.0242100.ref003","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.neubiorev.2013.12.006","article-title":"Psychological processing in chronic pain: A neural systems approach","volume":"39","author":"LE Simons","year":"2014","journal-title":"Neurosci Biobehav Rev"},{"key":"pone.0242100.ref004","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.neubiorev.2005.01.002","article-title":"Measuring emotional processes in animals: the utility of a cognitive approach","volume":"29","author":"ES Paul","year":"2005","journal-title":"Neurosci Biobehav Rev"},{"key":"pone.0242100.ref005","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.neubiorev.2010.06.006","article-title":"Reconsidering anhedonia in depression: Lessons from translational neuroscience","volume":"35","author":"MT Treadway","year":"2011","journal-title":"Neurosci Biobehav Rev"},{"key":"pone.0242100.ref006","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.jpain.2008.09.010","article-title":"Individual differences in pain sensitivity: Measurement, causation, and consequences","author":"CS Nielsen","year":"2009","journal-title":"J Pain"},{"key":"pone.0242100.ref007","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1111\/j.1526-4610.2010.01763.x","article-title":"Individual differences in the subjective experience of pain: New insights into mechanisms and models","author":"RC Coghill","year":"2010","journal-title":"Headache"},{"key":"pone.0242100.ref008","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1080\/21507740.2018.1496180","article-title":"Cognition doesn\u2019t only modulate pain perception; It\u2019s a central component of it","volume":"9","author":"K Wiech","year":"2018","journal-title":"AJOB Neurosci"},{"key":"pone.0242100.ref009","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s10865-012-9463-8","article-title":"More optimism, less pain! 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