{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T05:38:37Z","timestamp":1783575517540,"version":"3.55.0"},"reference-count":15,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T00:00:00Z","timestamp":1609113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>The global burden of cancer continues to increase largely because of the aging and growth of the world population alongside an increasing adoption of cancer-causing behaviors. Hence, the purpose of this study was to identify determinants of Non-Hodgkin lymphoma cancer among individuals who diagnosed at the Felegehiwot specialized hospital, North West Ethiopia, 2019.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>An institution-based unmatched case-control study was conducted at the Felegehiwot Specialized hospital from December 2018 up to June 2019. The sample size calculated using the two-population proportion formula. The final sample size was 486, (162 cases and 324 controls). The simple random sampling method was employed to catch up with the estimated samples. The collected data entered into the Epi-data version 3.1 software and analyzed using SPSS version 21 software. Descriptive statistics computed. Simple logistic analysis was run (at 95% CI and p-value &lt; 0.05) to identify the determinants of non-Hodgkin\u2019s lymphoma.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Result<\/jats:title>\n<jats:p>A total of 486 patients participated. Nearly one-third of the cases and controls were in the age group of 46\u201360 years. About 90% of cases and 91% of controls were orthodox Christian. Monthly income of \u226428 dollars (AOR = 2. 73, 95%CI: 1. 8, 4.2), male sex (AOR = 1. 8, 95%CI: 1.2, 2.8), ever had chemical exposure, (AOR = 11. 9, 95%CI: 7.6, 18.8), no regular physical exercise (AOR = 15. 5, 95%CI: 5.7, 42.3), and having hypertension [AOR = 0. 03; 95%CI:0.005, 0.2), lung disease (AOR = 0. 2; 95%CI: 0.06, 0.7), and chronic kidney and cardiac diseases (AOR = 0. 06; 95%CI: 0.01, 0.2) were the determinants of non-Hodgkin\u2019s lymphoma.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>The findings in this study suggest that having a low monthly income, being male sex, ever had chemical exposure, not engaged in regular physical exercise, and being diabetic were the determinants of non-Hodgkin\u2019s lymphoma.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0243561","type":"journal-article","created":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T19:16:22Z","timestamp":1609182982000},"page":"e0243561","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Determinants of non-Hodgkin\u2019s lymphoma at Felegehiwot specialized hospital, North West Ethiopia: A case-control study"],"prefix":"10.1371","volume":"15","author":[{"given":"Dessalegn","family":"Chekol","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melkamu","family":"Bedimo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihun","family":"Mulugeta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5073-6767","authenticated-orcid":true,"given":"Getasew Mulat","family":"Bantie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,12,28]]},"reference":[{"issue":"6","key":"pone.0243561.ref001","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1111\/j.1365-2141.2011.08772.x","article-title":"Lymphomas in sub\u2014Saharan Africa\u2013what can we learn and how can we help in improving diagnosis, managing patients and fostering translational research?","volume":"154","author":"KN Naresh","year":"2011","journal-title":"British journal of haematology"},{"issue":"106","key":"pone.0243561.ref002","article-title":"Patterns of Cancer in University of Gondar Hospital: North-West Ethiopia","volume":"1","author":"B Tefera","year":"2016","journal-title":"Journal of Oncology Medicine and Practice"},{"key":"pone.0243561.ref003","unstructured":"Organization WH. 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Lung Cancer. 2018."},{"issue":"1","key":"pone.0243561.ref004","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1542\/peds.110.1.42","article-title":"Psychological outcomes in long-term survivors of childhood leukemia, Hodgkin\u2019s disease, and non-Hodgkin\u2019s lymphoma: a report from the Childhood Cancer Survivor Study","volume":"110","author":"BJ Zebrack","year":"2002","journal-title":"Pediatrics"},{"issue":"2","key":"pone.0243561.ref005","doi-asserted-by":"crossref","first-page":"775","DOI":"10.7314\/APJCP.2013.14.2.775","article-title":"Case-control study of risk factors for Non-Hodgkin lymphoma in Mumbai, India","volume":"14","author":"G Balasubramaniam","year":"2013","journal-title":"Asian Pacific Journal of Cancer Prevention"},{"issue":"4","key":"pone.0243561.ref006","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1093\/jnci\/89.4.314","article-title":"Medical history risk factors for non-Hodgkin\u2019s lymphoma in older women","volume":"89","author":"JR Cerhan","year":"1997","journal-title":"Journal of the National Cancer Institute"},{"issue":"3","key":"pone.0243561.ref007","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1023\/A:1011274922701","article-title":"Environmental risk factors for non-Hodgkin\u2019s lymphoma: a population-based case\u2013control study in Languedoc-Roussillon, France","volume":"12","author":"P Fabbro-Peray","year":"2001","journal-title":"Cancer Causes & Control"},{"issue":"6","key":"pone.0243561.ref008","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1002\/(SICI)1097-0142(19990315)85:6<1353::AID-CNCR19>3.0.CO;2-1","article-title":"A case\u2013control study of non\u2010Hodgkin lymphoma and exposure to pesticides","volume":"85","author":"L Hardell","year":"1999","journal-title":"Cancer"},{"issue":"5","key":"pone.0243561.ref009","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1038\/bjc.2012.3","article-title":"Socioeconomic position, treatment, and survival of non-Hodgkin lymphoma in Denmark\u2013a nationwide study","volume":"106","author":"BL Frederiksen","year":"2012","journal-title":"British journal of cancer"},{"issue":"6","key":"pone.0243561.ref010","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1517\/17530059.2011.618185","article-title":"Risk factors of non-Hodgkin\u2019s lymphoma","volume":"5","author":"Y Zhang","year":"2011","journal-title":"Expert opinion on medical diagnostics"},{"key":"pone.0243561.ref011","doi-asserted-by":"crossref","first-page":"25768","DOI":"10.1038\/srep25768","article-title":"Exposure to organochlorine pesticides and non-Hodgkin lymphoma: a meta-analysis of observational studies","volume":"6","author":"D Luo","year":"2016","journal-title":"Scientific reports"},{"key":"pone.0243561.ref012","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/978930","article-title":"Current understanding of lifestyle and environmental factors and risk of non-hodgkin lymphoma: an epidemiological update","volume":"2012","author":"BA Bassig","year":"2012","journal-title":"Journal of cancer epidemiology"},{"issue":"3","key":"pone.0243561.ref013","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1158\/1055-9965.EPI-06-1081","article-title":"Obesity, diet and risk of non-Hodgkin lymphoma","volume":"16","author":"CF Skibola","year":"2007","journal-title":"Cancer Epidemiology and Prevention Biomarkers"},{"issue":"12","key":"pone.0243561.ref014","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1093\/aje\/kwi342","article-title":"Physical activity, obesity, energy intake, and the risk of non-Hodgkin\u2019s lymphoma: a population-based case-control study","volume":"162","author":"SY Pan","year":"2005","journal-title":"American journal of epidemiology"},{"issue":"12","key":"pone.0243561.ref015","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.2337\/dc08-1034","article-title":"Diabetes and risk of Non-Hodgkin\u2019s lymphoma: a meta-analysis of observational studies","volume":"31","author":"J Mitri","year":"2008","journal-title":"Diabetes care"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0243561","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T19:16:55Z","timestamp":1609183015000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0243561"}},"subtitle":[],"editor":[{"given":"Yan","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,12,28]]},"references-count":15,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2020,12,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0243561","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,28]]}}}