{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T19:22:36Z","timestamp":1762543356148,"version":"3.37.3"},"reference-count":66,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T00:00:00Z","timestamp":1607904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN\/06221-2015"],"award-info":[{"award-number":["RGPIN\/06221-2015"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Studies of the neural basis of human pain processing present many challenges because of the subjective and variable nature of pain, and the inaccessibility of the central nervous system. Neuroimaging methods, such as functional magnetic resonance imaging (fMRI), have provided the ability to investigate these neural processes, and yet commonly used analysis methods may not be optimally adapted for studies of pain. Here we present a comparison of model-driven and data-driven analysis methods, specifically for the study of human pain processing. Methods are tested using data from healthy control participants in two previous studies, with separate data sets spanning the brain, and the brainstem and spinal cord. Data are analyzed by fitting time-series responses to predicted BOLD responses in order to identify significantly responding regions (model-driven), as well as with connectivity analyses (data-driven) based on temporal correlations between responses in spatially separated regions, and with connectivity analyses based on structural equation modeling, allowing for multiple source regions to explain the signal variations in each target region. The results are assessed in terms of the amount of signal variance that can be explained in each region, and in terms of the regions and connections that are identified as having BOLD responses of interest. The characteristics of BOLD responses in identified regions are also investigated. The results demonstrate that data-driven approaches are more effective than model-driven approaches for fMRI studies of pain.<\/jats:p>","DOI":"10.1371\/journal.pone.0243723","type":"journal-article","created":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T18:43:48Z","timestamp":1607971428000},"page":"e0243723","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["A comparison of the effectiveness of functional MRI analysis methods for pain research: The new normal"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9814-260X","authenticated-orcid":true,"given":"Patrick W.","family":"Stroman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2966-169X","authenticated-orcid":true,"given":"Howard J. M.","family":"Warren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1750-2341","authenticated-orcid":true,"given":"Gabriela","family":"Ioachim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jocelyn M.","family":"Powers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaitlin","family":"McNeil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2020,12,14]]},"reference":[{"issue":"6","key":"pone.0243723.ref001","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0301-0082(02)00009-6","article-title":"Descending control of pain","volume":"66","author":"MJ Millan","year":"2002","journal-title":"Progress in neurobiology"},{"issue":"3","key":"pone.0243723.ref002","first-page":"249","article-title":"Pain terms: a list with definitions and notes on usage. Recommended by the IASP Subcommittee on Taxonomy.","volume":"6","year":"1979","journal-title":"Pain"},{"key":"pone.0243723.ref003","unstructured":"The Canadian Pain Coalition. The Status of Pain in Canada\u2013moving toward a Canadian Pain Strategy. Brief for the Parliamentary Committee on Palliative and Compassionate Care. Ottawa2010."},{"issue":"2","key":"pone.0243723.ref004","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1097\/SPC.0000000000000055","article-title":"Descending pain modulation and chronification of pain","volume":"8","author":"MH Ossipov","year":"2014","journal-title":"Current opinion in supportive and palliative care"},{"issue":"7","key":"pone.0243723.ref005","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/papr.12145","article-title":"The role of descending inhibitory pathways on chronic pain modulation and clinical implications","volume":"14","author":"M Kwon","year":"2014","journal-title":"Pain practice: the official journal of World Institute of Pain"},{"issue":"11","key":"pone.0243723.ref006","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1016\/j.jpain.2009.09.001","article-title":"How neuroimaging studies have challenged us to rethink: is chronic pain a disease?","volume":"10","author":"I Tracey","year":"2009","journal-title":"The journal of pain: official journal of the American Pain Society."