{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:22:15Z","timestamp":1790670135351,"version":"4.1.0"},"reference-count":63,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T00:00:00Z","timestamp":1605139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["GM24417-39\/40"],"award-info":[{"award-number":["GM24417-39\/40"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Although current malaria therapies inhibit pathways encoded in the parasite\u2019s genome, we have looked for anti-malaria drugs that can target an erythrocyte component because development of drug resistance might be suppressed if the parasite cannot mutate the drug\u2019s target. In search for such erythrocyte targets, we noted that human erythrocytes express tyrosine kinases, whereas the<jats:italic>Plasmodium falciparum<\/jats:italic>genome encodes no obvious tyrosine kinases. We therefore screened a library of tyrosine kinase inhibitors from Eli Lilly and Co. in a search for inhibitors with possible antimalarial activity. We report that although most tyrosine kinase inhibitors exerted no effect on parasite survival, a subset of tyrosine kinase inhibitors displayed potent anti-malarial activity. Moreover, all inhibitors found to block tyrosine phosphorylation of band 3 specifically suppressed<jats:italic>P<\/jats:italic>.<jats:italic>falciparum<\/jats:italic>survival at the parasite egress stage of its intra-erythrocyte life cycle. Conversely, tyrosine kinase inhibitors that failed to block band 3 tyrosine phosphorylation but still terminated the parasitemia were observed to halt parasite proliferation at other stages of the parasite\u2019s life cycle. Taken together these results suggest that certain erythrocyte tyrosine kinases may be important to<jats:italic>P<\/jats:italic>.<jats:italic>falciparum<\/jats:italic>maturation and that inhibitors that block these kinases may contribute to novel therapies for<jats:italic>P<\/jats:italic>.<jats:italic>falciparum<\/jats:italic>malaria.<\/jats:p>","DOI":"10.1371\/journal.pone.0242372","type":"journal-article","created":{"date-parts":[[2020,11,12]],"date-time":"2020-11-12T18:52:25Z","timestamp":1605207145000},"page":"e0242372","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["Identification of tyrosine kinase inhibitors that halt Plasmodium falciparum parasitemia"],"prefix":"10.1371","volume":"15","author":[{"given":"Kristina","family":"Kesely","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panae","family":"Noomuna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Vieth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Hipskind","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasturi","family":"Haldar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Pantaleo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Turrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip S.","family":"Low","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,11,12]]},"reference":[{"key":"pone.0242372.ref001","unstructured":"WHO. Top 10 Causes of Death [Internet]. 2018 [cited 2020 Apr 11]. Available from: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/the-top-10-causes-of-death."},{"key":"pone.0242372.ref002","doi-asserted-by":"crossref","first-page":"363","DOI":"10.2147\/IDR.S223873","article-title":"Prevalence of Malaria and Associated Risk Factors Among Febrile Children Under Five Years: A Cross-Sectional Study in Arba Minch Zuria District, South Ethiopia.","volume":"13","author":"A Abossie","year":"2020","journal-title":"Infect Drug Resist"},{"issue":"2","key":"pone.0242372.ref003","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.medmal.2019.06.002","article-title":"Changes in malaria epidemiology in France and worldwide, 2000\u20132015.","volume":"50","author":"M Thellier","year":"2020","journal-title":"M\u00e9decine Mal Infect"},{"issue":"2","key":"pone.0242372.ref004","article-title":"To study the outcome of life threatening complications in patients with complicated malaria.","volume":"4","author":"Kishorilal Prajapati","year":"2020","journal-title":"Int J Med Biomed Stud"},{"issue":"11","key":"pone.0242372.ref005","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1586\/eri.12.123","article-title":"Malaria in pregnancy: diagnosing infection and identifying fetal risk.","volume":"10","author":"AL Conroy","year":"2012","journal-title":"Expert Rev Anti Infect Ther."},{"issue":"10","key":"pone.0242372.ref006","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002914","article-title":"Early malaria infection, dysregulation of angiogenesis, metabolism and inflammation across pregnancy, and risk of preterm birth in Malawi: A cohort study.","volume":"16","author":"RE Elphinstone","year":"2019","journal-title":"PLoS Med."