{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T16:30:37Z","timestamp":1772209837307,"version":"3.50.1"},"reference-count":12,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T00:00:00Z","timestamp":1607472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"\n Objectives<\/jats:title>\n We report on the key clinical predictors of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and present a clinical decision rule that can risk stratify patients for COVID-19.<\/jats:p>\n <\/jats:sec>\n \n Design, participants and setting<\/jats:title>\n A prospective cohort of patients assessed for COVID-19 at a screening clinic in Melbourne, Australia. The primary outcome was a positive COVID-19 test from nasopharyngeal swab. A backwards stepwise logistic regression was used to derive a model of clinical variables predictive of a positive COVID-19 test. Internal validation of the final model was performed using bootstrapped samples and the model scoring derived from the coefficients, with modelling performed for increasing prevalence.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Of 4226 patients with suspected COVID-19 who were assessed, 2976 patients underwent SARS-CoV-2 testing (n = 108 SARS-CoV-2 positive) and were used to determine factors associated with a positive COVID-19 test. The 7 features associated with a positive COVID-19 test on multivariable analysis were:\n C<\/jats:bold>\n OVID-19 patient exposure or international travel,\n M<\/jats:bold>\n yalgia\/malaise,\n A<\/jats:bold>\n nosmia or ageusia,\n T<\/jats:bold>\n emperature,\n C<\/jats:bold>\n oryza\/sore throat,\n H<\/jats:bold>\n ypoxia\u2013oxygen saturation < 97%,\n 65<\/jats:bold>\n years or older\u2014summarized in the mnemonic\n C<\/jats:bold>\n OVID-\n MATCH65<\/jats:bold>\n . Internal validation showed an AUC of 0.836. A cut-off of \u2265 1.5 points was associated with a 92.6% sensitivity and 99.5% negative predictive value (NPV) for COVID-19.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n From the largest prospective outpatient cohort of suspected COVID-19 we define the clinical factors predictive of a positive SARS-CoV-2 test. The subsequent clinical decision rule, COVID-MATCH65, has a high sensitivity and NPV for SARS-CoV-2 and can be employed in the pandemic, adjusted for disease prevalence, to aid COVID-19 risk-assessment and vital testing resource allocation.<\/jats:p>\n <\/jats:sec>","DOI":"10.1371\/journal.pone.0243414","type":"journal-article","created":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T18:49:21Z","timestamp":1607539761000},"page":"e0243414","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["COVID-MATCH65\u2014A prospectively derived clinical decision rule for severe acute respiratory syndrome coronavirus 2"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5111-6367","authenticated-orcid":true,"given":"Jason A.","family":"Trubiano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Vogrin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia C.","family":"Smibert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nada","family":"Marhoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian A.","family":"Alexander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyra Y. L.","family":"Chua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fiona L.","family":"James","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas R. L.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sam E.","family":"Grigg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia L. 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