},{"issue":"4","key":"pone.0243723.ref007","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.ejpain.2004.11.001","article-title":"Human brain mechanisms of pain perception and regulation in health and disease","volume":"9","author":"AV Apkarian","year":"2005","journal-title":"Eur J Pain"},{"issue":"15","key":"pone.0243723.ref008","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1056\/NEJMoa1204471","article-title":"An fMRI-based neurologic signature of physical pain","volume":"368","author":"TD Wager","year":"2013","journal-title":"N Engl J Med"},{"issue":"5422","key":"pone.0243723.ref009","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1126\/science.284.5422.1979","article-title":"Dissociating pain from its anticipation in the human brain","volume":"284","author":"A Ploghaus","year":"1999","journal-title":"Science"},{"issue":"1","key":"pone.0243723.ref010","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.pneurobio.2010.10.005","article-title":"The pain matrix reloaded: a salience detection system for the body","volume":"93","author":"V Legrain","year":"2011","journal-title":"Progress in neurobiology"},{"issue":"4","key":"pone.0243723.ref011","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1002\/hbm.23106","article-title":"FMRI of spinal and supra-spinal correlates of temporal pain summation in fibromyalgia patients","volume":"37","author":"RL Bosma","year":"2016","journal-title":"Hum Brain Mapp"},{"key":"pone.0243723.ref012","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.neuroscience.2015.08.059","article-title":"Inter-individual differences in pain processing investigated by functional magnetic resonance imaging of the brainstem and spinal cord","volume":"307","author":"HS Khan","year":"2015","journal-title":"Neuroscience"},{"issue":"5","key":"pone.0243723.ref013","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1002\/jmri.24656","article-title":"Spinal cord response to stepwise and block presentation of thermal stimuli: a functional MRI study","volume":"41","author":"RL Bosma","year":"2015","journal-title":"J Magn Reson Imaging"},{"issue":"10","key":"pone.0243723.ref014","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.jpain.2014.07.006","article-title":"Music modulation of pain perception and pain-related activity in the brain, brain stem, and spinal cord: a functional magnetic resonance imaging study.","volume":"15","author":"CE Dobek","year":"2014","journal-title":"The journal of pain: official journal of the American Pain Society."},{"issue":"11","key":"pone.0243723.ref015","doi-asserted-by":"crossref","first-page":"e112325","DOI":"10.1371\/journal.pone.0112325","article-title":"Spinal fMRI reveals decreased descending inhibition during secondary mechanical hyperalgesia.","volume":"9","author":"T Rempe","year":"2014","journal-title":"PLoS One."},{"issue":"9","key":"pone.0243723.ref016","doi-asserted-by":"crossref","first-page":"e45560","DOI":"10.1371\/journal.pone.0045560","article-title":"Plasticity of the injured human spinal cord: insights revealed by spinal cord functional MRI.","volume":"7","author":"DW Cadotte","year":"2012","journal-title":"PLoS One."},{"key":"pone.0243723.ref017","article-title":"Changes in Pain Processing in the Spinal Cord and Brainstem after Spinal Cord Injury Characterized by Functional Magnetic Resonance Imaging.","author":"PW Stroman","year":"2016","journal-title":"J Neurotrauma"},{"key":"pone.0243723.ref018","article-title":"Diversity in the emotional modulation of pain perception: An account of individual variability.","author":"TA McIver","year":"2017","journal-title":"Eur J Pain"},{"issue":"1\u20132","key":"pone.0243723.ref019","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1615\/CritRevBiomedEng.2016016541","article-title":"Functional Magnetic Resonance Imaging of the Human Brainstem and Cervical Spinal Cord during Cognitive Modulation of Pain","volume":"44","author":"RH Leung","year":"2016","journal-title":"Crit Rev Biomed Eng"},{"issue":"12","key":"pone.0243723.ref020","doi-asserted-by":"crossref","first-page":"5038","DOI":"10.1002\/hbm.22993","article-title":"Neural correlates of temporal summation of second pain in the human brainstem and spinal cord","volume":"36","author":"RL Bosma","year":"2015","journal-title":"Hum Brain Mapp"},{"issue":"11","key":"pone.0243723.ref021","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.cub.2012.04.006","article-title":"Attention modulates spinal cord responses to