},{"key":"pone.0242372.ref007","unstructured":"WHO. Malaria [Internet]. 2020. Available from: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/malaria."},{"key":"pone.0242372.ref008","unstructured":"WHO. Malaria [Internet]. 2019 [cited 2019 Feb 10]. Available from: https:\/\/www.who.int\/news-room\/facts-in-pictures\/detail\/malaria."},{"issue":"6","key":"pone.0242372.ref009","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/S1473-3099(12)70064-6","article-title":"Poor-quality antimalarial drugs in southeast Asia and sub-Saharan Africa.","volume":"12","author":"GML Nayyar","year":"2012","journal-title":"Lancet Infect Dis"},{"key":"pone.0242372.ref010","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1051\/parasite\/2018021","article-title":"Plasmodium falciparum resistance to artemisinin-based combination therapies: A sword of Damocles in the path toward malaria elimination TT\u2014R\u00e9sistance de Plasmodium falciparum aux combinaisons th\u00e9rapeutiques \u00e0 base d\u2019art\u00e9misinine\u2009: une \u00e9p\u00e9e de Damocl\u00e8s.","volume":"25","author":"M Ouji","year":"2018","journal-title":"Parasite"},{"issue":"3","key":"pone.0242372.ref011","doi-asserted-by":"crossref","DOI":"10.1128\/microbiolspec.EI10-0013-2016","article-title":"Artemisinin-resistant Plasmodium falciparum malaria.","volume":"4","author":"RM Fairhurst","year":"2016","journal-title":"Microbiol Spectr"},{"issue":"7481","key":"pone.0242372.ref012","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/nature12876","article-title":"A molecular marker of artemisinin-resistant Plasmodium falciparum malaria","volume":"505","author":"F Ariey","year":"2014","journal-title":"Nature"},{"issue":"10","key":"pone.0242372.ref013","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1056\/NEJMc1612765","article-title":"Emergence of Indigenous Artemisinin-Resistant Plasmodium falciparum in Africa","volume":"376","author":"F Lu","year":"2017","journal-title":"N Engl J Med"},{"issue":"5","key":"pone.0242372.ref014","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1056\/NEJMoa0808859","article-title":"Artemisinin Resistance in Plasmodium falciparum Malaria","volume":"361","author":"AM Dondorp","year":"2009","journal-title":"N Engl J Med"},{"issue":"2","key":"pone.0242372.ref015","first-page":"82","article-title":"Resistance of Plasmodium falciparum to Sulfadoxine-Pyrimethamine (Dhfr and Dhps) and Artemisinin and Its Derivatives (K13): A Major Challenge for Malaria Elimination in West Africa.","volume":"8","author":"Val\u00e9rie B. Bazie","year":"2020","journal-title":"J Biosci Med"},{"issue":"10233","key":"pone.0242372.ref016","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/S0140-6736(20)30560-2","article-title":"Are three drugs for malaria better than two?","volume":"395","author":"PJ Rosenthal","year":"2020","journal-title":"Lancet"},{"issue":"10","key":"pone.0242372.ref017","doi-asserted-by":"crossref","first-page":"e338","DOI":"10.1016\/S1473-3099(19)30261-0","article-title":"Antimalarial drug resistance in Africa: the calm before the storm?","volume":"19","author":"MD Conrad","year":"2019","journal-title":"Lancet Infect Dis"},{"issue":"1","key":"pone.0242372.ref018","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1186\/s12936-020-03247-z","article-title":"Malaria in Venezuela: changes in the complexity of infection reflects the increment in transmission intensity.","volume":"19","author":"MA Pacheco","year":"2020","journal-title":"Malar J"},{"issue":"1","key":"pone.0242372.ref019","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s40249-016-0151-8","article-title":"Malaria: Global progress 2000\u20132015 and future challenges.","volume":"5","author":"RE Cibulskis","year":"2016","journal-title":"Infect Dis Poverty"},{"issue":"48","key":"pone.0242372.ref020","doi-asserted-by":"crossref","first-page":"13732","DOI":"10.1073\/pnas.1611904113","article-title":"Global transformation of erythrocyte properties via engagement of an SH2-like sequence in band 3","volume":"113","author":"E Puchulu-Campanella","year":"2016","journal-title":"Proc Natl Acad Sci"},{"issue":"22","key":"pone.0242372.ref021","doi-asserted-by":"crossref","first-page":"5998","DOI":"10.1182\/blood-2010-11-317024","article-title":"Regulation of membrane-cytoskeletal interactions by tyrosine phosphorylation of erythrocyte band 3","volume":"117","author":"E