{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T03:08:28Z","timestamp":1783652908987,"version":"3.55.0"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T00:00:00Z","timestamp":1606694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013238","name":"Faculty of Medicine Siriraj Hospital, Mahidol University","doi-asserted-by":"publisher","award":["R015720002"],"award-info":[{"award-number":["R015720002"]}],"id":[{"id":"10.13039\/501100013238","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\"><jats:title>Background<\/jats:title><jats:p>No consensus has yet been reached regarding the best anesthetic technique for inguinal hernia repair. This study aimed to compare postoperative clinical outcomes and inflammatory markers among patients who were anesthetized using local, spinal, or general anesthesia for inguinal hernia repair.<\/jats:p><\/jats:sec><jats:sec id=\"sec002\"><jats:title>Methods<\/jats:title><jats:p>This randomized controlled trial included patients scheduled to undergo elective unilateral inguinal hernioplasty at Siriraj Hospital during November 2014 to September 2015 study period. Patients were randomly assigned to the local (LA), spinal (SA), or general (GA) anesthesia groups. Primary outcomes were postoperative pain at rest and on mobilization at 8 and 24 hours after surgery.<\/jats:p><\/jats:sec><jats:sec id=\"sec003\"><jats:title>Results<\/jats:title><jats:p>Fifty-four patients were included, with 18 patients randomly assigned to each group. Patient demographic and clinical characteristics were similar among groups. There were no significant differences among groups for postoperative pain at rest or on mobilization at 8 and 24 hours after surgery. No significant differences were observed for interleukin-1\u03b2, interleukin-6, and interleukin-10 at any time points in any groups. Patients with local anesthesia was associated with less time spent in anesthesia (<jats:italic>p<\/jats:italic>= 0.010) and surgery (<jats:italic>p<\/jats:italic>= 0.009), lower intraoperative cost (<jats:italic>p<\/jats:italic>= 0.003) and total cost in hospital (<jats:italic>p<\/jats:italic>= 0.036); however, patient satisfaction in the local anesthesia group (94\/100) was statistically significantly lower than the spinal and general anesthesia groups (100\/100) (<jats:italic>p<\/jats:italic>= 0.010).<\/jats:p><\/jats:sec><jats:sec id=\"sec004\"><jats:title>Conclusions<\/jats:title><jats:p>No statistically significant difference was observed among groups for postoperative pain scores, duration of hospital stays, complications, or change in inflammatory markers. However, time spent in anesthesia and surgery, the intraoperative cost and total cost for hernia repair, and patient satisfaction were significantly lower in the local anesthesia group than in the other two groups.<\/jats:p><\/jats:sec>","DOI":"10.1371\/journal.pone.0242925","type":"journal-article","created":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T18:28:46Z","timestamp":1606760926000},"page":"e0242925","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["Postoperative clinical outcomes and inflammatory markers after inguinal hernia repair using local, spinal, or general anesthesia: A randomized controlled trial"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4508-5661","authenticated-orcid":true,"given":"Mingkwan","family":"Wongyingsinn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasawang","family":"Kohmongkoludom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atthaphorn","family":"Trakarnsanga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navin","family":"Horthongkham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,11,30]]},"reference":[{"issue":"11","key":"pone.0242925.ref001","first-page":"1730","article-title":"Inguinal hernia repair. 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A prospective study of 100 consecutive patients with emphasis of perioperative morbidity and patient acceptance","volume":"112","author":"FC Chang","year":"1977","journal-title":"Arch Surg"},{"issue":"4","key":"pone.0242925.ref007","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1097\/01.SLA.0000059992.76731.64","article-title":"Local or general anesthesia for open hernia repair: a randomized trial","volume":"237","author":"PJ O\u2019Dwyer","year":"2003","journal-title":"Ann Surg"},{"issue":"4","key":"pone.0242925.ref008","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/bjs.1800680416","article-title":"Recurrent inguinal hernia after local anaesthetic repair","volume":"68","author":"AN Kingsnorth","year":"1981","journal-title":"Br J Surg"},{"issue":"1","key":"pone.0242925.ref009","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/01.sla.0000130726.03886.93","article-title":"Choice of anesthesia and risk of reoperation for recurrence in groin hernia 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