pain","volume":"22","author":"C Sprenger","year":"2012","journal-title":"Curr Biol"},{"issue":"5951","key":"pone.0243723.ref022","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1126\/science.1180142","article-title":"Direct evidence for spinal cord involvement in placebo analgesia","volume":"326","author":"F Eippert","year":"2009","journal-title":"Science"},{"issue":"6359","key":"pone.0243723.ref023","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1126\/science.aan1221","article-title":"Interactions between brain and spinal cord mediate value effects in nocebo hyperalgesia","volume":"358","author":"A Tinnermann","year":"2017","journal-title":"Science"},{"issue":"34","key":"pone.0243723.ref024","doi-asserted-by":"crossref","first-page":"13784","DOI":"10.1523\/JNEUROSCI.2191-13.2013","article-title":"Facilitation of pain in the human spinal cord by nocebo treatment","volume":"33","author":"S Geuter","year":"2013","journal-title":"J Neurosci"},{"key":"pone.0243723.ref025","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.neuroimage.2016.02.058","article-title":"Reproducibility of resting state spinal cord networks in healthy volunteers at 7 Tesla.","volume":"133","author":"RL Barry","year":"2016","journal-title":"Neuroimage"},{"key":"pone.0243723.ref026","doi-asserted-by":"crossref","first-page":"e02812","DOI":"10.7554\/eLife.02812","article-title":"Resting state functional connectivity in the human spinal cord.","volume":"3","author":"RL Barry","year":"2014","journal-title":"eLife"},{"issue":"50","key":"pone.0243723.ref027","doi-asserted-by":"crossref","first-page":"18067","DOI":"10.1073\/pnas.1414293111","article-title":"Intrinsically organized resting state networks in the human spinal cord","volume":"111","author":"Y Kong","year":"2014","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"2","key":"pone.0243723.ref028","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s00421-009-1205-4","article-title":"Resting state networks in human cervical spinal cord observed with fMRI","volume":"108","author":"P Wei","year":"2010","journal-title":"European journal of applied physiology"},{"key":"pone.0243723.ref029","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.neuroscience.2019.02.009","article-title":"Investigation of Resting-State BOLD Networks in the Human Brainstem and Spinal Cord","volume":"404","author":"S Harita","year":"2019","journal-title":"Neuroscience"},{"issue":"5","key":"pone.0243723.ref030","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1089\/brain.2018.0659","article-title":"Comparing Coordinated Networks Across the Brainstem and Spinal Cord in the Resting State and Altered Cognitive State","volume":"9","author":"G Ioachim","year":"2019","journal-title":"Brain connectivity"},{"issue":"6","key":"pone.0243723.ref031","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1002\/mrm.26606","article-title":"Confirmation of resting-state BOLD fluctuations in the human brainstem and spinal cord after identification and removal of physiological noise","volume":"78","author":"S Harita","year":"2017","journal-title":"Magn Reson Med"},{"key":"pone.0243723.ref032","article-title":"Pain processing in the human brainstem and spinal cord before, during, and after the application of noxious heat stimuli","author":"PW Stroman","year":"2018","journal-title":"Pain"},{"issue":"12","key":"pone.0243723.ref033","doi-asserted-by":"crossref","first-page":"e0167317","DOI":"10.1371\/journal.pone.0167317","article-title":"Continuous Descending Modulation of the Spinal Cord Revealed by Functional MRI.","volume":"11","author":"PW Stroman","year":"2016","journal-title":"PLoS One."},{"key":"pone.0243723.ref034","article-title":"Pain Processing in the Human Brainstem and Spinal Cord Before, During and After Expected Noxious Heat Stimuli","author":"PW Stroman","year":"2018","journal-title":"Pain"},{"issue":"2","key":"pone.0243723.ref035","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/mrm.1910250220","article-title":"Time course EPI of human brain function during task activation","volume":"25","author":"PA Bandettini","year":"1992","journal-title":"Magn ResonMed"},{"key":"pone.0243723.ref036","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/hbm.460010207","article-title":"Analysis of functional MRI time-series.","volume":"1","author":"KJ Friston","year":"1994","journal-title":"HumBrain Mapp."