{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T04:12:46Z","timestamp":1747195966198,"version":"3.40.5"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T00:00:00Z","timestamp":1607040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Mercy Health Youngstown, LLC Medical Research Committee","award":["M2018-3"],"award-info":[{"award-number":["M2018-3"]}]},{"name":"Mercy Health Foundation Mahoning Valley"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>The objective of this study is to describe how screen-preventable loss of life (screen-PLL) can be used to analyze the distribution of life savings with mammographic screening. The determination of screen-PLL with mammography is possible using a natural history model of breast cancer that simulates clinical and pathologic events of this disease. This investigation uses a Monte Carlo Markov model with data from the Surveillance, Epidemiology, and End Results Program; American Cancer Society; and National Vital Statistics System. Populations of one million women per screening strategy are simulated over a lifetime with mammographic screening based on current guidelines of the American Cancer Society (ACS), United States Preventive Services Task Force (USPSTF), triennial screening from age 50\u201370, and no screening. Screen-PLL curves are generated and show guideline performance over a lifetime. The screen-PLL curve with no screening is determined by tumor discovery through clinical awareness and has the highest values of screen-PLL. The ACS and USPSTF strategies demonstrate screen-PLL curves favoring the elderly. The curve for triennial screening is more uniform than the ACS or USPSTF curves but could be improved by adding screen(s) at either end of the 50\u201370 age range. This study introduces the use of screen-PLL as a tool to improve the understanding of screening guidelines and allowing a more balanced allocation of life savings across an aging population. The method presented shows how screen-PLL can be used to analyze and potentially improve breast cancer screening guidelines.<\/jats:p>","DOI":"10.1371\/journal.pone.0243113","type":"journal-article","created":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T19:14:36Z","timestamp":1607109276000},"page":"e0243113","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["A method for evaluating breast cancer screening strategies using screen-preventable loss of life"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0079-2223","authenticated-orcid":true,"given":"Kimbroe J.","family":"Carter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Castro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0634-1688","authenticated-orcid":true,"given":"Roy N.","family":"Morcos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2020,12,4]]},"reference":[{"issue":"946","key":"pone.0243113.ref001","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1136\/pgmj.2003.018226","article-title":"History of medical screening: from concepts to action","volume":"80","author":"A Morabia","year":"2004","journal-title":"Postgrad Med J"},{"key":"pone.0243113.ref002","doi-asserted-by":"crossref","first-page":"57","DOI":"10.14694\/EdBook_AM.2015.35.57","article-title":"Early Detection of Breast Cancer: Past, Present, and Future","author":"JD Schiffman","year":"2015","journal-title":"Am Soc Clin Oncol Educ Book"},{"key":"pone.0243113.ref003","first-page":"1S","article-title":"Premature mortality in the United States: public health issues in the use of years of potential life lost","volume":"35","author":"Centers for Disease Control (CDC)","year":"1986","journal-title":"MMWR Suppl"},{"key":"pone.0243113.ref004","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/2049-3258-72-34","article-title":"Premature mortality in Belgium in 1993\u20132009: leading causes, regional disparities and 15 years change","volume":"72","author":"F Renard","year":"2014","journal-title":"Arch Public Health"},{"key":"pone.0243113.ref005","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1503\/cmaj.110334","article-title":"Canadian Task Force on Preventive Health Care. 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