{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T15:23:19Z","timestamp":1778944999381,"version":"3.51.4"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T00:00:00Z","timestamp":1607904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>This study reviewed 395 young adults, 18\u201335 year-old, admitted for COVID-19 to one of the eleven hospitals in New York City public health system. Demographics, comorbidities, clinical course, outcomes and characteristics linked to hospitalization were analyzed including temporal survival analysis. Fifty-seven percent of patients had a least one major comorbidity. Mortality without comorbidity was in 3.8% patients. Further investigation of admission features and medical history was conducted. Comorbidities associated with mortality were diabetes (n = 54 deceased\/73 diagnosed,74% tested POS;98.2% with diabetic history deceased; Wilcoxon p (<jats:italic>Wp<\/jats:italic>) = .044), hypertension (14\/44,32% POS, 25.5%;<jats:italic>Wp<\/jats:italic>= 0.030), renal (6\/16, 37.5% POS,11%;<jats:italic>Wp<\/jats:italic>= 0.000), and cardiac (6\/21, 28.6% POS,11%;<jats:italic>Wp<\/jats:italic>= 0.015). Kaplan survival plots were statistically significant for these four indicators. Data suggested glucose &gt;215 or hemoglobin A1c &gt;9.5 for young adults on admission was associated with increased mortality. Clinically documented respiratory distress on admission was statistically significant outcome related to mortality (<jats:italic>X<\/jats:italic><jats:sup>2<\/jats:sup>= 236.6842, df = 1, p &lt; .0001). Overall, 28.9% required supportive oxygen beyond nasal cannula. Nasal cannula oxygen alone was required for 71.1%, who all lived. Non-invasive ventilation was required for 7.8%, and invasive mechanical ventilation 21.0% (in which 7.3% lived, 13.7% died). Temporal survival analysis demonstrated statistically significant response for Time to Death &lt;10 days (<jats:italic>X<\/jats:italic><jats:sup>2<\/jats:sup>= 18.508, df = 1, p = .000); risk lessened considerably for 21 day cut off (<jats:italic>X<\/jats:italic><jats:sup>2<\/jats:sup>= 3.464, df = 1, p = .063), followed by 31 or more days of hospitalization (<jats:italic>X<\/jats:italic><jats:sup>2<\/jats:sup>= 2.212, df = 1, p = .137).<\/jats:p>","DOI":"10.1371\/journal.pone.0243343","type":"journal-article","created":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T18:45:49Z","timestamp":1607971549000},"page":"e0243343","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":49,"title":["Characteristics, comorbidities and survival analysis of young adults hospitalized with COVID-19 in New York City"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4511-3183","authenticated-orcid":true,"given":"Brian L.","family":"Altonen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana 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