{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T20:05:40Z","timestamp":1777320340963,"version":"3.51.4"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T00:00:00Z","timestamp":1606953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18590815"],"award-info":[{"award-number":["18590815"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21590898"],"award-info":[{"award-number":["21590898"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"name":"a Grant in Aid of Japanese Arteriosclerosis Prevention Fund"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Light to moderate alcohol consumption has protective effects on all-cause death and coronary artery disease in women. It is thought that light to moderate alcohol consumption has a beneficial effect on vascular function in women. We measured flow-mediated vasodilation (FMD) in 702 women aged 17\u201386 years who provided information on alcohol consumption. We divided the subjects into four groups: non-drinkers (0 g\/week), light drinkers (&gt;0 to 140 g\/week), moderate drinkers (&gt;140 to 280 g\/week) and heavy drinkers (&gt;280 g\/week). There was no significant difference in FMD among the four groups. Multivariate regression analysis revealed that alcohol consumption in non-drinkers and light drinkers was not an independent predictor of FMD (\u03b2 = \u22120.001, P = 0.98). We compared 50 moderate drinkers and 50 non-drinkers matched for age and medical histories and 22 heavy drinkers and 22 non-drinkers in matched pair analysis. There was no significant difference in FMD between moderate drinkers and non-drinkers (8.2\u00b14.3% vs. 8.1\u00b13.5, P = 0.91), while FMD in heavy drinkers was significantly lower than that in non-drinkers (5.9\u00b12.5% vs. 8.9\u00b13.5%, P = 0.002). These findings suggest that heavy alcohol consumption is associated with endothelial dysfunction but that light to moderate alcohol consumption is not associated with endothelial dysfunction in women.<\/jats:p>\n<jats:p><jats:bold>Clinical trial registration information<\/jats:bold> This study was approved by principal authorities and ethical issues in Japan (University Hospital Medical Information Network UMIN000012952, 01\/12\/2009). <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.umin.ac.jp\/\" xlink:type=\"simple\">www.umin.ac.jp\/<\/jats:ext-link>.<\/jats:p>","DOI":"10.1371\/journal.pone.0243216","type":"journal-article","created":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T18:46:06Z","timestamp":1607021166000},"page":"e0243216","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["Endothelial function is preserved in light to moderate alcohol drinkers but is impaired in heavy drinkers in women: Flow-mediated Dilation Japan (FMD-J) study"],"prefix":"10.1371","volume":"15","author":[{"given":"Nozomu","family":"Oda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Kajikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Maruhashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Kishimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farina Mohamad","family":"Yusoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chikara","family":"Goto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayumu","family":"Nakashima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirofumi","family":"Tomiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bonpei","family":"Takase","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Yamashina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5813-3672","authenticated-orcid":true,"given":"Yukihito","family":"Higashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2020,12,3]]},"reference":[{"key":"pone.0243216.ref001","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.3109\/10826088109039174","article-title":"Alcohol abuse in ancient Egypt: the recorded evidence","volume":"16","author":"N. el-Guebaly","year":"1981","journal-title":"Int J Addict"},{"key":"pone.0243216.ref002","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1111\/j.1360-0443.2009.02696.x","article-title":"Gender and alcohol consumption: patterns from the multinational GENACIS project","volume":"104","author":"R. 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