{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T02:32:54Z","timestamp":1781663574944,"version":"3.54.5"},"reference-count":49,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T00:00:00Z","timestamp":1607472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Treatment for peritoneal malignancy (PM) can include cytoreductive surgery (CRS) and heated intrapertioneal chemotherapy (HIPEC) and is associated with morbidity and mortality. Physical, psychological and nutritional outcomes are important pre-operatively. The aim of this pilot study was to investigate these outcomes in patients with PM before and after CRS-HIPEC.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Between June 2018 and November 2019, participants were recruited to a single-centre study. Primary outcome was cardiopulmonary exercise testing (CPET) variables oxygen uptake (VO<jats:sub>2<\/jats:sub>) at anaerobic threshold (AT) and at peak. Secondary outcome measures were upper and lower body strength, health related quality of life (HRQoL) and the surgical fear questionnaire. Exploratory outcomes included body mass index, nutrient intake and post-operative outcome. All participants were asked to undertake assessments pre CRS-HIPEC and 12 weeks following the procedure.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Thirty-nine patients were screened, 38 were eligible and 16 were recruited. Ten female and 6 male, median (IQR) age 53 (42\u201363) years. Of the 16 patients recruited, 14 proceeded with CRS-HIPEC and 10 competed the follow up assessment at week 12. Pre-operative VO<jats:sub>2<\/jats:sub> at AT and peak was 16.8 (13.7\u201318) ml.kg<jats:sup>-1<\/jats:sup>.min<jats:sup>-1<\/jats:sup> and 22.2 (19.3\u201325.3) ml.kg<jats:sup>-1<\/jats:sup>.min<jats:sup>-1<\/jats:sup>, upper body strength was 25.9 (20.3\u201341.5) kg, lower body strength was 14 (10.4\u201320.3) sec, HRQoL (overall health status) was 72.5 (46.3\u201380) % whilst overall surgical fear was 39 (30.5\u201351). The VO<jats:sub>2<\/jats:sub> at AT decreased significantly (p = 0.05) and HRQoL improved (p = 0.04) between pre and post- CRS-HIPEC. There were no significant differences for any of the other outcome measures.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>This pilot study showed a significant decrease in VO<jats:sub>2<\/jats:sub> at AT and an improvement in overall HRQoL at the 12 week follow up. The findings will inform a larger study design to investigate a prehabilitation and rehabilitation cancer survivorship programme.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0242816","type":"journal-article","created":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T21:55:45Z","timestamp":1607550945000},"page":"e0242816","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Physical, psychological and nutritional outcomes in a cohort of Irish patients with metastatic peritoneal malignancy scheduled for cytoreductive surgery (CRS) and heated intrapertioneal chemotherapy (HIPEC): An exploratory pilot study"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0842-672X","authenticated-orcid":true,"given":"Lisa","family":"Loughney","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noel","family":"McCaffrey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire M.","family":"Timon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Grundy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"McCarren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronan","family":"Cahill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niall","family":"Moyna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurgen","family":"Mulsow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,12,9]]},"reference":[{"issue":"1","key":"pone.0242816.ref001","first-page":"87","article-title":"Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for gastric cancer and other less common disease histologies: is it time?","volume":"7","author":"PL Feingold","year":"2016","journal-title":"J Gastrointest Oncol"},{"issue":"7","key":"pone.0242816.ref002","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1245\/s10434-012-2264-z","article-title":"The treatment of peritoneal carcinomatosis of colorectal cancer with complete cytoreductive surgery and hyperthermic intraperitoneal peroperative chemotherapy (HIPEC) with oxaliplatin: a Belgian multicentre prospective phase II clinical study","volume":"19","author":"D Hompes","year":"2012","journal-title":"Ann Surg Oncol"},{"key":"pone.0242816.ref003","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.critrevonc.2016.01.017","article-title":"Progress in treatments for colorectal cancer peritoneal metastases during the years 2010\u20132015: a systematic review","volume":"100","author":"D Baratti","year":"2016","journal-title":"Crit Rev Oncol Hematol"},{"issue":"3","key":"pone.0242816.ref004","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.clcc.2012.01.001","article-title":"Current status of cytoreductive surgery with hyperthermic intraperitoneal chemotherapy in patients with peritoneal carcinomatosis from colorectal cancer","volume":"11","author":"T Weber","year":"2012","journal-title":"Clin Colorectal Cancer"},{"issue":"5","key":"pone.0242816.ref005","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.jamcollsurg.2006.12.048","article-title":"Cytoreductive surgery and intraperitoneal hyperthermic chemotherapy for peritoneal surface malignancy: Experience with 501 procedures","volume":"204","author":"EA Levine","year":"2007","journal-title":"J Am Coll Surg"},{"issue":"6","key":"pone.0242816.ref006","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1097\/SLA.0b013e3181a45d86","article-title":"Should the treatment of peritoneal carcinomatosis by cytoreductive surgery and hyperthermic intraperitoneal chemotherapy still be regarded as a highly morbid procedure? 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