Ferru","year":"2011","journal-title":"Blood"},{"issue":"4","key":"pone.0242372.ref022","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1111\/bjh.16671","article-title":"Inhibition of Band 3 tyrosine phosphorylation: a new mechanism for treatment of sickle cell disease","volume":"190","author":"P Noomuna","year":"2020","journal-title":"Br J Haematol"},{"issue":"19","key":"pone.0242372.ref023","doi-asserted-by":"crossref","first-page":"3469","DOI":"10.1002\/pmic.201000269","article-title":"Analysis of changes in tyrosine and serine phosphorylation of red cell membrane proteins induced by P. falciparum growth","volume":"10","author":"A Pantaleo","year":"2010","journal-title":"Proteomics"},{"issue":"10","key":"pone.0242372.ref024","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0164895","article-title":"Inhibition of an Erythrocyte Tyrosine Kinase with Imatinib Prevents Plasmodium falciparum Egress and Terminates Parasitemia.","volume":"11","author":"KR Kesely","year":"2016","journal-title":"PLoS One"},{"key":"pone.0242372.ref025","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/1471-2164-5-79","article-title":"Protein kinases of the human malaria parasite Plasmodium falciparum: the kinome of a divergent eukaryote","volume":"5","author":"P Ward","year":"2004","journal-title":"BMC Genomics"},{"key":"pone.0242372.ref026","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/ncomms1558","article-title":"Global kinomic and phospho-proteomic analyses of the human malaria parasite Plasmodium falciparum.","volume":"2","author":"L Solyakov","year":"2011","journal-title":"Nat Commun"},{"issue":"2","key":"pone.0242372.ref027","doi-asserted-by":"crossref","first-page":"131","DOI":"10.2174\/138955706775475939","article-title":"The use of anticancer drugs in antiparasitic chemotherapy.","volume":"6","author":"M-Q Klinkert","year":"2006","journal-title":"Mini Rev Med Chem"},{"issue":"6","key":"pone.0242372.ref028","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1111\/j.1462-5822.2011.01582.x","article-title":"Activation of a PAK-MEK signalling pathway in malaria parasite-infected erythrocytes","volume":"13","author":"A Sicard","year":"2011","journal-title":"Cell Microbiol"},{"issue":"12","key":"pone.0242372.ref029","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.0030528","article-title":"Erythrocyte G protein as a novel target for malarial chemotherapy.","volume":"3","author":"SC Murphy","year":"2006","journal-title":"PLoS Med"},{"issue":"7","key":"pone.0242372.ref030","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0002732","article-title":"Genistein-supplemented diet decreases malaria liver infection in mice and constitutes a potential prophylactic strategy","volume":"3","author":"M Cunha-Rodrigues","year":"2008","journal-title":"PLoS One"},{"issue":"6","key":"pone.0242372.ref031","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1007\/BF01969742","article-title":"Inhibition of invasion and intraerythrocytic development of Plasmodium falciparum by kinase inhibitors","volume":"52","author":"AR Dluzewski","year":"1996","journal-title":"Experientia"},{"issue":"2","key":"pone.0242372.ref032","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1039\/C4MD00441H","article-title":"Evaluation of aromatic 6-substituted thienopyramidines as scaffolds against parasites that cause trypanosomiasis, leishmaniasis, and malaria.","volume":"6","author":"JL Woodring","year":"2015","journal-title":"Medchemcomm"},{"issue":"4254","key":"pone.0242372.ref033","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1126\/science.781840","article-title":"Human malaria parasites in continuous culture","volume":"193","author":"W Trager","year":"1976","journal-title":"Science"},{"issue":"6","key":"pone.0242372.ref034","doi-asserted-by":"crossref","first-page":"3608","DOI":"10.1128\/AAC.02896-15","article-title":"Oxadiazoles Have Butyrate-Specific Conditional Activity against Mycobacterium tuberculosis","volume":"60","author":"JV Early","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"issue":"10 Pt B","key":"pone.0242372.ref035","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1016\/j.bbapap.2015.03.014","article-title":"Perspective on computational and structural aspects of kinase discovery from IPK2014","volume":"1854","author":"E Martin","year":"2015","journal-title":"Biochim Biophys Acta"},{"issue":"7","key":"pone.0242372.ref036","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/j.bbapap.2012.12.023","article-title":"What general conclusions can we draw from kinase profiling data sets?","volume":"1834","author":"JJ Sutherland","year":"2013","journal-title":"Biochim Biophys Acta\u2014Proteins Proteomics"},{"issue":"8","key":"pone.0242372.ref037","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1182\/blood-2016-11-748053","article-title":"Syk inhibitors interfere with erythrocyte membrane modification during P falciparum growth and suppress parasite egress","volume":"130","author":"A Pantaleo","year":"2017","journal-title":"Blood"},{"issue":"2\u20133","key":"pone.0242372.ref038","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0162-0134(03)00236-8","article-title":"Mechanism of insulin sensitization by BMOV (bis maltolato oxo vanadium); unliganded vanadium (VO4) as the active component.","volume":"96","author":"KG Peters","year":"2003","journal-title":"J Inorg Biochem"},{"issue":"2","key":"pone.0242372.ref039","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1021\/cr020607t","article-title":"The chemistry and biochemistry of vanadium and the biological activities exerted by vanadium compounds","volume":"104","author":"DC Crans","year":"2004","journal-title":"Chem Rev"},{"issue":"1","key":"pone.0242372.ref040","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1182\/blood.V100.1.276","article-title":"Band 3 is an anchor protein and a target for SHP-2 tyrosine phosphatase in human erythrocytes","volume":"100","author":"L Bordin","year":"2002","journal-title":"Blood"},{"issue":"12","key":"pone.0242372.ref041","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0004015","article-title":"The Effect of Oxidant and the Non-Oxidant Alteration of Cellular Thiol Concentration on the Formation of Protein Mixed-Disulfides in HEK 293 Cells.","volume":"3","author":"JL Gilge","year":"2008","journal-title":"PLoS One"},{"issue":"1\u20133","key":"pone.0242372.ref042","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/0014-5793(91)81405-W","article-title":"Inhibition of protein tyrosine phosphatase activity by diamide is reversed by epidermal growth factor in fibroblasts","volume":"295","author":"HP Monteiro","year":"1991","journal-title":"FEBS Lett"},{"issue":"5367","key":"pone.0242372.ref043","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1126\/science.280.5367.1212","article-title":"Kinases and Phosphatases\u2014A Marriage Is Consummated","volume":"280","author":"E Hafen","year":"1998","journal-title":"Science (80-)"},{"issue":"2","key":"pone.0242372.ref044","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0092-8674(95)90405-0","article-title":"Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling","volume":"80","author":"T Hunter","year":"1995","journal-title":"Cell"},{"issue":"30","key":"pone.0242372.ref045","doi-asserted-by":"crossref","first-page":"15052","DOI":"10.1073\/pnas.1900163116","article-title":"Dynamic allostery-based molecular workings of kinase:peptide complexes","volume":"116","author":"LG Ahuja","year":"2019","journal-title":"Proc Natl Acad Sci"},{"issue":"1","key":"pone.0242372.ref046","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s10822-011-9517-y","article-title":"The future of molecular dynamics simulations in drug discovery","volume":"26","author":"DW Borhani","year":"2012","journal-title":"J Comput Aided Mol Des"},{"issue":"15","key":"pone.0242372.ref047","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1002\/jcc.24714","article-title":"Are induced fit protein conformational changes caused by ligand-binding predictable? A molecular dynamics investigation","volume":"38","author":"C Gao","year":"2017","journal-title":"J Comput Chem"},{"issue":"5","key":"pone.0242372.ref048","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.1021\/acs.jctc.7b01170","article-title":"Predicting the Conformational Variability of Abl Tyrosine Kinase using Molecular Dynamics Simulations and Markov State Models.","volume":"14","author":"Y Meng","year":"2018","journal-title":"J Chem Theory Comput"},{"issue":"7","key":"pone.0242372.ref049","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1021\/ja512751q","article-title":"Accurate and reliable prediction of relative ligand binding potency in prospective drug discovery by way of a modern free-energy calculation protocol and force field","volume":"137","author":"L Wang","year":"2015","journal-title":"J Am Chem Soc"},{"issue":"11","key":"pone.0242372.ref050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1004578","article-title":"Towards a Molecular Understanding of the Link between Imatinib Resistance and Kinase Conformational Dynamics.","volume":"11","author":"S Lovera","year":"2015","journal-title":"PLoS