{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T20:10:34Z","timestamp":1790453434904,"version":"4.1.0"},"reference-count":48,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T00:00:00Z","timestamp":1605830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["26305-9"],"award-info":[{"award-number":["26305-9"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Muscle depletion and sarcopenic obesity are related to a higher morbimortality risk in chronic kidney disease (CKD). We evaluated bed-side measures\/indexes associated with low muscle mass, sarcopenia, obesity, and sarcopenic obesity in CKD and proposed cutoffs for each parameter. Sarcopenia was diagnosed according to the European Working Group on Sarcopenia in Older People revised consensus applying dual energy X-ray absorptiometry (DXA) and hand grip strength (HGS), and obesity according to the International Society for Clinical Densitometry. Anthropometric parameters including calf (CC) and waist (WC) circumferences and WC\/height (WC\/H); bioelectrical impedance data including appendicular fat free mass (AFFM) and fat mass index (FMI) were assessed. ROC analysis and area under the curve (AUC) were applied for performance analyses. AFFM and CC presented the best performances for low muscle mass diagnosis\u2013AFFM AUC for women was 0.96 and for men, 0.94, and CC AUC for women was 0.89 and for men, 0.85. FMI and WC\/H were the best parameters for obesity diagnosis\u2013FMI AUC for women was 0.99 and for men, 0.96, and WC\/H AUC for women was 0.94 and for men, 0.95. The cutoffs (sensibility and specificity, respectively) for women were AFFM\u226415.87 (90%; 96%), CC\u226435.5 (76%; 94%), FMI&gt;12.58 (100%; 93%), and WC\/H&gt;0.66 (91%; 84%); and for men, AFFM\u226421.43 (98%; 84%), CC\u226437 (88%; 69%), FMI&gt;8.82 (93%; 88%), and WC\/H&gt;0.60 (95%; 80%). Sensibility and specificity for sarcopenia diagnosis were for AFFM+HGS in women 85% and 99% and in men, 100% and 99%; for CC+HGS in women 85% and 99% and in men, 100% and 100%; and for sarcopenic obesity were for FMI+AFFM in women 75% and 97% and in men, 75% and 95%. The tested bed-side measures\/indexes presented excellent performance.<\/jats:p>","DOI":"10.1371\/journal.pone.0242671","type":"journal-article","created":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T21:06:40Z","timestamp":1605906400000},"page":"e0242671","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":34,"title":["Bed-side measures for diagnosis of low muscle mass, sarcopenia, obesity, and sarcopenic obesity in patients with chronic kidney disease under non-dialysis-dependent, dialysis dependent and kidney transplant therapy"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4966-314X","authenticated-orcid":true,"given":"Nat\u00e1lia Tomborelli","family":"Bellafronte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Ruiz","family":"Sizoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Vega-Piris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula Garcia","family":"Chiarello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermina Barril","family":"Cuadrado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,11,20]]},"reference":[{"key":"pone.0242671.ref001","article-title":"Analysis of the Global Burden of Disease study highlights the global, regional, and national trends of chronic kidney disease epidemiology from 1990 to 2016","author":"Y Xie","year":"2018","journal-title":"Kidney Int"},{"key":"pone.0242671.ref002","article-title":"Prevalence and Disease Burden of Chronic Kidney Disease","author":"JC Lv","year":"2019","journal-title":"Advances in Experimental Medicine and Biology"},{"key":"pone.0242671.ref003","article-title":"Global Burden of Disease Study 2016 (GBD 2016) Results","author":"Institute for Health Metrics and Evaluation","year":"2017","journal-title":"Glob Burd Dis Collab Netw"},{"key":"pone.0242671.ref004","article-title":"Uraemic sarcopenia: Aetiology and implications","author":"IH Fahal","year":"2014","journal-title":"Nephrology Dialysis Transplantation"},{"key":"pone.0242671.ref005","article-title":"Mitochondrial activity and skeletal muscle insulin resistance in kidney disease","author":"JE Carr\u00e9","year":"2019","journal-title":"International Journal of Molecular Sciences"},{"key":"pone.0242671.ref006","article-title":"Sarcopenia, Obesity, and Mortality in US Adults With and Without Chronic Kidney Disease","author":"L Androga","year":"2017","journal-title":"Kidney Int Reports"},{"key":"pone.0242671.ref007","article-title":"Low appendicular muscle mass is associated with mortality in peritoneal dialysis patients: A single-center cohort study","author":"SH Kang","year":"2017","journal-title":"Eur J Clin Nutr"},{"key":"pone.0242671.ref008","article-title":"Sarcopenia and its components in adult renal transplant recipients: prevalence and association with body adiposity","author":"APM Menna Barreto","year":"2019","journal-title":"Br J Nutr"},{"key":"pone.0242671.ref009","article-title":"Body composition is associated with clinical outcomes in patients with non\u2013dialysis-dependent chronic kidney disease","author":"TY Lin","year":"2018","journal-title":"Kidney Int"},{"key":"pone.0242671.ref010","article-title":"Hidden Obesity in Dialysis Patients: Clinical Implications","author":"MK Abramowitz","year":"2016","journal-title":"Seminars in dialysis"},{"key":"pone.0242671.ref011","article-title":"Sarcopenia, Relative Sarcopenia and Excess Adiposity in Chronic Kidney Disease","author":"S Ziolkowski","year":"2018","journal-title":"JCSM Clin Reports"},{"key":"pone.0242671.ref012","article-title":"Impact of percent body fat on all-cause mortality among adequate dialysis patients with and without insulin resistance: A multi-center prospective cohort study","author":"Wong TC Duong T Van","year":"2019","journal-title":"Nutrients"},{"key":"pone.0242671.ref013","article-title":"The Official Positions of the International Society for Clinical Densitometry: Body Composition Analysis Reporting","author":"S Petak","year":"2013","journal-title":"J Clin Densitom"},{"key":"pone.0242671.ref014","author":"M Zamboni","year":"2019","journal-title":"Sarcopenia and obesity. 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