{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T12:20:13Z","timestamp":1776774013164,"version":"3.51.2"},"reference-count":65,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T00:00:00Z","timestamp":1605571200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000182","name":"Medical Research and Materiel Command","doi-asserted-by":"publisher","award":["A-14-002"],"award-info":[{"award-number":["A-14-002"]}],"id":[{"id":"10.13039\/100000182","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\"><jats:title>Background and objective<\/jats:title><jats:p>Resuscitative Endovascular Balloon Occlusion of Aorta (REBOA) has emerged as a potential life-saving maneuver for the management of non-compressible torso hemorrhage in trauma patients. Complete REBOA (cREBOA) is inherently associated with the burden of ischemia reperfusion injury (IRI) and organ dysfunction. However, the distal organ inflammation and its association with organ injury have been little investigated. This study was conducted to assess these adverse effects of cREBOA following massive hemorrhage in swine.<\/jats:p><\/jats:sec><jats:sec id=\"sec002\"><jats:title>Methods<\/jats:title><jats:p>Spontaneously breathing and consciously sedated Sinclair pigs were subjected to exponential hemorrhage of 65% total blood volume over 60 minutes. Animals were randomized into 3 groups (n = 7): (1) Positive control (PC) received immediate transfusion of shed blood after hemorrhage, (2) 30min-cREBOA (A30) received Zone 1 cREBOA for 30 minutes, and (3) 60min-cREBOA (A60) given Zone 1 cREBOA for 60 minutes. The A30 and A60 groups were followed by resuscitation with shed blood post-cREBOA and observed for 4h. Metabolic and hemodynamic effects, coagulation parameters, inflammatory and end organ consequences were monitored and assessed.<\/jats:p><\/jats:sec><jats:sec id=\"sec003\"><jats:title>Results<\/jats:title><jats:p>Compared with 30min-cREBOA, 60min-cREBOA resulted in (1) increased IL-6, TNF-\u03b1, and IL-1\u03b2 in distal organs (kidney, jejunum, and liver) (<jats:italic>p<\/jats:italic>&lt; 0.05) and decreased reduced glutathione in kidney and liver (<jats:italic>p<\/jats:italic>&lt; 0.05), (2) leukopenia, neutropenia, and coagulopathy (<jats:italic>p<\/jats:italic>&lt; 0.05), (3) blood pressure decline (<jats:italic>p &lt;<\/jats:italic>0.05), (4) metabolic acidosis and hyperkalemia (<jats:italic>p<\/jats:italic>&lt; 0.05), and (5) histological injury of kidney and jejunum (<jats:italic>p<\/jats:italic>&lt; 0.05) as well as higher levels of creatinine, AST, and ALT (<jats:italic>p<\/jats:italic>&lt; 0.05).<\/jats:p><\/jats:sec><jats:sec id=\"sec004\"><jats:title>Conclusion<\/jats:title><jats:p>30min-cREBOA seems to be a feasible and effective adjunct in supporting central perfusion during severe hemorrhage. However, prolonged cREBOA (60min) adverse effects such as distal organ inflammation and injury must be taken into serious consideration.<\/jats:p><\/jats:sec>","DOI":"10.1371\/journal.pone.0242450","type":"journal-article","created":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T18:26:48Z","timestamp":1605637608000},"page":"e0242450","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":22,"title":["Distal organ inflammation and injury after resuscitative endovascular balloon occlusion of the aorta in a porcine model of severe hemorrhagic shock"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7570-9888","authenticated-orcid":true,"given":"Yansong","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael 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