{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:42:28Z","timestamp":1790196148010,"version":"4.1.0"},"reference-count":56,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T00:00:00Z","timestamp":1606953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background and purpose<\/jats:title>\n<jats:p>Ischemic stroke is a widespread disease carrying high morbidity and mortality. Transesophageal echocardiography (TEE) is considered an important tool in the work-up of patients with acute ischemic stroke (AIS) and transient ischemic attack (TIA) patients; its utility is limited by a semi-invasive nature. The purpose of this study was to evaluate the probability of treatment change due to TEE findings (yield) in the work-up of AIS and TIA patients.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Retrospective data on patients with AIS or TIA who underwent TEE examination between 2000\u20132013 were collected from the institutional registry.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>The average age of 1284 patients who were included in the study was 57\u00b110.4, 66% of patients were male. The most frequent TEE findings included aortic plaques in 54% and patent foramen ovale (PFO) in 15%. TEE findings led to treatment change in 135 (10.5%) patients; anticoagulant treatment was initiated in 110 of them (81%). Most common etiology for switch to anticoagulation was aortic plaques (71 patients); PFO was second most common reason (26 patients). Significant TEE findings (thrombus, endocarditis, tumor) were found in 1.9% of patients, they were more common in young patients (&lt;55; 56% of the patients).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>The beginning of anticoagulation treatment in patients with thick and complicated plaques was found frequently in our study. Significant TEE findings, were infrequent, constituted an absolute indication for treatment change and were more common in younger patients.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0243142","type":"journal-article","created":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T18:45:08Z","timestamp":1607021108000},"page":"e0243142","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["The effect of TEE on treatment change in patients with acute ischemic stroke"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9555-8044","authenticated-orcid":true,"given":"Polina","family":"Specktor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey","family":"Yalonetsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoram","family":"Agmon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliot","family":"Sprecher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faten Haj","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Telman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,12,3]]},"reference":[{"key":"pone.0243142.ref001","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1161\/01.STR.0000199613.38911.b2","article-title":"The lifetime risk of stroke: Estimates from the Framingham study","volume":"37","author":"S Seshadri","year":"2006","journal-title":"Stroke"},{"key":"pone.0243142.ref002","first-page":"388","article-title":"The national Israeli stroke registry: 2016\u20132017 report","author":"I Zuker","year":"2019","journal-title":"ICDC- Isr Cent Dis Control"},{"key":"pone.0243142.ref003","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/0140-6736(92)91658-U","article-title":"Epidemiology of stroke","volume":"339","author":"R Bonita","year":"1992","journal-title":"Lancet"},{"key":"pone.0243142.ref004","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1001\/archneur.1989.00520430021013","article-title":"Cardiogenic brain embolism. 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