Comput Biol"},{"issue":"2","key":"pone.0242372.ref051","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/S0021-9258(17)42204-6","article-title":"Phosphorylation of human erythrocyte band 3 by endogenous p72syk","volume":"269","author":"ML Harrison","year":"1994","journal-title":"J Biol Chem"},{"issue":"2","key":"pone.0242372.ref052","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1042\/BJ20081557","article-title":"Oxidized and poorly glycosylated band 3 is selectively phosphorylated by Syk kinase to form large membrane clusters in normal and G6PD-deficient red blood cells","volume":"418","author":"A Pantaleo","year":"2009","journal-title":"Biochem J"},{"issue":"1","key":"pone.0242372.ref053","doi-asserted-by":"crossref","first-page":"4015","DOI":"10.1038\/s41467-020-17829-7","article-title":"Analysis of erythrocyte signalling pathways during Plasmodium falciparum infection identifies targets for host-directed antimalarial intervention.","volume":"11","author":"JD Adderley","year":"2020","journal-title":"Nat Commun"},{"issue":"1","key":"pone.0242372.ref054","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0009-9120(02)00423-X","article-title":"Oxidative stress in patients with non-complicated malaria","volume":"36","author":"A Pab\u00f3n","year":"2003","journal-title":"Clin Biochem"},{"issue":"2","key":"pone.0242372.ref055","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ijpara.2003.09.011","article-title":"Oxidative stress in malaria parasite-infected erythrocytes: host\u2013parasite interactions","volume":"34","author":"K Becker","year":"2004","journal-title":"Int J Parasitol"},{"issue":"5","key":"pone.0242372.ref056","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1179\/135100003225002934","article-title":"Oxidative stress and rheology in severe malaria","volume":"8","author":"AM Dondorp","year":"2003","journal-title":"Redox Rep"},{"issue":"1\u20132","key":"pone.0242372.ref057","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/S0014-5793(97)00263-9","article-title":"Erythrocyte thiol status regulates band 3 phosphotyrosine level via oxidation\/reduction of band 3-associated phosphotyrosine phosphatase","volume":"406","author":"Y Zipser","year":"1997","journal-title":"FEBS Lett"},{"issue":"1","key":"pone.0242372.ref058","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1006\/abbi.1993.1205","article-title":"Role of oxygen and carbon radicals in hemoglobin oxidation","volume":"302","author":"M Minetti","year":"1993","journal-title":"Arch Biochem Biophys"},{"issue":"753","key":"pone.0242372.ref059","article-title":"Syk Kinase Inhibitors Synergize with Artemisinins by Enhancing Oxidative Stress in Plasmodium falciparum-Parasitized Erythrocytes.","volume":"9","author":"I. Tsamesidis","year":"2020","journal-title":"Antioxidants."},{"key":"pone.0242372.ref060","article-title":"Band 3 Erythrocyte Membrane Protein Acts as Redox Stress Sensor Leading to Its Phosphorylation by p72 Syk.","volume":"2016","author":"A Pantaleo","year":"2016","journal-title":"Hindawi"},{"issue":"5","key":"pone.0242372.ref061","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/j.cell.2011.07.020","article-title":"Global proteomic assessment of the classical protein-tyrosine phosphatome and \u201cRedoxome.\u201d","volume":"146","author":"R Karisch","year":"2011","journal-title":"Cell"},{"issue":"Pt 1","key":"pone.0242372.ref062","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1042\/bj20020359","article-title":"Ca2+ promotes erythrocyte band 3 tyrosine phosphorylation via dissociation of phosphotyrosine phosphatase from band 3","volume":"368","author":"Y Zipser","year":"2002","journal-title":"Biochem J"},{"issue":"9","key":"pone.0242372.ref063","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1182\/blood-2009-02-203216","article-title":"Adducin forms a bridge between the erythrocyte membrane and its cytoskeleton and regulates membrane cohesion","volume":"114","author":"WA Anong","year":"2009","journal-title":"Blood"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0242372","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,27]],"date-time":"2022-11-27T21:59:21Z","timestamp":1669586361000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0242372"}},"subtitle":[],"editor":[{"given":"Gordon","family":"Langsley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,11,12]]},"references-count":63,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2020,11,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0242372","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,12]]}}}