{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T15:20:39Z","timestamp":1781882439185,"version":"3.54.5"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2020,12,7]],"date-time":"2020-12-07T00:00:00Z","timestamp":1607299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"YuanLiTong Enterprise"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>PM<jats:sub>2.5<\/jats:sub> causes abnormal immune response and asthma in animals. In this study, a Balb\/c mouse animal model was exposed to PM<jats:sub>2.5<\/jats:sub> to induce asthma. <jats:italic>Lactobacillus paracasei<\/jats:italic> HB89 was fed at the same time, in order to observe whether <jats:italic>L<\/jats:italic>. <jats:italic>paracasei<\/jats:italic> HB89 mitigates respiratory tract allergies stimulated by PM<jats:sub>2.5<\/jats:sub>. The results showed that PM<jats:sub>2.5<\/jats:sub> stimulated a significant increase in white blood cells and immunoglobulin (IgE) in OVA-induced allergic Balb\/c mice, and IgE in the blood further triggered the release of histamine in the lung immune cells. This not only increased overall immune cell counts, but the lymphocyte counts also increased significantly, resulting in significant inhibitions of cytokines INF-r and TGF-\u03b2, and induction of IL-4, IL-5, IL-13 and IL-17a. After feeding with HB89, apart from the absence of observable changes in body weight, the total white blood cell count in the animal blood and IgE response were also be reduced; the proliferation of immune cells in the lungs caused by PM<jats:sub>2.5<\/jats:sub> was slowed down; and histamine and cytokines INF-r and TGF-\u03b2 were secreted in large quantities, but IL- 4, IL-5, IL-13, IL-17a were inhibited, which effectively reduced the possibility of asthma induction.<\/jats:p>","DOI":"10.1371\/journal.pone.0243062","type":"journal-article","created":{"date-parts":[[2020,12,7]],"date-time":"2020-12-07T21:34:51Z","timestamp":1607376891000},"page":"e0243062","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["Administration of Lactobacillus paracasei HB89 mitigates PM2.5-induced enhancement of inflammation and allergic airway response in murine asthma model"],"prefix":"10.1371","volume":"15","author":[{"given":"Ching-Hung","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Yi","family":"Tseng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1574-6425","authenticated-orcid":true,"given":"Ming-Wei","family":"Chao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,12,7]]},"reference":[{"issue":"9","key":"pone.0243062.ref001","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.jacc.2008.05.029","article-title":"Air pollution and cardiovascular injury epidemiology, toxicology, and mechanisms","volume":"52","author":"BZ Simkhovich","year":"2008","journal-title":"Journal of the American College of Cardiology"},{"issue":"7","key":"pone.0243062.ref002","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.tem.2015.05.002","article-title":"Epidemiology of air pollution and diabetes","volume":"26","author":"E Thiering","year":"2015","journal-title":"Trends in endocrinology and metabolism: TEM"},{"key":"pone.0243062.ref003","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.ijcard.2015.11.100","article-title":"Ambient air pollution and out-of-hospital cardiac arrest","volume":"203","author":"SH Kang","year":"2016","journal-title":"International journal of cardiology"},{"key":"pone.0243062.ref004","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.envint.2015.09.021","article-title":"Exposure to long-term air pollution and road traffic noise in relation to cholesterol: A cross-sectional study","volume":"85","author":"M Sorensen","year":"2015","journal-title":"Environment international"},{"issue":"1\u20133","key":"pone.0243062.ref005","first-page":"73","volume":"279","author":"M-W Chao","year":"2011","journal-title":"Diesel exhaust particle exposure causes redistribution of endothelial tube VE-cadherin"},{"key":"pone.0243062.ref006","unstructured":"(2015) E. 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