},{"key":"pone.0243723.ref037","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.neuroimage.2016.04.006","article-title":"The connectivity domain: Analyzing resting state fMRI data using feature-based data-driven and model-based methods.","volume":"134","author":"A Iraji","year":"2016","journal-title":"Neuroimage"},{"issue":"6843","key":"pone.0243723.ref038","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/35084005","article-title":"Neurophysiological investigation of the basis of the fMRI signal","volume":"412","author":"NK Logothetis","year":"2001","journal-title":"Nature"},{"issue":"1","key":"pone.0243723.ref039","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1089\/brain.2011.0008","article-title":"Functional and effective connectivity: a review","volume":"1","author":"KJ Friston","year":"2011","journal-title":"Brain connectivity"},{"issue":"4","key":"pone.0243723.ref040","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1002\/mrm.1910340409","article-title":"Functional connectivity in the motor cortex of resting human brain using echo-planar MRI","volume":"34","author":"B Biswal","year":"1995","journal-title":"Magn ResonMed"},{"issue":"4","key":"pone.0243723.ref041","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1615\/CritRevBiomedEng.2017020438","article-title":"Validation of Structural Equation Modeling Methods for Functional MRI Data Acquired in the Human Brainstem and Spinal Cord.","volume":"44","author":"PW Stroman","year":"2016","journal-title":"Crit Rev Biomed Eng."},{"issue":"Pt 2","key":"pone.0243723.ref042","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.2044-8317.1984.tb00802.x","article-title":"Some algebraic properties of the Reticular Action Model for moment structures","volume":"37","author":"JJ McArdle","year":"1984","journal-title":"The British journal of mathematical and statistical psychology"},{"issue":"2","key":"pone.0243723.ref043","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1152\/jn.1997.78.2.992","article-title":"Characteristics of temporal summation of second pain sensations elicited by brief contact of glabrous skin by a preheated thermode.","volume":"78","author":"CJ Vierck","year":"1997","journal-title":"Journal of neurophysiology"},{"issue":"173","key":"pone.0243723.ref044","first-page":"1","article-title":"Ten Key Insights into the Use of Spinal Cord fMRI","volume":"8","author":"JM Powers","year":"2018","journal-title":"Brain sciences"},{"issue":"5","key":"pone.0243723.ref045","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.mri.2014.01.007","article-title":"Assessment of data acquisition parameters, and analysis techniques for noise reduction in spinal cord fMRI data","volume":"32","author":"RL Bosma","year":"2014","journal-title":"Magn Reson Imaging"},{"issue":"1\u20132","key":"pone.0243723.ref046","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/nbm.1940070104","article-title":"Spin-echo and gradient-echo EPI of human brain activation using BOLD contrast: a comparative study at 1.5 T","volume":"7","author":"PA Bandettini","year":"1994","journal-title":"NMR Biomed"},{"issue":"3","key":"pone.0243723.ref047","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1006\/nimg.2001.1005","article-title":"An Investigation of the Value of Spin-Echo-Based fMRI Using a Stroop Color\u2014Word Matching Task and EPI at 3 T.","volume":"15","author":"DG Norris","year":"2002","journal-title":"Neuroimage"},{"issue":"15","key":"pone.0243723.ref048","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1089\/neu.2015.4257","article-title":"Changes in Pain Processing in the Spinal Cord and Brainstem after Spinal Cord Injury Characterized by Functional Magnetic Resonance Imaging","volume":"33","author":"PW Stroman","year":"2016","journal-title":"Journal of Neurotrauma"},{"issue":"11","key":"pone.0243723.ref049","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0112325","article-title":"Spinal fMRI Reveals Decreased Descending Inhibition during Secondary Mechanical Hyperalgesia.","volume":"9","author":"T Rempe","year":"2014","journal-title":"PLoS ONE."},{"issue":"1","key":"pone.0243723.ref050","doi-asserted-by":"crossref","first-page":"102","DOI":"10.3171\/2012.5.AOSPINE1278","article-title":"A systematic review of spinal fMRI research: outlining the elements of experimental design","volume":"17","author":"DW Cadotte","year":"2012","journal-title":"J Neurosurg Spine"},{"issue":"11","key":"pone.0243723.ref051","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1109\/TMI.2010.2053043","article-title":"Intensity-based image registration by minimizing residual complexity","volume":"29","author":"A Myronenko","year":"2010","journal-title":"IEEE Trans Med Imaging"},{"key":"pone.0243723.ref052","article-title":"Validation of structural equation modeling (SEM) methods for functional MRI data acquired in the human brainstem and spinal cord.","author":"PW Stroman","year":"2017","journal-title":"Critical Reviews in Biomedical Engineering"},{"key":"pone.0243723.ref053","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.neuroimage.2017.10.041","article-title":"PAM50: Unbiased multimodal template of the brainstem and spinal cord aligned with the ICBM152 space.","volume":"165","author":"B De Leener","year":"2018","journal-title":"Neuroimage"},{"key":"pone.0243723.ref054","first-page":"79","volume-title":"INTERNAL ARCHITECTURE OF THE BRAIN STEM WITH KEY AXIAL SECTIONS. Duvernoy's Atlas of the Human Brain Stem and Cerebellum","author":"DH Naidich TP","year":"2009"},{"issue":"3","key":"pone.0243723.ref055","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1089\/brain.2012.0073","article-title":"Conn: a functional connectivity toolbox for correlated and anticorrelated brain networks.","volume":"2","author":"S Whitfield-Gabrieli","year":"2012","journal-title":"Brain connectivity"},{"issue":"Pt A","key":"pone.0243723.ref056","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.neuroimage.2016.10.009","article-title":"SCT: Spinal Cord Toolbox, an open-source software for processing spinal cord MRI data.","volume":"145","author":"B De Leener","year":"2017","journal-title":"Neuroimage"},{"issue":"4","key":"pone.0243723.ref057","first-page":"417","article-title":"Fila radicularia of the ventral and dorsal radices of the human spinal cord","volume":"128","author":"J Lang","year":"1982","journal-title":"Gegenbaurs Morphol Jahrb"},{"issue":"8","key":"pone.0243723.ref058","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1002\/hbm.24935","article-title":"In vivo anatomical mapping of human locus coeruleus functional connectivity at 3 T MRI.","volume":"41","author":"T Liebe","year":"2020","journal-title":"Hum Brain Mapp."},{"issue":"42","key":"pone.0243723.ref059","doi-asserted-by":"crossref","first-page":"8225","DOI":"10.1523\/JNEUROSCI.1162-19.2019","article-title":"Parabrachial Complex: A Hub for Pain and Aversion","volume":"39","author":"MC Chiang","year":"2019","journal-title":"J Neurosci"},{"key":"pone.0243723.ref060","first-page":"79","volume-title":"INTERNAL ARCHITECTURE OF THE BRAIN STEM WITH KEY AXIAL SECTIONS. Duvernoy's Atlas of the Human Brain Stem and Cerebellum","author":"TP Naidich","year":"2009"},{"volume-title":"Co-planar stereotaxic atlas of the human brain.","year":"1988","author":"J Talairach","key":"pone.0243723.ref061"},{"issue":"3","key":"pone.0243723.ref062","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/joa.12493","article-title":"'Herde K. Revisiting the segmental organization of the human spinal cord","volume":"229","author":"D Leijnse JN","year":"2016","journal-title":"J Anat"},{"key":"pone.0243723.ref063","doi-asserted-by":"crossref","first-page":"180063","DOI":"10.1038\/sdata.2018.63","article-title":"A high-resolution probabilistic in vivo atlas of human subcortical brain nuclei","volume":"5","author":"WM Pauli","year":"2018","journal-title":"Scientific data"},{"issue":"4","key":"pone.0243723.ref064","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.neuroimage.2009.06.012","article-title":"In vivo mapping of the human locus coeruleus","volume":"47","author":"NI Keren","year":"2009","journal-title":"Neuroimage"},{"issue":"6","key":"pone.0243723.ref065","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1097\/NEN.0b013e3182588293","article-title":"Neuroanatomic connectivity of the human ascending arousal system critical to consciousness and its disorders","volume":"71","author":"BL Edlow","year":"2012","journal-title":"Journal of neuropathology and experimental neurology"},{"issue":"3","key":"pone.0243723.ref066","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1006\/nimg.1995.1023","article-title":"Analysis of fMRI time-series revisited\u2014again.","volume":"2","author":"KJ Worsley","year":"1995","journal-title":"NeuroImage"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0243723","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,17]],"date-time":"2021-04-17T14:23:02Z","timestamp":1618669382000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0243723"}},"subtitle":[],"editor":[{"given":"Niels","family":"Bergsland","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,12,14]]},"references-count":66,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2020,12,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0243723","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2020,12,14]]}}}